ES2246603B1 - Procedimiento para la preparacion de esteres de hidroxitirosol, esteres obtenidos y utilizacion. - Google Patents

Procedimiento para la preparacion de esteres de hidroxitirosol, esteres obtenidos y utilizacion. Download PDF

Info

Publication number
ES2246603B1
ES2246603B1 ES200201554A ES200201554A ES2246603B1 ES 2246603 B1 ES2246603 B1 ES 2246603B1 ES 200201554 A ES200201554 A ES 200201554A ES 200201554 A ES200201554 A ES 200201554A ES 2246603 B1 ES2246603 B1 ES 2246603B1
Authority
ES
Spain
Prior art keywords
hydroxytyrosol
preparation
esters
esters according
catalyst
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
ES200201554A
Other languages
English (en)
Spanish (es)
Other versions
ES2246603A1 (es
Inventor
Felipe Alcudia Gonzalez
Arturo Cert Ventula
Jose Luis Espartero Sanchez
Raquel Mateo Briz
Mariana Trujillo Perez-Lanzac
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Consejo Superior de Investigaciones Cientificas CSIC
Universidad de Sevilla
Original Assignee
Consejo Superior de Investigaciones Cientificas CSIC
Universidad de Sevilla
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to ES200201554A priority Critical patent/ES2246603B1/es
Application filed by Consejo Superior de Investigaciones Cientificas CSIC, Universidad de Sevilla filed Critical Consejo Superior de Investigaciones Cientificas CSIC
Priority to JP2004518798A priority patent/JP2005531641A/ja
Priority to EP03738140A priority patent/EP1541544A1/en
Priority to AU2003244661A priority patent/AU2003244661A1/en
Priority to PCT/ES2003/000327 priority patent/WO2004005237A1/es
Priority to US11/027,791 priority patent/US20050154058A1/en
Priority to TNP2005000001A priority patent/TNSN05001A1/fr
Priority to MA28031A priority patent/MA27315A1/fr
Publication of ES2246603A1 publication Critical patent/ES2246603A1/es
Application granted granted Critical
Publication of ES2246603B1 publication Critical patent/ES2246603B1/es
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00—Preparation of carboxylic acid esters
    • C07C67/03—Preparation of carboxylic acid esters by reacting an ester group with a hydroxy group
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/105—Plant extracts, their artificial duplicates or their derivatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
    • A61K31/222—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin with compounds having aromatic groups, e.g. dipivefrine, ibopamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/37—Esters of carboxylic acids
    • A61K8/375—Esters of carboxylic acids the alcohol moiety containing more than one hydroxy group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/02—Nutrients, e.g. vitamins, minerals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00—Preparation of carboxylic acid esters
    • C07C67/02—Preparation of carboxylic acid esters by interreacting ester groups, i.e. transesterification
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/52—Stabilizers
    • A61K2800/522—Antioxidants; Radical scavengers

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Emergency Medicine (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Nutrition Science (AREA)
  • Mycology (AREA)
  • Botany (AREA)
  • Polymers & Plastics (AREA)
  • Food Science & Technology (AREA)
  • Birds (AREA)
  • Dermatology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Obesity (AREA)
  • Diabetes (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Cosmetics (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Food Preservation Except Freezing, Refrigeration, And Drying (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
ES200201554A 2002-07-03 2002-07-03 Procedimiento para la preparacion de esteres de hidroxitirosol, esteres obtenidos y utilizacion. Expired - Fee Related ES2246603B1 (es)

Priority Applications (8)

Application Number Priority Date Filing Date Title
ES200201554A ES2246603B1 (es) 2002-07-03 2002-07-03 Procedimiento para la preparacion de esteres de hidroxitirosol, esteres obtenidos y utilizacion.
EP03738140A EP1541544A1 (en) 2002-07-03 2003-07-02 Method of preparing hydroxytyrosol esters, esters thus obtained and use of same
AU2003244661A AU2003244661A1 (en) 2002-07-03 2003-07-02 Method of preparing hydroxytyrosol esters, esters thus obtained and use of same
PCT/ES2003/000327 WO2004005237A1 (es) 2002-07-03 2003-07-02 Procedimiento para la preparación de ésteres de hidroxitirosol, ésteres obtenidos y utilización
JP2004518798A JP2005531641A (ja) 2002-07-03 2003-07-02 ヒドロキシチロソールエステルの製法、該製法によって得られる該エステルおよび該エステルの使用
US11/027,791 US20050154058A1 (en) 2002-07-03 2004-12-30 Method of preparing hydroxytyrosol esters, esters thus obtained and use of same
TNP2005000001A TNSN05001A1 (fr) 2002-07-03 2005-01-03 Methode de preparation d'esters d'hydroxytyrosol, les esters ainsi obtenus et leur utilisation
MA28031A MA27315A1 (fr) 2002-07-03 2005-01-03 Methode de preparation d'esters d'hydroxytyrosol, les esters ainsi obtenus et leur utilisation

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES200201554A ES2246603B1 (es) 2002-07-03 2002-07-03 Procedimiento para la preparacion de esteres de hidroxitirosol, esteres obtenidos y utilizacion.

