JP2006507307A5 - - Google Patents
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- Publication number
- JP2006507307A5 JP2006507307A5 JP2004550330A JP2004550330A JP2006507307A5 JP 2006507307 A5 JP2006507307 A5 JP 2006507307A5 JP 2004550330 A JP2004550330 A JP 2004550330A JP 2004550330 A JP2004550330 A JP 2004550330A JP 2006507307 A5 JP2006507307 A5 JP 2006507307A5
- Authority
- JP
- Japan
- Prior art keywords
- independently
- pharmaceutical composition
- aryl
- heterocycle
- alkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 125000000623 heterocyclic group Chemical group 0.000 claims 47
- 239000008194 pharmaceutical composition Substances 0.000 claims 42
- 125000000217 alkyl group Chemical group 0.000 claims 31
- 125000003118 aryl group Chemical group 0.000 claims 30
- 150000001875 compounds Chemical class 0.000 claims 30
- 125000001424 substituent group Chemical group 0.000 claims 30
- 125000003710 aryl alkyl group Chemical group 0.000 claims 23
- 125000000592 heterocycloalkyl group Chemical group 0.000 claims 20
- 229910052739 hydrogen Inorganic materials 0.000 claims 20
- 239000001257 hydrogen Substances 0.000 claims 20
- 150000002431 hydrogen Chemical class 0.000 claims 16
- 229910052736 halogen Inorganic materials 0.000 claims 15
- 150000002367 halogens Chemical class 0.000 claims 15
- 125000003545 alkoxy group Chemical group 0.000 claims 13
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 12
- 150000003839 salts Chemical class 0.000 claims 12
- 239000012453 solvate Substances 0.000 claims 12
- 125000004429 atom Chemical group 0.000 claims 11
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 10
- -1 hydroxy, carboxy Chemical group 0.000 claims 8
- LRFVTYWOQMYALW-UHFFFAOYSA-N 9H-xanthine Chemical class O=C1NC(=O)NC2=C1NC=N2 LRFVTYWOQMYALW-UHFFFAOYSA-N 0.000 claims 7
- 102000014150 Interferons Human genes 0.000 claims 7
- 108010050904 Interferons Proteins 0.000 claims 7
- 125000004423 acyloxy group Chemical group 0.000 claims 7
- 230000001772 anti-angiogenic effect Effects 0.000 claims 7
- 125000004093 cyano group Chemical group *C#N 0.000 claims 7
- 125000001188 haloalkyl group Chemical group 0.000 claims 7
- 125000001072 heteroaryl group Chemical group 0.000 claims 7
- 125000002768 hydroxyalkyl group Chemical group 0.000 claims 7
- 229940079322 interferon Drugs 0.000 claims 7
- 125000004963 sulfonylalkyl group Chemical group 0.000 claims 7
- 125000004001 thioalkyl group Chemical group 0.000 claims 7
- 102000018997 Growth Hormone Human genes 0.000 claims 6
- 108010051696 Growth Hormone Proteins 0.000 claims 6
- 108010025020 Nerve Growth Factor Proteins 0.000 claims 6
- 102000007072 Nerve Growth Factors Human genes 0.000 claims 6
- 239000003963 antioxidant agent Substances 0.000 claims 6
- 230000003078 antioxidant effect Effects 0.000 claims 6
- 230000003115 biocidal effect Effects 0.000 claims 6
- 239000000122 growth hormone Substances 0.000 claims 6
- 102000006495 integrins Human genes 0.000 claims 6
- 108010044426 integrins Proteins 0.000 claims 6
- 239000003900 neurotrophic factor Substances 0.000 claims 6
- 239000003075 phytoestrogen Substances 0.000 claims 6
- 150000003180 prostaglandins Chemical class 0.000 claims 6
- 150000003431 steroids Chemical class 0.000 claims 6
- 239000000587 angiogenesis modulating agent Substances 0.000 claims 5
- 229940076002 angiogenesis modulator Drugs 0.000 claims 5
- 239000003242 anti bacterial agent Substances 0.000 claims 5
- 230000003110 anti-inflammatory effect Effects 0.000 claims 5
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 4
- 229910052757 nitrogen Inorganic materials 0.000 claims 4
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 4
- 230000002265 prevention Effects 0.000 claims 4
