JP2005535707A5 - - Google Patents
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- Publication number
- JP2005535707A5 JP2005535707A5 JP2004527871A JP2004527871A JP2005535707A5 JP 2005535707 A5 JP2005535707 A5 JP 2005535707A5 JP 2004527871 A JP2004527871 A JP 2004527871A JP 2004527871 A JP2004527871 A JP 2004527871A JP 2005535707 A5 JP2005535707 A5 JP 2005535707A5
- Authority
- JP
- Japan
- Prior art keywords
- group
- pharmaceutical composition
- effective amount
- growth hormone
- subject
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 239000008194 pharmaceutical composition Substances 0.000 claims 26
- 230000009286 beneficial effect Effects 0.000 claims 13
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 10
- 102000012004 Ghrelin Human genes 0.000 claims 8
- 101800001586 Ghrelin Proteins 0.000 claims 8
- 102000018997 Growth Hormone Human genes 0.000 claims 8
- 108010051696 Growth Hormone Proteins 0.000 claims 8
- GNKDKYIHGQKHHM-RJKLHVOGSA-N ghrelin Chemical compound C([C@H](NC(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)CN)COC(=O)CCCCCCC)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC=1N=CNC=1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N1[C@@H](CCC1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O)C1=CC=CC=C1 GNKDKYIHGQKHHM-RJKLHVOGSA-N 0.000 claims 8
- 239000000122 growth hormone Substances 0.000 claims 8
- 230000028327 secretion Effects 0.000 claims 8
- 201000010099 disease Diseases 0.000 claims 7
- 150000003839 salts Chemical class 0.000 claims 7
- 230000002526 effect on cardiovascular system Effects 0.000 claims 6
- 230000001737 promoting effect Effects 0.000 claims 6
- 208000016261 weight loss Diseases 0.000 claims 6
- 230000004580 weight loss Effects 0.000 claims 6
- 239000000556 agonist Substances 0.000 claims 5
- 238000012423 maintenance Methods 0.000 claims 4
- 239000000203 mixture Substances 0.000 claims 4
- 206010006895 Cachexia Diseases 0.000 claims 3
- 239000005557 antagonist Substances 0.000 claims 3
- 208000035475 disorder Diseases 0.000 claims 3
- 208000030507 AIDS Diseases 0.000 claims 2
- 206010007558 Cardiac failure chronic Diseases 0.000 claims 2
- 208000024172 Cardiovascular disease Diseases 0.000 claims 2
- 230000000747 cardiac effect Effects 0.000 claims 2
- 206010012601 diabetes mellitus Diseases 0.000 claims 2
- 230000000694 effects Effects 0.000 claims 2
- 238000009472 formulation Methods 0.000 claims 2
- 230000001939 inductive effect Effects 0.000 claims 2
- 230000004584 weight gain Effects 0.000 claims 2
- 235000019786 weight gain Nutrition 0.000 claims 2
- 208000032841 Bulimia Diseases 0.000 claims 1
- 206010006550 Bulimia nervosa Diseases 0.000 claims 1
- 208000002249 Diabetes Complications Diseases 0.000 claims 1
- 206010012655 Diabetic complications Diseases 0.000 claims 1
- 208000032928 Dyslipidaemia Diseases 0.000 claims 1
- 206010057671 Female sexual dysfunction Diseases 0.000 claims 1
- 206010056438 Growth hormone deficiency Diseases 0.000 claims 1
- 206010020772 Hypertension Diseases 0.000 claims 1
- 208000017170 Lipid metabolism disease Diseases 0.000 claims 1
- 206010057672 Male sexual dysfunction Diseases 0.000 claims 1
- 206010028980 Neoplasm Diseases 0.000 claims 1
- 208000008589 Obesity Diseases 0.000 claims 1
- 208000017442 Retinal disease Diseases 0.000 claims 1
- 206010038923 Retinopathy Diseases 0.000 claims 1
- 208000021017 Weight Gain Diseases 0.000 claims 1
- 208000022531 anorexia Diseases 0.000 claims 1
- 235000019789 appetite Nutrition 0.000 claims 1