Publications (2)

Publication Number Publication Date
ES2246603A1 ES2246603A1 (es) 2006-02-16
ES2246603B1 true ES2246603B1 (es) 2007-06-16

Family

ID=30011353

Family Applications (1)

Application Number Title Priority Date Filing Date
ES200201554A Expired - Fee Related ES2246603B1 (es) 2002-07-03 2002-07-03 Procedimiento para la preparacion de esteres de hidroxitirosol, esteres obtenidos y utilizacion.

Country Status (8)

Country Link
US (1) US20050154058A1 (enExample)
EP (1) EP1541544A1 (enExample)
JP (1) JP2005531641A (enExample)
AU (1) AU2003244661A1 (enExample)
ES (1) ES2246603B1 (enExample)
MA (1) MA27315A1 (enExample)
TN (1) TNSN05001A1 (enExample)
WO (1) WO2004005237A1 (enExample)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2239908B1 (es) * 2004-03-26 2006-12-16 Consejo Superior De Investigaciones Cientificas. Utilizacion de aceite de orujo de centrifugacion refinado como retardador de la aterosclerosis.
JP4745948B2 (ja) * 2006-12-07 2011-08-10 花王株式会社 食品用保存料および飲食品
US7737149B2 (en) 2006-12-21 2010-06-15 Astrazeneca Ab N-[5-[2-(3,5-dimethoxyphenyl)ethyl]-2H-pyrazol-3-yl]-4-(3,5-dimethylpiperazin-1-yl)benzamide and salts thereof
ES2311394B2 (es) * 2007-02-22 2009-10-21 Universidad De Granada Alimento funcional obtenido por reincorporacion de ingredientes naturales de la aceituna al aceite de oliva.
ITMI20070519A1 (it) * 2007-03-15 2008-09-16 Maurizio Barontini Procedimento per la preparazione di derivati dell'idrossitirosolo e di idrossitirosolo
FR2919800B1 (fr) * 2007-08-06 2010-08-27 Biochimie Appliquee Solabia So Compositions cosmetiques et/ou dermatologiques contenant un ester de tyrosol ou d'hydroxytyrosol et d'acide gras insature, et leurs utilisations
ES2362531B1 (es) * 2009-12-21 2012-06-07 Consejo Superior De Investigaciones Científicas (Csic) Derivados fenólicos lipófilos como surfactantes.
US8846723B2 (en) 2010-07-29 2014-09-30 Eastman Chemical Company Esters of O-substituted hydroxy carboxylic acids and preparations thereof
US8613940B2 (en) 2010-09-03 2013-12-24 Eastman Chemical Company Carbonate derivatives as skin care
ES2387590B1 (es) * 2010-09-27 2013-10-31 Consejo Superior De Investigaciones Científicas (Csic) Procedimiento de obtención de aceites o grasas con alto contenido antioxidante.
US8329938B2 (en) 2011-02-21 2012-12-11 Eastman Chemical Company Hydroxyalkanoic acid and hydroxyalkanoice acid oligomer esters of retinol
ES2395317B1 (es) 2011-07-08 2014-04-16 Consejo Superior De Investigaciones Cientificas (Csic) Procedimiento para la obtención de extracto de hidroxitirosol, extracto mezcla de hidroxitirosol y 3,4-dihidroxifenilglicol, y extracto de acetato de hidroxitirosilo, a partir de subproductos del olivo y su purificación.
US9334229B2 (en) * 2013-11-04 2016-05-10 Eastman Chemical Company Hydroxytyrosol derivatives, their method of preparation and use in personal care
DE102018006661A1 (de) 2018-08-23 2020-02-27 Klüber Lubrication München Se & Co. Kg Schmiermittelzusammensetzung
CN111196757A (zh) * 2020-01-16 2020-05-26 中国农业大学 抗氧化剂共价结合的亚油酸及其制备方法和用途
JP2022135398A (ja) * 2021-03-05 2022-09-15 国立研究開発法人物質・材料研究機構 接着剤組成物、接着剤層付き基板、及び、高分子化合物

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2193874A1 (es) * 2002-04-03 2003-11-01 Puleva Biotech Sa Compuestos naturales y derivados de estos para la prevencion y el tratamiento de enfermedades cardiovasculares, hepaticas, renales y cosmeticas.