- 125000004183 alkoxy alkyl group Chemical group 0.000 claims 3
- 125000000547 substituted alkyl group Chemical group 0.000 claims 3
- 125000004103 aminoalkyl group Chemical group 0.000 claims 2
- 125000001316 cycloalkyl alkyl group Chemical group 0.000 claims 2
- 125000000753 cycloalkyl group Chemical group 0.000 claims 2
- 239000003112 inhibitor Substances 0.000 claims 2
- 125000003107 substituted aryl group Chemical group 0.000 claims 2
- UEJJHQNACJXSKW-UHFFFAOYSA-N 2-(2,6-dioxopiperidin-3-yl)-1H-isoindole-1,3(2H)-dione Chemical compound O=C1C2=CC=CC=C2C(=O)N1C1CCC(=O)NC1=O UEJJHQNACJXSKW-UHFFFAOYSA-N 0.000 claims 1
- 206010003694 Atrophy Diseases 0.000 claims 1
- 229940118135 JNK inhibitor Drugs 0.000 claims 1
- 239000012825 JNK inhibitor Substances 0.000 claims 1
- 206010029113 Neovascularisation Diseases 0.000 claims 1
- BYPFEZZEUUWMEJ-UHFFFAOYSA-N Pentoxifylline Chemical compound O=C1N(CCCCC(=O)C)C(=O)N(C)C2=C1N(C)C=N2 BYPFEZZEUUWMEJ-UHFFFAOYSA-N 0.000 claims 1
- 125000005083 alkoxyalkoxy group Chemical group 0.000 claims 1
- 125000004453 alkoxycarbonyl group Chemical group 0.000 claims 1
- 125000005078 alkoxycarbonylalkyl group Chemical group 0.000 claims 1
- 125000001118 alkylidene group Chemical group 0.000 claims 1
- 125000002431 aminoalkoxy group Chemical group 0.000 claims 1
- 125000001691 aryl alkyl amino group Chemical group 0.000 claims 1
- 125000002102 aryl alkyloxo group Chemical group 0.000 claims 1
- 125000001769 aryl amino group Chemical group 0.000 claims 1
- 125000005160 aryl oxy alkyl group Chemical group 0.000 claims 1
- 125000004104 aryloxy group Chemical group 0.000 claims 1
- 230000037444 atrophy Effects 0.000 claims 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 1
- 125000000000 cycloalkoxy group Chemical group 0.000 claims 1
- 125000006310 cycloalkyl amino group Chemical group 0.000 claims 1
- 125000005112 cycloalkylalkoxy group Chemical group 0.000 claims 1
- 125000005842 heteroatom Chemical group 0.000 claims 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 1
- 229960001476 pentoxifylline Drugs 0.000 claims 1
- 230000000649 photocoagulation Effects 0.000 claims 1
- 238000002428 photodynamic therapy Methods 0.000 claims 1
- 239000003504 photosensitizing agent Substances 0.000 claims 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 1
- 125000000472 sulfonyl group Chemical group *S(*)(=O)=O 0.000 claims 1
- 229960003433 thalidomide Drugs 0.000 claims 1
- 238000002560 therapeutic procedure Methods 0.000 claims 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US42289602P | 2002-10-31 | 2002-10-31 | |
| US10/699,105 US20040092568A1 (en) | 2002-10-31 | 2003-10-30 | Methods for the treatment, prevention and management of macular degeneration |
| PCT/US2003/034662 WO2004041191A2 (en) | 2002-10-31 | 2003-10-31 | Methods for the treatment, prevention and management of macular degeneration |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2006507307A JP2006507307A (ja) | 2006-03-02 |
| JP2006507307A5 true JP2006507307A5 (enExample) | 2006-12-07 |
Family
ID=32233518
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004550330A Pending JP2006507307A (ja) | 2002-10-31 | 2003-10-31 | 黄斑変性を治療、予防および管理するための方法 |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US20040092568A1 (enExample) |
| EP (1) | EP1565188A2 (enExample) |
| JP (1) | JP2006507307A (enExample) |
| KR (1) | KR20050061596A (enExample) |
| AU (1) | AU2003286802A1 (enExample) |
| BR (1) | BR0315939A (enExample) |
| CA (1) | CA2504028A1 (enExample) |
| MX (1) | MXPA05004550A (enExample) |
| NZ (1) | NZ540187A (enExample) |
| TW (1) | TW200420290A (enExample) |
