JP2005527551A - Ｄｈａおよびローズマリーのコビーズレットおよびそれらの使用方法。 - Google Patents
Ｄｈａおよびローズマリーのコビーズレットおよびそれらの使用方法。 Download PDFInfo
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Classifications
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/02—Algae
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/167—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction with an outer layer or coating comprising drug; with chemically bound drugs or non-active substances on their surface
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
- A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
- A61K9/2081—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets with microcapsules or coated microparticles according to A61K9/50
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Epidemiology (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Medical Informatics (AREA)
- Alternative & Traditional Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Ophthalmology & Optometry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
- Medicines Containing Plant Substances (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
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| US36835202P | 2002-03-28 | 2002-03-28 | |
| PCT/US2003/008558 WO2003082249A1 (en) | 2002-03-28 | 2003-03-19 | Co-beadlet of dha and rosemary and methods of use |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2005332089A Division JP2006077024A (ja) | 2002-03-28 | 2005-11-16 | Ｄｈａおよびローズマリーのコビーズレットおよびそれらの使用方法。 |
Publications (2)
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| JP2005527551A true JP2005527551A (ja) | 2005-09-15 |
| JP2005527551A5 JP2005527551A5 (https=) | 2006-01-05 |
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| JP2003579787A Pending JP2005527551A (ja) | 2002-03-28 | 2003-03-19 | Ｄｈａおよびローズマリーのコビーズレットおよびそれらの使用方法。 |
| JP2005332089A Pending JP2006077024A (ja) | 2002-03-28 | 2005-11-16 | Ｄｈａおよびローズマリーのコビーズレットおよびそれらの使用方法。 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
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| JP2005332089A Pending JP2006077024A (ja) | 2002-03-28 | 2005-11-16 | Ｄｈａおよびローズマリーのコビーズレットおよびそれらの使用方法。 |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US20050147698A1 (https=) |
| EP (1) | EP1487418B1 (https=) |
| JP (2) | JP2005527551A (https=) |
| AR (1) | AR039171A1 (https=) |
| AT (1) | ATE398445T1 (https=) |
| AU (1) | AU2003220417B2 (https=) |
| BR (1) | BR0308713A (https=) |
| CA (1) | CA2478154A1 (https=) |
| DE (1) | DE60321669D1 (https=) |
| DK (1) | DK1487418T3 (https=) |
| WO (1) | WO2003082249A1 (https=) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2006077024A (ja) * | 2002-03-28 | 2006-03-23 | Alcon Inc | Ｄｈａおよびローズマリーのコビーズレットおよびそれらの使用方法。 |
| JP2011084482A (ja) * | 2009-10-13 | 2011-04-28 | Asahi Kasei Chemicals Corp | 脂肪酸、トリグリセリドまたはその混合物を含むマルチコアマイクロカプセルを含有する錠剤およびその製法 |
| JP2016128494A (ja) * | 2005-12-21 | 2016-07-14 | ブルーディ、テクノロジー、ソシエダッド、リミターダＢｒｕｄｙ Ｔｅｃｈｎｏｌｏｇｙ，Ｓ．Ｌ． | 細胞の酸化的損傷に関連した病変を治療するためのｄｈａ、ｅｐａまたはｄｈａ由来のｅｐａの使用 |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7239755B1 (en) * | 1997-07-30 | 2007-07-03 | Lg Electronics Inc. | Method of reducing a blocking artifact when coding moving picture |
| US20040115290A1 (en) | 2001-06-20 | 2004-06-17 | Tripp Matthew L. | Modulation of inflammation by hops fractions and derivatives |
| US8142819B2 (en) | 2002-10-21 | 2012-03-27 | Metaproteomics, Llc | Synergistic compositions that treat or inhibit pathological conditions associated with inflammatory response |
| US7666449B2 (en) | 2001-06-20 | 2010-02-23 | Metaproteomics, Llc | Anti-inflammatory pharmaceutical compositions for reducing inflammation and the treatment or prevention of gastric toxicity |
