JP2005535630A5 - - Google Patents
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- Publication number
- JP2005535630A5 JP2005535630A5 JP2004516575A JP2004516575A JP2005535630A5 JP 2005535630 A5 JP2005535630 A5 JP 2005535630A5 JP 2004516575 A JP2004516575 A JP 2004516575A JP 2004516575 A JP2004516575 A JP 2004516575A JP 2005535630 A5 JP2005535630 A5 JP 2005535630A5
- Authority
- JP
- Japan
- Prior art keywords
- substituted
- atoms
- carbon atoms
- disubstituted
- monosubstituted
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 125000002947 alkylene group Chemical group 0.000 claims description 13
- 125000004430 oxygen atom Chemical group O* 0.000 claims description 13
- 229920006395 saturated elastomer Polymers 0.000 claims description 12
- 125000004434 sulfur atom Chemical group 0.000 claims description 12
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 10
- 125000000623 heterocyclic group Chemical group 0.000 claims description 9
- 125000002950 monocyclic group Chemical group 0.000 claims description 8
- 125000004433 nitrogen atom Chemical group N* 0.000 claims description 8
- 125000002619 bicyclic group Chemical group 0.000 claims description 6
- 229910052757 nitrogen Inorganic materials 0.000 claims description 5
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 claims description 4
- -1 1H-pyridin-1-yl Chemical group 0.000 claims 38
- 125000004432 carbon atom Chemical group C* 0.000 claims 19
- 125000006297 carbonyl amino group Chemical group [H]N([*:2])C([*:1])=O 0.000 claims 10
- 239000000203 mixture Substances 0.000 claims 9
- 239000012453 solvate Substances 0.000 claims 9
- 150000001875 compounds Chemical class 0.000 claims 8
- 125000000217 alkyl group Chemical group 0.000 claims 7
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 7
- ZUOUZKKEUPVFJK-UHFFFAOYSA-N diphenyl Chemical compound C1=CC=CC=C1C1=CC=CC=C1 ZUOUZKKEUPVFJK-UHFFFAOYSA-N 0.000 claims 4
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 3
- 125000000843 phenylene group Chemical group C1(=C(C=CC=C1)*)* 0.000 claims 3
- 125000004214 1-pyrrolidinyl group Chemical group [H]C1([H])N(*)C([H])([H])C([H])([H])C1([H])[H] 0.000 claims 2
- 235000010290 biphenyl Nutrition 0.000 claims 2
- 239000004305 biphenyl Substances 0.000 claims 2
- 125000004573 morpholin-4-yl group Chemical group N1(CCOCC1)* 0.000 claims 2
- 125000001624 naphthyl group Chemical group 0.000 claims 2
- 125000004194 piperazin-1-yl group Chemical group [H]N1C([H])([H])C([H])([H])N(*)C([H])([H])C1([H])[H] 0.000 claims 2
- 125000000587 piperidin-1-yl group Chemical group [H]C1([H])N(*)C([H])([H])C([H])([H])C([H])([H])C1([H])[H] 0.000 claims 2
- 125000000676 alkoxyimino group Chemical group 0.000 claims 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims 1
- 125000002529 biphenylenyl group Chemical group C1(=CC=CC=2C3=CC=CC=C3C12)* 0.000 claims 1
- 125000002993 cycloalkylene group Chemical group 0.000 claims 1
- 125000000896 monocarboxylic acid group Chemical group 0.000 claims 1
- 229910052760 oxygen Inorganic materials 0.000 claims 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 1
- 125000006239 protecting group Chemical group 0.000 claims 1
- 125000000464 thioxo group Chemical group S=* 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10229070A DE10229070A1 (de) | 2002-06-28 | 2002-06-28 | Phenylderivate 5 |
| PCT/EP2003/005898 WO2004002477A1 (de) | 2002-06-28 | 2003-06-05 | 2-(phenyl)-2h-pyrazol-3-carbonsäure-n-4-(thioxo-heterocyclyl)-phenyl-amid derivate und entsprechende imino-heterocyclyl derivate sowie verwandte verbindungen als inhibitoren der koagulationsfaktoren xa und/oder viia zur behandlung bon thrombosen |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2005535630A JP2005535630A (ja) | 2005-11-24 |
| JP2005535630A5 true JP2005535630A5 (https=) | 2006-07-27 |
Family
ID=29723536
