JP2005526745A5 - - Google Patents
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- Publication number
- JP2005526745A5 JP2005526745A5 JP2003572956A JP2003572956A JP2005526745A5 JP 2005526745 A5 JP2005526745 A5 JP 2005526745A5 JP 2003572956 A JP2003572956 A JP 2003572956A JP 2003572956 A JP2003572956 A JP 2003572956A JP 2005526745 A5 JP2005526745 A5 JP 2005526745A5
- Authority
- JP
- Japan
- Prior art keywords
- azaspiro
- hydrogen
- alkyl
- group
- amino
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 229910052739 hydrogen Inorganic materials 0.000 claims 18
- 239000001257 hydrogen Substances 0.000 claims 18
- -1 hydroxy, formyl Chemical group 0.000 claims 16
- 150000008627 azaspiro compounds Chemical class 0.000 claims 12
- 150000002431 hydrogen Chemical class 0.000 claims 10
- 239000003814 drug Substances 0.000 claims 9
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 8
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 7
- 229910052736 halogen Inorganic materials 0.000 claims 7
- 150000002367 halogens Chemical class 0.000 claims 7
- 229940079593 drug Drugs 0.000 claims 6
- DMEGYFMYUHOHGS-UHFFFAOYSA-N heptamethylene Natural products C1CCCCCC1 DMEGYFMYUHOHGS-UHFFFAOYSA-N 0.000 claims 6
- 125000000464 thioxo group Chemical group S=* 0.000 claims 6
- RGSFGYAAUTVSQA-UHFFFAOYSA-N Cyclopentane Chemical compound C1CCCC1 RGSFGYAAUTVSQA-UHFFFAOYSA-N 0.000 claims 4
- OAKJQQAXSVQMHS-UHFFFAOYSA-N Hydrazine Chemical compound NN OAKJQQAXSVQMHS-UHFFFAOYSA-N 0.000 claims 4
- 229910052799 carbon Inorganic materials 0.000 claims 4
- 125000004432 carbon atom Chemical group C* 0.000 claims 4
- 125000004043 oxo group Chemical group O=* 0.000 claims 4
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 claims 3
- ZOYWDMBYQNFNDE-UHFFFAOYSA-N 2-azaspiro[4.4]nonane-3-thione Chemical compound C1NC(=S)CC11CCCC1 ZOYWDMBYQNFNDE-UHFFFAOYSA-N 0.000 claims 3
- VQISVGCZRGIOFD-UHFFFAOYSA-N 2-azaspiro[4.5]decane-3-thione Chemical compound C1NC(=S)CC21CCCCC2 VQISVGCZRGIOFD-UHFFFAOYSA-N 0.000 claims 3
- RBRHMJWQHKXACY-UHFFFAOYSA-N 2-azaspiro[4.6]undecane-3-thione Chemical compound C1NC(=S)CC21CCCCCC2 RBRHMJWQHKXACY-UHFFFAOYSA-N 0.000 claims 3
- 150000001408 amides Chemical class 0.000 claims 3
- 125000006729 (C2-C5) alkenyl group Chemical group 0.000 claims 2
- 125000006730 (C2-C5) alkynyl group Chemical group 0.000 claims 2
- XDTMQSROBMDMFD-UHFFFAOYSA-N Cyclohexane Chemical compound C1CCCCC1 XDTMQSROBMDMFD-UHFFFAOYSA-N 0.000 claims 2
- 208000002193 Pain Diseases 0.000 claims 2
- 125000004429 atom Chemical group 0.000 claims 2
- 230000001684 chronic effect Effects 0.000 claims 2
- 125000005842 heteroatom Chemical group 0.000 claims 2
- 125000000623 heterocyclic group Chemical group 0.000 claims 2
- 125000004674 methylcarbonyl group Chemical group CC(=O)* 0.000 claims 2
- 229910052760 oxygen Inorganic materials 0.000 claims 2
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 2
- 150000003839 salts Chemical class 0.000 claims 2
- 229920006395 saturated elastomer Polymers 0.000 claims 2
