JP2005521701A - 細菌外毒素処置のための非抗菌性テトラサイクリンアナログ類の使用およびその調合物 - Google Patents
細菌外毒素処置のための非抗菌性テトラサイクリンアナログ類の使用およびその調合物 Download PDFInfo
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- JP2005521701A JP2005521701A JP2003579565A JP2003579565A JP2005521701A JP 2005521701 A JP2005521701 A JP 2005521701A JP 2003579565 A JP2003579565 A JP 2003579565A JP 2003579565 A JP2003579565 A JP 2003579565A JP 2005521701 A JP2005521701 A JP 2005521701A
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- tetracycline
- exotoxin
- cmt
- bacterium
- pharmaceutically acceptable
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N37/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids
- A01N37/18—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids containing the group —CO—N<, e.g. carboxylic acid amides or imides; Thio analogues thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/65—Tetracyclines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/02—Antidotes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/04—Chelating agents
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Toxicology (AREA)
- Oncology (AREA)
- Immunology (AREA)
- Microbiology (AREA)
- Communicable Diseases (AREA)
- Mycology (AREA)
- Plant Pathology (AREA)
- Pest Control & Pesticides (AREA)
- Agronomy & Crop Science (AREA)
- Engineering & Computer Science (AREA)
- Dentistry (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Environmental Sciences (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US36847802P | 2002-03-29 | 2002-03-29 | |
| PCT/US2003/009570 WO2003082011A1 (en) | 2002-03-29 | 2003-03-27 | Use of non-antibacterial tetracycline analogs and formulations thereof for the treatment of bacterial exotoxins |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2005521701A true JP2005521701A (ja) | 2005-07-21 |
| JP2005521701A5 JP2005521701A5 (https=) | 2006-05-18 |
Family
ID=28675499
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003579565A Pending JP2005521701A (ja) | 2002-03-29 | 2003-03-27 | 細菌外毒素処置のための非抗菌性テトラサイクリンアナログ類の使用およびその調合物 |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US20040014731A1 (https=) |
| EP (2) | EP2250887B1 (https=) |
| JP (1) | JP2005521701A (https=) |
| KR (1) | KR20040094833A (https=) |
| AT (1) | ATE489081T1 (https=) |
| AU (1) | AU2003226112B9 (https=) |
| CA (1) | CA2475202A1 (https=) |
| DE (1) | DE60335093D1 (https=) |
| ES (1) | ES2359346T3 (https=) |
| NZ (1) | NZ534950A (https=) |
| WO (1) | WO2003082011A1 (https=) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2004091483A2 (en) * | 2003-04-07 | 2004-10-28 | Shire Laboratories, Inc. | Once daily formulations of tetracyclines |
| US20060252731A1 (en) * | 2005-05-06 | 2006-11-09 | Pfeiffer David F | Methods of treating recurrent aphthous stomatitis |
| US20070015738A1 (en) * | 2005-07-15 | 2007-01-18 | Walker Stephen G | Use of non-antibacterial tetracycline formulations for inhibiting bacterial spores from becoming infectious vegetative cells |
| WO2007011699A2 (en) * | 2005-07-15 | 2007-01-25 | Research Foundation Of State University Of New York | Use of non-antibacterial tetracycline formulations for inhibiting bacterial spores |
| US8440646B1 (en) * | 2006-10-11 | 2013-05-14 | Paratek Pharmaceuticals, Inc. | Substituted tetracycline compounds for treatment of Bacillus anthracis infections |
| AU2016235151A1 (en) | 2015-03-24 | 2017-10-12 | Paratek Pharmaceuticals, Inc. | Minocycline compounds for biodefense |
| US20250177318A1 (en) * | 2022-01-04 | 2025-06-05 | The Research Foundation For The State University Of New York | Cmt-3 formulations and methods of using the same |
Family Cites Families (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR1430859A (https=) * | 1960-05-23 | 1966-05-25 | ||
| GB1034934A (en) * | 1962-10-29 | 1966-07-06 | American Cyanamid Co | New tetracycline compounds and manufacture thereof |
| DE2011281A1 (en) * | 1970-03-10 | 1971-09-16 | Leningradskij Nautschno-Issledowatelskij Institut Antibiotikow, Leningrad (Sowjetunion) | Polyantibiotic with antimicrobial activity |
| US4935412A (en) | 1983-12-29 | 1990-06-19 | The Research Foundation Of State University Of New York | Non-antibacterial tetracycline compositions possessing anti-collagenolytic properties and methods of preparing and using same |
| US4925833A (en) | 1983-12-29 | 1990-05-15 | The Research Foundation Of State University Of New York | Use of tetracycline to enhance bone protein synthesis and/or treatment of osteoporosis |
| US4704383A (en) * | 1983-12-29 | 1987-11-03 | The Research Foundation Of State University Of New York | Non-antibacterial tetracycline compositions possessing anti-collagenolytic properties and methods of preparing and using same |