- 230000036528 appetite Effects 0.000 claims 1
- 230000004596 appetite loss Effects 0.000 claims 1
- 230000037396 body weight Effects 0.000 claims 1
- 230000037182 bone density Effects 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 210000004413 cardiac myocyte Anatomy 0.000 claims 1
- 238000002512 chemotherapy Methods 0.000 claims 1
- 201000001883 cholelithiasis Diseases 0.000 claims 1
- 150000001875 compounds Chemical class 0.000 claims 1
- 206010061428 decreased appetite Diseases 0.000 claims 1
- 238000000502 dialysis Methods 0.000 claims 1
- 210000002889 endothelial cell Anatomy 0.000 claims 1
- 208000001130 gallstones Diseases 0.000 claims 1
- 206010021654 increased appetite Diseases 0.000 claims 1
- 208000019017 loss of appetite Diseases 0.000 claims 1
- 235000021266 loss of appetite Nutrition 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 210000003205 muscle Anatomy 0.000 claims 1
- 230000006654 negative regulation of apoptotic process Effects 0.000 claims 1
- 235000020824 obesity Nutrition 0.000 claims 1
- 201000008482 osteoarthritis Diseases 0.000 claims 1
- 230000036581 peripheral resistance Effects 0.000 claims 1
- 230000017363 positive regulation of growth Effects 0.000 claims 1
- 238000001959 radiotherapy Methods 0.000 claims 1
- 238000011084 recovery Methods 0.000 claims 1
- 230000004936 stimulating effect Effects 0.000 claims 1
- 230000000638 stimulation Effects 0.000 claims 1
- 230000001629 suppression Effects 0.000 claims 1
- 230000001052 transient effect Effects 0.000 claims 1
- 210000003556 vascular endothelial cell Anatomy 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US40226302P | 2002-08-09 | 2002-08-09 | |
| PCT/US2003/024834 WO2004014415A1 (en) | 2002-08-09 | 2003-08-08 | Growth hormone releasing peptides |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009014262A Division JP5025668B2 (ja) | 2002-08-09 | 2009-01-26 | 成長ホルモン放出ペプチド |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2005535707A JP2005535707A (ja) | 2005-11-24 |
| JP2005535707A5 true JP2005535707A5 (https=) | 2006-03-02 |
| JP4365319B2 JP4365319B2 (ja) | 2009-11-18 |
Family
ID=31715820
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004527871A Expired - Fee Related JP4365319B2 (ja) | 2002-08-09 | 2003-08-08 | 成長ホルモン放出ペプチド |
| JP2009014262A Expired - Fee Related JP5025668B2 (ja) | 2002-08-09 | 2009-01-26 | 成長ホルモン放出ペプチド |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009014262A Expired - Fee Related JP5025668B2 (ja) | 2002-08-09 | 2009-01-26 | 成長ホルモン放出ペプチド |
Country Status (22)
| Country | Link |
|---|---|
| US (7) | US7456253B2 (https=) |
| EP (2) | EP2130548A3 (https=) |
| JP (2) | JP4365319B2 (https=) |
| KR (1) | KR100967572B1 (https=) |
| CN (3) | CN101108875A (https=) |
| AR (2) | AR040965A1 (https=) |
| AT (1) | ATE447411T1 (https=) |
| AU (1) | AU2003259062B2 (https=) |
| BR (2) | BR122016015852B8 (https=) |
| CA (1) | CA2494300C (https=) |
| CZ (1) | CZ20041254A3 (https=) |
| DE (1) | DE60329923D1 (https=) |
| DK (1) | DK1542716T3 (https=) |
| ES (1) | ES2334223T3 (https=) |
| IL (1) | IL165998A (https=) |
| MX (1) | MXPA05000974A (https=) |
| NO (1) | NO20050205L (https=) |
| PL (1) | PL212138B1 (https=) |
| RU (2) | RU2323941C2 (https=) |
| SG (1) | SG177006A1 (https=) |
| TW (1) | TWI331922B (https=) |
| WO (1) | WO2004014415A1 (https=) |
Families Citing this family (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI331922B (en) * | 2002-08-09 | 2010-10-21 | Ipsen Pharma Sas | Growth hormone releasing peptides |
