EA009861B1 - Fab-фрагменты моноклонального антитела человека, направленные против гликопротеина e2 hcv и обладающие нейтрализующей активностью in vitro - Google Patents
Fab-фрагменты моноклонального антитела человека, направленные против гликопротеина e2 hcv и обладающие нейтрализующей активностью in vitro Download PDFInfo
- Publication number
- EA009861B1 EA009861B1 EA200401081A EA200401081A EA009861B1 EA 009861 B1 EA009861 B1 EA 009861B1 EA 200401081 A EA200401081 A EA 200401081A EA 200401081 A EA200401081 A EA 200401081A EA 009861 B1 EA009861 B1 EA 009861B1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- antibody
- human monoclonal
- fragment
- fragments
- virus
- Prior art date
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Classifications
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- G—PHYSICS
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- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/576—Immunoassay; Biospecific binding assay; Materials therefor for hepatitis
- G01N33/5767—Immunoassay; Biospecific binding assay; Materials therefor for hepatitis non-A, non-B hepatitis
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/08—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
- C07K16/10—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses from RNA viruses
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
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- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/08—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
- C07K16/10—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses from RNA viruses
- C07K16/1081—Togaviridae, e.g. flavivirus, rubella virus, hog cholera virus
- C07K16/109—Hepatitis C virus; Hepatitis G virus
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- G—PHYSICS
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- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/576—Immunoassay; Biospecific binding assay; Materials therefor for hepatitis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
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- C—CHEMISTRY; METALLURGY
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- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/55—Fab or Fab'
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- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/005—Assays involving biological materials from specific organisms or of a specific nature from viruses
- G01N2333/08—RNA viruses
- G01N2333/18—Togaviridae; Flaviviridae
Landscapes
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- Analytical Chemistry (AREA)
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- Oncology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT2002RM000049A ITRM20020049A1 (it) | 2002-01-30 | 2002-01-30 | Frammenti fab di anticorpi monoclonali umani diretti contro la glicoproteina e2 di hcv e dotati di potere neutralizzante in vitro. |
| PCT/IT2003/000032 WO2003064473A2 (en) | 2002-01-30 | 2003-01-29 | Human monoclonal antibody fab fragments directed against hcv e2 glycoprotein and endowed with in vitro neutralizing activity |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| EA200401081A1 EA200401081A1 (ru) | 2005-10-27 |
| EA009861B1 true EA009861B1 (ru) | 2008-04-28 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EA200401081A EA009861B1 (ru) | 2002-01-30 | 2003-01-29 | Fab-фрагменты моноклонального антитела человека, направленные против гликопротеина e2 hcv и обладающие нейтрализующей активностью in vitro |
Country Status (17)
| Country | Link |
|---|---|
| US (2) | US20050084845A1 (enExample) |
| EP (1) | EP1476468B9 (enExample) |
| JP (1) | JP4287280B2 (enExample) |
| KR (1) | KR101002791B1 (enExample) |
| CN (1) | CN1856508A (enExample) |
| AT (1) | ATE407147T1 (enExample) |
| AU (1) | AU2003208000B2 (enExample) |
