JP2005535594A5 - - Google Patents
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- Publication number
- JP2005535594A5 JP2005535594A5 JP2004506748A JP2004506748A JP2005535594A5 JP 2005535594 A5 JP2005535594 A5 JP 2005535594A5 JP 2004506748 A JP2004506748 A JP 2004506748A JP 2004506748 A JP2004506748 A JP 2004506748A JP 2005535594 A5 JP2005535594 A5 JP 2005535594A5
- Authority
- JP
- Japan
- Prior art keywords
- heterocycle
- aryl
- occurrence
- alkyl
- independently selected
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 125000000623 heterocyclic group Chemical group 0.000 claims 45
- 125000000217 alkyl group Chemical group 0.000 claims 31
- 125000003118 aryl group Chemical group 0.000 claims 30
- 125000001424 substituent group Chemical group 0.000 claims 29
- 125000003710 aryl alkyl group Chemical group 0.000 claims 23
- 229910052739 hydrogen Inorganic materials 0.000 claims 20
- 239000001257 hydrogen Substances 0.000 claims 20
- 150000001875 compounds Chemical class 0.000 claims 15
- 229910052736 halogen Inorganic materials 0.000 claims 15
- 150000002367 halogens Chemical class 0.000 claims 15
- 125000000592 heterocycloalkyl group Chemical group 0.000 claims 15
- 125000003545 alkoxy group Chemical group 0.000 claims 13
- 150000002431 hydrogen Chemical group 0.000 claims 12
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 12
- 201000010099 disease Diseases 0.000 claims 10
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 10
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 10
- 150000003839 salts Chemical class 0.000 claims 10
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 8
- -1 hydroxy, carboxy Chemical group 0.000 claims 8
- 125000004423 acyloxy group Chemical group 0.000 claims 7
- 125000004429 atom Chemical group 0.000 claims 7
- 125000004093 cyano group Chemical group *C#N 0.000 claims 7
- 125000001188 haloalkyl group Chemical group 0.000 claims 7
- 125000001072 heteroaryl group Chemical group 0.000 claims 7
- 125000002768 hydroxyalkyl group Chemical group 0.000 claims 7
- 125000004963 sulfonylalkyl group Chemical group 0.000 claims 7
- 125000004001 thioalkyl group Chemical group 0.000 claims 7
- 208000030507 AIDS Diseases 0.000 claims 5
- 206010007558 Cardiac failure chronic Diseases 0.000 claims 5
- 206010014666 Endocarditis bacterial Diseases 0.000 claims 5
- 208000019693 Lung disease Diseases 0.000 claims 5
- 208000003250 Mixed connective tissue disease Diseases 0.000 claims 5
- 206010028980 Neoplasm Diseases 0.000 claims 5
- 208000001647 Renal Insufficiency Diseases 0.000 claims 5
- 206010039710 Scleroderma Diseases 0.000 claims 5
- 208000009361 bacterial endocarditis Diseases 0.000 claims 5
- 201000011510 cancer Diseases 0.000 claims 5
- 230000001684 chronic effect Effects 0.000 claims 5
- 208000020832 chronic kidney disease Diseases 0.000 claims 5
- 239000003814 drug Substances 0.000 claims 5
- 208000028208 end stage renal disease Diseases 0.000 claims 5
- 201000000523 end stage renal failure Diseases 0.000 claims 5
- 201000007119 infective endocarditis Diseases 0.000 claims 5
- 201000006370 kidney failure Diseases 0.000 claims 5
- 201000008482 osteoarthritis Diseases 0.000 claims 5
- 230000000069 prophylactic effect Effects 0.000 claims 5
- 206010039073 rheumatoid arthritis Diseases 0.000 claims 5
- 229940124597 therapeutic agent Drugs 0.000 claims 5
- 201000008827 tuberculosis Diseases 0.000 claims 5
- 229910052757 nitrogen Inorganic materials 0.000 claims 4
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 4
- 125000004183 alkoxy alkyl group Chemical group 0.000 claims 3
- 125000000753 cycloalkyl group Chemical group 0.000 claims 3
- 125000005842 heteroatom Chemical group 0.000 claims 3
- 125000000547 substituted alkyl group Chemical group 0.000 claims 3
- 239000012825 JNK inhibitor Substances 0.000 claims 2
- 229940118135 JNK inhibitor Drugs 0.000 claims 2
- 239000004480 active ingredient Substances 0.000 claims 2