| WO2004027064A2 (en) * | 2002-09-18 | 2004-04-01 | Centre Hospitalier De L'universite De Montreal (Chum) | Ghrh analogues |
| WO2004071448A2 (en) * | 2003-02-12 | 2004-08-26 | Transtech Pharma Inc. | Substituted azole derivatives as inhibitors of protein tyrosine phosphatases |
| WO2006045314A2 (en) * | 2004-10-27 | 2006-05-04 | Gastrotech Pharma A/S | Use of a growth hormone secretatogue for increasing or maintaining lean body mass and/or for treatment of chronic obstructive pulmonary disease |
| JP2008521840A (ja) * | 2004-11-30 | 2008-06-26 | ガストロテック・ファルマ・アクティーゼルスカブ | 成長ホルモン分泌促進物質レセプター１ａリガンド |
| US8138218B2 (en) | 2005-07-22 | 2012-03-20 | Ipsen Pharma S.A.S. | Growth hormone secretagogues |
| ES2740108T3 (es) * | 2005-09-29 | 2020-02-05 | Ipsen Pharma | Composición para uso en el tratamiento de dismotilidad gastrointestinal |
| EP1818061A1 (en) * | 2005-12-02 | 2007-08-15 | Charite-Universitätsmedizin Berlin | Use of ghrelin for stimulating hair growth |
| CU23592A1 (es) * | 2006-02-28 | 2010-11-11 | Ct Ingenieria Genetica Biotech | Método para prevenir y eliminar las fibrosis y otras formas de depósito patológico en los tejidos aplicando el péptido secretagogo ghrp-6 |
| EP2012809B1 (en) * | 2006-03-10 | 2013-05-22 | Ipsen Pharma | Use of a ghrelin agonist to improve the catabolic effects of glucocorticoid treatment |
| WO2007127457A2 (en) * | 2006-04-28 | 2007-11-08 | The Administrators Of The Tulane Educational Fund | Ghrelin/growth hormone releasing peptide/growth hormone secretatogue receptor antagonists and uses thereof |
| AU2007300526B2 (en) * | 2006-09-27 | 2011-07-21 | Ipsen Pharma S.A.S. | Analogs of ghrelin substituted at the N-terminal |
| KR20090119785A (ko) | 2007-03-12 | 2009-11-19 | 유키지루시 뉴교 가부시키가이샤 | 성장 호르몬 분비 촉진제 |
| TW200916113A (en) * | 2007-08-08 | 2009-04-16 | Sod Conseils Rech Applic | Method for inhibiting inflammation and pro-inflammatory cytokine/chemokine expression using a ghrelin analogue |
| WO2009108364A2 (en) * | 2008-02-27 | 2009-09-03 | Ipsen Pharma S.A.S. | Antagonistic analogues of ghrh |
| US9724381B2 (en) | 2009-05-12 | 2017-08-08 | The Administrators Of The Tulane Educational Fund | Methods of inhibiting the ghrelin/growth hormone secretatogue receptor pathway and uses thereof |
| MX343499B (es) * | 2010-03-15 | 2016-11-08 | Ipsen Pharma Sas | Composiciones farmaceuticas de ligandos receptores de secretagoga de la hormona de crecimiento. |
| AR088392A1 (es) * | 2011-10-18 | 2014-05-28 | Aileron Therapeutics Inc | Macrociclos peptidomimeticos |
| UA115542C2 (uk) * | 2011-12-23 | 2017-11-27 | Іпсен Мануфекчерінг Айрленд Лімітед | Процес синтезу терапевтичних пептидів |
| US10039813B2 (en) | 2012-02-07 | 2018-08-07 | Massachusetts Institute Of Technology | Use of antagonists of ghrelin or ghrelin receptor to prevent or treat stress-sensitive psychiatric illness |
| EP2705835A1 (en) * | 2012-06-08 | 2014-03-12 | Ipsen Pharma S.A.S. | Aqueous gelling compositions of soluble active pharmaceutical peptides providing modified release |
| WO2014144231A1 (en) | 2013-03-15 | 2014-09-18 | Massachusetts Institute Of Technology | Use of antagonists of growth hormone or growth hormone receptor to prevent or treat stress-sensitive psychiatric illness |
| US9119832B2 (en) | 2014-02-05 | 2015-09-01 | The Regents Of The University Of California | Methods of treating mild brain injury |
| AU2015227278A1 (en) | 2014-03-04 | 2016-10-06 | Allergan Gi Corp. | Process for the liquid phase synthesis of H-Inp-(D)Bal-(D)Trp-Phe-Apc-NH2, and pharmaceutically acceptable salts thereof |
