JP2005534752A5 - - Google Patents
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- Publication number
- JP2005534752A5 JP2005534752A5 JP2004525093A JP2004525093A JP2005534752A5 JP 2005534752 A5 JP2005534752 A5 JP 2005534752A5 JP 2004525093 A JP2004525093 A JP 2004525093A JP 2004525093 A JP2004525093 A JP 2004525093A JP 2005534752 A5 JP2005534752 A5 JP 2005534752A5
- Authority
- JP
- Japan
- Prior art keywords
- antibody
- antigen
- galnac
- binding fragment
- compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000012634 fragment Substances 0.000 claims 15
- 150000001875 compounds Chemical class 0.000 claims 12
- 239000000427 antigen Substances 0.000 claims 11
- 108091007433 antigens Proteins 0.000 claims 11
- 102000036639 antigens Human genes 0.000 claims 11
- 230000027455 binding Effects 0.000 claims 11
- 238000000034 method Methods 0.000 claims 9
- 241000589876 Campylobacter Species 0.000 claims 7
- 244000144972 livestock Species 0.000 claims 7
- 241000196324 Embryophyta Species 0.000 claims 6
- 244000052769 pathogen Species 0.000 claims 6
- 239000008194 pharmaceutical composition Substances 0.000 claims 6
- 241001465754 Metazoa Species 0.000 claims 5
- 102000008394 Immunoglobulin Fragments Human genes 0.000 claims 4
- 108010021625 Immunoglobulin Fragments Proteins 0.000 claims 4
- 108090000623 proteins and genes Proteins 0.000 claims 4
- 239000000523 sample Substances 0.000 claims 4
- 241000282836 Camelus dromedarius Species 0.000 claims 3
- 238000009007 Diagnostic Kit Methods 0.000 claims 3
- 235000017274 Diospyros sandwicensis Nutrition 0.000 claims 3
- 241000282412 Homo Species 0.000 claims 3
- 241000282838 Lama Species 0.000 claims 3
- 241000282826 Camelus Species 0.000 claims 2
- 102000003886 Glycoproteins Human genes 0.000 claims 2
- 108090000288 Glycoproteins Proteins 0.000 claims 2
- 229940024606 amino acid Drugs 0.000 claims 2
- 235000001014 amino acid Nutrition 0.000 claims 2
- 150000001413 amino acids Chemical class 0.000 claims 2
- 235000013361 beverage Nutrition 0.000 claims 2
- 150000004676 glycans Chemical class 0.000 claims 2
- 230000001717 pathogenic effect Effects 0.000 claims 2
- PZUPAGRIHCRVKN-UHFFFAOYSA-N 5-[5-[3,4-dihydroxy-6-[(3,4,5-trihydroxyoxan-2-yl)oxymethyl]-5-[3,4,5-trihydroxy-6-[(3,4,5-trihydroxyoxan-2-yl)oxymethyl]oxan-2-yl]oxyoxan-2-yl]oxy-3,4-dihydroxy-6-[(3,4,5-trihydroxyoxan-2-yl)oxymethyl]oxan-2-yl]oxy-6-(hydroxymethyl)oxane-2,3,4-triol Chemical compound OCC1OC(O)C(O)C(O)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(COC4C(C(O)C(O)CO4)O)O3)O)C(COC3C(C(O)C(O)CO3)O)O2)O)C(COC2C(C(O)C(O)CO2)O)O1 PZUPAGRIHCRVKN-UHFFFAOYSA-N 0.000 claims 1
- DCXYFEDJOCDNAF-UHFFFAOYSA-N Asparagine Natural products OC(=O)C(N)CC(N)=O DCXYFEDJOCDNAF-UHFFFAOYSA-N 0.000 claims 1
- 241000894006 Bacteria Species 0.000 claims 1
- 206010051226 Campylobacter infection Diseases 0.000 claims 1
- 241000588724 Escherichia coli Species 0.000 claims 1
- DCXYFEDJOCDNAF-REOHCLBHSA-N L-asparagine Chemical compound OC(=O)[C@@H](N)CC(N)=O DCXYFEDJOCDNAF-REOHCLBHSA-N 0.000 claims 1
- 238000005481 NMR spectroscopy Methods 0.000 claims 1
- 102000015636 Oligopeptides Human genes 0.000 claims 1
- 108010038807 Oligopeptides Proteins 0.000 claims 1
- 239000000654 additive Substances 0.000 claims 1
- 230000000996 additive effect Effects 0.000 claims 1
- 229960001230 asparagine Drugs 0.000 claims 1
- 235000009582 asparagine Nutrition 0.000 claims 1
- 230000001580 bacterial effect Effects 0.000 claims 1
- 238000011109 contamination Methods 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 239000003337 fertilizer Substances 0.000 claims 1
