NZ534950A - Use of non-antibacterial tetracycline analogs and formulations thereof for the treatment of bacterial exotoxins - Google Patents
Use of non-antibacterial tetracycline analogs and formulations thereof for the treatment of bacterial exotoxinsInfo
- Publication number
- NZ534950A NZ534950A NZ534950A NZ53495003A NZ534950A NZ 534950 A NZ534950 A NZ 534950A NZ 534950 A NZ534950 A NZ 534950A NZ 53495003 A NZ53495003 A NZ 53495003A NZ 534950 A NZ534950 A NZ 534950A
- Authority
- NZ
- New Zealand
- Prior art keywords
- cmt
- bacteria
- tetracycline
- exotoxin
- pharmaceutically acceptable
- Prior art date
Links
- 239000004098 Tetracycline Substances 0.000 title claims abstract description 105
- 235000019364 tetracycline Nutrition 0.000 title claims abstract description 105
- 231100000776 exotoxin Toxicity 0.000 title claims abstract description 85
- 239000002095 exotoxin Substances 0.000 title claims abstract description 85
- 229960002180 tetracycline Drugs 0.000 title claims abstract description 85
- 229930101283 tetracycline Natural products 0.000 title claims abstract description 85
- 150000003522 tetracyclines Chemical class 0.000 title claims abstract description 85
- 230000001580 bacterial effect Effects 0.000 title claims abstract description 10
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- 238000011282 treatment Methods 0.000 title description 12
- 239000000203 mixture Substances 0.000 title description 7
- 238000009472 formulation Methods 0.000 title description 3
- 241000894006 Bacteria Species 0.000 claims abstract description 70
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- HISOCSRUFLPKDE-KLXQUTNESA-N cmt-2 Chemical compound C1=CC=C2[C@](O)(C)C3CC4C(N(C)C)C(O)=C(C#N)C(=O)[C@@]4(O)C(O)=C3C(=O)C2=C1O HISOCSRUFLPKDE-KLXQUTNESA-N 0.000 claims abstract description 5
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- 238000003825 pressing Methods 0.000 description 1
- 230000017854 proteolysis Effects 0.000 description 1
- 230000000717 retained effect Effects 0.000 description 1
- 229950000614 sancycline Drugs 0.000 description 1
- 210000002027 skeletal muscle Anatomy 0.000 description 1
- 235000002639 sodium chloride Nutrition 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 238000010561 standard procedure Methods 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 239000008117 stearic acid Substances 0.000 description 1
- 238000010254 subcutaneous injection Methods 0.000 description 1
- 239000007929 subcutaneous injection Substances 0.000 description 1
- 235000000346 sugar Nutrition 0.000 description 1
- QAOWNCQODCNURD-UHFFFAOYSA-N sulfuric acid group Chemical class S(O)(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 1
- 238000007910 systemic administration Methods 0.000 description 1
- 239000000454 talc Substances 0.000 description 1
- 235000012222 talc Nutrition 0.000 description 1
- 229910052623 talc Inorganic materials 0.000 description 1
- 230000008685 targeting Effects 0.000 description 1
- 229940072172 tetracycline antibiotic Drugs 0.000 description 1
- 231100000827 tissue damage Toxicity 0.000 description 1
- 235000015112 vegetable and seed oil Nutrition 0.000 description 1
- 235000019871 vegetable fat Nutrition 0.000 description 1
- 229910052725 zinc Inorganic materials 0.000 description 1
- 239000011701 zinc Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N37/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids
- A01N37/18—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids containing the group —CO—N<, e.g. carboxylic acid amides or imides; Thio analogues thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/65—Tetracyclines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/02—Antidotes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/04—Chelating agents
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Toxicology (AREA)
- Oncology (AREA)
- Immunology (AREA)
- Microbiology (AREA)
- Communicable Diseases (AREA)
- Mycology (AREA)
- Plant Pathology (AREA)
- Pest Control & Pesticides (AREA)
- Agronomy & Crop Science (AREA)
- Engineering & Computer Science (AREA)
