JP2005531641A5 - - Google Patents
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- Publication number
- JP2005531641A5 JP2005531641A5 JP2004518798A JP2004518798A JP2005531641A5 JP 2005531641 A5 JP2005531641 A5 JP 2005531641A5 JP 2004518798 A JP2004518798 A JP 2004518798A JP 2004518798 A JP2004518798 A JP 2004518798A JP 2005531641 A5 JP2005531641 A5 JP 2005531641A5
- Authority
- JP
- Japan
- Prior art keywords
- ester
- hydroxytyrosol
- catalyst
- additive
- acylating agent
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- JUUBCHWRXWPFFH-UHFFFAOYSA-N Hydroxytyrosol Chemical compound OCCC1=CC=C(O)C(O)=C1 JUUBCHWRXWPFFH-UHFFFAOYSA-N 0.000 claims 26
- 235000003248 hydroxytyrosol Nutrition 0.000 claims 23
- 229940095066 hydroxytyrosol Drugs 0.000 claims 23
- 238000000034 method Methods 0.000 claims 21
- -1 hydroxytyrosol ester Chemical class 0.000 claims 20
- 239000003054 catalyst Substances 0.000 claims 10
- 150000002148 esters Chemical class 0.000 claims 10
- 239000003795 chemical substances by application Substances 0.000 claims 7
- 239000000654 additive Substances 0.000 claims 6
- 230000000996 additive effect Effects 0.000 claims 6
- 125000004432 carbon atom Chemical group C* 0.000 claims 5
- 238000006243 chemical reaction Methods 0.000 claims 5
- 238000009472 formulation Methods 0.000 claims 5
- 239000000203 mixture Substances 0.000 claims 5
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical group [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 4
- 125000002252 acyl group Chemical group 0.000 claims 4
- 125000003342 alkenyl group Chemical group 0.000 claims 4
- 239000003814 drug Substances 0.000 claims 4
- 239000002904 solvent Substances 0.000 claims 4
- 125000000217 alkyl group Chemical group 0.000 claims 3
- 150000001875 compounds Chemical class 0.000 claims 3
- 239000000490 cosmetic additive Substances 0.000 claims 3
- CFFZDZCDUFSOFZ-UHFFFAOYSA-N 3,4-Dihydroxy-phenylacetic acid Chemical class OC(=O)CC1=CC=C(O)C(O)=C1 CFFZDZCDUFSOFZ-UHFFFAOYSA-N 0.000 claims 2
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical group OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 claims 2
- 230000002378 acidificating effect Effects 0.000 claims 2
- 239000003963 antioxidant agent Substances 0.000 claims 2
- 125000003118 aryl group Chemical group 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 150000007524 organic acids Chemical class 0.000 claims 2
- RFWGABANNQMHMZ-UHFFFAOYSA-N 8-acetoxy-7-acetyl-6,7,7a,8-tetrahydro-5H-benzo[g][1,3]dioxolo[4',5':4,5]benzo[1,2,3-de]quinoline Natural products CC=C1C(CC(=O)OCCC=2C=C(O)C(O)=CC=2)C(C(=O)OC)=COC1OC1OC(CO)C(O)C(O)C1O RFWGABANNQMHMZ-UHFFFAOYSA-N 0.000 claims 1
- LSNNMFCWUKXFEE-UHFFFAOYSA-M Bisulfite Chemical compound OS([O-])=O LSNNMFCWUKXFEE-UHFFFAOYSA-M 0.000 claims 1
- HKVGJQVJNQRJPO-UHFFFAOYSA-N Demethyloleuropein Natural products O1C=C(C(O)=O)C(CC(=O)OCCC=2C=C(O)C(O)=CC=2)C(=CC)C1OC1OC(CO)C(O)C(O)C1O HKVGJQVJNQRJPO-UHFFFAOYSA-N 0.000 claims 1
- 102000004190 Enzymes Human genes 0.000 claims 1
- 108090000790 Enzymes Proteins 0.000 claims 1
- 102000004882 Lipase Human genes 0.000 claims 1
- 108090001060 Lipase Proteins 0.000 claims 1
- 239000004367 Lipase Substances 0.000 claims 1
