JP2005521701A5 - - Google Patents
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- Publication number
- JP2005521701A5 JP2005521701A5 JP2003579565A JP2003579565A JP2005521701A5 JP 2005521701 A5 JP2005521701 A5 JP 2005521701A5 JP 2003579565 A JP2003579565 A JP 2003579565A JP 2003579565 A JP2003579565 A JP 2003579565A JP 2005521701 A5 JP2005521701 A5 JP 2005521701A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutical composition
- cmt
- composition according
- tetracycline
- group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000008194 pharmaceutical composition Substances 0.000 claims 33
- 241000894006 Bacteria Species 0.000 claims 19
- 239000004098 Tetracycline Substances 0.000 claims 18
- 150000003839 salts Chemical class 0.000 claims 18
- 229960002180 tetracycline Drugs 0.000 claims 18
- 229930101283 tetracycline Natural products 0.000 claims 18
- 235000019364 tetracycline Nutrition 0.000 claims 18
- 150000003522 tetracyclines Chemical class 0.000 claims 18
- 241000193738 Bacillus anthracis Species 0.000 claims 12
- 239000002095 exotoxin Substances 0.000 claims 10
- 231100000776 exotoxin Toxicity 0.000 claims 10
- OTLLEIBWKHEHGU-UHFFFAOYSA-N 2-[5-[[5-(6-aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy]-3,4-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-3,5-dihydroxy-4-phosphonooxyhexanedioic acid Chemical compound C1=NC=2C(N)=NC=NC=2N1C(C(C1O)O)OC1COC1C(CO)OC(OC(C(O)C(OP(O)(O)=O)C(O)C(O)=O)C(O)=O)C(O)C1O OTLLEIBWKHEHGU-UHFFFAOYSA-N 0.000 claims 9
- 229940065181 bacillus anthracis Drugs 0.000 claims 7
- 241000588832 Bordetella pertussis Species 0.000 claims 6
- 102000000584 Calmodulin Human genes 0.000 claims 6
- 108010041952 Calmodulin Proteins 0.000 claims 6
- 241000193468 Clostridium perfringens Species 0.000 claims 6
- 241000124008 Mammalia Species 0.000 claims 6
- 102000005741 Metalloproteases Human genes 0.000 claims 6
- 108010006035 Metalloproteases Proteins 0.000 claims 6
- 241000589517 Pseudomonas aeruginosa Species 0.000 claims 6
- 230000003115 biocidal effect Effects 0.000 claims 6
- 230000000845 anti-microbial effect Effects 0.000 claims 5
- 230000000844 anti-bacterial effect Effects 0.000 claims 4
- MYSWGUAQZAJSOK-UHFFFAOYSA-N ciprofloxacin Chemical compound C12=CC(N3CCNCC3)=C(F)C=C2C(=O)C(C(=O)O)=CN1C1CC1 MYSWGUAQZAJSOK-UHFFFAOYSA-N 0.000 claims 4
- MWUTTXATIMURBN-VSAOOKSHSA-N (4aS,5aS,6S,12aR)-3,6,10,11-tetrahydroxy-6-methyl-1,12-dioxo-4a,5,5a,12a-tetrahydro-4H-tetracene-2-carboxamide Chemical compound C[C@]1(O)[C@H]2C[C@H]3CC(O)=C(C(N)=O)C(=O)[C@H]3C(=O)C2=C(O)c2c(O)cccc12 MWUTTXATIMURBN-VSAOOKSHSA-N 0.000 claims 3
- NBRQRXRBIHVLGI-OWXODZSWSA-N (4as,5ar,12ar)-1,10,11,12a-tetrahydroxy-3,12-dioxo-4a,5,5a,6-tetrahydro-4h-tetracene-2-carboxamide Chemical compound C1C2=CC=CC(O)=C2C(O)=C(C2=O)[C@@H]1C[C@@H]1[C@@]2(O)C(O)=C(C(=O)N)C(=O)C1 NBRQRXRBIHVLGI-OWXODZSWSA-N 0.000 claims 3
- XCCHQGIGHCRZOS-KBKZQPOHSA-N (4as,5as,6s,12ar)-1,6,10,11,12a-pentahydroxy-6-methyl-3,12-dioxo-4,4a,5,5a-tetrahydrotetracene-2-carboxamide Chemical compound C1=CC=C2[C@@](C)(O)[C@@H](C[C@@H]3[C@](C(O)=C(C(N)=O)C(=O)C3)(O)C3=O)C3=C(O)C2=C1O XCCHQGIGHCRZOS-KBKZQPOHSA-N 0.000 claims 3
- 241000606124 Bacteroides fragilis Species 0.000 claims 3
- 101100221122 Caenorhabditis elegans cmt-1 gene Proteins 0.000 claims 3
- HISOCSRUFLPKDE-KLXQUTNESA-N cmt-2 Chemical compound C1=CC=C2[C@](O)(C)C3CC4C(N(C)C)C(O)=C(C#N)C(=O)[C@@]4(O)C(O)=C3C(=O)C2=C1O HISOCSRUFLPKDE-KLXQUTNESA-N 0.000 claims 3
- BVFDLIAWTKFZQD-JXVDNWKRSA-N cmt-8 Chemical compound O=C1C2=C(O)C=CC=C2C(C)[C@@H]2C1=C(O)[C@]1(O)C(=O)C(C(N)=O)=C(O)C[C@@H]1C2O BVFDLIAWTKFZQD-JXVDNWKRSA-N 0.000 claims 3
- 239000003814 drug Substances 0.000 claims 3
- 239000000203 mixture Substances 0.000 claims 3
- SGKRLCUYIXIAHR-AKNGSSGZSA-N (4s,4ar,5s,5ar,6r,12ar)-4-(dimethylamino)-1,5,10,11,12a-pentahydroxy-6-methyl-3,12-dioxo-4a,5,5a,6-tetrahydro-4h-tetracene-2-carboxamide Chemical compound C1=CC=C2[C@H](C)[C@@H]([C@H](O)[C@@H]3[C@](C(O)=C(C(N)=O)C(=O)[C@H]3N(C)C)(O)C3=O)C3=C(O)C2=C1O SGKRLCUYIXIAHR-AKNGSSGZSA-N 0.000 claims 2