- 125000004103 aminoalkyl group Chemical group 0.000 claims 2
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 2
- 125000003107 substituted aryl group Chemical group 0.000 claims 2
- 125000005083 alkoxyalkoxy group Chemical group 0.000 claims 1
- 125000004453 alkoxycarbonyl group Chemical group 0.000 claims 1
- 125000005078 alkoxycarbonylalkyl group Chemical group 0.000 claims 1
- 125000001118 alkylidene group Chemical group 0.000 claims 1
- 125000002431 aminoalkoxy group Chemical group 0.000 claims 1
- 125000001691 aryl alkyl amino group Chemical group 0.000 claims 1
- 125000002102 aryl alkyloxo group Chemical group 0.000 claims 1
- 125000001769 aryl amino group Chemical group 0.000 claims 1
- 125000004104 aryloxy group Chemical group 0.000 claims 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 1
- 125000000000 cycloalkoxy group Chemical group 0.000 claims 1
- 125000001316 cycloalkyl alkyl group Chemical group 0.000 claims 1
- 125000005112 cycloalkylalkoxy group Chemical group 0.000 claims 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 1
- 125000000472 sulfonyl group Chemical group *S(*)(=O)=O 0.000 claims 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims 1
- 0 **c1n[n]c2ccc(*)cc12 Chemical compound **c1n[n]c2ccc(*)cc12 0.000 description 4
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US38320202P | 2002-05-24 | 2002-05-24 | |
| US10/443,263 US20040034084A1 (en) | 2002-05-24 | 2003-05-22 | Methods for using JNK inhibitors for treating or preventing disease-related wasting |
| PCT/US2003/016333 WO2003099221A2 (en) | 2002-05-24 | 2003-05-23 | Methods for using jnk inhibitors for treating or preventing disease-related wasting |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2005535594A JP2005535594A (ja) | 2005-11-24 |
| JP2005535594A5 true JP2005535594A5 (enExample) | 2006-03-23 |
Family
ID=29586989
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004506748A Pending JP2005535594A (ja) | 2002-05-24 | 2003-05-23 | 疾患に関連した消耗を治療または予防するためのｊｎｋ阻害剤の使用方法 |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US20040034084A1 (enExample) |
| EP (1) | EP1507528A4 (enExample) |
| JP (1) | JP2005535594A (enExample) |
| CN (1) | CN1668299A (enExample) |
| AU (1) | AU2003256259A1 (enExample) |
| CA (1) | CA2487073A1 (enExample) |
| IL (1) | IL165359A0 (enExample) |
| MX (1) | MXPA04011599A (enExample) |
| NZ (1) | NZ537055A (enExample) |
| WO (1) | WO2003099221A2 (enExample) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP4219289B2 (ja) * | 2004-03-10 | 2009-02-04 | 独立行政法人科学技術振興機構 | 多環性ケトン化合物及びその製造方法 |
| US20110008327A1 (en) | 2004-03-29 | 2011-01-13 | Cheng Jin Q | Compositions including triciribine and epidermal growth factor receptor inhibitor compounds or salts thereof and methods of use thereof |
| US20100028339A1 (en) | 2004-03-29 | 2010-02-04 | Cheng Jin Q | Compositions including triciribine and trastuzumab and methods of use thereof |
| US20100009928A1 (en) | 2004-03-29 | 2010-01-14 | Cheng Jin Q | Compositions including triciribine and taxanes and methods of use thereof |
| US20100173864A1 (en) | 2004-03-29 | 2010-07-08 | Cheng Jin Q | Compositions including triciribine and one or more platinum compounds and methods of use thereof |
| LT2574341T (lt) | 2004-03-29 | 2017-09-11 | University Of South Florida | Navikų ir vėžio efektyvus gydymas triciribino fosfatu |
| US20100009929A1 (en) | 2004-03-29 | 2010-01-14 | Cheng Jin Q | Compositions including triciribine and bortezomib and derivatives thereof and methods of use thereof |
| PE20060373A1 (es) * | 2004-06-24 | 2006-04-29 | Smithkline Beecham Corp | Derivados 3-piperidinil-7-carboxamida-indazol como inhibidores de la actividad cinasa de ikk2 |
| KR20070038565A (ko) * | 2004-07-27 | 2007-04-10 | 노파르티스 아게 | Ｈｓｐ９０의 억제제 |
| MX2007001155A (es) * | 2004-07-29 | 2007-08-14 | Creabilis Therapeutics Spa | Uso de inhibidores de k-252a y de quinasa para la prevencion o el tratamiento de patologias asociadas con hmgb1. |