| CA (1) | CA2474801C (enExample) |
| DE (1) | DE60323333D1 (enExample) |
| DK (1) | DK1476468T3 (enExample) |
| EA (1) | EA009861B1 (enExample) |
| ES (1) | ES2314179T3 (enExample) |
| IT (1) | ITRM20020049A1 (enExample) |
| NZ (1) | NZ534922A (enExample) |
| RU (1) | RU2004126238A (enExample) |
| WO (1) | WO2003064473A2 (enExample) |
| ZA (1) | ZA200406187B (enExample) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7723306B2 (en) | 2004-05-10 | 2010-05-25 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Spray-dried powder comprising at least one 1,4 O-linked saccharose-derivative and methods for their preparation |
| US7727962B2 (en) | 2004-05-10 | 2010-06-01 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Powder comprising new compositions of oligosaccharides and methods for their preparation |
| US7611709B2 (en) * | 2004-05-10 | 2009-11-03 | Boehringer Ingelheim Pharma Gmbh And Co. Kg | 1,4 O-linked saccharose derivatives for stabilization of antibodies or antibody derivatives |
| ITTO20070066A1 (it) | 2007-01-30 | 2008-07-31 | Pomona Biotechnologies Llc | Anticorpi monoclonali anti-idiotipo mimotopi dell'antigene gp 120 di hiv |
| WO2008107187A1 (en) * | 2007-03-06 | 2008-09-12 | Ribovax Biotechnologies S.A. | Antibodies specific for rubella virus |
| CN101809033A (zh) | 2007-07-25 | 2010-08-18 | 日本国立感染症研究所 | 对丙型肝炎病毒(hcv)感染具有抑制活性的抗体和其用途 |
| AU2008341542B2 (en) * | 2007-12-17 | 2014-12-04 | Medical Research Council Technology | Hepatitis C virus antibodies |
| ITTO20080204A1 (it) | 2008-03-17 | 2009-09-18 | Pomona Biotechnologies Llc | Anticorpi monoclonali atti a reagire con una pluralita di sottotipi del virus influenzale a |
| ITTO20080398A1 (it) | 2008-05-27 | 2009-11-28 | Pomona Biotechnologies Llc | Anticorpi monoclonali aventi proprieta' di cross-neutralizzazione omosubtipica per virus influenzali di tipo a sottotipo h1 |
| WO2010035292A1 (en) * | 2008-09-24 | 2010-04-01 | Natimab Therapeutics S.R.L. | The use of a human monoclonal anti-hcv antibody as a medicament for the therapeutic treatment and prevention of hcv infections |
| US20100104555A1 (en) * | 2008-10-24 | 2010-04-29 | The Scripps Research Institute | HCV neutralizing epitopes |
| ITTO20080964A1 (it) * | 2008-12-22 | 2010-06-23 | Natimab Therapeutics S R L | Anticorpo monoclonale anti-hcv come medicamento per il trattamento terapeutico e la prevenzione di infezioni da hcv |
| IT1395961B1 (it) | 2009-06-01 | 2012-11-02 | Pomona Biotechnologies Llc | Anticorpi monoclonali come medicamento per il trattamento terapeutico e/o profilattico delle infezioni da virus influenzale a (h1n1) di origine suina (s-oiv) |
| CN102596996B (zh) | 2009-10-30 | 2014-06-18 | 东丽株式会社 | 对丙型肝炎病毒(hcv)具有感染抑制活性的抗体及其用途 |
| JP6095984B2 (ja) | 2010-03-01 | 2017-03-15 | アニョロ, ヴィンセントAGNELLO, Vincent | Ｈｃｖ感染患者のクリオグロブリン血症性血管炎およびｂ細胞悪性腫瘍のための予後マーカー |
| CN104119436B (zh) * | 2013-04-27 | 2016-12-28 | 中国科学院上海生命科学研究院 | 抗丙型肝炎病毒的中和性全人单克隆抗体 |
| GB201415714D0 (en) * | 2014-09-05 | 2014-10-22 | Medical Res Council | Antibodies and antigen binding fragments thereof |
| CN105254756B (zh) * | 2015-11-27 | 2018-09-07 | 武汉大学 | 一种针对丙型肝炎病毒包膜蛋白e2的单克隆抗体及应用 |
| KR20180001380U (ko) | 2016-10-31 | 2018-05-10 | 대우조선해양 주식회사 | 해양구조물의 발로 작동시키는 캡스탄 |
| CN118440204A (zh) | 2019-12-27 | 2024-08-06 | 凯奥目生物科学株式会社 | 抗cdcp1抗体 |
| US20230312744A1 (en) | 2020-09-02 | 2023-10-05 | The University Of Tokyo | Modulatory Substance of Tumor Immune Microenvironment, and Preventive, Diagnostic and/or Therapeutic Utilization of the Same |
| US20250375498A1 (en) | 2022-07-28 | 2025-12-11 | The University Of Tokyo | Neurotrimin function inhibitor |
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| WO2000005266A1 (en) * | 1998-07-21 | 2000-02-03 | Connex Gesellschaft Zur Optimierung Von Forschung Und Entwicklung Mbh | Anti hepatitis c virus antibody and uses thereof |