- 125000001424 substituent group Chemical group 0.000 claims 2
- 229910052717 sulfur Inorganic materials 0.000 claims 2
- FHFHJCMWCPQJLQ-UHFFFAOYSA-N 1-(2-azaspiro[4.5]decan-2-yl)ethanone Chemical compound C1N(C(=O)C)CCC21CCCCC2 FHFHJCMWCPQJLQ-UHFFFAOYSA-N 0.000 claims 1
- UYUUEEXDJGLCLY-UHFFFAOYSA-N 2-azaspiro[4.6]undecane Chemical compound C1NCCC21CCCCCC2 UYUUEEXDJGLCLY-UHFFFAOYSA-N 0.000 claims 1
- 125000000217 alkyl group Chemical group 0.000 claims 1
- 230000002757 inflammatory effect Effects 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 208000004296 neuralgia Diseases 0.000 claims 1
- 208000021722 neuropathic pain Diseases 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10210190A DE10210190A1 (de) | 2002-03-07 | 2002-03-07 | Aza-Spiroverbindungen |
| PCT/EP2003/001986 WO2003074486A1 (de) | 2002-03-07 | 2003-02-27 | Aza-spiroverbindungen zur behandlug von schmerzen |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2005526745A JP2005526745A (ja) | 2005-09-08 |
| JP2005526745A5 true JP2005526745A5 (https=) | 2006-04-13 |
Family
ID=27771112
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003572956A Pending JP2005526745A (ja) | 2002-03-07 | 2003-02-27 | 痛みを治療するためのアザスピロ化合物 |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US20050288351A1 (https=) |
| EP (2) | EP1520854A3 (https=) |
| JP (1) | JP2005526745A (https=) |
| KR (1) | KR20040091638A (https=) |
| CN (1) | CN1324011C (https=) |
| AT (1) | ATE298745T1 (https=) |
| AU (1) | AU2003215603A1 (https=) |
| BR (1) | BR0307922A (https=) |
| CA (1) | CA2477124A1 (https=) |
| DE (2) | DE10210190A1 (https=) |
| ES (1) | ES2242944T3 (https=) |
| MX (1) | MXPA04008669A (https=) |
| NO (1) | NO20044239L (https=) |
| PL (1) | PL372431A1 (https=) |
| PT (1) | PT1485352E (https=) |
| RU (1) | RU2322438C2 (https=) |
| UA (1) | UA78987C2 (https=) |
| WO (1) | WO2003074486A1 (https=) |
| ZA (1) | ZA200406245B (https=) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW201607923A (zh) * | 2014-07-15 | 2016-03-01 | 歌林達有限公司 | 被取代之氮螺環（４．５）癸烷衍生物 |
| CN107216335B (zh) * | 2017-06-29 | 2019-04-30 | 上海药明康德新药开发有限公司 | 一种叔丁基1-(羟甲基)-3-氧杂-9-氮杂螺[5.5]十一烷-9-甲酸基酯制法 |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2866734A (en) * | 1956-12-05 | 1958-12-30 | Us Vitamin Corp | 3-pyridylethyl 2, 4-oxazolidinediones and process |
| US3150143A (en) * | 1960-07-19 | 1964-09-22 | Geschicketer Fund For Medical | Therapeutically active nu-substituted azaspiranes |
| US3398151A (en) * | 1966-02-01 | 1968-08-20 | Mead Johnson & Co | Azaspirodecanediones and azaspiroundecanediones |
| US3629276A (en) * | 1969-07-16 | 1971-12-21 | Abbott Lab | 2-amino-5-spiro-substituted-oxazo compounds |
| US4430335A (en) * | 1983-02-09 | 1984-02-07 | Hoechst-Roussel Pharmaceuticals Inc. | Substituted 1-azaspiro[4,5]decanes and their analgesic compositions |
| GB8916447D0 (en) * | 1989-07-19 | 1989-09-06 | Ici Plc | Composition,process and use |
| US5319135A (en) * | 1989-08-25 | 1994-06-07 | Warner-Lambert Company | Process for cyclic amino acid anticonvulsant compounds |