- 210000003754 fetus Anatomy 0.000 claims 1
- 239000003673 groundwater Substances 0.000 claims 1
- 238000004008 high resolution magic-angle spinning Methods 0.000 claims 1
- 230000002163 immunogen Effects 0.000 claims 1
- 229960001438 immunostimulant agent Drugs 0.000 claims 1
- 239000003022 immunostimulating agent Substances 0.000 claims 1
- 230000003308 immunostimulating effect Effects 0.000 claims 1
- 238000004091 panning Methods 0.000 claims 1
- 244000144977 poultry Species 0.000 claims 1
- 239000002689 soil Substances 0.000 claims 1
- 230000009870 specific binding Effects 0.000 claims 1
- 238000004611 spectroscopical analysis Methods 0.000 claims 1
- 229940124597 therapeutic agent Drugs 0.000 claims 1
- 229960005486 vaccine Drugs 0.000 claims 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 1
Images
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US39973502P | 2002-08-01 | 2002-08-01 | |
| US60/399,735 | 2002-08-01 | ||
| PCT/CA2003/001156 WO2004013151A2 (en) | 2002-08-01 | 2003-07-30 | Campylobacter glycans and glycopeptides |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2005534752A JP2005534752A (ja) | 2005-11-17 |
| JP2005534752A5 true JP2005534752A5 (enExample) | 2006-09-07 |
| JP4718174B2 JP4718174B2 (ja) | 2011-07-06 |
Family
ID=31495764
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004525093A Expired - Fee Related JP4718174B2 (ja) | 2002-08-01 | 2003-07-30 | カンピロバクターグリカンおよびグリコペプチド |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US7598354B2 (enExample) |
| EP (1) | EP1527080B1 (enExample) |
| JP (1) | JP4718174B2 (enExample) |
| CN (1) | CN1671722A (enExample) |
| AU (1) | AU2003254665C1 (enExample) |
| BR (1) | BR0312896A (enExample) |
| CA (1) | CA2494223C (enExample) |
| ES (1) | ES2391525T3 (enExample) |
| WO (1) | WO2004013151A2 (enExample) |
Families Citing this family (45)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7173003B2 (en) | 2001-10-10 | 2007-02-06 | Neose Technologies, Inc. | Granulocyte colony stimulating factor: remodeling and glycoconjugation of G-CSF |
| US7214660B2 (en) * | 2001-10-10 | 2007-05-08 | Neose Technologies, Inc. | Erythropoietin: remodeling and glycoconjugation of erythropoietin |
| DK1481057T3 (da) | 2002-03-07 | 2006-05-15 | Eidgenoess Tech Hochschule | System og fremgangsmåde til fremstilling af rekombinante glycosylerede proteiner i en prokaryot vært |
| AU2002952121A0 (en) * | 2002-10-17 | 2002-10-31 | Alchemia Limited | Novel carbohydrate based anti-bacterials |
| CA2522345A1 (en) | 2003-04-09 | 2004-11-18 | Neose Technologies, Inc. | Glycopegylation methods and proteins/peptides produced by the methods |
| WO2005012484A2 (en) | 2003-07-25 | 2005-02-10 | Neose Technologies, Inc. | Antibody-toxin conjugates |
| US20080305992A1 (en) | 2003-11-24 | 2008-12-11 | Neose Technologies, Inc. | Glycopegylated erythropoietin |
| US8633157B2 (en) | 2003-11-24 | 2014-01-21 | Novo Nordisk A/S | Glycopegylated erythropoietin |
| EP1694351A2 (en) * | 2003-12-03 | 2006-08-30 | Neose Technologies, Inc. | Glycopegylated follicle stimulating hormone |
| WO2006010143A2 (en) | 2004-07-13 | 2006-01-26 | Neose Technologies, Inc. | Branched peg remodeling and glycosylation of glucagon-like peptide-1 [glp-1] |
| EP1814573B1 (en) | 2004-10-29 | 2016-03-09 | ratiopharm GmbH | Remodeling and glycopegylation of fibroblast growth factor (fgf) |
| CA2593682C (en) | 2005-01-10 | 2016-03-22 | Neose Technologies, Inc. | Glycopegylated granulocyte colony stimulating factor |