| WO2016138099A1 (en) | 2015-02-24 | 2016-09-01 | Massachusetts Institute Of Technology | Use of ghrelin or functional ghrelin receptor agonists to prevent and treat stress-sensitive psychiatric illness |
| WO2017075535A1 (en) | 2015-10-28 | 2017-05-04 | Oxeia Biopharmaceuticals, Inc. | Methods of treating neurodegenerative conditions |
| US10111929B1 (en) * | 2017-04-07 | 2018-10-30 | Ez Ip, Llc | Growth hormone releasing factor analogs and uses |
| CN113072617B (zh) * | 2021-03-30 | 2023-08-08 | 成都诺和晟泰生物科技有限公司 | 一种多肽化合物及其应用 |
| CN113045625B (zh) * | 2021-03-30 | 2023-11-07 | 成都诺和晟泰生物科技有限公司 | 作为生长激素促分泌素受体激动剂的多肽及其应用 |
| CN114805487B (zh) * | 2022-06-07 | 2024-03-12 | 成都诺和晟泰生物科技有限公司 | 一种多肽化合物及其应用 |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5264565A (en) | 1991-01-22 | 1993-11-23 | Affymax Technologies, N.V. | Nucleic acid encoding the D2 /Ml chimeric receptor |
| JP3131049B2 (ja) * | 1992-09-30 | 2001-01-31 | マツダ株式会社 | 車両のサスペンション装置 |
| HU224345B1 (hu) | 1993-12-23 | 2005-08-29 | Novo Nordisk A/S. | Növekedési hormont felszabadító tulajdonságú peptidek, ezeket hatóanyagként tartalmazó gyógyszerkészítmények és alkalmazásuk |
| US7067326B2 (en) * | 1994-01-13 | 2006-06-27 | The Trustees Of Columbia University In The City Of New York | Synthetic receptors, libraries and uses thereof |
| RU2110275C1 (ru) * | 1994-09-09 | 1998-05-10 | Дейгин Владислав Исакович | Способ получения пептида, обладающего анаболической активностью, стимулирующего увеличение массы тела, развитие эпидермального слоя и роста волосяного покрова |
| JP3810083B2 (ja) * | 1994-09-27 | 2006-08-16 | アーダナ・バイオサイエンス・リミテツド | 成長因子の放出を促進し得る２−アルキルトリプトファン含有ペプチド化合物 |
| US20020111461A1 (en) * | 1999-05-21 | 2002-08-15 | Todd C. Somers | Low molecular weight peptidomimetic growth hormone secretagogues |
| US5798337A (en) | 1994-11-16 | 1998-08-25 | Genentech, Inc. | Low molecular weight peptidomimetic growth hormone secretagogues |
| US5776718A (en) * | 1995-03-24 | 1998-07-07 | Arris Pharmaceutical Corporation | Reversible protease inhibitors |
| BR9608909A (pt) | 1995-06-22 | 1999-03-02 | Novo Nordisk As | Composto composição farmacêutica processos para estimular a liberação do hormônio do crescimento da patuitária e aumentar a velocidade e extensão do crescimento dos animais para aumentar a produção de leite ou lã de animais ou para para doenças e uso do composto |
| DE69637587D1 (de) | 1995-07-26 | 2008-08-21 | Astrazeneca Ab | Chimäre rezeptoren und verfahren zur identifizieren verbindungen mit einem aktivität als metabotropischen glutamatrezeptoren sowie verwendung solcher verbindungen in der behandlung von neurologischer erkrankungen und neurologischenstörrungen |
| US6124263A (en) * | 1998-11-16 | 2000-09-26 | Asta Medica Ag | Treatment of tumors by administration of growth hormone releasing compounds and their antagonists |
| US5932548A (en) * | 1998-06-03 | 1999-08-03 | Deghenghi; Romano | Lysine containing peptides for treatment of heart disease |
| AU5671099A (en) * | 1998-08-14 | 2000-03-06 | The Administrators Of The Tulane Eductional Fund | Compounds having growth hormone releasing activity |
| KR100827973B1 (ko) | 1999-07-23 | 2008-05-21 | 겐지 간가와 | 신규 펩티드 |
| US20020187938A1 (en) | 2000-07-24 | 2002-12-12 | Romano Deghenghi | Ghrelin antagonists |
| TWI331922B (en) * | 2002-08-09 | 2010-10-21 | Ipsen Pharma Sas | Growth hormone releasing peptides |
