JP2005532332A5 - - Google Patents
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- JP2005532332A5 JP2005532332A5 JP2004506824A JP2004506824A JP2005532332A5 JP 2005532332 A5 JP2005532332 A5 JP 2005532332A5 JP 2004506824 A JP2004506824 A JP 2004506824A JP 2004506824 A JP2004506824 A JP 2004506824A JP 2005532332 A5 JP2005532332 A5 JP 2005532332A5
- Authority
- JP
- Japan
- Prior art keywords
- neuregulin
- composition
- functional fragment
- kit
- protein
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- 102000014413 Neuregulin Human genes 0.000 claims 54
- 108050003475 Neuregulin Proteins 0.000 claims 54
- 239000000203 mixture Substances 0.000 claims 53
- 239000003814 drug Substances 0.000 claims 19
- 206010047470 Viral myocarditis Diseases 0.000 claims 18
- 108020004707 nucleic acids Proteins 0.000 claims 13
- 150000007523 nucleic acids Chemical class 0.000 claims 13
- 230000000069 prophylaxis Effects 0.000 claims 13
- 206010048610 Cardiotoxicity Diseases 0.000 claims 11
- 231100000259 cardiotoxicity Toxicity 0.000 claims 11
- 230000002708 enhancing Effects 0.000 claims 11
- 239000008194 pharmaceutical composition Substances 0.000 claims 11
- 238000004519 manufacturing process Methods 0.000 claims 9
- 239000005541 ACE inhibitor Substances 0.000 claims 8
- 241000124008 Mammalia Species 0.000 claims 8
- 208000010125 Myocardial Infarction Diseases 0.000 claims 8
- 239000003795 chemical substances by application Substances 0.000 claims 8
- 230000000694 effects Effects 0.000 claims 7
- 230000003405 preventing Effects 0.000 claims 7
- 102100015657 NRG2 Human genes 0.000 claims 5
- 101700080329 NRG2 Proteins 0.000 claims 5
- 102100015651 NRG3 Human genes 0.000 claims 5
- 101700055981 NRG3 Proteins 0.000 claims 5
- 102100015654 NRG4 Human genes 0.000 claims 5
- 102400000058 Neuregulin-1 Human genes 0.000 claims 5
- 108090000556 Neuregulin-1 Proteins 0.000 claims 5
- 108010063491 Neuregulin-4 Proteins 0.000 claims 5
- 125000003275 alpha amino acid group Chemical group 0.000 claims 5
- 230000000747 cardiac effect Effects 0.000 claims 5
- 230000003111 delayed Effects 0.000 claims 5
- 239000003937 drug carrier Substances 0.000 claims 5
- 206010003119 Arrhythmia Diseases 0.000 claims 4
- 206010007521 Cardiac arrhythmias Diseases 0.000 claims 4
- 239000000546 pharmaceutic aid Substances 0.000 claims 4
- 239000002464 receptor antagonist Substances 0.000 claims 4
- 230000002861 ventricular Effects 0.000 claims 4
- 206010007559 Cardiac failure congestive Diseases 0.000 claims 3
- 208000005846 Cardiomyopathy Diseases 0.000 claims 3
- 241000700605 Viruses Species 0.000 claims 3
- 230000001154 acute Effects 0.000 claims 3
- 201000008031 cardiomyopathy Diseases 0.000 claims 3
- 230000001684 chronic Effects 0.000 claims 3
- 201000006233 congestive heart failure Diseases 0.000 claims 3
- 230000002107 myocardial Effects 0.000 claims 3
- SNIOPGDIGTZGOP-UHFFFAOYSA-N 1,2,3-propanetrioltrinitrate Chemical compound [O-][N+](=O)OCC(O[N+]([O-])=O)CO[N+]([O-])=O SNIOPGDIGTZGOP-UHFFFAOYSA-N 0.000 claims 2
- 229930006677 A03BA01 - Atropine Natural products 0.000 claims 2
- 229930000680 A04AD01 - Scopolamine Natural products 0.000 claims 2
- 229940064005 Antibiotic throat preparations Drugs 0.000 claims 2
- 229940083879 Antibiotics FOR TREATMENT OF HEMORRHOIDS AND ANAL FISSURES FOR TOPICAL USE Drugs 0.000 claims 2
- 229940042052 Antibiotics for systemic use Drugs 0.000 claims 2
- 229940042786 Antitubercular Antibiotics Drugs 0.000 claims 2
- RKUNBYITZUJHSG-SPUOUPEWSA-N Atropine Chemical compound O([C@H]1C[C@H]2CC[C@@H](C1)N2C)C(=O)C(CO)C1=CC=CC=C1 RKUNBYITZUJHSG-SPUOUPEWSA-N 0.000 claims 2
- 229960000396 Atropine Drugs 0.000 claims 2
- 229940093922 Gynecological Antibiotics Drugs 0.000 claims 2
- STECJAGHUSJQJN-GAUPFVANSA-N Hyoscine Natural products C1([C@H](CO)C(=O)OC2C[C@@H]3N([C@H](C2)[C@@H]2[C@H]3O2)C)=CC=CC=C1 STECJAGHUSJQJN-GAUPFVANSA-N 0.000 claims 2
- 206010061216 Infarction Diseases 0.000 claims 2
- 208000009525 Myocarditis Diseases 0.000 claims 2
- 229940014995 Nitroglycerin Drugs 0.000 claims 2
- 239000000006 Nitroglycerin Substances 0.000 claims 2
- STECJAGHUSJQJN-FWXGHANASA-N Scopolamine Chemical compound C1([C@@H](CO)C(=O)O[C@H]2C[C@@H]3N([C@H](C2)[C@@H]2[C@H]3O2)C)=CC=CC=C1 STECJAGHUSJQJN-FWXGHANASA-N 0.000 claims 2