| US8158160B2 (en) | 2001-11-13 | 2012-04-17 | Eric Hauser Kuhrts | Anti-inflammatory cyclooxygenase inhibitors |
| AR039170A1 (es) * | 2002-03-28 | 2005-02-09 | Bio Dar Ltd | Co-granulos de dha y romero y metodos de uso |
| NZ543726A (en) | 2003-05-22 | 2009-08-28 | Metaproteomics Llc | Anti-inflammatory pharmaceutical compositions for reducing inflammation and the treatment or prevention of gastric toxicity |
| US7914831B2 (en) | 2004-02-27 | 2011-03-29 | Metaproteomics, Llc | Synergistic anti-inflammatory pharmaceutical compositions and related methods using curcuminoids or methylxanthines |
| FR2882894B1 (fr) * | 2005-03-11 | 2009-04-03 | Larena Sa | Composition alimentaire suppletive |
| CA2618613A1 (en) * | 2005-08-09 | 2007-02-22 | Metaproteomics, Llc | Protein kinase modulation by hops and acacia products |
| NZ579340A (en) | 2007-03-19 | 2012-05-25 | Metaproteomics Llc | Methods and compositions for promoting bone and joint health comprising berberine |
| US8652544B2 (en) * | 2008-01-11 | 2014-02-18 | U.S. Nutraceuticals, LLC | Chia seed composition |
| AU2011211461B2 (en) * | 2008-01-11 | 2011-11-17 | U.S. Nutraceuticals, Llc D/B/A Valensa International | Chia seed composition |
| US20100159029A1 (en) * | 2008-12-23 | 2010-06-24 | Alcon Research, Ltd. | Composition and nutritional supplements for improving ocular health and reducing ocular inflammatory response |
| WO2011057183A1 (en) | 2009-11-06 | 2011-05-12 | Alcon Research, Ltd. | Nutritional supplements for relief of dry eye |
Citations (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH07508417A (ja) * | 1992-07-06 | 1995-09-21 | ダノチェモ アクチェセルスカベト | マイクロカプセル封入油又は脂肪製品 |
| JPH0892129A (ja) * | 1993-10-08 | 1996-04-09 | Kanagawa Kagaku Kenkyusho:Kk | 眼発作治療薬 |
| JPH08134026A (ja) * | 1994-10-20 | 1996-05-28 | Prospa Bv | アミノアルコール類の塩およびこれを含有する医薬処方物 |
| JPH1029938A (ja) * | 1996-07-17 | 1998-02-03 | Maruha Corp | 虚血性眼疾患の予防および／または治療剤 |
| JPH10287563A (ja) * | 1997-02-17 | 1998-10-27 | Sagami Chem Res Center | 動体視力改善剤 |
| JPH11193229A (ja) * | 1997-10-07 | 1999-07-21 | Eisai Co Ltd | 乳化粉末の製造方法 |
| WO1999061035A1 (de) * | 1998-05-22 | 1999-12-02 | Greither, Peter | Präparat auf der basis der artischockenpflanze, insbesondere zur verwendung als arzneimittel oder nahrungsergänzungsmittel |
| WO2000019984A2 (de) * | 1998-10-02 | 2000-04-13 | Röhm Gmbh | Überzogene arzneiformen mit kontrollierter wirkstoffabgabe |
| JP2005527559A (ja) * | 2002-03-28 | 2005-09-15 | アルコン，インコーポレイテッド | ＤＨＡおよびローズマリーのｃｏ−ビードレットならびに使用方法 |
| JP2006077024A (ja) * | 2002-03-28 | 2006-03-23 | Alcon Inc | Ｄｈａおよびローズマリーのコビーズレットおよびそれらの使用方法。 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3998753A (en) * | 1974-08-13 | 1976-12-21 | Hoffmann-La Roche Inc. | Water dispersible carotenoid preparations and processes thereof |
| CH627449A5 (de) * | 1977-03-25 | 1982-01-15 | Hoffmann La Roche | Verfahren zur herstellung von mikrokristallinem vitamin a-acetat, sowie von trockenen, frei-fliessenden praeparaten, in welchen vitamin a-acetat in mikrokristalliner form vorliegt. |
| AU552068B2 (en) * | 1981-09-21 | 1986-05-22 | Asama Chemical Co. Ltd. | Preservation of edible oils |
| US4670247A (en) * | 1983-07-05 | 1987-06-02 | Hoffman-Laroche Inc. | Process for preparing fat-soluble vitamin active beadlets |
| JPH07236418A (ja) * | 1994-02-25 | 1995-09-12 | Kanegafuchi Chem Ind Co Ltd | ドコサヘキサエン酸、エイコサペンタエン酸用抗酸化矯臭剤 |
| JP3545148B2 (ja) * | 1996-01-08 | 2004-07-21 | 味の素株式会社 | 食用マイクロカプセル及びそれを含有する食品 |
| JP3640005B2 (ja) * | 1996-09-25 | 2005-04-20 | 日本たばこ産業株式会社 | ソフトカプセル用皮膜 |
| JPH10286079A (ja) * | 1997-04-16 | 1998-10-27 | Yasumasa Morita | 薬草ハーブと不飽和脂肪酸ｄ．ｈ．ａ（ドコサヘキ サエン酸）を混入した海産物海苔 |