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004516575A Pending JP2005535630A (ja) | 2002-06-28 | 2003-06-05 | ２−（フェニル）−２Ｈ−ピラゾール−３−カルボン酸−Ｎ−４−（チオキソ−ヘテロサイクル）−フェニル−アミド誘導体、ならびに対応するイミノ−ヘテロサイクル誘導体、および関連する化合物の、凝固因子Ｘａおよび／またはＶＩＩａの阻害剤として、血栓症の治療のための使用 |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US20050203127A1 (https=) |
| EP (2) | EP1679073A1 (https=) |
| JP (1) | JP2005535630A (https=) |
| AR (1) | AR040472A1 (https=) |
| AU (1) | AU2003238475A1 (https=) |
| CA (1) | CA2491271A1 (https=) |
| DE (1) | DE10229070A1 (https=) |
| WO (1) | WO2004002477A1 (https=) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2416384A1 (en) * | 2000-07-17 | 2003-01-16 | Takeda Chemical Industries, Ltd. | Sulfone derivatives, their production and use |
| US20070004736A1 (en) * | 2002-11-22 | 2007-01-04 | Keiji Kubo | Imidazole derivative, process for producing the same, and use |
| TWI396686B (zh) | 2004-05-21 | 2013-05-21 | Takeda Pharmaceutical | 環狀醯胺衍生物、以及其製品和用法 |
| DE102004051277A1 (de) * | 2004-10-21 | 2006-04-27 | Merck Patent Gmbh | Heterocyclische Carbonylverbindungen |
| WO2006047415A2 (en) | 2004-10-26 | 2006-05-04 | Janssen Pharmaceutica, N.V. | Factor xa compounds |
| DE102005038947A1 (de) * | 2005-05-18 | 2006-11-30 | Grünenthal GmbH | Substituierte Benzo[d]isoxazol-3-yl-amin-Verbindungen und deren Verwendung in Arzneimitteln |
| DE102005045115A1 (de) * | 2005-09-21 | 2007-04-05 | Siemens Ag | Verfahren und Vorrichtung zum Betrieb eines Kommunikationsendgeräts |
| CA2739488A1 (en) | 2008-10-15 | 2010-04-22 | Boehringer Ingelheim International Gmbh | Fused heteroaryl diamide compounds useful as mmp-13 inhibitors |
| CA2738929A1 (en) | 2008-10-17 | 2010-04-22 | Boehringer Ingelheim International Gmbh | Heteroaryl substituted indole compounds useful as mmp-13 inhibitors |
| CN102918034B (zh) | 2010-03-30 | 2015-06-03 | 维颂公司 | 多取代芳族化合物作为凝血酶的抑制剂 |
| LT2968297T (lt) | 2013-03-15 | 2019-01-10 | Verseon Corporation | Multipakeistieji aromatiniai junginiai kaip serino proteazės inhibitoriai |
| ES2791749T3 (es) | 2013-03-15 | 2020-11-05 | Verseon Corp | Halogenopirazoles como inhibidores de la trombina |
| ES2670550T3 (es) | 2013-10-14 | 2018-05-30 | Eisai R&D Management Co., Ltd. | Derivados de quinolina selectivamente sustituidos |
| SG10202103278TA (en) | 2013-10-14 | 2021-04-29 | Eisai R&D Man Co Ltd | Selectively substituted quinoline compounds |
| KR102736869B1 (ko) | 2014-03-07 | 2024-12-02 | 바이오크리스트파마슈티컬즈,인코포레이티드 | 인간 혈장 칼리크레인 저해제 |
| CN106687445A (zh) | 2014-09-17 | 2017-05-17 | 维颂公司 | 作为丝氨酸蛋白酶抑制剂的吡唑基取代的吡啶酮化合物 |
| RU2017131562A (ru) | 2015-02-27 | 2019-03-27 | Версеон Корпорейшн | Замещенные пиразольные соединения как ингибиторы сериновых протеаз |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU730224B2 (en) * | 1996-12-23 | 2001-03-01 | Du Pont Pharmaceuticals Company | Nitrogen containing heteroaromatics as factor Xa inhibitors |
| US6020357A (en) * | 1996-12-23 | 2000-02-01 | Dupont Pharmaceuticals Company | Nitrogen containing heteroaromatics as factor Xa inhibitors |
| ZA985247B (en) * | 1997-06-19 | 1999-12-17 | Du Pont Merck Pharma | Guanidine mimics as factor Xa inhibitors. |
| SK174699A3 (en) * | 1997-06-19 | 2000-08-14 | Du Pont Pharm Co | Inhibitors of factor xa with a neutral p1 specificity group |
| US5998424A (en) * | 1997-06-19 | 1999-12-07 | Dupont Pharmaceuticals Company | Inhibitors of factor Xa with a neutral P1 specificity group |
-
2002
- 2002-06-28 DE DE10229070A patent/DE10229070A1/de not_active Withdrawn
-
2003
- 2003-06-05 EP EP06000157A patent/EP1679073A1/de not_active Withdrawn
- 2003-06-05 CA CA002491271A patent/CA2491271A1/en not_active Abandoned
- 2003-06-05 US US10/519,356 patent/US20050203127A1/en not_active Abandoned
- 2003-06-05 EP EP03732540A patent/EP1517685A1/de not_active Withdrawn
- 2003-06-05 AU AU2003238475A patent/AU2003238475A1/en not_active Abandoned
- 2003-06-05 JP JP2004516575A patent/JP2005535630A/ja active Pending
- 2003-06-05 WO PCT/EP2003/005898 patent/WO2004002477A1/de not_active Ceased
- 2003-06-27 AR AR20030102321A patent/AR040472A1/es not_active Application Discontinuation
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