- Dentistry (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Environmental Sciences (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US36847802P | 2002-03-29 | 2002-03-29 | |
| PCT/US2003/009570 WO2003082011A1 (en) | 2002-03-29 | 2003-03-27 | Use of non-antibacterial tetracycline analogs and formulations thereof for the treatment of bacterial exotoxins |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NZ534950A true NZ534950A (en) | 2006-04-28 |
Family
ID=28675499
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NZ534950A NZ534950A (en) | 2002-03-29 | 2003-03-27 | Use of non-antibacterial tetracycline analogs and formulations thereof for the treatment of bacterial exotoxins |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US20040014731A1 (https=) |
| EP (2) | EP2250887B1 (https=) |
| JP (1) | JP2005521701A (https=) |
| KR (1) | KR20040094833A (https=) |
| AT (1) | ATE489081T1 (https=) |
| AU (1) | AU2003226112B9 (https=) |
| CA (1) | CA2475202A1 (https=) |
| DE (1) | DE60335093D1 (https=) |
| ES (1) | ES2359346T3 (https=) |
| NZ (1) | NZ534950A (https=) |
| WO (1) | WO2003082011A1 (https=) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2004091483A2 (en) * | 2003-04-07 | 2004-10-28 | Shire Laboratories, Inc. | Once daily formulations of tetracyclines |
| US20060252731A1 (en) * | 2005-05-06 | 2006-11-09 | Pfeiffer David F | Methods of treating recurrent aphthous stomatitis |
| US20070015738A1 (en) * | 2005-07-15 | 2007-01-18 | Walker Stephen G | Use of non-antibacterial tetracycline formulations for inhibiting bacterial spores from becoming infectious vegetative cells |
| WO2007011699A2 (en) * | 2005-07-15 | 2007-01-25 | Research Foundation Of State University Of New York | Use of non-antibacterial tetracycline formulations for inhibiting bacterial spores |
| US8440646B1 (en) * | 2006-10-11 | 2013-05-14 | Paratek Pharmaceuticals, Inc. | Substituted tetracycline compounds for treatment of Bacillus anthracis infections |
| AU2016235151A1 (en) | 2015-03-24 | 2017-10-12 | Paratek Pharmaceuticals, Inc. | Minocycline compounds for biodefense |
| US20250177318A1 (en) * | 2022-01-04 | 2025-06-05 | The Research Foundation For The State University Of New York | Cmt-3 formulations and methods of using the same |
Family Cites Families (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR1430859A (https=) * | 1960-05-23 | 1966-05-25 | ||
| GB1034934A (en) * | 1962-10-29 | 1966-07-06 | American Cyanamid Co | New tetracycline compounds and manufacture thereof |
| DE2011281A1 (en) * | 1970-03-10 | 1971-09-16 | Leningradskij Nautschno-Issledowatelskij Institut Antibiotikow, Leningrad (Sowjetunion) | Polyantibiotic with antimicrobial activity |
| US4935412A (en) | 1983-12-29 | 1990-06-19 | The Research Foundation Of State University Of New York | Non-antibacterial tetracycline compositions possessing anti-collagenolytic properties and methods of preparing and using same |
| US4925833A (en) | 1983-12-29 | 1990-05-15 | The Research Foundation Of State University Of New York | Use of tetracycline to enhance bone protein synthesis and/or treatment of osteoporosis |
| US4704383A (en) * | 1983-12-29 | 1987-11-03 | The Research Foundation Of State University Of New York | Non-antibacterial tetracycline compositions possessing anti-collagenolytic properties and methods of preparing and using same |
| US4666897A (en) | 1983-12-29 | 1987-05-19 | Research Foundation Of State University | Inhibition of mammalian collagenolytic enzymes by tetracyclines |
| EP0256713A3 (en) * | 1986-08-06 | 1989-02-15 | Merck & Co. Inc. | Therapeutic human antipseudomonas aeruginosa antibodies |
| US5308839A (en) * | 1989-12-04 | 1994-05-03 | The Research Foundation Of State University Of New York | Composition comprising non-steroidal anti-inflammatory agent tenidap and effectively non-antibacterial tetracycline |
| US5045538A (en) | 1990-06-28 | 1991-09-03 | The Research Foundation Of State University Of New York | Inhibition of wasting and protein degradation of mammalian muscle by tetracyclines |
| DK0599397T3 (da) | 1992-11-17 | 1996-09-16 | Univ New York State Res Found | Tetracycliner, herunder non-mikrobielle, kemisk-modificerede tetracycliner, inhiberer overdreven collagentværbinding ved diabetes |