| WO2002055560A2 (en) * | 2000-12-01 | 2002-07-18 | The Gouvernment Of The United States Of America, As Represented By The Secretary Department Of Health And Human Services | Monoclonal antibodies specific for the e2 glycoprotein of hepatitis c virus and their use in the diagnosis, treatment, and prevention of hepatitis c |
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| US7091324B2 (en) * | 1998-11-05 | 2006-08-15 | Board Of Trustees Of Leland Stanford Junior University | Prevention and treatment of HCV infection employing antibodies directed against conformational epitopes |
| AU2001273363A1 (en) | 2000-07-12 | 2002-01-21 | General Instrument Corporation | Method and apparatus for downloading objects via an inband channel with minimal subscriber impact |
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Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
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| WO2000005266A1 (en) * | 1998-07-21 | 2000-02-03 | Connex Gesellschaft Zur Optimierung Von Forschung Und Entwicklung Mbh | Anti hepatitis c virus antibody and uses thereof |
| WO2002055560A2 (en) * | 2000-12-01 | 2002-07-18 | The Gouvernment Of The United States Of America, As Represented By The Secretary Department Of Health And Human Services | Monoclonal antibodies specific for the e2 glycoprotein of hepatitis c virus and their use in the diagnosis, treatment, and prevention of hepatitis c |
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| ALLANDER T. ET AL.: "RECOMBINANT HUMAN MONOCLONAL ANTIBODIES AGAINST DIFFERENT CONFORMATIONAL EPITOPES OF THE E2 ENVELOPE GLYCOPROTEIN OF HEPATITIS C VIRUS THAT INHIBIT ITS INTERACTION WITH CD81" JOURNAL OF GENERAL VIROLOGY, SOCIETY FOR GENERAL MICROBIOLOGY, READING, GB, vol. 81, 2000, pages 2451-2459, XP002939743, ISSN: 0022-1317, page 2452, left-hand column, paragraph 3 - paragraph 4, page 2456, left-hand column, line 12 - line 28, page 2457, left-hand column, line 32 - line 42 * |
| BURIONI ROBERTO ET AL.: "Nonneutralizing human antibody fragments against hepatitis C virus E2 glycoprotein modulate neutralization of binding activity of human recombinant Fabs". VIROLOGY, vol. 288, no. 1, 15 September 2001 (2001-09-15), pages 29-35, XP002250414, ISSN: 0042-6822, abstract, page 29, left-hand column, last line -page 30, paragraph 2; figure 1 * |
| ROSA D. ET AL.: "A QUANTITATIVE TEST TO ESTIMATE NEUTRALIZING ANTIBODIES TO THE HEPATITIS C VIRUS: CYTOFLUORIMETRIC ASSESSMENT OF ENVELOPE GLYCOPROTEIN 2 BINDING TO TARGET CELLS", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA, NATIONAL ACADEMY OF SCIENCE. WASHINGTON, US, vol. 93, no. 3, 1 March 1996 (1996-03-01), pages 1759-1763, XP000615446, ISSN: 0027-8424, abstract page 1759, right-hand column, paragraph 1 - paragraph 2, page 1761, left-hand column, last paragraph - right-hand column, paragraph 2 * |
Also Published As
| Publication number | Publication date |
|---|---|
| KR20040077745A (ko) | 2004-09-06 |
| EP1476468B1 (en) | 2008-09-03 |
| WO2003064473A2 (en) | 2003-08-07 |
| EA200401081A1 (ru) | 2005-10-27 |
| US7727529B2 (en) | 2010-06-01 |
| JP4287280B2 (ja) | 2009-07-01 |
| JP2005531286A (ja) | 2005-10-20 |
| ITRM20020049A1 (it) | 2003-07-30 |
| CA2474801A1 (en) | 2003-08-07 |
| NZ534922A (en) | 2008-07-31 |
| ES2314179T3 (es) | 2009-03-16 |
| CA2474801C (en) | 2012-03-20 |
| WO2003064473A3 (en) | 2003-12-24 |
| US20080241162A1 (en) | 2008-10-02 |
| US20050084845A1 (en) | 2005-04-21 |
| ZA200406187B (en) | 2006-06-28 |
| DE60323333D1 (de) | 2008-10-16 |
| EP1476468B9 (en) | 2009-04-08 |
| ATE407147T1 (de) | 2008-09-15 |
| AU2003208000B2 (en) | 2010-05-20 |
| CN1856508A (zh) | 2006-11-01 |
| EP1476468A2 (en) | 2004-11-17 |
| RU2004126238A (ru) | 2005-04-20 |
| KR101002791B1 (ko) | 2010-12-21 |
| ITRM20020049A0 (it) | 2002-01-30 |
| DK1476468T3 (da) | 2009-01-19 |
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