| US6582721B1 (en) * | 1999-09-17 | 2003-06-24 | Alcon, Inc. | Stable carotene-xanthophyll beadlet compositions and methods of use |
| US7704542B2 (en) * | 2001-09-12 | 2010-04-27 | Xanodyne Pharmaceuticals, Inc. | Vitamin/mineral compositions with DHA |
| DE20205184U1 (de) | 2002-03-27 | 2002-12-19 | Bartz, Volker, 35440 Linden | Blutfettsenker zur oralen Einnahme |
-
2003
- 2003-03-19 DK DK03716722T patent/DK1487418T3/da active
- 2003-03-19 BR BR0308713-1A patent/BR0308713A/pt not_active IP Right Cessation
- 2003-03-19 JP JP2003579787A patent/JP2005527551A/ja active Pending
- 2003-03-19 DE DE60321669T patent/DE60321669D1/de not_active Expired - Lifetime
- 2003-03-19 AT AT03716722T patent/ATE398445T1/de not_active IP Right Cessation
- 2003-03-19 US US10/504,195 patent/US20050147698A1/en not_active Abandoned
- 2003-03-19 EP EP03716722A patent/EP1487418B1/en not_active Revoked
- 2003-03-19 CA CA002478154A patent/CA2478154A1/en not_active Abandoned
- 2003-03-19 AU AU2003220417A patent/AU2003220417B2/en not_active Ceased
- 2003-03-19 WO PCT/US2003/008558 patent/WO2003082249A1/en not_active Ceased
- 2003-03-27 AR ARP030101083A patent/AR039171A1/es unknown
-
2005
- 2005-11-16 JP JP2005332089A patent/JP2006077024A/ja active Pending
-
2008
- 2008-03-13 US US12/047,378 patent/US20080152710A1/en not_active Abandoned
Patent Citations (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH07508417A (ja) * | 1992-07-06 | 1995-09-21 | ダノチェモ アクチェセルスカベト | マイクロカプセル封入油又は脂肪製品 |
| JPH0892129A (ja) * | 1993-10-08 | 1996-04-09 | Kanagawa Kagaku Kenkyusho:Kk | 眼発作治療薬 |
| JPH08134026A (ja) * | 1994-10-20 | 1996-05-28 | Prospa Bv | アミノアルコール類の塩およびこれを含有する医薬処方物 |
| JPH1029938A (ja) * | 1996-07-17 | 1998-02-03 | Maruha Corp | 虚血性眼疾患の予防および／または治療剤 |
| JPH10287563A (ja) * | 1997-02-17 | 1998-10-27 | Sagami Chem Res Center | 動体視力改善剤 |
| JPH11193229A (ja) * | 1997-10-07 | 1999-07-21 | Eisai Co Ltd | 乳化粉末の製造方法 |
| WO1999061035A1 (de) * | 1998-05-22 | 1999-12-02 | Greither, Peter | Präparat auf der basis der artischockenpflanze, insbesondere zur verwendung als arzneimittel oder nahrungsergänzungsmittel |
| WO2000019984A2 (de) * | 1998-10-02 | 2000-04-13 | Röhm Gmbh | Überzogene arzneiformen mit kontrollierter wirkstoffabgabe |
| JP2005527559A (ja) * | 2002-03-28 | 2005-09-15 | アルコン，インコーポレイテッド | ＤＨＡおよびローズマリーのｃｏ−ビードレットならびに使用方法 |
| JP2006077024A (ja) * | 2002-03-28 | 2006-03-23 | Alcon Inc | Ｄｈａおよびローズマリーのコビーズレットおよびそれらの使用方法。 |
Non-Patent Citations (1)
| Title |
|---|
| JPN7009002543, "ＲＯＰＵＦＡ（Ｒ） ‘１０’ｎ−３ Ｆｏｏｄ Ｐｏｗｄｅｒ", Ｐｒｏｄｕｃｔ Ｄａｔａ Ｒｏｃｈｅ Ｖｉｔａｍｉｎｓ, 2000, ｐ．１／２−２／２, Ｆ．Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ｌｔｄ * |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2006077024A (ja) * | 2002-03-28 | 2006-03-23 | Alcon Inc | Ｄｈａおよびローズマリーのコビーズレットおよびそれらの使用方法。 |
| JP2016128494A (ja) * | 2005-12-21 | 2016-07-14 | ブルーディ、テクノロジー、ソシエダッド、リミターダＢｒｕｄｙ Ｔｅｃｈｎｏｌｏｇｙ，Ｓ．Ｌ． | 細胞の酸化的損傷に関連した病変を治療するためのｄｈａ、ｅｐａまたはｄｈａ由来のｅｐａの使用 |
| JP2011084482A (ja) * | 2009-10-13 | 2011-04-28 | Asahi Kasei Chemicals Corp | 脂肪酸、トリグリセリドまたはその混合物を含むマルチコアマイクロカプセルを含有する錠剤およびその製法 |
Also Published As
| Publication number | Publication date |
|---|---|
| BR0308713A (pt) | 2005-01-04 |
| WO2003082249A1 (en) | 2003-10-09 |
| ATE398445T1 (de) | 2008-07-15 |
| EP1487418B1 (en) | 2008-06-18 |
| US20080152710A1 (en) | 2008-06-26 |
| HK1070558A1 (en) | 2005-06-24 |
| AR039171A1 (es) | 2005-02-09 |
| EP1487418A1 (en) | 2004-12-22 |
| EP1487418A4 (en) | 2005-07-13 |
| JP2006077024A (ja) | 2006-03-23 |
| CA2478154A1 (en) | 2003-10-09 |
| AU2003220417B2 (en) | 2009-03-12 |
| AU2003220417A1 (en) | 2003-10-13 |
| US20050147698A1 (en) | 2005-07-07 |
| DE60321669D1 (de) | 2008-07-31 |
| DK1487418T3 (da) | 2008-09-15 |
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