JP2005528377A5 - - Google Patents
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- JP2005528377A5 JP2005528377A5 JP2003581773A JP2003581773A JP2005528377A5 JP 2005528377 A5 JP2005528377 A5 JP 2005528377A5 JP 2003581773 A JP2003581773 A JP 2003581773A JP 2003581773 A JP2003581773 A JP 2003581773A JP 2005528377 A5 JP2005528377 A5 JP 2005528377A5
- Authority
- JP
- Japan
- Prior art keywords
- con
- het
- coor
- atoms
- hal
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- 125000004430 oxygen atom Chemical group O* 0.000 claims description 8
- 125000004434 sulfur atom Chemical group 0.000 claims description 8
- 229920006395 saturated elastomer Polymers 0.000 claims description 7
- 125000004433 nitrogen atom Chemical group N* 0.000 claims description 6
- 125000006615 aromatic heterocyclic group Chemical group 0.000 claims description 5
- 125000002619 bicyclic group Chemical group 0.000 claims description 5
- 239000000203 mixture Substances 0.000 claims description 5
- 125000002950 monocyclic group Chemical group 0.000 claims description 5
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 claims description 4
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 4
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims description 3
- 229910052731 fluorine Inorganic materials 0.000 claims description 3
- 229910052794 bromium Inorganic materials 0.000 claims description 2
- 229910052801 chlorine Inorganic materials 0.000 claims description 2
- 229910052740 iodine Inorganic materials 0.000 claims description 2
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims description 2
- 239000012453 solvate Substances 0.000 claims description 2
- 125000002947 alkylene group Chemical group 0.000 claims 4
- 125000004432 carbon atom Chemical group C* 0.000 claims 4
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 2
- ZUOUZKKEUPVFJK-UHFFFAOYSA-N diphenyl Chemical compound C1=CC=CC=C1C1=CC=CC=C1 ZUOUZKKEUPVFJK-UHFFFAOYSA-N 0.000 claims 2
- 229910052757 nitrogen Inorganic materials 0.000 claims 2
- 125000000217 alkyl group Chemical group 0.000 claims 1
- 235000010290 biphenyl Nutrition 0.000 claims 1
- 239000004305 biphenyl Substances 0.000 claims 1
- 229910052799 carbon Inorganic materials 0.000 claims 1
- 125000002993 cycloalkylene group Chemical group 0.000 claims 1
- 229910052736 halogen Inorganic materials 0.000 claims 1
- 150000002367 halogens Chemical class 0.000 claims 1
- 125000000623 heterocyclic group Chemical group 0.000 claims 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 1
- 125000001624 naphthyl group Chemical group 0.000 claims 1
- 229910052760 oxygen Inorganic materials 0.000 claims 1
- 125000006239 protecting group Chemical group 0.000 claims 1
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 description 3
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
- 125000004214 1-pyrrolidinyl group Chemical group [H]C1([H])N(*)C([H])([H])C([H])([H])C1([H])[H] 0.000 description 1
- -1 2-dimethylaminoethylimino Chemical group 0.000 description 1
- KXDHJXZQYSOELW-UHFFFAOYSA-M Carbamate Chemical compound NC([O-])=O KXDHJXZQYSOELW-UHFFFAOYSA-M 0.000 description 1
- 238000009835 boiling Methods 0.000 description 1
- 239000012043 crude product Substances 0.000 description 1
- 238000004821 distillation Methods 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 150000002576 ketones Chemical class 0.000 description 1
- DILRJUIACXKSQE-UHFFFAOYSA-N n',n'-dimethylethane-1,2-diamine Chemical compound CN(C)CCN DILRJUIACXKSQE-UHFFFAOYSA-N 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
- LMSDRBQUIRGULI-XZVFQGBBSA-N tert-butyl n-[[3-[[(1s)-1-(2-chlorophenyl)-2-[3-methyl-4-[(2r)-5-methyl-2-sulfanyl-3,4-dihydro-2h-pyrrol-1-ium-1-yl]anilino]-2-oxoethyl]amino]phenyl]methyl]carbamate;iodide Chemical compound [I-].S[C@@H]1CCC(C)=[N+]1C(C(=C1)C)=CC=C1NC(=O)[C@H](C=1C(=CC=CC=1)Cl)NC1=CC=CC(CNC(=O)OC(C)(C)C)=C1 LMSDRBQUIRGULI-XZVFQGBBSA-N 0.000 description 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10214832A DE10214832A1 (de) | 2002-04-04 | 2002-04-04 | Phenylderivate 4 |
