JP2005526016A - Ｄｎａの投薬形態 - Google Patents
Ｄｎａの投薬形態 Download PDFInfo
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- JP2005526016A JP2005526016A JP2003561581A JP2003561581A JP2005526016A JP 2005526016 A JP2005526016 A JP 2005526016A JP 2003561581 A JP2003561581 A JP 2003561581A JP 2003561581 A JP2003561581 A JP 2003561581A JP 2005526016 A JP2005526016 A JP 2005526016A
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- JP
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- Prior art keywords
- dna
- delivery device
- drug delivery
- plasmid
- skin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/167—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction with an outer layer or coating comprising drug; with chemically bound drugs or non-active substances on their surface
- A61K9/1676—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction with an outer layer or coating comprising drug; with chemically bound drugs or non-active substances on their surface having a drug-free core with discrete complete coating layer containing drug
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- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
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- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
- A61K9/0021—Intradermal administration, e.g. through microneedle arrays, needleless injectors
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
- A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
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- A—HUMAN NECESSITIES
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- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/20—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing sulfur, e.g. dimethyl sulfoxide [DMSO], docusate, sodium lauryl sulfate or aminosulfonic acids
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/145—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic compounds
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- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Dermatology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0201736.6A GB0201736D0 (en) | 2002-01-25 | 2002-01-25 | DNA dosage forms |
| PCT/GB2003/000282 WO2003061636A2 (en) | 2002-01-25 | 2003-01-23 | Dna dosage forms |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2005526016A true JP2005526016A (ja) | 2005-09-02 |
| JP2005526016A5 JP2005526016A5 (enExample) | 2006-02-09 |
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| JP2003561581A Pending JP2005526016A (ja) | 2002-01-25 | 2003-01-23 | Ｄｎａの投薬形態 |
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| Country | Link |
|---|---|
| US (1) | US20050080028A1 (enExample) |
| EP (1) | EP1467720B1 (enExample) |
| JP (1) | JP2005526016A (enExample) |
| AT (1) | ATE427105T1 (enExample) |
| AU (1) | AU2003202685A1 (enExample) |
| CA (1) | CA2473679A1 (enExample) |
| DE (1) | DE60326930D1 (enExample) |
| ES (1) | ES2322572T3 (enExample) |
| GB (1) | GB0201736D0 (enExample) |
| WO (1) | WO2003061636A2 (enExample) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2007519613A (ja) * | 2003-10-23 | 2007-07-19 | アルザ・コーポレーシヨン | 微小突出部をコーティングするための安定化されたｄｎａの組成物 |
| JP2013052202A (ja) * | 2011-09-01 | 2013-03-21 | Kosumedei Seiyaku Kk | Ｄｎａワクチンマイクロニードル |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0017999D0 (en) * | 2000-07-21 | 2000-09-13 | Smithkline Beecham Biolog | Novel device |
