JP2005536464A - カンプトテシンのハロアルキルエステルおよびこれらの化合物を使用する癌治療方法 - Google Patents

カンプトテシンのハロアルキルエステルおよびこれらの化合物を使用する癌治療方法 Download PDF

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Publication number
JP2005536464A
JP2005536464A JP2004503475A JP2004503475A JP2005536464A JP 2005536464 A JP2005536464 A JP 2005536464A JP 2004503475 A JP2004503475 A JP 2004503475A JP 2004503475 A JP2004503475 A JP 2004503475A JP 2005536464 A JP2005536464 A JP 2005536464A
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Prior art keywords
cancer
tumor
composition
compound
group
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JP2004503475A
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Japanese (ja)
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JP2005536464A5 (https=
Inventor
ジソン，カオ
ベッピーノ，ジョバネラ，シー．
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Stehlin Foundation for Cancer Research
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Stehlin Foundation for Cancer Research
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Publication of JP2005536464A publication Critical patent/JP2005536464A/ja
Publication of JP2005536464A5 publication Critical patent/JP2005536464A5/ja
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/22—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains four or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
JP2004503475A 2002-05-06 2003-04-22 カンプトテシンのハロアルキルエステルおよびこれらの化合物を使用する癌治療方法 Pending JP2005536464A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10/139,817 US6703399B2 (en) 2002-05-06 2002-05-06 Halo-alkyl esters of camptothecins and methods of treating cancer using these compounds
PCT/US2003/012650 WO2003095461A1 (en) 2002-05-06 2003-04-22 Halo-alkyl esters of camptothecins and methods of treating cancer using these compounds

Publications (2)

Publication Number Publication Date
JP2005536464A true JP2005536464A (ja) 2005-12-02
JP2005536464A5 JP2005536464A5 (https=) 2006-06-01

Family

ID=29399359

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2004503475A Pending JP2005536464A (ja) 2002-05-06 2003-04-22 カンプトテシンのハロアルキルエステルおよびこれらの化合物を使用する癌治療方法

Country Status (6)

Country Link
US (1) US6703399B2 (https=)
EP (1) EP1501836A1 (https=)
JP (1) JP2005536464A (https=)
AU (1) AU2003231068A1 (https=)
CA (1) CA2484816C (https=)
WO (1) WO2003095461A1 (https=)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2010500350A (ja) * 2006-08-11 2010-01-07 ザ クリストゥス ステーリン ファウンデーション フォー キャンサー リサーチ カンプトテシンのエステルの製造法
JP2014520125A (ja) * 2011-06-23 2014-08-21 東北林業大学 １０−メトキシカンプトテシン誘導体、その製造方法及び使用

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100723454B1 (ko) * 2004-08-21 2007-05-30 페어차일드코리아반도체 주식회사 높은 열 방출 능력을 구비한 전력용 모듈 패키지 및 그제조방법
US20040204435A1 (en) * 2003-04-09 2004-10-14 Joachim Liehr Alternating treatment with topoisomerase I and topoisomerase II inhibitors
US7517891B2 (en) * 2005-10-27 2009-04-14 Glyconix Corporation Camptothecin derivatives and improved synthetic methods
WO2008070009A2 (en) * 2006-12-01 2008-06-12 Alza Corporation Treating solid tumors and monocytic leukemia using topoisomerase inhibitors in liposomes
US7572803B2 (en) * 2007-10-25 2009-08-11 The Christus Stehlin Foundation For Cancer Research Hydrated crystalline esters of camptothecin
US20130121921A1 (en) 2011-11-11 2013-05-16 The Christus Stehlin Foundation For Cancer Research Rodent Therapeutic Model And Methods
CN103864811A (zh) * 2012-12-13 2014-06-18 天津科技大学 一种新颖的10-羟基喜树碱20位衍生物制备方法及其在抗肿瘤药物中的应用
WO2025077773A1 (zh) * 2023-10-10 2025-04-17 上海翊维康医药有限责任公司 新的i型拓扑异构酶抑制剂及其制备方法和用途

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5612393A (en) * 1979-07-10 1981-02-06 Yakult Honsha Co Ltd Novel camptothecin derivative
JP2004537592A (ja) * 2001-08-10 2004-12-16 フアルマシア・イタリア・エツセ・ピー・アー フルオロリンカーおよび酵素によって活性化される薬剤抱合体のリンカーとしてのその使用

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4399282A (en) 1979-07-10 1983-08-16 Kabushiki Kaisha Yakult Honsha Camptothecin derivatives
US5552154A (en) 1989-11-06 1996-09-03 The Stehlin Foundation For Cancer Research Method for treating cancer with water-insoluble s-camptothecin of the closed lactone ring form and derivatives thereof
US6080751A (en) 1992-01-14 2000-06-27 The Stehlin Foundation For Cancer Research Method for treating pancreatic cancer in humans with water-insoluble S-camptothecin of the closed lactone ring form and derivatives thereof
US5880131A (en) 1993-10-20 1999-03-09 Enzon, Inc. High molecular weight polymer-based prodrugs
US5965566A (en) 1993-10-20 1999-10-12 Enzon, Inc. High molecular weight polymer-based prodrugs
US5646159A (en) 1994-07-20 1997-07-08 Research Triangle Institute Water-soluble esters of camptothecin compounds
US5731316A (en) 1996-01-30 1998-03-24 The Stehlin Foundation For Cancer Research Derivatives of camptothecin and methods of treating cancer using these derivatives
US6407118B1 (en) 1996-01-30 2002-06-18 The Stehlin Foundation For Cancer Research Derivatives of camptothecin and methods of treating cancer using these derivatives
US6096336A (en) 1996-01-30 2000-08-01 The Stehlin Foundation For Cancer Research Liposomal prodrugs comprising derivatives of camptothecin and methods of treating cancer using these prodrugs
US5922877A (en) 1997-08-05 1999-07-13 The Stehlin Foundation For Cancer Research Methods of preparing and purifying 9-nitro-20-camptothecin
US6228855B1 (en) 1999-08-03 2001-05-08 The Stehlin Foundation For Cancer Research Aromatic esters of camptothecins and methods to treat cancers
US6350756B1 (en) 2001-01-18 2002-02-26 California Pacific Medical Center Camptothecin derivatives

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5612393A (en) * 1979-07-10 1981-02-06 Yakult Honsha Co Ltd Novel camptothecin derivative
JP2004537592A (ja) * 2001-08-10 2004-12-16 フアルマシア・イタリア・エツセ・ピー・アー フルオロリンカーおよび酵素によって活性化される薬剤抱合体のリンカーとしてのその使用

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2010500350A (ja) * 2006-08-11 2010-01-07 ザ クリストゥス ステーリン ファウンデーション フォー キャンサー リサーチ カンプトテシンのエステルの製造法
JP2014520125A (ja) * 2011-06-23 2014-08-21 東北林業大学 １０−メトキシカンプトテシン誘導体、その製造方法及び使用

Also Published As

Publication number Publication date
US6703399B2 (en) 2004-03-09
AU2003231068A1 (en) 2003-11-11
EP1501836A1 (en) 2005-02-02
US20030212087A1 (en) 2003-11-13
WO2003095461A1 (en) 2003-11-20
CA2484816A1 (en) 2003-11-20
CA2484816C (en) 2011-06-07

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