| US5523297A (en) | 1993-03-02 | 1996-06-04 | The Research Foundation Of State University Of New York | Inhibition of excessive phospholipase A2 activity and/or production by non-antimicrobial tetracyclines |
| US6043231A (en) | 1993-03-02 | 2000-03-28 | The Research Foundation Of State Univ. Of New York | Inhibition of excessive phospholipase A2 activity and/or production by non-antimicrobial tetracyclines |
| EP0736302A3 (en) * | 1995-03-23 | 1997-06-04 | Stichting Rega V Z W | Protease inhibitors, DNA construction for protease expression and a method for measuring proteases and / or protease inhibitors |
| US5744453A (en) * | 1996-01-05 | 1998-04-28 | Mintz; Clifford S. | Polyamine conjugates for treatment of infection |
| US6245735B1 (en) * | 1996-07-29 | 2001-06-12 | The Brigham And Women's Hospital, Inc. | Methods and products for treating pseudomonas infection |
| US5789395A (en) * | 1996-08-30 | 1998-08-04 | The Research Foundation Of State University Of New York | Method of using tetracycline compounds for inhibition of endogenous nitric oxide production |
| US6063775A (en) * | 1997-04-29 | 2000-05-16 | Berman; Charles L. | Retardation of metalloproteinase incidental to HIV and/or AIDS |
| US6277061B1 (en) * | 1998-03-31 | 2001-08-21 | The Research Foundation Of State University Of New York | Method of inhibiting membrane-type matrix metalloproteinase |
| US6015804A (en) * | 1998-09-11 | 2000-01-18 | The Research Foundation Of State University Of New York | Method of using tetracycline compounds to enhance interleukin-10 production |
| US6384081B2 (en) * | 1998-10-09 | 2002-05-07 | Charles L. Berman | Treatment of diseases of the eye characterized by the formation of metalloproteinase |
| DE69932846T2 (de) * | 1998-11-18 | 2007-03-15 | Collagenex Pharmaceuticals, Inc. | Neue 4-dedimethylaminotetracyclinderivate |
| US6506740B1 (en) * | 1998-11-18 | 2003-01-14 | Robert A. Ashley | 4-dedimethylaminotetracycline derivatives |
| US6172040B1 (en) * | 1999-05-28 | 2001-01-09 | A. Satyanarayan Naidu | Immobilized lactoferrin antimicrobial agents and the use thereof |
-
2003
- 2003-03-27 WO PCT/US2003/009570 patent/WO2003082011A1/en not_active Ceased
- 2003-03-27 NZ NZ534950A patent/NZ534950A/en not_active IP Right Cessation
- 2003-03-27 JP JP2003579565A patent/JP2005521701A/ja active Pending
- 2003-03-27 EP EP10174817.6A patent/EP2250887B1/en not_active Expired - Lifetime
- 2003-03-27 CA CA002475202A patent/CA2475202A1/en not_active Abandoned
- 2003-03-27 ES ES03745650T patent/ES2359346T3/es not_active Expired - Lifetime
- 2003-03-27 AU AU2003226112A patent/AU2003226112B9/en not_active Ceased
- 2003-03-27 US US10/400,737 patent/US20040014731A1/en not_active Abandoned
- 2003-03-27 EP EP03745650A patent/EP1496742B1/en not_active Expired - Lifetime
- 2003-03-27 DE DE60335093T patent/DE60335093D1/de not_active Expired - Lifetime
- 2003-03-27 KR KR10-2004-7014877A patent/KR20040094833A/ko not_active Ceased
- 2003-03-27 AT AT03745650T patent/ATE489081T1/de not_active IP Right Cessation
-
2007
- 2007-08-06 US US11/890,546 patent/US20080233151A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| ES2359346T3 (es) | 2011-05-20 |
| JP2005521701A (ja) | 2005-07-21 |
| AU2003226112B9 (en) | 2008-06-05 |
| AU2003226112B2 (en) | 2008-05-01 |
| DE60335093D1 (de) | 2011-01-05 |
| WO2003082011A1 (en) | 2003-10-09 |
| EP1496742A1 (en) | 2005-01-19 |
| ATE489081T1 (de) | 2010-12-15 |
| EP1496742B1 (en) | 2010-11-24 |
| EP2250887B1 (en) | 2013-04-24 |
| EP2250887A2 (en) | 2010-11-17 |
| AU2003226112A1 (en) | 2003-10-13 |
| CA2475202A1 (en) | 2003-10-09 |
| US20080233151A1 (en) | 2008-09-25 |
| EP1496742A4 (en) | 2007-04-11 |
| US20040014731A1 (en) | 2004-01-22 |
| EP2250887A3 (en) | 2010-11-24 |
| KR20040094833A (ko) | 2004-11-10 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PSEA | Patent sealed | ||
| RENW | Renewal (renewal fees accepted) | ||
| RENW | Renewal (renewal fees accepted) | ||
| RENW | Renewal (renewal fees accepted) |
Free format text: PATENT RENEWED FOR 3 YEARS UNTIL 27 MAR 2016 BY CPA GLOBAL Effective date: 20130211 |
|
| LAPS | Patent lapsed |