- 239000003242 anti bacterial agent Substances 0.000 claims 2
- 239000004599 antimicrobial Substances 0.000 claims 2
- 229960003405 ciprofloxacin Drugs 0.000 claims 2
- 229960003722 doxycycline Drugs 0.000 claims 2
- 208000024891 symptom Diseases 0.000 claims 2
- 229960005486 vaccine Drugs 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US36847802P | 2002-03-29 | 2002-03-29 | |
| PCT/US2003/009570 WO2003082011A1 (en) | 2002-03-29 | 2003-03-27 | Use of non-antibacterial tetracycline analogs and formulations thereof for the treatment of bacterial exotoxins |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2005521701A JP2005521701A (ja) | 2005-07-21 |
| JP2005521701A5 true JP2005521701A5 (https=) | 2006-05-18 |
Family
ID=28675499
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003579565A Pending JP2005521701A (ja) | 2002-03-29 | 2003-03-27 | 細菌外毒素処置のための非抗菌性テトラサイクリンアナログ類の使用およびその調合物 |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US20040014731A1 (https=) |
| EP (2) | EP2250887B1 (https=) |
| JP (1) | JP2005521701A (https=) |
| KR (1) | KR20040094833A (https=) |
| AT (1) | ATE489081T1 (https=) |
| AU (1) | AU2003226112B9 (https=) |
| CA (1) | CA2475202A1 (https=) |
| DE (1) | DE60335093D1 (https=) |
| ES (1) | ES2359346T3 (https=) |
| NZ (1) | NZ534950A (https=) |
| WO (1) | WO2003082011A1 (https=) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2004091483A2 (en) * | 2003-04-07 | 2004-10-28 | Shire Laboratories, Inc. | Once daily formulations of tetracyclines |
| US20060252731A1 (en) * | 2005-05-06 | 2006-11-09 | Pfeiffer David F | Methods of treating recurrent aphthous stomatitis |
| US20070015738A1 (en) * | 2005-07-15 | 2007-01-18 | Walker Stephen G | Use of non-antibacterial tetracycline formulations for inhibiting bacterial spores from becoming infectious vegetative cells |
| WO2007011699A2 (en) * | 2005-07-15 | 2007-01-25 | Research Foundation Of State University Of New York | Use of non-antibacterial tetracycline formulations for inhibiting bacterial spores |
| US8440646B1 (en) * | 2006-10-11 | 2013-05-14 | Paratek Pharmaceuticals, Inc. | Substituted tetracycline compounds for treatment of Bacillus anthracis infections |
| AU2016235151A1 (en) | 2015-03-24 | 2017-10-12 | Paratek Pharmaceuticals, Inc. | Minocycline compounds for biodefense |
| US20250177318A1 (en) * | 2022-01-04 | 2025-06-05 | The Research Foundation For The State University Of New York | Cmt-3 formulations and methods of using the same |
Family Cites Families (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR1430859A (https=) * | 1960-05-23 | 1966-05-25 | ||
| GB1034934A (en) * | 1962-10-29 | 1966-07-06 | American Cyanamid Co | New tetracycline compounds and manufacture thereof |
| DE2011281A1 (en) * | 1970-03-10 | 1971-09-16 | Leningradskij Nautschno-Issledowatelskij Institut Antibiotikow, Leningrad (Sowjetunion) | Polyantibiotic with antimicrobial activity |
| US4935412A (en) | 1983-12-29 | 1990-06-19 | The Research Foundation Of State University Of New York | Non-antibacterial tetracycline compositions possessing anti-collagenolytic properties and methods of preparing and using same |
| US4925833A (en) | 1983-12-29 | 1990-05-15 | The Research Foundation Of State University Of New York | Use of tetracycline to enhance bone protein synthesis and/or treatment of osteoporosis |
| US4704383A (en) * | 1983-12-29 | 1987-11-03 | The Research Foundation Of State University Of New York | Non-antibacterial tetracycline compositions possessing anti-collagenolytic properties and methods of preparing and using same |
| US4666897A (en) | 1983-12-29 | 1987-05-19 | Research Foundation Of State University | Inhibition of mammalian collagenolytic enzymes by tetracyclines |
