JP2005528884A5 - - Google Patents
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- Publication number
- JP2005528884A5 JP2005528884A5 JP2003536404A JP2003536404A JP2005528884A5 JP 2005528884 A5 JP2005528884 A5 JP 2005528884A5 JP 2003536404 A JP2003536404 A JP 2003536404A JP 2003536404 A JP2003536404 A JP 2003536404A JP 2005528884 A5 JP2005528884 A5 JP 2005528884A5
- Authority
- JP
- Japan
- Prior art keywords
- seq
- antibody
- nos
- host cell
- cdr3
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 238000002360 preparation method Methods 0.000 claims 33
- 239000013604 expression vector Substances 0.000 claims 26
- 239000002773 nucleotide Substances 0.000 claims 21
- 125000003729 nucleotide group Chemical group 0.000 claims 21
- 238000004113 cell culture Methods 0.000 claims 13
- 238000012258 culturing Methods 0.000 claims 13
- 108091033319 polynucleotide Proteins 0.000 claims 13
- 239000002157 polynucleotide Substances 0.000 claims 13
- 102000040430 polynucleotide Human genes 0.000 claims 13
- 125000003275 alpha amino acid group Chemical group 0.000 claims 10
- 238000000034 method Methods 0.000 claims 9
- 102000004169 proteins and genes Human genes 0.000 claims 9
- 108090000623 proteins and genes Proteins 0.000 claims 9
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 4
- 208000035475 disorder Diseases 0.000 claims 4
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 3
- 239000000427 antigen Substances 0.000 claims 3
- 102000036639 antigens Human genes 0.000 claims 3
- 108091007433 antigens Proteins 0.000 claims 3
- 150000001875 compounds Chemical class 0.000 claims 2
- 229940127089 cytotoxic agent Drugs 0.000 claims 2
- 239000002254 cytotoxic agent Substances 0.000 claims 2
- 231100000599 cytotoxic agent Toxicity 0.000 claims 2
- 238000001514 detection method Methods 0.000 claims 2
- 239000007787 solid Substances 0.000 claims 2
- 206010008342 Cervix carcinoma Diseases 0.000 claims 1
- 206010009944 Colon cancer Diseases 0.000 claims 1
- 208000000461 Esophageal Neoplasms Diseases 0.000 claims 1
- 206010030155 Oesophageal carcinoma Diseases 0.000 claims 1
- 208000006265 Renal cell carcinoma Diseases 0.000 claims 1
- 208000006105 Uterine Cervical Neoplasms Diseases 0.000 claims 1
- 150000001413 amino acids Chemical class 0.000 claims 1
- 238000003556 assay Methods 0.000 claims 1
- 230000030833 cell death Effects 0.000 claims 1
- 201000010881 cervical cancer Diseases 0.000 claims 1
- 208000029742 colonic neoplasm Diseases 0.000 claims 1
- 238000003745 diagnosis Methods 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 201000004101 esophageal cancer Diseases 0.000 claims 1
- 230000001939 inductive effect Effects 0.000 claims 1
- 230000003211 malignant effect Effects 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 208000002154 non-small cell lung carcinoma Diseases 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 238000000746 purification Methods 0.000 claims 1
- 208000029729 tumor suppressor gene on chromosome 11 Diseases 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US34365701P | 2001-10-18 | 2001-10-18 | |
| US37771602P | 2002-05-02 | 2002-05-02 | |