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2003026636A (ja) * 2001-07-10 2003-01-29 Gekkeikan Sake Co Ltd 脂質代謝系酵素を阻害するチロゾール誘導体

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2193874A1 (es) * 2002-04-03 2003-11-01 Puleva Biotech Sa Compuestos naturales y derivados de estos para la prevencion y el tratamiento de enfermedades cardiovasculares, hepaticas, renales y cosmeticas.

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
BARALDI, P.G. y col. Preparation of 3,4-dihydroxy-1- benzeneethanol: a reinvestigation.Liebigs Annalen der Chemie. 1983, Vol 4, páginas 684-686, ISSN 0170-2041. Todo el documento *
BUISMAN, G.J.H. y col. Enzymatic esterifications of functionalized phenols for the synthesis of lipophilic antioxidants. Biotechnology Letters. 1998, Vol.20, Nº 2, páginas 131-136, ISSN 0141-5492. \\ X Página 132, columna 1, párrafo 5; página 133, columna 2, párrafo 3 - página 134, columna 1, párrafo 1. 22-24 *
GORDON, M.H. y col. Antioxidant activity of hidroxytyrosol acetate compared with that of other olive oil polyphenols. Journal of Agricultural and Food Chemistry. 2001, Vol 49, Nº 5, páginas 2480-2485, ISSN 0021-8561. \\ X Página 2481, columna 1, párrafo 3. 17,19,21 *

Also Published As

Publication number Publication date
TNSN05001A1 (fr) 2007-05-14
US20050154058A1 (en) 2005-07-14
ES2246603A1 (es) 2006-02-16
AU2003244661A1 (en) 2004-01-23
JP2005531641A (ja) 2005-10-20
MA27315A1 (fr) 2005-05-02
EP1541544A1 (en) 2005-06-15
WO2004005237B1 (es) 2004-03-25
WO2004005237A1 (es) 2004-01-15

Similar Documents

Publication Publication Date Title
ES2246603B1 (es) Procedimiento para la preparacion de esteres de hidroxitirosol, esteres obtenidos y utilizacion.
KR101140194B1 (ko) 항균제 및 그것을 함유하는 피부 외용제
ES2411958T5 (es) Método para producir un concentrado de ésteres de los ácidos icosapentaenoico y docosahexaenoico
Mateos et al. New lipophilic tyrosyl esters. Comparative antioxidant evaluation with hydroxytyrosyl esters
KR100895912B1 (ko) 환원형 보효소 ｑ10을 안정화하기 위한 방법 및 조성물
ES2201006T3 (es) Empleo de trigliceridos sinteticos a base de acido linoleico conjugado para la obtencion de agentes para el tratamiento de estados catabolicos.
ES2482115T3 (es) Composiciones de derivados polifenólicos estilbénicos y sus aplicaciones para luchar contra las patologías y el envejecimiento de los organismos vivos
Oh et al. Quercetin and its ester derivatives inhibit oxidation of food, LDL and DNA
EP0618203A1 (en) 3-O-acylated catechins and method of producing same
US9725675B2 (en) Lipid-soluble formulations containing mixtures of antioxidants
TW200417595A (en) Composition containing organic substance having double bond with improved oxidation stability
JP2009155257A (ja) 抗菌剤及びそれを含有する口腔用組成物並びに飲食品
WO2010033034A1 (en) Antioxidant composition for marine oils comprising tocopherol, rosemary extract, ascorbic acid and green tea extract
Peng et al. Metabolic, toxicological, chemical, and commercial perspectives on esterification of dietary polyphenols: a review
CA2098942A1 (en) Antioxidant compositions
Kahveci et al. Phenolipids as new antioxidants: Production, activity, and potential applications
JP2005531641A5 (enExample)
CN101909618A (zh) 类黄酮多酚衍生物的组合物及其用于对抗活生物体的病理学状态和衰老的应用
JP2003055314A (ja) ヒドロキシけい皮酸誘導体及びこれを用いた抗酸化剤
Oh Preparation of resveratrol and quercetin derivatives and their effects on antioxidant and biological activities
Zhang Enzymatic Synthesis of Glycerol-Based Galloyl Structured Lipids: Characterization and Application as Antioxidants
ES2362531B1 (es) Derivados fenólicos lipófilos como surfactantes.
KR20240099313A (ko) 레티노이드를 포함하는 안정한 조성물
Moersel et al. Martin Doert, Karolina Jaworska, Joerg
HK1151717A (en) Compositions containing flavanoid polyphenol derivatives, and applications thereof in controlling diseases and ageing of living organisms

Legal Events

Date Code Title Description
EC2A Search report published

Date of ref document: 20060216

Kind code of ref document: A1

FG2A Definitive protection

Ref document number: 2246603B1

Country of ref document: ES

FD2A Announcement of lapse in spain

Effective date: 20211118