| EP1676574A3 (en) | 2004-12-30 | 2006-07-26 | Johnson & Johnson Vision Care, Inc. | Methods for promoting survival of transplanted tissues and cells |
| NZ590283A (en) | 2008-07-14 | 2012-11-30 | Gilead Sciences Inc | Imidazolylpyrimidine compounds as hdac and / or cdk inhibitors |
| AU2009271019A1 (en) | 2008-07-14 | 2010-01-21 | Gilead Sciences, Inc. | Fused heterocyclyc inhibitors of histone deacetylase and/or cyclin-dependent kinases |
| EP2303841A1 (en) | 2008-07-14 | 2011-04-06 | Gilead Sciences, Inc. | Oxindolyl inhibitor compounds |
| CA2731323A1 (en) | 2008-07-28 | 2010-02-04 | Gilead Sciences, Inc. | Cycloalkylidene and heterocycloalkylidene histone deacetylase inhibitor compounds |
| CA2763167A1 (en) | 2009-06-08 | 2010-12-16 | Gilead Sciences, Inc. | Cycloalkylcarbamate benzamide aniline hdac inhibitor compounds |
| EP2440519A1 (en) | 2009-06-08 | 2012-04-18 | Gilead Sciences, Inc. | Alkanoylamino benzamide aniline hdac inihibitor compounds |
| US10624948B2 (en) * | 2013-06-26 | 2020-04-21 | Xigen Inflammation Ltd. | Use of cell-permeable peptide inhibitors of the JNK signal transduction pathway for the treatment of various diseases |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3994890A (en) * | 1974-01-31 | 1976-11-30 | Chugai Seiyaku Kabushiki Kaisha | 1-Aminoalkyl, 3-phenyl indazoles |
| US4198518A (en) * | 1977-09-02 | 1980-04-15 | Ciba-Geigy Corporation | Process for the production of 3-substituted pyrazolanthrones |
| JPS57109787A (en) * | 1980-12-26 | 1982-07-08 | Chugai Pharmaceut Co Ltd | Pyrazoloindazole derivative |
| US4788195A (en) * | 1986-01-13 | 1988-11-29 | American Cyanamid Company | 4,5,6-substituted-N-(substituted-phenyl)-2-pyrimidinamines |
| US4973690A (en) * | 1988-04-12 | 1990-11-27 | Ciba-Geigy Corporation | Novel ureas |
| US4966622A (en) * | 1988-04-12 | 1990-10-30 | Ciba-Geigy Corporation | N-phenyl-N-pyrimidin-2-ylureas |
| JP2515162B2 (ja) * | 1990-02-23 | 1996-07-10 | 富士写真フイルム株式会社 | メチン化合物 |
| GB9016449D0 (en) * | 1990-07-26 | 1990-09-12 | Ici Plc | Anionic compounds |
| DE69230387T2 (de) * | 1991-04-22 | 2000-06-29 | Fuji Photo Film Co., Ltd. | Photographische Silberhalogenidmaterialien und Verfahren zu ihrer Verarbeitung |
| JP2692021B2 (ja) * | 1991-09-13 | 1997-12-17 | 富士写真フイルム株式会社 | ハロゲン化銀感光材料 |
| US5516775A (en) * | 1992-08-31 | 1996-05-14 | Ciba-Geigy Corporation | Further use of pyrimidine derivatives |
| WO1996004909A1 (en) * | 1994-08-12 | 1996-02-22 | Takeda Chemical Industries, Ltd. | Use of quinone and hydroquinone derivatives for the teatment of cachexia |
| AP1147A (en) * | 1996-05-03 | 2003-02-25 | Pfizer | Substituted indazole derivatives and related compounds. |
| US6162613A (en) * | 1998-02-18 | 2000-12-19 | Vertex Pharmaceuticals, Inc. | Methods for designing inhibitors of serine/threonine-kinases and tyrosine kinases |
| US6897231B2 (en) * | 2000-07-31 | 2005-05-24 | Signal Pharmaceuticals, Inc. | Indazole derivatives as JNK inhibitors and compositions and methods related thereto |
| US6987184B2 (en) * | 2001-02-15 | 2006-01-17 | Signal Pharmaceuticals, Llc | Isothiazoloanthrones, isoxazoloanthrones, isoindolanthrones and derivatives thereof as JNK inhibitors and compositions and methods related |
-
2003
- 2003-05-22 US US10/443,263 patent/US20040034084A1/en not_active Abandoned
- 2003-05-23 IL IL16535903A patent/IL165359A0/xx unknown
- 2003-05-23 CA CA002487073A patent/CA2487073A1/en not_active Abandoned
- 2003-05-23 JP JP2004506748A patent/JP2005535594A/ja active Pending
- 2003-05-23 WO PCT/US2003/016333 patent/WO2003099221A2/en not_active Ceased
- 2003-05-23 MX MXPA04011599A patent/MXPA04011599A/es not_active Application Discontinuation
- 2003-05-23 CN CNA038166992A patent/CN1668299A/zh active Pending
- 2003-05-23 AU AU2003256259A patent/AU2003256259A1/en not_active Abandoned
- 2003-05-23 NZ NZ537055A patent/NZ537055A/en unknown
- 2003-05-23 EP EP03755458A patent/EP1507528A4/en not_active Withdrawn