| WO (1) | WO2004041191A2 (enExample) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6984652B2 (en) * | 2003-09-05 | 2006-01-10 | Warner-Lambert Company Llc | Gyrase inhibitors |
| US7803824B2 (en) * | 2004-10-29 | 2010-09-28 | Alcon, Inc. | Use of inhibitors of Jun N-terminal kinases to treat glaucoma |
| US20060094753A1 (en) * | 2004-10-29 | 2006-05-04 | Alcon, Inc. | Use of inhibitors of Jun N-terminal kinases for the treatment of glaucomatous retinopathy and ocular diseases |
| ES2284308B1 (es) * | 2005-03-08 | 2008-08-01 | Bsh Electrodomesticos España, S.A. | Tambor para maquina lavadora de ropa. |
| CA2663545A1 (en) * | 2006-09-19 | 2008-03-27 | Phylogica Limited | Neuroprotective peptide inhibitors of ap-1 signaling and uses thereof |
| JP5640005B2 (ja) | 2008-07-14 | 2014-12-10 | ギリアード サイエンシーズ， インコーポレイテッド | Ｈｄａｃおよび／またはｃｄｋ阻害剤としてのイミダゾシルピリジン化合物 |
| EP2303881A2 (en) | 2008-07-14 | 2011-04-06 | Gilead Sciences, Inc. | Fused heterocyclyc inhibitors of histone deacetylase and/or cyclin-dependent kinases |
| EP2303841A1 (en) | 2008-07-14 | 2011-04-06 | Gilead Sciences, Inc. | Oxindolyl inhibitor compounds |
| KR20110038159A (ko) | 2008-07-28 | 2011-04-13 | 길리애드 사이언시즈, 인코포레이티드 | 사이클로알킬리덴 및 헤테로사이클로알킬리덴 히스톤 데아세틸라아제 억제제 화합물 |
| EP2374825A1 (en) | 2008-12-17 | 2011-10-12 | Keio University | Photodynamic therapeutic agent showing accumulation of cell-specific functions |
| EA201171188A1 (ru) * | 2009-03-30 | 2012-05-30 | Сантен Фармасьютикал Ко., Лтд. | Профилактическое или терапевтическое средство против болезни сетчатки и способ профилактики или лечения болезни сетчатки с использованием jnk (c-jun-аминоконцевая киназа)-ингибиторного пептида, а также применение указанного пептида |
| CA2763786C (en) | 2009-06-08 | 2014-09-30 | Gilead Sciences, Inc. | Alkanoylamino benzamide aniline hdac inihibitor compounds |
| ES2463826T3 (es) | 2009-06-08 | 2014-05-29 | Gilead Sciences, Inc. | Compuestos inhibidores de HDAC de cicloalquilcarbamato benzamida anilina |
| CN115784993A (zh) * | 2022-11-23 | 2023-03-14 | 四川大学华西医院 | 一种3-氨基吲唑类化合物的制备及其治疗帕金森病的应用 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5075116A (en) * | 1989-04-20 | 1991-12-24 | Lahaye Laboratories, Inc. | Composition and method for treatment of macular degeneration |
| KR20080028516A (ko) * | 1999-08-19 | 2008-03-31 | 시그널 파머슈티컬스 인크 | Ｊｎｋ억제제로서의 피라졸로안트론과 그 유도체 및 이를함유하는 조성물 |
| US6204270B1 (en) * | 1999-11-12 | 2001-03-20 | Eyal S. Ron | Ophthalmic and mucosal preparations |
| JP4739632B2 (ja) * | 2000-02-05 | 2011-08-03 | バーテックス ファーマシューティカルズ インコーポレイテッド | Ｅｒｋのインヒビターとして有用なピラゾール組成物 |
| US6897231B2 (en) * | 2000-07-31 | 2005-05-24 | Signal Pharmaceuticals, Inc. | Indazole derivatives as JNK inhibitors and compositions and methods related thereto |
| US7129242B2 (en) * | 2000-12-06 | 2006-10-31 | Signal Pharmaceuticals, Llc | Anilinopyrimidine derivatives as JNK pathway inhibitors and compositions and methods related thereto |
-
2003
- 2003-10-30 US US10/699,105 patent/US20040092568A1/en not_active Abandoned
- 2003-10-31 NZ NZ540187A patent/NZ540187A/en unknown
- 2003-10-31 BR BR0315939-6A patent/BR0315939A/pt not_active IP Right Cessation
- 2003-10-31 TW TW092130487A patent/TW200420290A/zh unknown
- 2003-10-31 CA CA002504028A patent/CA2504028A1/en not_active Abandoned
- 2003-10-31 JP JP2004550330A patent/JP2006507307A/ja active Pending
- 2003-10-31 EP EP03778016A patent/EP1565188A2/en not_active Withdrawn
- 2003-10-31 MX MXPA05004550A patent/MXPA05004550A/es unknown
- 2003-10-31 WO PCT/US2003/034662 patent/WO2004041191A2/en not_active Ceased
- 2003-10-31 KR KR1020057007658A patent/KR20050061596A/ko not_active Withdrawn
- 2003-10-31 AU AU2003286802A patent/AU2003286802A1/en not_active Abandoned
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