- 229940024982 Topical Antifungal Antibiotics Drugs 0.000 claims 2
- 229960001138 acetylsalicylic acid Drugs 0.000 claims 2
- 230000003042 antagnostic Effects 0.000 claims 2
- 239000005557 antagonist Substances 0.000 claims 2
- 239000003242 anti bacterial agent Substances 0.000 claims 2
- 230000001396 anti-anti-diuretic Effects 0.000 claims 2
- 230000000111 anti-oxidant Effects 0.000 claims 2
- 230000000840 anti-viral Effects 0.000 claims 2
- 239000003963 antioxidant agent Substances 0.000 claims 2
- BSYNRYMUTXBXSQ-UHFFFAOYSA-N aspirin Chemical compound CC(=O)OC1=CC=CC=C1C(O)=O BSYNRYMUTXBXSQ-UHFFFAOYSA-N 0.000 claims 2
- 230000003115 biocidal Effects 0.000 claims 2
- OYPRJOBELJOOCE-UHFFFAOYSA-N calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 claims 2
- 229910052791 calcium Inorganic materials 0.000 claims 2
- 239000011575 calcium Substances 0.000 claims 2
- 239000000480 calcium channel blocker Substances 0.000 claims 2
- -1 cardioprotectants Substances 0.000 claims 2
- 201000010099 disease Diseases 0.000 claims 2
- 201000009910 diseases by infectious agent Diseases 0.000 claims 2
- 239000002934 diuretic Substances 0.000 claims 2
- 230000004064 dysfunction Effects 0.000 claims 2
- 239000003527 fibrinolytic agent Substances 0.000 claims 2
- 229960003711 glyceryl trinitrate Drugs 0.000 claims 2
- 229940079866 intestinal antibiotics Drugs 0.000 claims 2
- 230000003680 myocardial damage Effects 0.000 claims 2
- 235000015097 nutrients Nutrition 0.000 claims 2
- 229940005935 ophthalmologic Antibiotics Drugs 0.000 claims 2
- 230000002265 prevention Effects 0.000 claims 2
- 229960002646 scopolamine Drugs 0.000 claims 2
- 229960000103 thrombolytic agents Drugs 0.000 claims 2
- 230000001256 tonic Effects 0.000 claims 2
- 235000015961 tonic Nutrition 0.000 claims 2
- 229940034982 ANTINEOPLASTIC AGENTS Drugs 0.000 claims 1
- 206010000830 Acute leukaemia Diseases 0.000 claims 1
- 206010005003 Bladder cancer Diseases 0.000 claims 1
- 206010006187 Breast cancer Diseases 0.000 claims 1
- 206010007554 Cardiac failure Diseases 0.000 claims 1
- 206010007572 Cardiac hypertrophy Diseases 0.000 claims 1
- 208000008787 Cardiovascular Disease Diseases 0.000 claims 1
- 206010008342 Cervix carcinoma Diseases 0.000 claims 1
- 229940030606 DIURETICS Drugs 0.000 claims 1
- 241001466953 Echovirus Species 0.000 claims 1
- 206010014665 Endocarditis Diseases 0.000 claims 1
- 241000991587 Enterovirus C Species 0.000 claims 1
- 206010017758 Gastric cancer Diseases 0.000 claims 1
- 210000001308 Heart Ventricles Anatomy 0.000 claims 1
- 206010019280 Heart failure Diseases 0.000 claims 1
- 229940047124 Interferons Drugs 0.000 claims 1
- 102000014150 Interferons Human genes 0.000 claims 1
- 108010050904 Interferons Proteins 0.000 claims 1
- 229940047122 Interleukins Drugs 0.000 claims 1
- 102000015696 Interleukins Human genes 0.000 claims 1
- 108010063738 Interleukins Proteins 0.000 claims 1
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims 1
- 206010025323 Lymphomas Diseases 0.000 claims 1
- 241000701076 Macacine alphaherpesvirus 1 Species 0.000 claims 1
- 206010029260 Neuroblastoma Diseases 0.000 claims 1
- 206010030155 Oesophageal carcinoma Diseases 0.000 claims 1
- 206010025310 Other lymphomas Diseases 0.000 claims 1
- 208000007888 Sinus Tachycardia Diseases 0.000 claims 1
- 206010073145 Soft tissue cancer Diseases 0.000 claims 1
- 229960000716 TONICS Drugs 0.000 claims 1
- 208000001871 Tachycardia Diseases 0.000 claims 1
- 206010057644 Testis cancer Diseases 0.000 claims 1
- 206010047295 Ventricular hypertrophy Diseases 0.000 claims 1
- 230000004075 alteration Effects 0.000 claims 1
- 239000004599 antimicrobial Substances 0.000 claims 1
- 239000002246 antineoplastic agent Substances 0.000 claims 1
- 239000000164 antipsychotic agent Substances 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 201000010881 cervical cancer Diseases 0.000 claims 1
- 230000003247 decreasing Effects 0.000 claims 1
- 230000003205 diastolic Effects 0.000 claims 1
- 230000001882 diuretic Effects 0.000 claims 1
- 229940079593 drugs Drugs 0.000 claims 1
- 239000003623 enhancer Substances 0.000 claims 1
- 201000004101 esophageal cancer Diseases 0.000 claims 1
- 230000002401 inhibitory effect Effects 0.000 claims 1