| AU2004268616B2 (en) | 2003-08-25 | 2010-10-07 | 3M Innovative Properties Company | Delivery of immune response modifier compounds |
| US7591806B2 (en) * | 2004-05-18 | 2009-09-22 | Bai Xu | High-aspect-ratio microdevices and methods for transdermal delivery and sampling of active substances |
| DE602005025138D1 (de) | 2004-08-16 | 2011-01-13 | Fuctional Microstructures Ltd | Verfahren zur herstellung einer mikronadel oder eines mikroimplantats |
| US8048017B2 (en) * | 2005-05-18 | 2011-11-01 | Bai Xu | High-aspect-ratio microdevices and methods for transdermal delivery and sampling of active substances |
| US8043250B2 (en) * | 2005-05-18 | 2011-10-25 | Nanomed Devices, Inc. | High-aspect-ratio microdevices and methods for transdermal delivery and sampling of active substances |
| JP2009502261A (ja) * | 2005-07-25 | 2009-01-29 | ナノテクノロジー ビクトリア ピーティーワイ リミテッド | マイクロアレイデバイス |
| CA2629193C (en) | 2005-11-18 | 2016-03-29 | 3M Innovative Properties Company | Coatable compositions, coatings derived therefrom and microarrays having such coatings |
| US10525246B2 (en) | 2006-12-22 | 2020-01-07 | Nanomed Skincare, Inc. | Microdevice and method for transdermal delivery and sampling of active substances |
| US20080214987A1 (en) * | 2006-12-22 | 2008-09-04 | Nanomed Devices, Inc. | Microdevice And Method For Transdermal Delivery And Sampling Of Active Substances |
| US8512679B2 (en) | 2011-03-04 | 2013-08-20 | Elwha Llc | Glassy compositions |
| CN103717249B (zh) | 2011-06-15 | 2017-03-22 | 克洛恩泰克制药股份公司 | 注射针和装置 |
| KR101314091B1 (ko) * | 2011-07-26 | 2013-10-04 | 연세대학교 산학협력단 | 치료 부위내 경피 유전자 전달을 위한 일렉트로 마이크로니들 집적체 및 이의 제조방법 |
| WO2013076305A1 (en) * | 2011-11-25 | 2013-05-30 | Danmarks Tekniske Universitet | Formulation of solid nano-sized particles in a gel-forming system |
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| JPH08510639A (ja) * | 1993-04-19 | 1996-11-12 | メディソーブ・テクノロジーズ・インターナショナル・リミテッド・パートナーシップ | 細胞取込みと遺伝子発現の促進と標的化をもたらす接合体と核酸のカプセル化 |
| JPH09501936A (ja) * | 1993-08-26 | 1997-02-25 | ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア | 生物活性ペプチドをコードする裸のポリヌクレオチドを投与するための方法、組成物および装置 |
| WO1997040839A1 (en) * | 1996-04-26 | 1997-11-06 | Merck & Co., Inc. | Dna vaccine formulations |
| WO2000044438A1 (en) * | 1999-01-28 | 2000-08-03 | Cyto Pulse Sciences, Inc. | Delivery of macromolecules into cells |
| JP2001157715A (ja) * | 1999-09-24 | 2001-06-12 | Becton Dickinson & Co | 皮膚の擦過に適した方法及び用具 |
| JP2001213807A (ja) * | 1989-06-26 | 2001-08-07 | Powderject Vaccines Inc | 動物の体細胞の粒子媒介形質転換 |
| JP2005502399A (ja) * | 2001-08-03 | 2005-01-27 | サイト パルス サイエンシズ、インコーポレイテッド | 治療剤でコーティングされた電極及びその使用法 |
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| JPH0832638B2 (ja) * | 1989-05-25 | 1996-03-29 | カイロン コーポレイション | サブミクロン油滴乳剤を含んで成るアジュバント製剤 |
| US5697901A (en) * | 1989-12-14 | 1997-12-16 | Elof Eriksson | Gene delivery by microneedle injection |
| US5804566A (en) * | 1993-08-26 | 1998-09-08 | The Regents Of The University Of California | Methods and devices for immunizing a host through administration of naked polynucleotides with encode allergenic peptides |
| US6290991B1 (en) * | 1994-12-02 | 2001-09-18 | Quandrant Holdings Cambridge Limited | Solid dose delivery vehicle and methods of making same |