| US9187546B2 (en) | 2005-04-08 | 2015-11-17 | Novo Nordisk A/S | Compositions and methods for the preparation of protease resistant human growth hormone glycosylation mutants |
| ES2535084T3 (es) * | 2005-05-11 | 2015-05-05 | Eth Zurich | Proteínas N-glicosiladas recombinantes procedentes de células procariotas |
| US20070105755A1 (en) * | 2005-10-26 | 2007-05-10 | Neose Technologies, Inc. | One pot desialylation and glycopegylation of therapeutic peptides |
| US20090048440A1 (en) | 2005-11-03 | 2009-02-19 | Neose Technologies, Inc. | Nucleotide Sugar Purification Using Membranes |
| CN101516388B (zh) | 2006-07-21 | 2012-10-31 | 诺和诺德公司 | 通过o-联糖基化序列的肽的糖基化 |
| US8969532B2 (en) | 2006-10-03 | 2015-03-03 | Novo Nordisk A/S | Methods for the purification of polypeptide conjugates comprising polyalkylene oxide using hydrophobic interaction chromatography |
| EP2144923B1 (en) | 2007-04-03 | 2013-02-13 | BioGeneriX AG | Methods of treatment using glycopegylated g-csf |
| WO2008154639A2 (en) | 2007-06-12 | 2008-12-18 | Neose Technologies, Inc. | Improved process for the production of nucleotide sugars |
| WO2009089154A2 (en) | 2008-01-03 | 2009-07-16 | Cornell Research Foundation, Inc. | Glycosylated protein expression in prokaryotes |
| CN102037004A (zh) * | 2008-01-08 | 2011-04-27 | 生物种属学股份公司 | 使用寡糖基转移酶的多肽的糖缀合 |
| SI2257307T1 (sl) | 2008-02-20 | 2018-09-28 | Glaxosmithkline Biologicals S.A. | Biokonjugati, izdelani iz rekombinantnih N-glikoziliranih proteinov iz prokariontskih celic |
| US20130189239A1 (en) | 2008-02-27 | 2013-07-25 | Novo Nordisk A/S | Conjugated Factor VIII Molecules |
| CN102365359B (zh) * | 2009-03-27 | 2014-10-29 | 瑞士联邦苏黎世技术大学 | 呈递空肠弯曲杆菌n-聚糖或其衍生物的肠沙门氏菌 |
| NO2501406T3 (enExample) | 2009-11-19 | 2018-05-19 | ||
| CA2789505C (en) | 2010-02-11 | 2017-12-05 | The Governors Of The University Of Alberta | N-linked glycan compounds |
| EP2561085B1 (en) * | 2010-04-20 | 2019-08-14 | National Research Council of Canada | Cell-based production of nonulosonates |
| WO2011138361A1 (en) | 2010-05-06 | 2011-11-10 | Glycovaxyn | Capsular gram-positive bacteria bioconjugate vaccines |
| US9308246B2 (en) | 2010-05-28 | 2016-04-12 | The United States Of America As Represented By The Secretary Of The Navy | Capsule composition for use as immunogen against Campylobacter jejuni |
| JP6135046B2 (ja) * | 2012-04-20 | 2017-05-31 | 株式会社島津製作所 | 糖ペプチドの質量分析法 |
| CA2907795C (en) | 2013-04-05 | 2023-09-05 | The Governors Of The University Of Alberta | Campylobacter vaccine |
| ES2755042T3 (es) * | 2015-01-26 | 2020-04-21 | Cadena Bio Inc | Composiciones de oligosacáridos para el uso como alimento para animales y sus métodos para producirlas |
| WO2017117539A1 (en) | 2015-12-30 | 2017-07-06 | Northwestern University | Cell-free glycoprotein synthesis (cfgps) in prokaryotic cell lysates enriched with components for glycosylation |
| US10829795B2 (en) | 2016-07-14 | 2020-11-10 | Northwestern University | Method for rapid in vitro synthesis of glycoproteins via recombinant production of N-glycosylated proteins in prokaryotic cell lysates |
| US11898187B2 (en) | 2017-08-15 | 2024-02-13 | Northwestern University | Protein glycosylation sites by rapid expression and characterization of N-glycosyltransferases |
| CN111491662A (zh) * | 2017-12-19 | 2020-08-04 | 阿尔伯塔大学理事会 | 产气荚膜梭菌表面聚糖及其应用 |
| US11530432B2 (en) | 2018-03-19 | 2022-12-20 | Northwestern University | Compositions and methods for rapid in vitro synthesis of bioconjugate vaccines in vitro via production and N-glycosylation of protein carriers in detoxified prokaryotic cell lysates |