| EP0256713A3 (en) * | 1986-08-06 | 1989-02-15 | Merck & Co. Inc. | Therapeutic human antipseudomonas aeruginosa antibodies |
| US5308839A (en) * | 1989-12-04 | 1994-05-03 | The Research Foundation Of State University Of New York | Composition comprising non-steroidal anti-inflammatory agent tenidap and effectively non-antibacterial tetracycline |
| US5045538A (en) | 1990-06-28 | 1991-09-03 | The Research Foundation Of State University Of New York | Inhibition of wasting and protein degradation of mammalian muscle by tetracyclines |
| DK0599397T3 (da) | 1992-11-17 | 1996-09-16 | Univ New York State Res Found | Tetracycliner, herunder non-mikrobielle, kemisk-modificerede tetracycliner, inhiberer overdreven collagentværbinding ved diabetes |
| US5523297A (en) | 1993-03-02 | 1996-06-04 | The Research Foundation Of State University Of New York | Inhibition of excessive phospholipase A2 activity and/or production by non-antimicrobial tetracyclines |
| US6043231A (en) | 1993-03-02 | 2000-03-28 | The Research Foundation Of State Univ. Of New York | Inhibition of excessive phospholipase A2 activity and/or production by non-antimicrobial tetracyclines |
| EP0736302A3 (en) * | 1995-03-23 | 1997-06-04 | Stichting Rega V Z W | Protease inhibitors, DNA construction for protease expression and a method for measuring proteases and / or protease inhibitors |
| US5744453A (en) * | 1996-01-05 | 1998-04-28 | Mintz; Clifford S. | Polyamine conjugates for treatment of infection |
| US6245735B1 (en) * | 1996-07-29 | 2001-06-12 | The Brigham And Women's Hospital, Inc. | Methods and products for treating pseudomonas infection |
| US5789395A (en) * | 1996-08-30 | 1998-08-04 | The Research Foundation Of State University Of New York | Method of using tetracycline compounds for inhibition of endogenous nitric oxide production |
| US6063775A (en) * | 1997-04-29 | 2000-05-16 | Berman; Charles L. | Retardation of metalloproteinase incidental to HIV and/or AIDS |
| US6277061B1 (en) * | 1998-03-31 | 2001-08-21 | The Research Foundation Of State University Of New York | Method of inhibiting membrane-type matrix metalloproteinase |
| US6015804A (en) * | 1998-09-11 | 2000-01-18 | The Research Foundation Of State University Of New York | Method of using tetracycline compounds to enhance interleukin-10 production |
| US6384081B2 (en) * | 1998-10-09 | 2002-05-07 | Charles L. Berman | Treatment of diseases of the eye characterized by the formation of metalloproteinase |
| DE69932846T2 (de) * | 1998-11-18 | 2007-03-15 | Collagenex Pharmaceuticals, Inc. | Neue 4-dedimethylaminotetracyclinderivate |
| US6506740B1 (en) * | 1998-11-18 | 2003-01-14 | Robert A. Ashley | 4-dedimethylaminotetracycline derivatives |
| US6172040B1 (en) * | 1999-05-28 | 2001-01-09 | A. Satyanarayan Naidu | Immobilized lactoferrin antimicrobial agents and the use thereof |
-
2003
- 2003-03-27 WO PCT/US2003/009570 patent/WO2003082011A1/en not_active Ceased
- 2003-03-27 NZ NZ534950A patent/NZ534950A/en not_active IP Right Cessation
- 2003-03-27 JP JP2003579565A patent/JP2005521701A/ja active Pending
- 2003-03-27 EP EP10174817.6A patent/EP2250887B1/en not_active Expired - Lifetime
- 2003-03-27 CA CA002475202A patent/CA2475202A1/en not_active Abandoned
- 2003-03-27 ES ES03745650T patent/ES2359346T3/es not_active Expired - Lifetime
- 2003-03-27 AU AU2003226112A patent/AU2003226112B9/en not_active Ceased
- 2003-03-27 US US10/400,737 patent/US20040014731A1/en not_active Abandoned
- 2003-03-27 EP EP03745650A patent/EP1496742B1/en not_active Expired - Lifetime
- 2003-03-27 DE DE60335093T patent/DE60335093D1/de not_active Expired - Lifetime
- 2003-03-27 KR KR10-2004-7014877A patent/KR20040094833A/ko not_active Ceased
- 2003-03-27 AT AT03745650T patent/ATE489081T1/de not_active IP Right Cessation
-
2007
- 2007-08-06 US US11/890,546 patent/US20080233151A1/en not_active Abandoned
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