- 238000001990 intravenous administration Methods 0.000 claims 1
- 230000002427 irreversible Effects 0.000 claims 1
- 150000002632 lipids Chemical class 0.000 claims 1
- 201000007270 liver cancer Diseases 0.000 claims 1
- 201000005202 lung cancer Diseases 0.000 claims 1
- 201000008968 osteosarcoma Diseases 0.000 claims 1
- 238000007254 oxidation reaction Methods 0.000 claims 1
- MYMOFIZGZYHOMD-UHFFFAOYSA-N oxygen Chemical compound O=O MYMOFIZGZYHOMD-UHFFFAOYSA-N 0.000 claims 1
- 229910052760 oxygen Inorganic materials 0.000 claims 1
- 239000001301 oxygen Substances 0.000 claims 1
- 230000003449 preventive Effects 0.000 claims 1
- 230000002035 prolonged Effects 0.000 claims 1
- 102000004169 proteins and genes Human genes 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
- 238000005086 pumping Methods 0.000 claims 1
- 230000035939 shock Effects 0.000 claims 1
- 201000011549 stomach cancer Diseases 0.000 claims 1
- 201000010874 syndrome Diseases 0.000 claims 1
- 201000003120 testicular cancer Diseases 0.000 claims 1
- 201000002510 thyroid cancer Diseases 0.000 claims 1
- 239000003029 tricyclic antidepressant agent Substances 0.000 claims 1
- 201000005112 urinary bladder cancer Diseases 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/CN2002/000349 WO2003099320A1 (en) | 2002-05-24 | 2002-05-24 | Neuregulin based methods and compositions for treating viral myocarditis and dilated cardiomyopathy |
| PCT/CN2003/000355 WO2003099300A1 (en) | 2002-05-24 | 2003-05-15 | Neuregulin based methods and compositions for treating cardiovascular diseases |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010223952A Division JP5809789B2 (ja) | 2002-05-24 | 2010-10-01 | 薬学的組成物、およびキット |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2005532332A JP2005532332A (ja) | 2005-10-27 |
| JP2005532332A5 true JP2005532332A5 (US20040106767A1-20040603-C00005.png) | 2006-07-06 |
Family
ID=29555543
Family Applications (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004506824A Pending JP2005532332A (ja) | 2002-05-24 | 2003-05-15 | 心血管疾患を処置するためのニューレギュリン法および組成物 |
| JP2010223952A Expired - Lifetime JP5809789B2 (ja) | 2002-05-24 | 2010-10-01 | 薬学的組成物、およびキット |
| JP2014000319A Expired - Lifetime JP5964868B2 (ja) | 2002-05-24 | 2014-01-06 | 心血管疾患を処置するためのニューレギュリン法および組成物 |
| JP2016018132A Expired - Lifetime JP6603149B2 (ja) | 2002-05-24 | 2016-02-02 | 心血管疾患を処置するためのニューレギュリン法および組成物 |
| JP2017214721A Pending JP2018052957A (ja) | 2002-05-24 | 2017-11-07 | 心血管疾患を処置するためのニューレギュリン法および組成物 |
Family Applications After (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010223952A Expired - Lifetime JP5809789B2 (ja) | 2002-05-24 | 2010-10-01 | 薬学的組成物、およびキット |
| JP2014000319A Expired - Lifetime JP5964868B2 (ja) | 2002-05-24 | 2014-01-06 | 心血管疾患を処置するためのニューレギュリン法および組成物 |
| JP2016018132A Expired - Lifetime JP6603149B2 (ja) | 2002-05-24 | 2016-02-02 | 心血管疾患を処置するためのニューレギュリン法および組成物 |
| JP2017214721A Pending JP2018052957A (ja) | 2002-05-24 | 2017-11-07 | 心血管疾患を処置するためのニューレギュリン法および組成物 |
Country Status (8)
Families Citing this family (70)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AUPP785098A0 (en) | 1998-12-21 | 1999-01-21 | Victor Chang Cardiac Research Institute, The | Treatment of heart disease |
| US8388672B2 (en) | 1999-08-09 | 2013-03-05 | Cardiokinetix, Inc. | System for improving cardiac function by sealing a partitioning membrane within a ventricle |
| US8257428B2 (en) | 1999-08-09 | 2012-09-04 | Cardiokinetix, Inc. | System for improving cardiac function |
| US7674222B2 (en) | 1999-08-09 | 2010-03-09 | Cardiokinetix, Inc. | Cardiac device and methods of use thereof |
| US10307147B2 (en) | 1999-08-09 | 2019-06-04 | Edwards Lifesciences Corporation | System for improving cardiac function by sealing a partitioning membrane within a ventricle |
| US8529430B2 (en) | 2002-08-01 | 2013-09-10 | Cardiokinetix, Inc. | Therapeutic methods and devices following myocardial infarction |
| US9694121B2 (en) | 1999-08-09 | 2017-07-04 | Cardiokinetix, Inc. | Systems and methods for improving cardiac function |
| US8500795B2 (en) | 1999-08-09 | 2013-08-06 | Cardiokinetix, Inc. | Retrievable devices for improving cardiac function |
| US9332993B2 (en) | 2004-08-05 | 2016-05-10 | Cardiokinetix, Inc. | Devices and methods for delivering an endocardial device |
