JP2005533564A5 - - Google Patents
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- JP2005533564A5 JP2005533564A5 JP2004523269A JP2004523269A JP2005533564A5 JP 2005533564 A5 JP2005533564 A5 JP 2005533564A5 JP 2004523269 A JP2004523269 A JP 2004523269A JP 2004523269 A JP2004523269 A JP 2004523269A JP 2005533564 A5 JP2005533564 A5 JP 2005533564A5
- Authority
- JP
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- Prior art keywords
- plaque
- mect system
- mect
- computer
- subject
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 239000002872 contrast media Substances 0.000 claims 3
- 238000001514 detection method Methods 0.000 claims 2
- 230000002757 inflammatory Effects 0.000 claims 2
- 239000000427 antigen Substances 0.000 claims 1
- 102000038129 antigens Human genes 0.000 claims 1
- 108091007172 antigens Proteins 0.000 claims 1
- 238000002591 computed tomography Methods 0.000 claims 1
- PNDPGZBMCMUPRI-UHFFFAOYSA-N iodine Chemical compound II PNDPGZBMCMUPRI-UHFFFAOYSA-N 0.000 claims 1
- 229910052740 iodine Inorganic materials 0.000 claims 1
- 239000011630 iodine Substances 0.000 claims 1
- 239000000463 material Substances 0.000 claims 1
- 239000002184 metal Substances 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 210000000056 organs Anatomy 0.000 claims 1
- 200000000008 restenosis Diseases 0.000 claims 1
- 238000001228 spectrum Methods 0.000 claims 1
- 239000000758 substrate Substances 0.000 claims 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 1
Claims (10)
- 多重エネルギー・コンピュータ断層(MECT)システムであって、
被検体と交差するX線を送出するように構成された少なくとも1つの放射線源と、
前記X線を検出するように構成された少なくとも1つの検出器と、
前記検出器と結合させた制御装置と、
該MECTシステムにプラークの成分を検出するように指令するように構成されたコンピュータと、
を備え、
前記コンピュータは更に、
少なくとも1つの模擬ファントームを用いたルックアップ・テーブルの作成することと、
炎症性プラークに温度感受性造影剤を投与するようにユーザに指令した後に、前記プラークの成分の検出を反復すること、
を実行するように構成されている、MECTシステム。 - 前記ルックアップ・テーブルは様々なエネルギー・スペクトルに関して前記ファントームの選択された素地の様々な密度を投影データにマッピングしており、
前記コンピュータは、前記ルックアップ・テーブルを用いることによるプラークの成分の取得と、
を実行するように構成されている、請求項1に記載のMECTシステム。 - ルックアップ・テーブルを作成するために前記コンピュータは、
既知の材料特性の組を備えたファントームの第1組及び第2組の密度分布画像を、
該MECTシステムのスキャン範囲内での前記ファントームの配置のシミュレーション、及び
該MECTシステムを用いた第1及び第2のエネルギー・レベルでの前記ファントームのスキャンのシミュレーション、
によって取得するように構成されている、請求項1に記載のMECTシステム。 - プラークの成分を取得するために前記コンピュータは、
該MECTシステムのスキャン範囲内に被検体を配置させるように該MECTシステムに指令すること、
前記被検体の投影データを取得するために、前記第1及び第2のエネルギー・レベルで前記被検体をスキャンするように該MECTシステムに指令すること、
前記ルックアップ・テーブルから、前記被検体の投影データを、ヨウ素と水のうちの少なくとも一方を含む前記選択した素地の密度に逆マッピングすることによって、前記被検体の密度を決定すること、
を実行するように構成されている、請求項3に記載のMECTシステム。 - 前記コンピュータは、
プラークの脂質親和体、プラークのプラーク特異的抗原、及びプラークのプラーク細胞のうちの少なくとも1つに造影剤を投与するようにユーザに指令すること、
前記プラークの成分の検出を反復すること、
を実行するように構成されている、請求項1に記載のMECTシステム。 - 前記コンピュータは、
炎症性プラークに温度感受性造影剤を投与するようにユーザに指令すること、
を実行するように構成されている、請求項1に記載のMECTシステム。 - 前記コンピュータはプラークの成分を定量化するように構成されている、請求項1に記載のMECTシステム。
- プラークの成分を定量化するために前記コンピュータは、
前記プラークの組成分布を計算すること、
総プラーク負荷を計算すること、
を実行するように構成されている、請求項7に記載のMECTシステム。 - 前記コンピュータは、
前記被検体のある臓器の壁上にあるプラークの成分に関する2次元(2D)画像と3次元(3D)画像の少なくとも一方を表示するように表示デバイスに指令すること、
3D画像で前記プラークのボリュームをある観察点から観察することを可能にさせること、
を実行するように構成されている、請求項1に記載のMECTシステム。 - 前記コンピュータは、
金属製のステント及び弁のうちの少なくとも1つを有する被検体の画像の品質を、前記画像内のビーム硬化アーチファクトを除去することによって改善させること、
プラークの成分を検出する前記工程を反復することによって、金属製ステントのうちの少なくとも1つの内部にある再狭窄を描出可能にさせること、
を実行するように構成されている、請求項1に記載のMECTシステム。
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US39834102P | 2002-07-23 | 2002-07-23 | |
PCT/US2003/022861 WO2004008967A1 (en) | 2002-07-23 | 2003-07-23 | Methods and systems for detecting components of plaque |
Publications (3)
Publication Number | Publication Date |
---|---|
JP2005533564A JP2005533564A (ja) | 2005-11-10 |
JP2005533564A5 true JP2005533564A5 (ja) | 2008-09-18 |
JP4619781B2 JP4619781B2 (ja) | 2011-01-26 |
Family
ID=30771215
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2004523269A Expired - Fee Related JP4619781B2 (ja) | 2002-07-23 | 2003-07-23 | プラークの成分を検出するためのシステム |
Country Status (6)
Country | Link |
---|---|
US (1) | US7031426B2 (ja) |
EP (1) | EP1526808B1 (ja) |
JP (1) | JP4619781B2 (ja) |
CN (1) | CN100536774C (ja) |
AU (1) | AU2003252103A1 (ja) |
WO (1) | WO2004008967A1 (ja) |
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- 2003-07-23 EP EP03765895A patent/EP1526808B1/en not_active Expired - Fee Related
- 2003-07-23 AU AU2003252103A patent/AU2003252103A1/en not_active Abandoned
- 2003-07-23 CN CNB03801128XA patent/CN100536774C/zh not_active Expired - Fee Related
- 2003-07-23 WO PCT/US2003/022861 patent/WO2004008967A1/en active Application Filing
- 2003-07-23 JP JP2004523269A patent/JP4619781B2/ja not_active Expired - Fee Related
- 2003-07-23 US US10/625,437 patent/US7031426B2/en not_active Expired - Lifetime
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