- RFWGABANNQMHMZ-HYYSZPHDSA-N Oleuropein Chemical compound O([C@@H]1OC=C([C@H](C1=CC)CC(=O)OCCC=1C=C(O)C(O)=CC=1)C(=O)OC)[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O RFWGABANNQMHMZ-HYYSZPHDSA-N 0.000 claims 1
- 239000002253 acid Substances 0.000 claims 1
- 229910000147 aluminium phosphate Inorganic materials 0.000 claims 1
- 230000003078 antioxidant effect Effects 0.000 claims 1
- YCIMNLLNPGFGHC-UHFFFAOYSA-N catechol Chemical compound OC1=CC=CC=C1O YCIMNLLNPGFGHC-UHFFFAOYSA-N 0.000 claims 1
- 239000002537 cosmetic Substances 0.000 claims 1
- 229930004069 diterpene Natural products 0.000 claims 1
- 150000004141 diterpene derivatives Chemical class 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 238000005886 esterification reaction Methods 0.000 claims 1
- 150000002170 ethers Chemical class 0.000 claims 1
- 150000008282 halocarbons Chemical class 0.000 claims 1
- 229910052500 inorganic mineral Inorganic materials 0.000 claims 1
- 235000019421 lipase Nutrition 0.000 claims 1
- 239000011707 mineral Substances 0.000 claims 1
- 235000011576 oleuropein Nutrition 0.000 claims 1
- RFWGABANNQMHMZ-CARRXEGNSA-N oleuropein Natural products COC(=O)C1=CO[C@@H](O[C@H]2O[C@@H](CO)[C@H](O)[C@@H](O)[C@@H]2O)C(=CC)[C@H]1CC(=O)OCCc3ccc(O)c(O)c3 RFWGABANNQMHMZ-CARRXEGNSA-N 0.000 claims 1
- BIWKXNFEOZXNLX-BBHIFXBUSA-N oleuropein aglycone Chemical compound COC(=O)C1=CO[C@@H](O)\C(=C\C)[C@@H]1CC(=O)OCCC1=CC=C(O)C(O)=C1 BIWKXNFEOZXNLX-BBHIFXBUSA-N 0.000 claims 1
- DEBZOPZQKONWTK-KWCYVHTRSA-N oleuropein aglycone Natural products COC(=O)C1=CO[C@H](C)[C@@H](C=O)[C@@H]1CC(=O)OCCc1ccc(O)c(O)c1 DEBZOPZQKONWTK-KWCYVHTRSA-N 0.000 claims 1
- 238000007254 oxidation reaction Methods 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 1
- 229920006395 saturated elastomer Polymers 0.000 claims 1
- 125000005017 substituted alkenyl group Chemical group 0.000 claims 1
- 125000005457 triglyceride group Chemical group 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ES200201554A ES2246603B1 (es) | 2002-07-03 | 2002-07-03 | Procedimiento para la preparacion de esteres de hidroxitirosol, esteres obtenidos y utilizacion. |
| PCT/ES2003/000327 WO2004005237A1 (es) | 2002-07-03 | 2003-07-02 | Procedimiento para la preparación de ésteres de hidroxitirosol, ésteres obtenidos y utilización |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2005531641A JP2005531641A (ja) | 2005-10-20 |
| JP2005531641A5 true JP2005531641A5 (enExample) | 2006-08-17 |
Family
ID=30011353
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004518798A Pending JP2005531641A (ja) | 2002-07-03 | 2003-07-02 | ヒドロキシチロソールエステルの製法、該製法によって得られる該エステルおよび該エステルの使用 |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US20050154058A1 (enExample) |
| EP (1) | EP1541544A1 (enExample) |
| JP (1) | JP2005531641A (enExample) |
| AU (1) | AU2003244661A1 (enExample) |
| ES (1) | ES2246603B1 (enExample) |
| MA (1) | MA27315A1 (enExample) |
| TN (1) | TNSN05001A1 (enExample) |
| WO (1) | WO2004005237A1 (enExample) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2239908B1 (es) * | 2004-03-26 | 2006-12-16 | Consejo Superior De Investigaciones Cientificas. | Utilizacion de aceite de orujo de centrifugacion refinado como retardador de la aterosclerosis. |
| JP4745948B2 (ja) * | 2006-12-07 | 2011-08-10 | 花王株式会社 | 食品用保存料および飲食品 |