| US9332992B2 (en) | 2004-08-05 | 2016-05-10 | Cardiokinetix, Inc. | Method for making a laminar ventricular partitioning device |
| US9078660B2 (en) | 2000-08-09 | 2015-07-14 | Cardiokinetix, Inc. | Devices and methods for delivering an endocardial device |
| US10064696B2 (en) | 2000-08-09 | 2018-09-04 | Edwards Lifesciences Corporation | Devices and methods for delivering an endocardial device |
| WO2003099320A1 (en) | 2002-05-24 | 2003-12-04 | Zensun (Shanghai) Sci-Tech.Ltd | Neuregulin based methods and compositions for treating viral myocarditis and dilated cardiomyopathy |
| AU2003237367A1 (en) * | 2002-06-03 | 2003-12-19 | Chiron Corporation | Use of nrg4, or inhibitors thereof, in the treatment of colon and pancreatic cancer |
| CA2615122A1 (en) * | 2005-08-03 | 2007-02-15 | Immunogen, Inc. | Immunoconjugate formulations |
| CA2658326C (en) * | 2005-09-02 | 2013-04-23 | Morehouse School Of Medicine | Neuregulins for prevention and treatment of damage from acute assault on vascular and neuronal tissue |
| US20070213264A1 (en) | 2005-12-02 | 2007-09-13 | Mingdong Zhou | Neuregulin variants and methods of screening and using thereof |
| EP3363455A1 (en) * | 2005-12-30 | 2018-08-22 | Zensun (Shanghai) Science & Technology, Co., Ltd. | Extended release of neuregulin for improved cardiac function |
| WO2007130724A2 (en) | 2006-02-06 | 2007-11-15 | Northwind Ventures | Systems and methods for volume reduction |
| CA2686959C (en) | 2007-05-10 | 2017-06-13 | Acorda Therapeutics Inc. | Methods for detecting cardiac damage |
| CN103432681A (zh) * | 2007-05-25 | 2013-12-11 | 上海泽生科技开发有限公司 | 包含神经调节蛋白的药物制剂及装置 |
| CN101310766B (zh) * | 2007-05-25 | 2014-04-16 | 上海泽生科技开发有限公司 | 神经调节蛋白的新用途 |
| CN101310765A (zh) * | 2007-05-25 | 2008-11-26 | 上海泽生科技开发有限公司 | 神经调节蛋白应用于人的安全剂量 |
| US20090156488A1 (en) | 2007-09-12 | 2009-06-18 | Zensun (Shanghai) Science & Technology Limited | Use of neuregulin for organ preservation |
| ES2763184T3 (es) * | 2008-07-17 | 2020-05-27 | Acorda Therapeutics Inc | Dosificación terapéutica de una neurregulina en el tratamiento o profilaxis de la insuficiencia cardíaca |
| RU2501564C2 (ru) | 2008-08-15 | 2013-12-20 | Акорда Терапьютикс, Инк. | Композиции и способы для лечения во время не острых периодов после неврологического повреждения цнс |
| EP2346526A2 (en) | 2008-09-22 | 2011-07-27 | Massachusetts Institute of Technology | Compositions of and methods of using ligand dimers |
| EP2370093A4 (en) * | 2008-11-28 | 2012-08-29 | Zensun Shanghai Science And Technology Ltd | NEUREGULIN AND CARDIAC STEM CELLS |
| US8609620B2 (en) | 2008-11-28 | 2013-12-17 | Zensun (Shanghai) Science & Technology Ltd. | Neuregulin peptides and their use |
| CN102470161A (zh) | 2009-06-09 | 2012-05-23 | 上海泽生科技开发有限公司 | 神经调节蛋白用于治疗心力衰竭的有效剂量 |
| EP3087998B1 (en) | 2009-06-09 | 2019-09-04 | Zensun (Shanghai) Science & Technology, Co., Ltd. | Neuregulin based methods for treating heart failure |
| WO2011006072A2 (en) * | 2009-07-10 | 2011-01-13 | Northwestern University | Cardioprotective role of hepatic cells and hepatocyte secretory factors in myocardial ischemia |
| WO2011011388A2 (en) * | 2009-07-22 | 2011-01-27 | Children's Medical Center Corporation | Neuregulin induced regeneraton of heart muscle muscle |
| JP6096262B2 (ja) * | 2009-08-25 | 2017-03-15 | ゼンサン （シャンハイ） サイエンス アンド テクノロジー，シーオー．，エルティーディー． | ニューレグリンに基づく心不全の治療方法 |
| GB2487339A (en) * | 2009-10-23 | 2012-07-18 | Amorcyte Inc | Compositions and methods for treating progressive myocardial injury due to a vascular insufficiency |
| WO2011056578A2 (en) | 2009-10-26 | 2011-05-12 | Cardiokinetix, Inc. | Ventricular volume reduction |
| CN103772498B (zh) * | 2009-11-09 | 2015-07-15 | 上海泽生科技开发有限公司 | 纽兰格林及其用途 |
| CN102139095A (zh) * | 2010-01-29 | 2011-08-03 | 上海泽生科技开发有限公司 | 神经调节蛋白用于预防、治疗或延迟心脏缺血再灌注损伤的方法和组合物 |
| EP2555788B1 (en) * | 2010-03-24 | 2017-10-11 | Massachusetts Institute of Technology | NEUREGULIN DIMER FOR AN ErbB/HER RECEPTOR FOR USE IN REDUCING CARDIOTOXICITY. |
| CN104399062A (zh) * | 2011-01-11 | 2015-03-11 | 上海泽生科技开发有限公司 | 神经调节蛋白用于预防、治疗或延迟心脏缺血再灌注损伤的方法和组合物 |
| MY164530A (en) | 2011-03-02 | 2017-12-29 | Berg Llc | Interrogatory cell-based assays and uses thereof |