| US4666897A (en) | 1983-12-29 | 1987-05-19 | Research Foundation Of State University | Inhibition of mammalian collagenolytic enzymes by tetracyclines |
| EP0256713A3 (en) * | 1986-08-06 | 1989-02-15 | Merck & Co. Inc. | Therapeutic human antipseudomonas aeruginosa antibodies |
| US5308839A (en) * | 1989-12-04 | 1994-05-03 | The Research Foundation Of State University Of New York | Composition comprising non-steroidal anti-inflammatory agent tenidap and effectively non-antibacterial tetracycline |
| US5045538A (en) | 1990-06-28 | 1991-09-03 | The Research Foundation Of State University Of New York | Inhibition of wasting and protein degradation of mammalian muscle by tetracyclines |
| DK0599397T3 (da) | 1992-11-17 | 1996-09-16 | Univ New York State Res Found | Tetracycliner, herunder non-mikrobielle, kemisk-modificerede tetracycliner, inhiberer overdreven collagentværbinding ved diabetes |
| US5523297A (en) | 1993-03-02 | 1996-06-04 | The Research Foundation Of State University Of New York | Inhibition of excessive phospholipase A2 activity and/or production by non-antimicrobial tetracyclines |
| US6043231A (en) | 1993-03-02 | 2000-03-28 | The Research Foundation Of State Univ. Of New York | Inhibition of excessive phospholipase A2 activity and/or production by non-antimicrobial tetracyclines |
| EP0736302A3 (en) * | 1995-03-23 | 1997-06-04 | Stichting Rega V Z W | Protease inhibitors, DNA construction for protease expression and a method for measuring proteases and / or protease inhibitors |
| US5744453A (en) * | 1996-01-05 | 1998-04-28 | Mintz; Clifford S. | Polyamine conjugates for treatment of infection |
| US6245735B1 (en) * | 1996-07-29 | 2001-06-12 | The Brigham And Women's Hospital, Inc. | Methods and products for treating pseudomonas infection |
| US5789395A (en) * | 1996-08-30 | 1998-08-04 | The Research Foundation Of State University Of New York | Method of using tetracycline compounds for inhibition of endogenous nitric oxide production |
| US6063775A (en) * | 1997-04-29 | 2000-05-16 | Berman; Charles L. | Retardation of metalloproteinase incidental to HIV and/or AIDS |
| US6277061B1 (en) * | 1998-03-31 | 2001-08-21 | The Research Foundation Of State University Of New York | Method of inhibiting membrane-type matrix metalloproteinase |
| US6015804A (en) * | 1998-09-11 | 2000-01-18 | The Research Foundation Of State University Of New York | Method of using tetracycline compounds to enhance interleukin-10 production |
| US6384081B2 (en) * | 1998-10-09 | 2002-05-07 | Charles L. Berman | Treatment of diseases of the eye characterized by the formation of metalloproteinase |
| DE69932846T2 (de) * | 1998-11-18 | 2007-03-15 | Collagenex Pharmaceuticals, Inc. | Neue 4-dedimethylaminotetracyclinderivate |
| US6506740B1 (en) * | 1998-11-18 | 2003-01-14 | Robert A. Ashley | 4-dedimethylaminotetracycline derivatives |
| US6172040B1 (en) * | 1999-05-28 | 2001-01-09 | A. Satyanarayan Naidu | Immobilized lactoferrin antimicrobial agents and the use thereof |
-
2003
- 2003-03-27 WO PCT/US2003/009570 patent/WO2003082011A1/en not_active Ceased
- 2003-03-27 NZ NZ534950A patent/NZ534950A/en not_active IP Right Cessation
- 2003-03-27 JP JP2003579565A patent/JP2005521701A/ja active Pending
- 2003-03-27 EP EP10174817.6A patent/EP2250887B1/en not_active Expired - Lifetime
- 2003-03-27 CA CA002475202A patent/CA2475202A1/en not_active Abandoned
- 2003-03-27 ES ES03745650T patent/ES2359346T3/es not_active Expired - Lifetime
- 2003-03-27 AU AU2003226112A patent/AU2003226112B9/en not_active Ceased
- 2003-03-27 US US10/400,737 patent/US20040014731A1/en not_active Abandoned
- 2003-03-27 EP EP03745650A patent/EP1496742B1/en not_active Expired - Lifetime
- 2003-03-27 DE DE60335093T patent/DE60335093D1/de not_active Expired - Lifetime
- 2003-03-27 KR KR10-2004-7014877A patent/KR20040094833A/ko not_active Ceased
- 2003-03-27 AT AT03745650T patent/ATE489081T1/de not_active IP Right Cessation
-
2007
- 2007-08-06 US US11/890,546 patent/US20080233151A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| ES2359346T3 (es) | 2011-05-20 |
| AU2003226112B9 (en) | 2008-06-05 |
| AU2003226112B2 (en) | 2008-05-01 |
| DE60335093D1 (de) | 2011-01-05 |
| NZ534950A (en) | 2006-04-28 |
| WO2003082011A1 (en) | 2003-10-09 |
| EP1496742A1 (en) | 2005-01-19 |
| ATE489081T1 (de) | 2010-12-15 |
| EP1496742B1 (en) | 2010-11-24 |
| EP2250887B1 (en) | 2013-04-24 |
| EP2250887A2 (en) | 2010-11-17 |
| AU2003226112A1 (en) | 2003-10-13 |
| CA2475202A1 (en) | 2003-10-09 |
| US20080233151A1 (en) | 2008-09-25 |
| EP1496742A4 (en) | 2007-04-11 |
| US20040014731A1 (en) | 2004-01-22 |
| EP2250887A3 (en) | 2010-11-24 |
| KR20040094833A (ko) | 2004-11-10 |
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