| US5132451A (en) * | 1989-08-25 | 1992-07-21 | Warner-Lambert Company | Process for cyclic amino acid anticonvulsant compounds |
| RU95114363A (ru) * | 1992-11-09 | 1997-03-20 | Дзе Бутс Компани ПЛС. (GB) | Производные азаспиросоединений, способ их получения, фармацевтическая композиция, средства для лечения ожирения, средства для лечения аффективных расстройств |
| US5925672A (en) * | 1996-12-06 | 1999-07-20 | Neurosciences Research Foundation, Inc. | Methods of treating mental diseases, inflammation and pain |
| GB9708484D0 (en) * | 1997-04-25 | 1997-06-18 | Merck Sharp & Dohme | Therapeutic agents |
| DE19732928C2 (de) * | 1997-07-31 | 2000-05-18 | Gruenenthal Gmbh | Verwendung substituierter Imidazolidin-2,4-dion-Verbindungen als Schmerzmittel |
| US5948807A (en) * | 1997-09-03 | 1999-09-07 | Regents Of The University Of Minnesota | Spiroindanamines and Spiroindanimides |
| DE19751062A1 (de) * | 1997-11-18 | 1999-07-08 | Univ Ludwigs Albert | An 4-Stellung substituierte 2-Pyrrolidinon-Derivate zur Verringerung des extrazellulären Glutamat-Spiegels |
| WO1999061424A1 (en) * | 1998-05-26 | 1999-12-02 | Warner-Lambert Company | Conformationally constrained amino acid compounds having affinity for the alpha2delta subunit of a calcium channel |
-
2002
- 2002-03-07 DE DE10210190A patent/DE10210190A1/de not_active Ceased
-
2003
- 2003-02-27 MX MXPA04008669A patent/MXPA04008669A/es not_active Application Discontinuation
- 2003-02-27 WO PCT/EP2003/001986 patent/WO2003074486A1/de not_active Ceased
- 2003-02-27 CA CA002477124A patent/CA2477124A1/en not_active Abandoned
- 2003-02-27 EP EP04029311A patent/EP1520854A3/de not_active Withdrawn
- 2003-02-27 AU AU2003215603A patent/AU2003215603A1/en not_active Abandoned
- 2003-02-27 KR KR10-2004-7012680A patent/KR20040091638A/ko not_active Ceased
- 2003-02-27 ES ES03743342T patent/ES2242944T3/es not_active Expired - Lifetime
- 2003-02-27 UA UA20041008091A patent/UA78987C2/uk unknown
- 2003-02-27 AT AT03743342T patent/ATE298745T1/de not_active IP Right Cessation
- 2003-02-27 EP EP03743342A patent/EP1485352B1/de not_active Expired - Lifetime
- 2003-02-27 JP JP2003572956A patent/JP2005526745A/ja active Pending
- 2003-02-27 CN CNB038054388A patent/CN1324011C/zh not_active Expired - Fee Related
- 2003-02-27 PL PL03372431A patent/PL372431A1/xx not_active Application Discontinuation
- 2003-02-27 PT PT03743342T patent/PT1485352E/pt unknown
- 2003-02-27 RU RU2004129769/04A patent/RU2322438C2/ru not_active IP Right Cessation
- 2003-02-27 BR BR0307922-8A patent/BR0307922A/pt not_active IP Right Cessation
- 2003-02-27 DE DE50300710T patent/DE50300710D1/de not_active Expired - Fee Related
-
2004
- 2004-08-05 ZA ZA200406245A patent/ZA200406245B/xx unknown
- 2004-09-07 US US10/936,134 patent/US20050288351A1/en not_active Abandoned
- 2004-10-06 NO NO20044239A patent/NO20044239L/no not_active Application Discontinuation
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