| US8754044B2 (en) | 2011-05-03 | 2014-06-17 | Northwestern University | Neuroprotection by hepatic cells and hepatocyte secretory factors |
| WO2013053076A1 (en) | 2011-10-10 | 2013-04-18 | Zensun （Shanghai）Science & Technology Limited | Compositions and methods for treating heart failure |
| KR20200105524A (ko) | 2012-04-02 | 2020-09-07 | 버그 엘엘씨 | 조사적 세포 기반 분석 및 이의 사용 |
| EA201492178A1 (ru) | 2012-05-22 | 2015-12-30 | Берг Ллк | Основанные на клетках перекрестные анализы для идентификации маркеров индуцированной лекарственными средствами токсичности |
| AU2013315371A1 (en) | 2012-09-12 | 2015-04-09 | Berg Llc | Use of markers in the identification of cardiotoxic agents |
| WO2014051567A1 (en) * | 2012-09-26 | 2014-04-03 | Morehouse School Of Medicine | Chimeric neuregulins and method of making and use thereof |
| CA2884051A1 (en) | 2012-10-08 | 2014-04-17 | Zensun (Shanghai) Science & Technology, Ltd. | Compositions and methods for treating heart failure in diabetic patients |
| EP3610905B1 (en) | 2013-05-22 | 2021-03-31 | Zensun (Shanghai) Science & Technology, Co., Ltd. | Extended release of neuregulin for treating heart failure |
| AU2014336122B2 (en) | 2013-10-18 | 2020-06-25 | Attoquant Diagnostics Gmbh | Method for diagnosis of primary hyperaldosteronism |
| CN110946993A (zh) | 2014-01-03 | 2020-04-03 | 上海泽生科技开发股份有限公司 | 纽兰格林制剂的配方 |
| WO2015158743A1 (en) | 2014-04-15 | 2015-10-22 | Universiteit Antwerpen | Treatment of nephropathy |
| EP3191975A4 (en) | 2014-09-11 | 2018-04-18 | Berg LLC | Bayesian causal relationship network models for healthcare diagnosis and treatment based on patient data |
| CN105497876B (zh) * | 2014-09-24 | 2021-01-15 | 上海泽生科技开发股份有限公司 | 神经调节蛋白用于预防、治疗或延迟心脏室性心律失常的方法和组合物 |
| CA2962747C (en) | 2014-09-28 | 2023-02-28 | Cardiokinetix, Inc. | Apparatuses for treating cardiac dysfunction |
| CN111407882A (zh) | 2014-10-17 | 2020-07-14 | 上海泽生科技开发股份有限公司 | 神经调节蛋白用于预防、治疗或延迟射血分数保留的心力衰竭的方法和组合物 |
| US20170333529A1 (en) * | 2015-01-20 | 2017-11-23 | Universiteit Antwerpen | Neuregulin in the treatment of fibrotic disorders |
| CN104922153A (zh) * | 2015-04-02 | 2015-09-23 | 连祺周 | Nrg1-erbb4复合体在制备治疗心肌缺血的药物中的应用 |
| US10017574B2 (en) * | 2015-05-07 | 2018-07-10 | Yeda Research And Development Co. Ltd. | Methods, kits and devices for promoting cardiac regeneration |
| CN115919889A (zh) * | 2015-12-22 | 2023-04-07 | 雀巢产品有限公司 | 用于治疗肌肉减少症和虚弱的方法 |
| DE102018107407A1 (de) | 2017-03-28 | 2018-10-04 | Edwards Lifesciences Corporation | Positionieren, einsetzen und zurückholen von implantierbaren vorrichtungen |
| PE20210111A1 (es) * | 2018-04-11 | 2021-01-19 | Salubris Biotherapeutics Inc | Composiciones de proteina de fusion recombinante neuregulina-1 (nrg-1) humana y metodos para su uso |
| CN111407881A (zh) * | 2019-01-07 | 2020-07-14 | 上海泽生科技开发股份有限公司 | 神经调节蛋白用于预防、治疗或延迟心肌损伤的方法和组合物 |
| AR121035A1 (es) | 2019-04-01 | 2022-04-13 | Lilly Co Eli | Compuestos de neuregulina-4 y métodos de uso |
| CN109999015A (zh) * | 2019-04-24 | 2019-07-12 | 江苏省中医药研究院 | 紫草素在制备预防或治疗房颤药物中的用途 |
| WO2021052277A1 (zh) | 2019-09-16 | 2021-03-25 | 上海泽生科技开发股份有限公司 | 重组人神经调节蛋白衍生物及其用途 |
| CN110714068A (zh) * | 2019-11-14 | 2020-01-21 | 南通大学 | 膜蛋白分子ErbB4在制备治疗脑缺血损伤药物中的应用 |
| CN113289002A (zh) | 2020-02-24 | 2021-08-24 | 上海泽生科技开发股份有限公司 | 神经调节蛋白用于预防、治疗或延缓心力衰竭的方法和组合物 |
| CN113238060B (zh) * | 2021-05-08 | 2022-10-11 | 迈克生物股份有限公司 | 用于预测或诊断心肌炎的试剂盒 |
| WO2023070078A1 (en) * | 2021-10-22 | 2023-04-27 | The Research Institute At Nationwide Children's Hospital | Neuregulin for protection against respiratory viral infection and post-viral disease |
Family Cites Families (87)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3773919A (en) | 1969-10-23 | 1973-11-20 | Du Pont | Polylactide-drug mixtures |
| US4179337A (en) | 1973-07-20 | 1979-12-18 | Davis Frank F | Non-immunogenic polypeptides |
| US4263428A (en) | 1978-03-24 | 1981-04-21 | The Regents Of The University Of California | Bis-anthracycline nucleic acid function inhibitors and improved method for administering the same |
| JPS6023084B2 (ja) | 1979-07-11 | 1985-06-05 | 味の素株式会社 | 代用血液 |
| DE3169595D1 (en) | 1980-11-10 | 1985-05-02 | Gersonde Klaus | Method of preparing lipid vesicles by ultrasonic treatment, the use of this method and apparatus for its application |