| WO2019204346A1 (en) | 2018-04-16 | 2019-10-24 | Northwestern University | METHODS FOR CO-ACTIVATING IN VITRO NON-STANDARD AMINO ACID (nsAA) INCORPORATION AND GLYCOSYLATION IN CRUDE CELLLYSATES |
| WO2020072127A2 (en) | 2018-08-03 | 2020-04-09 | Northwestern University | On demand, portable, cell-free molecular sensing platform |
| EP3908669A4 (en) | 2019-01-11 | 2023-05-03 | Northwestern University | SYNTHESIS OF BIOCONJUGATED VACCINES IN PROKARYOT CELL LYSATE |
| US12325884B2 (en) | 2019-03-04 | 2025-06-10 | Northwestern University | Riboswitch-based fluoride sensing in cell-free extract |
| US12226410B2 (en) | 2019-10-18 | 2025-02-18 | Northwestern University | Methods for enhancing cellular clearance of pathological molecules via activation of the cellular protein ykt6 |
| WO2021081485A1 (en) | 2019-10-25 | 2021-04-29 | Northwestern University | Cell-free extract preparation protocol for enrichment of membrane vesicles and increased glycoprotein yields |
| WO2022256920A1 (en) * | 2021-06-07 | 2022-12-15 | The University Of British Columbia | Acholetin biopolymers and methods for enzymatic synthesis |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4925796A (en) * | 1986-03-07 | 1990-05-15 | Massachusetts Institute Of Technology | Method for enhancing glycoprotein stability |
| US5200344A (en) * | 1990-11-13 | 1993-04-06 | Blaser Martin J | Diagnostic testing for campylobacter jejuni or campylobacter coli infections using novel antigens |
| JPH09502604A (ja) * | 1993-08-27 | 1997-03-18 | エンテリック リサーチ ラボラトリーズ インコーポレイテッド | Ｃａｍｐｙｌｏｂａｃｔｅｒｊｅｊｕｎｉ抗原、並びにそれらの製造及び利用 |
| US5882902A (en) * | 1994-09-06 | 1999-03-16 | Bioflexin Ab | Amino acid conjugate |
| US5840547A (en) * | 1995-01-05 | 1998-11-24 | Ramot University Authority For Applied Research & Indfustrial Development Ltd. | Bioemulsifiers |
| US6676946B2 (en) * | 1997-03-27 | 2004-01-13 | Institut Pasteur | Multiple antigen glycopeptide carbohydrate vaccine comprising the same and use thereof |
| US6699705B2 (en) * | 1999-02-01 | 2004-03-02 | National Research Council Of Canada | Campylobacter glycosyltransferases for biosynthesis of gangliosides and ganglioside mimics |
| AU3513500A (en) * | 1999-03-05 | 2000-09-21 | Trustees Of Tufts College | Emulsan and emulsan analogs immunization formulations and use |
| US6512014B2 (en) * | 2000-12-13 | 2003-01-28 | Ramot University Authority For Applied Research And Industrial Development Limited | Compositions containing bioemulsifiers and a method for their preparation |
| EP2292273A3 (en) * | 2001-10-10 | 2011-11-23 | BioGeneriX AG | Remodeling and glycoconjugation of peptides |
| US20030232401A1 (en) * | 2002-06-12 | 2003-12-18 | Pugia Michael J. | Bacterial test method by glycated label binding |
| CA2623400C (en) * | 2005-09-21 | 2015-04-07 | Patricia Guerry | Immunogenic capsule composition for use as a vaccine component against campylobacter jejuni |
-
2003
- 2003-07-30 CN CNA038181851A patent/CN1671722A/zh active Pending
- 2003-07-30 EP EP03766087A patent/EP1527080B1/en not_active Expired - Lifetime
- 2003-07-30 US US10/523,459 patent/US7598354B2/en not_active Expired - Lifetime
- 2003-07-30 AU AU2003254665A patent/AU2003254665C1/en not_active Expired
- 2003-07-30 JP JP2004525093A patent/JP4718174B2/ja not_active Expired - Fee Related
- 2003-07-30 WO PCT/CA2003/001156 patent/WO2004013151A2/en not_active Ceased
- 2003-07-30 CA CA2494223A patent/CA2494223C/en not_active Expired - Lifetime
- 2003-07-30 BR BR0312896-2A patent/BR0312896A/pt not_active IP Right Cessation
- 2003-07-30 ES ES03766087T patent/ES2391525T3/es not_active Expired - Lifetime
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