| US7737149B2 (en) | 2006-12-21 | 2010-06-15 | Astrazeneca Ab | N-[5-[2-(3,5-dimethoxyphenyl)ethyl]-2H-pyrazol-3-yl]-4-(3,5-dimethylpiperazin-1-yl)benzamide and salts thereof |
| ES2311394B2 (es) * | 2007-02-22 | 2009-10-21 | Universidad De Granada | Alimento funcional obtenido por reincorporacion de ingredientes naturales de la aceituna al aceite de oliva. |
| ITMI20070519A1 (it) * | 2007-03-15 | 2008-09-16 | Maurizio Barontini | Procedimento per la preparazione di derivati dell'idrossitirosolo e di idrossitirosolo |
| FR2919800B1 (fr) * | 2007-08-06 | 2010-08-27 | Biochimie Appliquee Solabia So | Compositions cosmetiques et/ou dermatologiques contenant un ester de tyrosol ou d'hydroxytyrosol et d'acide gras insature, et leurs utilisations |
| ES2362531B1 (es) * | 2009-12-21 | 2012-06-07 | Consejo Superior De Investigaciones Científicas (Csic) | Derivados fenólicos lipófilos como surfactantes. |
| US8846723B2 (en) | 2010-07-29 | 2014-09-30 | Eastman Chemical Company | Esters of O-substituted hydroxy carboxylic acids and preparations thereof |
| US8613940B2 (en) | 2010-09-03 | 2013-12-24 | Eastman Chemical Company | Carbonate derivatives as skin care |
| ES2387590B1 (es) * | 2010-09-27 | 2013-10-31 | Consejo Superior De Investigaciones Científicas (Csic) | Procedimiento de obtención de aceites o grasas con alto contenido antioxidante. |
| US8329938B2 (en) | 2011-02-21 | 2012-12-11 | Eastman Chemical Company | Hydroxyalkanoic acid and hydroxyalkanoice acid oligomer esters of retinol |
| ES2395317B1 (es) | 2011-07-08 | 2014-04-16 | Consejo Superior De Investigaciones Cientificas (Csic) | Procedimiento para la obtención de extracto de hidroxitirosol, extracto mezcla de hidroxitirosol y 3,4-dihidroxifenilglicol, y extracto de acetato de hidroxitirosilo, a partir de subproductos del olivo y su purificación. |
| US9334229B2 (en) * | 2013-11-04 | 2016-05-10 | Eastman Chemical Company | Hydroxytyrosol derivatives, their method of preparation and use in personal care |
| DE102018006661A1 (de) | 2018-08-23 | 2020-02-27 | Klüber Lubrication München Se & Co. Kg | Schmiermittelzusammensetzung |
| CN111196757A (zh) * | 2020-01-16 | 2020-05-26 | 中国农业大学 | 抗氧化剂共价结合的亚油酸及其制备方法和用途 |
| JP2022135398A (ja) * | 2021-03-05 | 2022-09-15 | 国立研究開発法人物質・材料研究機構 | 接着剤組成物、接着剤層付き基板、及び、高分子化合物 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2003026636A (ja) * | 2001-07-10 | 2003-01-29 | Gekkeikan Sake Co Ltd | 脂質代謝系酵素を阻害するチロゾール誘導体 |
| ES2193874B1 (es) * | 2002-04-03 | 2005-03-01 | Puleva Biotech, S.A. | Compuestos naturales y derivados de estos para la prevencion y el tratamiento de enfermedades cardiovasculares, hepaticas, renales y cosmeticas. |
-
2002
- 2002-07-03 ES ES200201554A patent/ES2246603B1/es not_active Expired - Fee Related
-
2003
- 2003-07-02 EP EP03738140A patent/EP1541544A1/en not_active Withdrawn
- 2003-07-02 WO PCT/ES2003/000327 patent/WO2004005237A1/es not_active Ceased
- 2003-07-02 JP JP2004518798A patent/JP2005531641A/ja active Pending
- 2003-07-02 AU AU2003244661A patent/AU2003244661A1/en not_active Abandoned
-
2004
- 2004-12-30 US US11/027,791 patent/US20050154058A1/en not_active Abandoned
-
2005
- 2005-01-03 TN TNP2005000001A patent/TNSN05001A1/fr unknown
- 2005-01-03 MA MA28031A patent/MA27315A1/fr unknown
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