| IE52535B1 (en) | 1981-02-16 | 1987-12-09 | Ici Plc | Continuous release pharmaceutical compositions |
| US4485045A (en) | 1981-07-06 | 1984-11-27 | Research Corporation | Synthetic phosphatidyl cholines useful in forming liposomes |
| US4640835A (en) | 1981-10-30 | 1987-02-03 | Nippon Chemiphar Company, Ltd. | Plasminogen activator derivatives |
| EP0088046B1 (de) | 1982-02-17 | 1987-12-09 | Ciba-Geigy Ag | Lipide in wässriger Phase |
| US4738927A (en) | 1982-03-31 | 1988-04-19 | Ajinomoto Co. Inc. | Gene coded for interleukin-2 polypeptide, recombinant DNA carrying the said gene, a living cell line possessing the recombinant DNA, and method for producing interleukin-2 using the said cell |
| DE3218121A1 (de) | 1982-05-14 | 1983-11-17 | Leskovar, Peter, Dr.-Ing., 8000 München | Arzneimittel zur tumorbehandlung |
| DE3220116A1 (de) | 1982-05-28 | 1983-12-01 | Dr. Karl Thomae Gmbh, 7950 Biberach | Mikrobiologisch hergestellte (alpha)- und ss-interferone, dna-sequenzen, die fuer diese interferone codieren, mikroorganismen, die diese genetische information enthalten, und verfahren zu ihrer herstellung |
| EP0102324A3 (de) | 1982-07-29 | 1984-11-07 | Ciba-Geigy Ag | Lipide und Tenside in wässriger Phase |
| US4544545A (en) | 1983-06-20 | 1985-10-01 | Trustees University Of Massachusetts | Liposomes containing modified cholesterol for organ targeting |
| JPS607934A (ja) | 1983-06-29 | 1985-01-16 | Dai Ichi Seiyaku Co Ltd | リポソ−ムの製造方法 |
| HUT35524A (en) | 1983-08-02 | 1985-07-29 | Hoechst Ag | Process for preparing pharmaceutical compositions containing regulatory /regulative/ peptides providing for the retarded release of the active substance |
| EP0350973B1 (de) | 1983-09-26 | 1997-11-05 | Udo Dr. Ehrenfeld | Mittel und Erzeugnis für die Diagnose und Therapie von Tumoren sowie zur Behandlung von Schwächen der zelligen und humoralen Immunabwehr |
| DE3474511D1 (en) | 1983-11-01 | 1988-11-17 | Terumo Corp | Pharmaceutical composition containing urokinase |
| US4496689A (en) | 1983-12-27 | 1985-01-29 | Miles Laboratories, Inc. | Covalently attached complex of alpha-1-proteinase inhibitor with a water soluble polymer |
| US4569790A (en) | 1984-03-28 | 1986-02-11 | Cetus Corporation | Process for recovering microbially produced interleukin-2 and purified recombinant interleukin-2 compositions |
| DE3675588D1 (de) | 1985-06-19 | 1990-12-20 | Ajinomoto Kk | Haemoglobin, das an ein poly(alkenylenoxid) gebunden ist. |
| US4791192A (en) | 1986-06-26 | 1988-12-13 | Takeda Chemical Industries, Ltd. | Chemically modified protein with polyethyleneglycol |
| WO1989001489A1 (en) | 1987-08-10 | 1989-02-23 | Commonwealth Scientific And Industrial Research Or | Control of angiogenesis and compositions and methods therefor |
| SE463851B (sv) | 1988-09-02 | 1991-02-04 | Amsu Ltd | Komposition foer behandling av erektil dysfunktion via uretra |
| JPH02226533A (ja) | 1989-02-27 | 1990-09-10 | Mitsubishi Electric Corp | 情報記録媒体 |
| US5716930A (en) | 1991-04-10 | 1998-02-10 | Ludwig Institute For Cancer Research | Glial growth factors |
| US5530109A (en) | 1991-04-10 | 1996-06-25 | Ludwig Institute For Cancer Research | DNA encoding glial mitogenic factors |
| US7115554B1 (en) | 1993-05-06 | 2006-10-03 | Acorda Therapeutics, Inc. | Methods of increasing myotube formation or survival or muscle cell mitogenesis differentiation or survival using neuregulin GGF III |
| GB9107566D0 (en) | 1991-04-10 | 1991-05-29 | Ludwig Inst Cancer Res | Glial mitogenic factors,their preparation and use |
| IL101943A0 (en) | 1991-05-24 | 1992-12-30 | Genentech Inc | Structure,production and use of heregulin |
| US5834229A (en) | 1991-05-24 | 1998-11-10 | Genentech, Inc. | Nucleic acids vectors and host cells encoding and expressing heregulin 2-α |
| US5367060A (en) | 1991-05-24 | 1994-11-22 | Genentech, Inc. | Structure, production and use of heregulin |
| PL176408B1 (pl) | 1992-02-10 | 1999-05-31 | Interferon Sciences Inc | Kompozycja naturalnego alfa interferonu z ludzkich leukocytów krwi obwodowej i sposób wytwarzania kompozycji naturalnego alfa interferonu z ludzkich leukocytów krwi obwodowej |
| US6087323A (en) | 1992-04-03 | 2000-07-11 | Cambridge Neuroscience, Inc. | Use of neuregulins as modulators of cellular communication |