| PCT/US2002/033470 WO2003033674A2 (en) | 2001-10-18 | 2002-10-18 | Human antibodies that have mn binding and cell adhesion-neutralizing activity |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010020670A Division JP2010260845A (ja) | 2001-10-18 | 2010-02-01 | Ｍｎ結合および細胞接着中和活性を有するヒト抗体 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2005528884A JP2005528884A (ja) | 2005-09-29 |
| JP2005528884A5 true JP2005528884A5 (enExample) | 2006-01-05 |
Family
ID=26993561
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003536404A Pending JP2005528884A (ja) | 2001-10-18 | 2002-10-18 | Ｍｎ結合および細胞接着中和活性を有するヒト抗体 |
| JP2010020670A Pending JP2010260845A (ja) | 2001-10-18 | 2010-02-01 | Ｍｎ結合および細胞接着中和活性を有するヒト抗体 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010020670A Pending JP2010260845A (ja) | 2001-10-18 | 2010-02-01 | Ｍｎ結合および細胞接着中和活性を有するヒト抗体 |
Country Status (18)
| Country | Link |
|---|---|
| US (2) | US7462696B2 (enExample) |
| EP (1) | EP1438339A4 (enExample) |
| JP (2) | JP2005528884A (enExample) |
| KR (1) | KR20050037478A (enExample) |
| CN (1) | CN1606569A (enExample) |
| AR (1) | AR036833A1 (enExample) |
| BR (1) | BR0213968A (enExample) |
| CA (1) | CA2463943A1 (enExample) |
| CO (1) | CO5370684A1 (enExample) |
| DO (1) | DOP2002000494A (enExample) |
| HU (1) | HUP0600335A2 (enExample) |
| IL (1) | IL161411A0 (enExample) |
| MX (1) | MXPA04003508A (enExample) |
| PE (1) | PE20030473A1 (enExample) |
| PL (1) | PL374304A1 (enExample) |
| RU (1) | RU2317998C2 (enExample) |
| UY (1) | UY27499A1 (enExample) |
| WO (1) | WO2003033674A2 (enExample) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7658924B2 (en) | 2001-10-11 | 2010-02-09 | Amgen Inc. | Angiopoietin-2 specific binding agents |
| US20090162382A1 (en) * | 2002-03-01 | 2009-06-25 | Bernett Matthew J | Optimized ca9 antibodies and methods of using the same |
| US7504364B2 (en) | 2002-03-01 | 2009-03-17 | Receptors Llc | Methods of making arrays and artificial receptors |
| US7469076B2 (en) | 2003-09-03 | 2008-12-23 | Receptors Llc | Sensors employing combinatorial artificial receptors |
| WO2004075855A2 (en) * | 2003-02-26 | 2004-09-10 | Biomed Solutions, Llc | Process for in vivo treatment of specific biological targets in bodily fluid |
| EP1613737A4 (en) | 2003-03-28 | 2008-12-03 | Receptors Llc | ARTIFICIAL RECEPTORS COMPRISING REVERSIBLE IMMOBILIZED CONSTRUCTION BLOCKS AND METHODS |
| WO2005024382A2 (en) * | 2003-09-03 | 2005-03-17 | Receptors Llc | Nanodevices employing combinatorial artificial receptors |
| US7884052B2 (en) | 2004-09-03 | 2011-02-08 | Receptors Llc | Combinatorial artificial receptors including tether building blocks on scaffolds |
| EP1789792A2 (en) | 2004-09-11 | 2007-05-30 | Receptors LLC | Combinatorial artificial receptors including peptide building blocks |
| DOP2006000277A (es) * | 2005-12-12 | 2007-08-31 | Bayer Pharmaceuticals Corp | Anticuerpos anti mn y métodos para su utilización |
| US20140273033A1 (en) * | 2007-04-12 | 2014-09-18 | Universiteit Hasselt | Biomarkers for multiple sclerosis |
| JO2913B1 (en) | 2008-02-20 | 2015-09-15 | امجين إنك, | Antibodies directed towards angiopoietin-1 and angiopoietin-2 proteins and their uses |
