AU2003226112B9 - Use of non-antibacterial tetracycline analogs and formulations thereof for the treatment of bacterial exotoxins - Google Patents

Use of non-antibacterial tetracycline analogs and formulations thereof for the treatment of bacterial exotoxins Download PDF

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Publication number
AU2003226112B9
AU2003226112B9 AU2003226112A AU2003226112A AU2003226112B9 AU 2003226112 B9 AU2003226112 B9 AU 2003226112B9 AU 2003226112 A AU2003226112 A AU 2003226112A AU 2003226112 A AU2003226112 A AU 2003226112A AU 2003226112 B9 AU2003226112 B9 AU 2003226112B9
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AU
Australia
Prior art keywords
tetracycline
cmt
bacteria
mammal
exotoxin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU2003226112A
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English (en)
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AU2003226112B2 (en
AU2003226112A1 (en
Inventor
Lorne M Golub
Stephen G Walker
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Research Foundation of the State University of New York
Original Assignee
Research Foundation of the State University of New York
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Filing date
Publication date
Application filed by Research Foundation of the State University of New York filed Critical Research Foundation of the State University of New York
Publication of AU2003226112A1 publication Critical patent/AU2003226112A1/en
Application granted granted Critical
Publication of AU2003226112B2 publication Critical patent/AU2003226112B2/en
Publication of AU2003226112B9 publication Critical patent/AU2003226112B9/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N37/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids
    • A01N37/18—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids containing the group —CO—N<, e.g. carboxylic acid amides or imides; Thio analogues thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/65—Tetracyclines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/02—Antidotes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/04—Chelating agents

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Toxicology (AREA)
  • Oncology (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Communicable Diseases (AREA)
  • Mycology (AREA)
  • Plant Pathology (AREA)
  • Pest Control & Pesticides (AREA)
  • Agronomy & Crop Science (AREA)
  • Engineering & Computer Science (AREA)
  • Dentistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Environmental Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
AU2003226112A 2002-03-29 2003-03-27 Use of non-antibacterial tetracycline analogs and formulations thereof for the treatment of bacterial exotoxins Ceased AU2003226112B9 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US36847802P 2002-03-29 2002-03-29
US60/368,478 2002-03-29
PCT/US2003/009570 WO2003082011A1 (en) 2002-03-29 2003-03-27 Use of non-antibacterial tetracycline analogs and formulations thereof for the treatment of bacterial exotoxins

Publications (3)

Publication Number Publication Date
AU2003226112A1 AU2003226112A1 (en) 2003-10-13
AU2003226112B2 AU2003226112B2 (en) 2008-05-01
AU2003226112B9 true AU2003226112B9 (en) 2008-06-05

Family

ID=28675499

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2003226112A Ceased AU2003226112B9 (en) 2002-03-29 2003-03-27 Use of non-antibacterial tetracycline analogs and formulations thereof for the treatment of bacterial exotoxins

Country Status (11)

Country Link
US (2) US20040014731A1 (https=)
EP (2) EP2250887B1 (https=)
JP (1) JP2005521701A (https=)
KR (1) KR20040094833A (https=)
AT (1) ATE489081T1 (https=)
AU (1) AU2003226112B9 (https=)
CA (1) CA2475202A1 (https=)
DE (1) DE60335093D1 (https=)
ES (1) ES2359346T3 (https=)
NZ (1) NZ534950A (https=)
WO (1) WO2003082011A1 (https=)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004091483A2 (en) * 2003-04-07 2004-10-28 Shire Laboratories, Inc. Once daily formulations of tetracyclines
US20060252731A1 (en) * 2005-05-06 2006-11-09 Pfeiffer David F Methods of treating recurrent aphthous stomatitis
US20070015738A1 (en) * 2005-07-15 2007-01-18 Walker Stephen G Use of non-antibacterial tetracycline formulations for inhibiting bacterial spores from becoming infectious vegetative cells
WO2007011699A2 (en) * 2005-07-15 2007-01-25 Research Foundation Of State University Of New York Use of non-antibacterial tetracycline formulations for inhibiting bacterial spores
US8440646B1 (en) * 2006-10-11 2013-05-14 Paratek Pharmaceuticals, Inc. Substituted tetracycline compounds for treatment of Bacillus anthracis infections
AU2016235151A1 (en) 2015-03-24 2017-10-12 Paratek Pharmaceuticals, Inc. Minocycline compounds for biodefense
US20250177318A1 (en) * 2022-01-04 2025-06-05 The Research Foundation For The State University Of New York Cmt-3 formulations and methods of using the same

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5919775A (en) * 1996-08-30 1999-07-06 The Research Foundation Of The State University Of New York Method for inhibiting expression of inducible nitric oxide synthase with tetracycline
US6063775A (en) * 1997-04-29 2000-05-16 Berman; Charles L. Retardation of metalloproteinase incidental to HIV and/or AIDS
US6277061B1 (en) * 1998-03-31 2001-08-21 The Research Foundation Of State University Of New York Method of inhibiting membrane-type matrix metalloproteinase
US6384081B2 (en) * 1998-10-09 2002-05-07 Charles L. Berman Treatment of diseases of the eye characterized by the formation of metalloproteinase