| DE4221256C2 (de) | 1992-06-26 | 1997-07-10 | Lancaster Group Ag | Galenische Zusammensetzung für die topische Anwendung |
| US5869305A (en) | 1992-12-04 | 1999-02-09 | The University Of Pittsburgh | Recombinant viral vector system |
| EP0647449A1 (en) | 1993-06-24 | 1995-04-12 | Takeda Chemical Industries, Ltd. | Sustained-release preparation of anti-endothelin substance |
| US5834441A (en) | 1993-09-13 | 1998-11-10 | Rhone-Poulenc Rorer Pharmaceuticals Inc. | Adeno-associated viral (AAV) liposomes and methods related thereto |
| US5399699A (en) | 1994-01-24 | 1995-03-21 | Abbott Laboratories | Indole iminooxy derivatives which inhibit leukotriene biosynthesis |
| ES2161793T3 (es) | 1994-04-09 | 2001-12-16 | Hoffmann La Roche | Proceso para la produccion de alfa-interferona. |
| US5770567A (en) | 1994-11-14 | 1998-06-23 | Genentech, Inc. | Sensory and motor neuron derived factor (SMDF) |
| US6169070B1 (en) | 1995-03-10 | 2001-01-02 | Genentech, Inc. | Mer receptor activation by gas6 |
| US6750196B1 (en) | 1995-03-27 | 2004-06-15 | Acorda Therapeutics | Methods of treating disorders of the eye |
| US5741511A (en) | 1995-04-12 | 1998-04-21 | Sam Yang Co., Ltd. | Transdermal drug delivery device for treating erectile dysfunction |
| US5721139A (en) | 1995-05-10 | 1998-02-24 | Genentech, Inc. | Isolating and culturing schwann cells |
| US6033660A (en) | 1995-05-10 | 2000-03-07 | Genentech, Inc. | Method of treating a nervous system injury with cultured schwann cells |
| US5714385A (en) | 1995-05-10 | 1998-02-03 | Genentech, Inc. | Media for culturing schwann cells |
| US5912326A (en) | 1995-09-08 | 1999-06-15 | President And Fellows Of Harvard College | Cerebellum-derived growth factors |
| US5888767A (en) | 1996-11-27 | 1999-03-30 | The Johns Hopkins University School Of Medicine | Method of using a conditionally replicating viral vector to express a gene |
| US5941868A (en) | 1995-12-22 | 1999-08-24 | Localmed, Inc. | Localized intravascular delivery of growth factors for promotion of angiogenesis |
| US5736154A (en) | 1996-03-11 | 1998-04-07 | Fuisz Technologies Ltd. | Transdermal delivery system |
| US5968511A (en) | 1996-03-27 | 1999-10-19 | Genentech, Inc. | ErbB3 antibodies |
| US5834235A (en) | 1996-06-21 | 1998-11-10 | Health Research, Incorporated | Inferferon-α-induced protein |
| DE69740038D1 (US20040106767A1-20040603-C00005.png) | 1996-07-12 | 2010-12-16 | Genentech Inc | |
| CA2257839C (en) | 1996-07-12 | 2012-10-23 | Genentech, Inc. | Gamma-heregulin |
| US6593290B1 (en) | 1996-11-01 | 2003-07-15 | Genentech, Inc. | Treatment of inner ear hair cells |
| US6156728A (en) | 1996-11-01 | 2000-12-05 | Genentech, Inc. | Treatment of inner ear hair cells |
| US6136558A (en) * | 1997-02-10 | 2000-10-24 | Genentech, Inc. | Heregulin variants |
| EP0970207B1 (en) | 1997-02-10 | 2009-04-01 | Genentech, Inc. | Heregulin variants |
| US20020002276A1 (en) | 1997-02-10 | 2002-01-03 | Genentech, Inc. | Chimeric heteromultimer adhesins |
| WO1998055611A1 (en) | 1997-06-06 | 1998-12-10 | Regents Of The University Of Michigan | Neuregulin response element and uses therefor |
| US6121415A (en) | 1997-07-09 | 2000-09-19 | Genentech, Inc. | ErbB4 receptor-specific neuregolin related ligands and uses therefor |
| SE9703226D0 (sv) | 1997-09-08 | 1997-09-08 | Astra Ab | New pharmaceutical composition |
| JP2001519400A (ja) | 1997-10-14 | 2001-10-23 | ケンブリッジ ニューロサイエンス インク． | ニューレグリン使用を含む治療法 |
| US6197801B1 (en) | 1998-01-14 | 2001-03-06 | Usa Doctors Products, Inc. | Injectable pharmaceutical composition for treatment and reversal of erectile dysfunction |
| US5962274A (en) | 1998-03-13 | 1999-10-05 | Wake Forest University | Viral vector directed to predetermined target cells |
| AUPP785098A0 (en) * | 1998-12-21 | 1999-01-21 | Victor Chang Cardiac Research Institute, The | Treatment of heart disease |
| US6446242B1 (en) | 1999-04-02 | 2002-09-03 | Actel Corporation | Method and apparatus for storing a validation number in a field-programmable gate array |
| US6635249B1 (en) * | 1999-04-23 | 2003-10-21 | Cenes Pharmaceuticals, Inc. | Methods for treating congestive heart failure |
| US6933122B1 (en) | 1999-05-14 | 2005-08-23 | The Trustees Of Columbia University In The City Of New York | A-form of cytoplasmic domain of nARIA (CRD-neuregulin) and uses thereof |