| CN105467136B (zh) * | 2008-05-30 | 2018-02-16 | 埃克斯生物科技公司 | 白细胞介素‑1α抗体及使用方法 |
| HUE045435T2 (hu) | 2012-10-12 | 2019-12-30 | Medimmune Ltd | Pirrolobenzodiazepinek és konjugátumaik |
| JP6444902B2 (ja) | 2013-03-13 | 2018-12-26 | メドイミューン・リミテッドＭｅｄＩｍｍｕｎｅ Ｌｉｍｉｔｅｄ | ピロロベンゾジアゼピン及びその結合体 |
| AU2015241380B2 (en) * | 2014-04-03 | 2020-11-26 | AllerGenis LLC | Peptides, reagents and methods for detecting food allergy |
| JP6531166B2 (ja) | 2014-09-10 | 2019-06-12 | メドイミューン・リミテッドＭｅｄＩｍｍｕｎｅ Ｌｉｍｉｔｅｄ | ピロロベンゾジアゼピン及びそのコンジュゲート |
| JP2019534882A (ja) | 2016-10-11 | 2019-12-05 | メドイミューン・リミテッドＭｅｄＩｍｍｕｎｅ Ｌｉｍｉｔｅｄ | 免疫介在性療法薬を有する抗体−薬物コンジュゲート |
| CA3098103A1 (en) | 2018-05-23 | 2019-11-28 | Adc Therapeutics Sa | Molecular adjuvant |
| WO2022079211A1 (en) | 2020-10-16 | 2022-04-21 | Adc Therapeutics Sa | Glycoconjugates |
| GB202102396D0 (en) | 2021-02-19 | 2021-04-07 | Adc Therapeutics Sa | Molecular adjuvant |
| CA3236930A1 (en) | 2021-11-03 | 2022-04-21 | Hangzhou Dac Biotech Co., Ltd. | Specific conjugation of an antibody |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5859205A (en) * | 1989-12-21 | 1999-01-12 | Celltech Limited | Humanised antibodies |
| DE69133566T2 (de) * | 1990-01-12 | 2007-12-06 | Amgen Fremont Inc. | Bildung von xenogenen Antikörpern |
| US6297051B1 (en) * | 1997-01-24 | 2001-10-02 | Institute Of Virology, Slovak Academy Of Sciences | MN gene and protein |
| CA2192678C (en) * | 1994-06-15 | 2010-12-14 | Jan Zavada | Mn gene and protein |
| EP1123387B1 (en) * | 1998-10-23 | 2007-10-17 | Institute Of Virology | Mn gene and protein |
| US6689744B2 (en) * | 2000-09-22 | 2004-02-10 | Genentech, Inc. | Notch receptor agonists and uses |
-
2002
- 2002-10-16 AR ARP020103877A patent/AR036833A1/es unknown
- 2002-10-17 UY UY27499A patent/UY27499A1/es not_active Application Discontinuation
- 2002-10-17 DO DO2002000494A patent/DOP2002000494A/es unknown
- 2002-10-18 JP JP2003536404A patent/JP2005528884A/ja active Pending
- 2002-10-18 BR BR0213968-5A patent/BR0213968A/pt not_active IP Right Cessation
- 2002-10-18 PE PE2002001031A patent/PE20030473A1/es not_active Application Discontinuation
- 2002-10-18 CN CNA028254880A patent/CN1606569A/zh active Pending
- 2002-10-18 CO CO02094163A patent/CO5370684A1/es unknown
- 2002-10-18 MX MXPA04003508A patent/MXPA04003508A/es not_active Application Discontinuation
- 2002-10-18 US US10/273,541 patent/US7462696B2/en not_active Expired - Fee Related
- 2002-10-18 PL PL02374304A patent/PL374304A1/xx not_active Application Discontinuation
- 2002-10-18 HU HU0600335A patent/HUP0600335A2/hu unknown
- 2002-10-18 CA CA002463943A patent/CA2463943A1/en not_active Abandoned
- 2002-10-18 KR KR1020047005716A patent/KR20050037478A/ko not_active Withdrawn
- 2002-10-18 WO PCT/US2002/033470 patent/WO2003033674A2/en not_active Ceased
- 2002-10-18 RU RU2004115112/13A patent/RU2317998C2/ru not_active IP Right Cessation
- 2002-10-18 EP EP02786449A patent/EP1438339A4/en not_active Withdrawn
- 2002-10-18 IL IL16141102A patent/IL161411A0/xx unknown
-
2008
- 2008-12-08 US US12/330,504 patent/US20100240100A1/en not_active Abandoned
-
2010
- 2010-02-01 JP JP2010020670A patent/JP2010260845A/ja active Pending
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