| PCT/EP2003/002349 WO2003084533A1 (de) | 2002-04-04 | 2003-03-07 | N-`4-(2-imino-pyrrolidin-1-yl)phenyl!-acetemid-und entsprechende piperidinderivate als faktor xa inhibitoren zur behandlung von thromboembolischen erkrankungen |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2005528377A JP2005528377A (ja) | 2005-09-22 |
| JP2005528377A5 true JP2005528377A5 (https=) | 2006-05-11 |
Family
ID=28051091
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003581773A Pending JP2005528377A (ja) | 2002-04-04 | 2003-03-07 | Ｎ−’４−（２−イミノ−ピロリジン−１−イル）フェニル−アセトアミドおよび血栓塞栓症治療のための因子ｘａ阻害剤としての対応するピペリジン誘導体 |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US20050176760A1 (https=) |
| EP (1) | EP1490056B1 (https=) |
| JP (1) | JP2005528377A (https=) |
| AR (1) | AR039249A1 (https=) |
| AT (1) | ATE337779T1 (https=) |
| AU (1) | AU2003214102A1 (https=) |
| CA (1) | CA2481026A1 (https=) |
| DE (2) | DE10214832A1 (https=) |
| ES (1) | ES2271539T3 (https=) |
| WO (1) | WO2003084533A1 (https=) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1594505A4 (en) | 2003-02-11 | 2008-08-13 | Bristol Myers Squibb Co | PHENYLGLYCIN DERIVATIVES USEFUL AS SERINE PROTEASE INHIBITORS |
| WO2004072102A2 (en) | 2003-02-11 | 2004-08-26 | Bristol-Myers Squibb Company | Benzene acetamide compounds useful as serine protease inhibitors |
| EP1479680A1 (en) * | 2003-05-19 | 2004-11-24 | Aventis Pharma Deutschland GmbH | Azaindole derivatives as Factor Xa inhibitors |
| PE20061117A1 (es) | 2005-01-10 | 2006-10-13 | Bristol Myers Squibb Co | DERIVADOS DE FENILGLICINAMIDA COMO INHIBIDORES DEL FACTOR VIIa |
| CA2610354C (en) | 2005-05-31 | 2011-03-29 | Pfizer Inc. | Substituted aryloxy-n-bicyclomethyl acetamide compounds as vr1 antagonists |
| WO2007002313A2 (en) | 2005-06-24 | 2007-01-04 | Bristol-Myers Squibb Company | Phenylglycinamide and pyridylglycinamide derivatives useful as anticoagulants |
| US7625890B2 (en) | 2005-11-10 | 2009-12-01 | Smithkline Beecham Corp. | Substituted imidazo[4,5-c]pyridine compounds as Akt inhibitors |
| CN102633783A (zh) * | 2006-02-10 | 2012-08-15 | 转化技术制药公司 | 作为Aurora激酶抑制剂的苯并唑系衍生物、组合物和使用方法 |
| US8440662B2 (en) | 2010-10-31 | 2013-05-14 | Endo Pharmaceuticals, Inc. | Substituted quinazoline and pyrido-pyrimidine derivatives |
| WO2021138391A1 (en) | 2019-12-30 | 2021-07-08 | Tyra Biosciences, Inc. | Indazole compounds |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2540109B1 (fr) * | 1983-01-28 | 1985-08-30 | Logeais Labor Jacques | Imino-2 pyrrolidines, leur procede de preparation et leurs applications en therapeutique |
| JP2003500382A (ja) * | 1999-05-24 | 2003-01-07 | シーオーアール セラピューティクス インコーポレイテッド | Ｘａ因子の阻害剤 |
| AU5158100A (en) * | 1999-05-24 | 2000-12-12 | Cor Therapeutics, Inc. | Inhibitors of factor xa |
| DE10027025A1 (de) * | 2000-05-31 | 2001-12-06 | Merck Patent Gmbh | Clycinamide |
| DE10102322A1 (de) * | 2001-01-19 | 2002-07-25 | Merck Patent Gmbh | Phenylderivate |
-
2002
- 2002-04-04 DE DE10214832A patent/DE10214832A1/de not_active Withdrawn
-
2003
- 2003-03-07 ES ES03709758T patent/ES2271539T3/es not_active Expired - Lifetime
- 2003-03-07 CA CA002481026A patent/CA2481026A1/en not_active Abandoned
- 2003-03-07 AU AU2003214102A patent/AU2003214102A1/en not_active Abandoned
- 2003-03-07 JP JP2003581773A patent/JP2005528377A/ja active Pending
- 2003-03-07 DE DE50304858T patent/DE50304858D1/de not_active Expired - Fee Related
- 2003-03-07 US US10/510,046 patent/US20050176760A1/en not_active Abandoned
- 2003-03-07 AT AT03709758T patent/ATE337779T1/de not_active IP Right Cessation
- 2003-03-07 WO PCT/EP2003/002349 patent/WO2003084533A1/de not_active Ceased
- 2003-03-07 EP EP03709758A patent/EP1490056B1/de not_active Expired - Lifetime
- 2003-04-04 AR ARP030101174A patent/AR039249A1/es unknown
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