| DE69531992T2 (de) * | 1994-08-04 | 2004-07-22 | Elan Drug Delivery Ltd., Ruddington | Feste verabreichungssysteme zur gesteuerten freisetzung von darin eingebauten molekülen sowie verfahren zu deren herstellung |
| EP1100579B1 (en) * | 1998-07-13 | 2015-09-02 | Inovio Pharmaceuticals, Inc. | Skin and muscle-targeted gene therapy by pulsed electrical field |
| US6743211B1 (en) * | 1999-11-23 | 2004-06-01 | Georgia Tech Research Corporation | Devices and methods for enhanced microneedle penetration of biological barriers |
| US20020002136A1 (en) * | 2000-06-28 | 2002-01-03 | Hebert Rolland F. | Salts of glutathione |
| CA2414926A1 (en) * | 2000-07-07 | 2002-01-17 | Corixa Corporation | Microspheres and adjuvants for dna vaccine delivery |
| GB0017999D0 (en) * | 2000-07-21 | 2000-09-13 | Smithkline Beecham Biolog | Novel device |
| DE60233939D1 (de) * | 2001-04-20 | 2009-11-19 | Alza Corp | Mikroprojektionsanordnung mit einem überzug, der ein vorteilhaftes mittel enthält |
-
2002
- 2002-01-25 GB GBGB0201736.6A patent/GB0201736D0/en not_active Ceased
-
2003
- 2003-01-23 DE DE60326930T patent/DE60326930D1/de not_active Expired - Fee Related
- 2003-01-23 WO PCT/GB2003/000282 patent/WO2003061636A2/en not_active Ceased
- 2003-01-23 EP EP03701595A patent/EP1467720B1/en not_active Expired - Lifetime
- 2003-01-23 AU AU2003202685A patent/AU2003202685A1/en not_active Abandoned
- 2003-01-23 ES ES03701595T patent/ES2322572T3/es not_active Expired - Lifetime
- 2003-01-23 AT AT03701595T patent/ATE427105T1/de not_active IP Right Cessation
- 2003-01-23 JP JP2003561581A patent/JP2005526016A/ja active Pending
- 2003-01-23 CA CA002473679A patent/CA2473679A1/en not_active Abandoned
- 2003-01-23 US US10/502,285 patent/US20050080028A1/en not_active Abandoned
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| JP2001213807A (ja) * | 1989-06-26 | 2001-08-07 | Powderject Vaccines Inc | 動物の体細胞の粒子媒介形質転換 |
| JPH08510639A (ja) * | 1993-04-19 | 1996-11-12 | メディソーブ・テクノロジーズ・インターナショナル・リミテッド・パートナーシップ | 細胞取込みと遺伝子発現の促進と標的化をもたらす接合体と核酸のカプセル化 |
| JPH09501936A (ja) * | 1993-08-26 | 1997-02-25 | ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア | 生物活性ペプチドをコードする裸のポリヌクレオチドを投与するための方法、組成物および装置 |
| WO1997040839A1 (en) * | 1996-04-26 | 1997-11-06 | Merck & Co., Inc. | Dna vaccine formulations |
| WO2000044438A1 (en) * | 1999-01-28 | 2000-08-03 | Cyto Pulse Sciences, Inc. | Delivery of macromolecules into cells |
| JP2001157715A (ja) * | 1999-09-24 | 2001-06-12 | Becton Dickinson & Co | 皮膚の擦過に適した方法及び用具 |
| JP2005502399A (ja) * | 2001-08-03 | 2005-01-27 | サイト パルス サイエンシズ、インコーポレイテッド | 治療剤でコーティングされた電極及びその使用法 |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2007519613A (ja) * | 2003-10-23 | 2007-07-19 | アルザ・コーポレーシヨン | 微小突出部をコーティングするための安定化されたｄｎａの組成物 |
| JP2013052202A (ja) * | 2011-09-01 | 2013-03-21 | Kosumedei Seiyaku Kk | Ｄｎａワクチンマイクロニードル |
Also Published As
| Publication number | Publication date |
|---|---|
| GB0201736D0 (en) | 2002-03-13 |
| CA2473679A1 (en) | 2003-07-31 |
| ATE427105T1 (de) | 2009-04-15 |
| ES2322572T3 (es) | 2009-06-23 |
| EP1467720B1 (en) | 2009-04-01 |
| WO2003061636A2 (en) | 2003-07-31 |
| AU2003202685A1 (en) | 2003-09-02 |
| DE60326930D1 (de) | 2009-05-14 |
| US20050080028A1 (en) | 2005-04-14 |
| WO2003061636A3 (en) | 2003-11-27 |
| EP1467720A2 (en) | 2004-10-20 |
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