| WO2006045314A2 (en) | 2004-10-27 | 2006-05-04 | Gastrotech Pharma A/S | Use of a growth hormone secretatogue for increasing or maintaining lean body mass and/or for treatment of chronic obstructive pulmonary disease |
| ES2740108T3 (es) * | 2005-09-29 | 2020-02-05 | Ipsen Pharma | Composición para uso en el tratamiento de dismotilidad gastrointestinal |
| EP2012809B1 (en) * | 2006-03-10 | 2013-05-22 | Ipsen Pharma | Use of a ghrelin agonist to improve the catabolic effects of glucocorticoid treatment |
| TW200916113A (en) * | 2007-08-08 | 2009-04-16 | Sod Conseils Rech Applic | Method for inhibiting inflammation and pro-inflammatory cytokine/chemokine expression using a ghrelin analogue |
-
2003
- 2003-08-06 TW TW092121571A patent/TWI331922B/zh not_active IP Right Cessation
- 2003-08-08 BR BR122016015852A patent/BR122016015852B8/pt not_active IP Right Cessation
- 2003-08-08 DK DK03785034.4T patent/DK1542716T3/da active
- 2003-08-08 CN CNA2007101279712A patent/CN101108875A/zh active Pending
- 2003-08-08 US US10/484,473 patent/US7456253B2/en not_active Expired - Lifetime
- 2003-08-08 JP JP2004527871A patent/JP4365319B2/ja not_active Expired - Fee Related
- 2003-08-08 MX MXPA05000974A patent/MXPA05000974A/es active IP Right Grant
- 2003-08-08 EP EP09171176A patent/EP2130548A3/en not_active Withdrawn
- 2003-08-08 SG SG2007033848A patent/SG177006A1/en unknown
- 2003-08-08 RU RU2005106236/04A patent/RU2323941C2/ru active
- 2003-08-08 EP EP03785034A patent/EP1542716B1/en not_active Expired - Lifetime
- 2003-08-08 PL PL373605A patent/PL212138B1/pl unknown
- 2003-08-08 CN CNA038186810A patent/CN1674927A/zh active Pending
- 2003-08-08 CZ CZ20041254A patent/CZ20041254A3/cs unknown
- 2003-08-08 KR KR1020057001094A patent/KR100967572B1/ko not_active Expired - Fee Related
- 2003-08-08 AT AT03785034T patent/ATE447411T1/de active
- 2003-08-08 AU AU2003259062A patent/AU2003259062B2/en not_active Ceased
- 2003-08-08 CN CN201210307885.0A patent/CN102850436B/zh not_active Expired - Fee Related
- 2003-08-08 WO PCT/US2003/024834 patent/WO2004014415A1/en not_active Ceased
- 2003-08-08 ES ES03785034T patent/ES2334223T3/es not_active Expired - Lifetime
- 2003-08-08 DE DE60329923T patent/DE60329923D1/de not_active Expired - Lifetime
- 2003-08-08 AR ARP030102883A patent/AR040965A1/es active IP Right Grant
- 2003-08-08 BR BRPI0313273A patent/BRPI0313273B8/pt not_active IP Right Cessation
- 2003-08-08 CA CA2494300A patent/CA2494300C/en not_active Expired - Fee Related
-
2004
- 2004-12-27 IL IL165998A patent/IL165998A/en active IP Right Grant
-
2005
- 2005-01-13 NO NO20050205A patent/NO20050205L/no not_active Application Discontinuation
-
2007
- 2007-12-03 RU RU2007145026/04A patent/RU2007145026A/ru not_active Application Discontinuation
-
2008
- 2008-03-31 AR ARP080101348A patent/AR062801A2/es not_active Application Discontinuation
- 2008-06-09 US US12/157,224 patent/US8377865B2/en not_active Expired - Fee Related
-
2009
- 2009-01-26 JP JP2009014262A patent/JP5025668B2/ja not_active Expired - Fee Related
-
2013
- 2013-01-04 US US13/734,314 patent/US8859729B2/en not_active Expired - Fee Related
-
2014
- 2014-10-09 US US14/510,188 patent/US9409948B2/en not_active Expired - Fee Related
-
2016
- 2016-07-07 US US15/203,956 patent/US20160311855A1/en not_active Abandoned
-
2017
- 2017-08-29 US US15/688,979 patent/US20170362275A1/en not_active Abandoned
-
2019
- 2019-09-25 US US16/581,960 patent/US20200017548A1/en not_active Abandoned
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