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1430859A (https=) * 1960-05-23 1966-05-25
GB1034934A (en) * 1962-10-29 1966-07-06 American Cyanamid Co New tetracycline compounds and manufacture thereof
DE2011281A1 (en) * 1970-03-10 1971-09-16 Leningradskij Nautschno-Issledowatelskij Institut Antibiotikow, Leningrad (Sowjetunion) Polyantibiotic with antimicrobial activity
US4935412A (en) 1983-12-29 1990-06-19 The Research Foundation Of State University Of New York Non-antibacterial tetracycline compositions possessing anti-collagenolytic properties and methods of preparing and using same
US4925833A (en) 1983-12-29 1990-05-15 The Research Foundation Of State University Of New York Use of tetracycline to enhance bone protein synthesis and/or treatment of osteoporosis
US4704383A (en) * 1983-12-29 1987-11-03 The Research Foundation Of State University Of New York Non-antibacterial tetracycline compositions possessing anti-collagenolytic properties and methods of preparing and using same
US4666897A (en) 1983-12-29 1987-05-19 Research Foundation Of State University Inhibition of mammalian collagenolytic enzymes by tetracyclines
EP0256713A3 (en) * 1986-08-06 1989-02-15 Merck & Co. Inc. Therapeutic human antipseudomonas aeruginosa antibodies
US5308839A (en) * 1989-12-04 1994-05-03 The Research Foundation Of State University Of New York Composition comprising non-steroidal anti-inflammatory agent tenidap and effectively non-antibacterial tetracycline
US5045538A (en) 1990-06-28 1991-09-03 The Research Foundation Of State University Of New York Inhibition of wasting and protein degradation of mammalian muscle by tetracyclines
DK0599397T3 (da) 1992-11-17 1996-09-16 Univ New York State Res Found Tetracycliner, herunder non-mikrobielle, kemisk-modificerede tetracycliner, inhiberer overdreven collagentværbinding ved diabetes
US5523297A (en) 1993-03-02 1996-06-04 The Research Foundation Of State University Of New York Inhibition of excessive phospholipase A2 activity and/or production by non-antimicrobial tetracyclines
US6043231A (en) 1993-03-02 2000-03-28 The Research Foundation Of State Univ. Of New York Inhibition of excessive phospholipase A2 activity and/or production by non-antimicrobial tetracyclines
EP0736302A3 (en) * 1995-03-23 1997-06-04 Stichting Rega V Z W Protease inhibitors, DNA construction for protease expression and a method for measuring proteases and / or protease inhibitors
US5744453A (en) * 1996-01-05 1998-04-28 Mintz; Clifford S. Polyamine conjugates for treatment of infection
US6245735B1 (en) * 1996-07-29 2001-06-12 The Brigham And Women's Hospital, Inc. Methods and products for treating pseudomonas infection
US6015804A (en) * 1998-09-11 2000-01-18 The Research Foundation Of State University Of New York Method of using tetracycline compounds to enhance interleukin-10 production
DE69932846T2 (de) * 1998-11-18 2007-03-15 Collagenex Pharmaceuticals, Inc. Neue 4-dedimethylaminotetracyclinderivate
US6506740B1 (en) * 1998-11-18 2003-01-14 Robert A. Ashley 4-dedimethylaminotetracycline derivatives
US6172040B1 (en) * 1999-05-28 2001-01-09 A. Satyanarayan Naidu Immobilized lactoferrin antimicrobial agents and the use thereof

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5919775A (en) * 1996-08-30 1999-07-06 The Research Foundation Of The State University Of New York Method for inhibiting expression of inducible nitric oxide synthase with tetracycline
US6063775A (en) * 1997-04-29 2000-05-16 Berman; Charles L. Retardation of metalloproteinase incidental to HIV and/or AIDS
US6277061B1 (en) * 1998-03-31 2001-08-21 The Research Foundation Of State University Of New York Method of inhibiting membrane-type matrix metalloproteinase
US6384081B2 (en) * 1998-10-09 2002-05-07 Charles L. Berman Treatment of diseases of the eye characterized by the formation of metalloproteinase

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Greenwald et al, Biologic properties of non-antibiotic, chemically modified tetracyclines (CMTs):a structured, annotated bibliography. 2001, Vol.8, p237-242 *

Also Published As

Publication number Publication date
ES2359346T3 (es) 2011-05-20
JP2005521701A (ja) 2005-07-21
AU2003226112B2 (en) 2008-05-01
DE60335093D1 (de) 2011-01-05
NZ534950A (en) 2006-04-28
WO2003082011A1 (en) 2003-10-09
EP1496742A1 (en) 2005-01-19
ATE489081T1 (de) 2010-12-15
EP1496742B1 (en) 2010-11-24
EP2250887B1 (en) 2013-04-24
EP2250887A2 (en) 2010-11-17
AU2003226112A1 (en) 2003-10-13
CA2475202A1 (en) 2003-10-09
US20080233151A1 (en) 2008-09-25
EP1496742A4 (en) 2007-04-11
US20040014731A1 (en) 2004-01-22
EP2250887A3 (en) 2010-11-24
KR20040094833A (ko) 2004-11-10

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SREP Specification republished
SREP Specification republished
FGA Letters patent sealed or granted (standard patent)
MK14 Patent ceased section 143(a) (annual fees not paid) or expired