| CN1138785C (zh) * | 1999-06-04 | 2004-02-18 | 周明东 | 生长因子神经调节蛋白及其类似物的新应用 |
| AU7873200A (en) | 1999-10-08 | 2001-04-23 | Uab Research Foundation | Smdf and ggf neuregulin splice variant isoforms and uses thereof |
| US6811788B2 (en) | 2000-01-19 | 2004-11-02 | Baofa Yu | Combinations and methods for treating neoplasms |
| EP1252186B1 (de) | 2000-02-11 | 2006-01-11 | ProteoSys AG | Verwendung von neuregulin-beta als indikator und/oder target |
| US20020094954A1 (en) | 2000-02-28 | 2002-07-18 | Decode Genetics, Ehf, | Human schizophrenia gene |
| CA2400595A1 (en) * | 2000-02-28 | 2001-09-07 | Decode Genetics Ehf | Human schizophrenia gene |
| US6544759B1 (en) | 2000-04-21 | 2003-04-08 | Yeda Research And Development Co. Ltd | Polynucleotides encoding a novel growth factor which acts through ErbB-4 kinase receptor tyrosine |
| WO2003099320A1 (en) * | 2002-05-24 | 2003-12-04 | Zensun (Shanghai) Sci-Tech.Ltd | Neuregulin based methods and compositions for treating viral myocarditis and dilated cardiomyopathy |
| CN1498656A (zh) | 2002-11-08 | 2004-05-26 | 上海泽生科技开发有限公司 | 神经调节蛋白用于心肌梗死治疗的方法和组合物 |
| JP2004348674A (ja) * | 2003-05-26 | 2004-12-09 | Noritsu Koki Co Ltd | 領域検出方法及びその装置 |
| CN1715926B (zh) | 2004-07-02 | 2011-08-17 | 上海泽生科技开发有限公司 | 神经调节蛋白突变体的应用 |
| CN1743005A (zh) | 2004-09-02 | 2006-03-08 | 上海泽生科技开发有限公司 | Pi3－k抑制剂的新用途及组合物 |
| CN1743006A (zh) | 2004-09-02 | 2006-03-08 | 上海泽生科技开发有限公司 | Mapk抑制剂的新用途及组合物 |
| US20070213264A1 (en) * | 2005-12-02 | 2007-09-13 | Mingdong Zhou | Neuregulin variants and methods of screening and using thereof |
| EP3363455A1 (en) * | 2005-12-30 | 2018-08-22 | Zensun (Shanghai) Science & Technology, Co., Ltd. | Extended release of neuregulin for improved cardiac function |
| US9580515B2 (en) * | 2006-08-21 | 2017-02-28 | Zensun (Shanghai) Science & Technology, Co., Ltd. | Neukinase, a downstream protein of neuregulin |
| US20090156488A1 (en) * | 2007-09-12 | 2009-06-18 | Zensun (Shanghai) Science & Technology Limited | Use of neuregulin for organ preservation |
-
2002
- 2002-05-24 WO PCT/CN2002/000349 patent/WO2003099320A1/en not_active Application Discontinuation
- 2002-05-24 AU AU2002304965A patent/AU2002304965A1/en not_active Abandoned
- 2002-09-18 AU AU2002336030A patent/AU2002336030A1/en not_active Abandoned
- 2002-09-18 WO PCT/CN2002/000664 patent/WO2003099321A1/en not_active Application Discontinuation
-
2003
- 2003-05-15 CN CNB038118661A patent/CN100522997C/zh not_active Expired - Lifetime
- 2003-05-15 CA CA2487112A patent/CA2487112C/en not_active Expired - Fee Related
- 2003-05-15 CN CN2006101543547A patent/CN1935254B/zh not_active Expired - Lifetime
- 2003-05-15 EP EP12194239.5A patent/EP2606901A1/en not_active Withdrawn
- 2003-05-15 ES ES03732172.6T patent/ES2627547T3/es not_active Expired - Lifetime
- 2003-05-15 WO PCT/CN2003/000355 patent/WO2003099300A1/en active Application Filing
- 2003-05-15 CN CN2009101185220A patent/CN101491670B/zh not_active Expired - Lifetime
- 2003-05-15 CN CNA200610139361XA patent/CN101007027A/zh active Pending
- 2003-05-15 JP JP2004506824A patent/JP2005532332A/ja active Pending
- 2003-05-15 EP EP03732172.6A patent/EP1553960B1/en not_active Expired - Lifetime
- 2003-05-15 AU AU2003238336A patent/AU2003238336B2/en not_active Expired
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- 2004-11-24 US US10/997,167 patent/US7795212B2/en not_active Expired - Lifetime
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2010
- 2010-09-10 US US12/879,023 patent/US8785387B2/en not_active Expired - Lifetime
- 2010-10-01 JP JP2010223952A patent/JP5809789B2/ja not_active Expired - Lifetime
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2014
- 2014-01-06 JP JP2014000319A patent/JP5964868B2/ja not_active Expired - Lifetime
- 2014-05-06 US US14/271,198 patent/US9555076B2/en not_active Expired - Lifetime
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2016
- 2016-02-02 JP JP2016018132A patent/JP6603149B2/ja not_active Expired - Lifetime
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2017
- 2017-01-30 US US15/419,946 patent/US20170360889A1/en not_active Abandoned
- 2017-11-07 JP JP2017214721A patent/JP2018052957A/ja active Pending
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