JP2009501718A5 - - Google Patents

Info

Publication number

JP2009501718A5

JP2009501718A5 JP2008521632A JP2008521632A JP2009501718A5 JP 2009501718 A5 JP2009501718 A5 JP 2009501718A5 JP 2008521632 A JP2008521632 A JP 2008521632A JP 2008521632 A JP2008521632 A JP 2008521632A JP 2009501718 A5 JP2009501718 A5 JP 2009501718A5

Authority

JP

Japan

Prior art keywords

pharmaceutical composition

composition according

col

antibacterial tetracycline

clostridium

Prior art date

2006-07-14

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Pending

Links

• Espacenet
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• 239000008194 pharmaceutical composition Substances 0.000 claims 23
• 230000000844 anti-bacterial effect Effects 0.000 claims 15
• 239000004098 Tetracycline Substances 0.000 claims 14
• 229960002180 tetracycline Drugs 0.000 claims 14
• 229930101283 tetracycline Natural products 0.000 claims 14
• 235000019364 tetracycline Nutrition 0.000 claims 14
• 150000003522 tetracyclines Chemical class 0.000 claims 12
• 241000894006 Bacteria Species 0.000 claims 4
• 241000124008 Mammalia Species 0.000 claims 3
• 210000004666 bacterial spore Anatomy 0.000 claims 3
• 208000015181 infectious disease Diseases 0.000 claims 3
• 241000193830 Bacillus <bacterium> Species 0.000 claims 2
• 241000193403 Clostridium Species 0.000 claims 2
• 210000004027 cell Anatomy 0.000 claims 2
• 230000002458 infectious effect Effects 0.000 claims 2
• -1 tetracycline compounds Chemical class 0.000 claims 2
• SGKRLCUYIXIAHR-AKNGSSGZSA-N (4s,4ar,5s,5ar,6r,12ar)-4-(dimethylamino)-1,5,10,11,12a-pentahydroxy-6-methyl-3,12-dioxo-4a,5,5a,6-tetrahydro-4h-tetracene-2-carboxamide Chemical compound C1=CC=C2[C@H](C)[C@@H]([C@H](O)[C@@H]3[C@](C(O)=C(C(N)=O)C(=O)[C@H]3N(C)C)(O)C3=O)C3=C(O)C2=C1O SGKRLCUYIXIAHR-AKNGSSGZSA-N 0.000 claims 1
• FFTVPQUHLQBXQZ-KVUCHLLUSA-N (4s,4as,5ar,12ar)-4,7-bis(dimethylamino)-1,10,11,12a-tetrahydroxy-3,12-dioxo-4a,5,5a,6-tetrahydro-4h-tetracene-2-carboxamide Chemical group C1C2=C(N(C)C)C=CC(O)=C2C(O)=C2[C@@H]1C[C@H]1[C@H](N(C)C)C(=O)C(C(N)=O)=C(O)[C@@]1(O)C2=O FFTVPQUHLQBXQZ-KVUCHLLUSA-N 0.000 claims 1
• 241000193738 Bacillus anthracis Species 0.000 claims 1
• 241000193755 Bacillus cereus Species 0.000 claims 1
• 241000193163 Clostridioides difficile Species 0.000 claims 1
• 241000193155 Clostridium botulinum Species 0.000 claims 1
• 241000193468 Clostridium perfringens Species 0.000 claims 1
• 241000193449 Clostridium tetani Species 0.000 claims 1
• 241000193159 Hathewaya histolytica Species 0.000 claims 1
• 229940065181 bacillus anthracis Drugs 0.000 claims 1
• 230000001580 bacterial effect Effects 0.000 claims 1
• ZXFCRFYULUUSDW-OWXODZSWSA-N chembl2104970 Chemical group C([C@H]1C2)C3=CC=CC(O)=C3C(=O)C1=C(O)[C@@]1(O)[C@@H]2CC(O)=C(C(=O)N)C1=O ZXFCRFYULUUSDW-OWXODZSWSA-N 0.000 claims 1
• 201000010099 disease Diseases 0.000 claims 1
• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
• 229960003722 doxycycline Drugs 0.000 claims 1
• 230000002401 inhibitory effect Effects 0.000 claims 1
• 229960004023 minocycline Drugs 0.000 claims 1
• 150000003839 salts Chemical class 0.000 claims 1