JP2005531286A5 - - Google Patents

Info

Publication number

JP2005531286A5

JP2005531286A5 JP2003564093A JP2003564093A JP2005531286A5 JP 2005531286 A5 JP2005531286 A5 JP 2005531286A5 JP 2003564093 A JP2003564093 A JP 2003564093A JP 2003564093 A JP2003564093 A JP 2003564093A JP 2005531286 A5 JP2005531286 A5 JP 2005531286A5

Authority

JP

Japan

Prior art keywords

antibody

hcv

human

heavy chain

light chain

Prior art date

2003-01-29

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
• Global Dossier
• Discuss

• 230000003472 neutralizing effect Effects 0.000 claims description 6
• 229960005486 vaccine Drugs 0.000 claims description 6
• 230000000699 topical effect Effects 0.000 claims description 2
• 208000015181 infectious disease Diseases 0.000 claims 3
• 239000013060 biological fluid Substances 0.000 claims 2
• 239000003795 chemical substances by application Substances 0.000 claims 2
• 239000000203 mixture Substances 0.000 claims 2
• 108020004707 nucleic acids Proteins 0.000 claims 2
• 102000039446 nucleic acids Human genes 0.000 claims 2
• 150000007523 nucleic acids Chemical class 0.000 claims 2
• 239000013598 vector Substances 0.000 claims 2
• 101710132593 Protein E2 Proteins 0.000 claims 1
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• 125000003275 alpha amino acid group Chemical group 0.000 claims 1
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• 238000001415 gene therapy Methods 0.000 claims 1
• SHFKGANKURXVMY-LCWPZEQJSA-N hcv e2 protein Chemical compound CC(C)[C@@H](C(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]([C@@H](C)CC)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@H](C)NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CC=1NC=NC=1)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)CNC(=O)CNC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)CNC(=O)[C@H](CC(O)=O)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)CCSC)C(C)C)[C@@H](C)O)[C@@H](C)O)C(C)C)[C@@H](C)O)[C@@H](C)O)[C@@H](C)O)CC1=CC=CC=C1 SHFKGANKURXVMY-LCWPZEQJSA-N 0.000 claims 1
• 238000001727 in vivo Methods 0.000 claims 1
• 230000002401 inhibitory effect Effects 0.000 claims 1
• 238000000034 method Methods 0.000 claims 1
• 239000002773 nucleotide Substances 0.000 claims 1
• 125000003729 nucleotide group Chemical group 0.000 claims 1
• 239000002674 ointment Substances 0.000 claims 1
• 238000002360 preparation method Methods 0.000 claims 1
• 238000004393 prognosis Methods 0.000 claims 1
• 210000001236 prokaryotic cell Anatomy 0.000 claims 1
• 238000003259 recombinant expression Methods 0.000 claims 1
• 230000004043 responsiveness Effects 0.000 claims 1
• 230000001225 therapeutic effect Effects 0.000 claims 1
• 241000700605 Viruses Species 0.000 description 1
• 230000003302 anti-idiotype Effects 0.000 description 1
• 229940079593 drug Drugs 0.000 description 1
• 239000003814 drug Substances 0.000 description 1
• 238000000338 in vitro Methods 0.000 description 1
• 238000011031 large-scale manufacturing process Methods 0.000 description 1
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• 102000004196 processed proteins & peptides Human genes 0.000 description 1
• 108090000765 processed proteins & peptides Proteins 0.000 description 1
• 230000000069 prophylactic effect Effects 0.000 description 1
• 239000000126 substance Substances 0.000 description 1
• 238000002560 therapeutic procedure Methods 0.000 description 1
• 230000014599 transmission of virus Effects 0.000 description 1