JP2005519936A5 - - Google Patents
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- Publication number
- JP2005519936A5 JP2005519936A5 JP2003569207A JP2003569207A JP2005519936A5 JP 2005519936 A5 JP2005519936 A5 JP 2005519936A5 JP 2003569207 A JP2003569207 A JP 2003569207A JP 2003569207 A JP2003569207 A JP 2003569207A JP 2005519936 A5 JP2005519936 A5 JP 2005519936A5
- Authority
- JP
- Japan
- Prior art keywords
- derivative
- combination
- pharmaceutically acceptable
- acceptable salt
- pharmaceutical composition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 150000003839 salts Chemical class 0.000 claims 13
- 239000004480 active ingredient Substances 0.000 claims 9
- 239000008194 pharmaceutical composition Substances 0.000 claims 7
- 208000002193 Pain Diseases 0.000 claims 6
- OROGSEYTTFOCAN-DNJOTXNNSA-N codeine Chemical compound C([C@H]1[C@H](N(CC[C@@]112)C)C3)=C[C@H](O)[C@@H]1OC1=C2C3=CC=C1OC OROGSEYTTFOCAN-DNJOTXNNSA-N 0.000 claims 6
- 229940111134 coxibs Drugs 0.000 claims 5
- 239000003255 cyclooxygenase 2 inhibitor Substances 0.000 claims 5
- 239000003814 drug Substances 0.000 claims 5
- 229940127240 opiate Drugs 0.000 claims 5
- 239000002599 prostaglandin synthase inhibitor Substances 0.000 claims 5
- RZVAJINKPMORJF-UHFFFAOYSA-N Acetaminophen Chemical compound CC(=O)NC1=CC=C(O)C=C1 RZVAJINKPMORJF-UHFFFAOYSA-N 0.000 claims 4
- ZRVUJXDFFKFLMG-UHFFFAOYSA-N Meloxicam Chemical compound OC=1C2=CC=CC=C2S(=O)(=O)N(C)C=1C(=O)NC1=NC=C(C)S1 ZRVUJXDFFKFLMG-UHFFFAOYSA-N 0.000 claims 4
- 229960001929 meloxicam Drugs 0.000 claims 4
- 229960005489 paracetamol Drugs 0.000 claims 4
- 229940122204 Cyclooxygenase inhibitor Drugs 0.000 claims 3
- 229960004126 codeine Drugs 0.000 claims 3
- OROGSEYTTFOCAN-UHFFFAOYSA-N hydrocodone Natural products C1C(N(CCC234)C)C2C=CC(O)C3OC2=C4C1=CC=C2OC OROGSEYTTFOCAN-UHFFFAOYSA-N 0.000 claims 3
- 230000000917 hyperalgesic effect Effects 0.000 claims 3
- TVYLLZQTGLZFBW-ZBFHGGJFSA-N (R,R)-tramadol Chemical compound COC1=CC=CC([C@]2(O)[C@H](CCCC2)CN(C)C)=C1 TVYLLZQTGLZFBW-ZBFHGGJFSA-N 0.000 claims 2
- 239000002552 dosage form Substances 0.000 claims 2
- BQJCRHHNABKAKU-KBQPJGBKSA-N morphine Chemical compound O([C@H]1[C@H](C=C[C@H]23)O)C4=C5[C@@]12CCN(C)[C@@H]3CC5=CC=C4O BQJCRHHNABKAKU-KBQPJGBKSA-N 0.000 claims 2
- 229960004380 tramadol Drugs 0.000 claims 2
- TVYLLZQTGLZFBW-GOEBONIOSA-N tramadol Natural products COC1=CC=CC([C@@]2(O)[C@@H](CCCC2)CN(C)C)=C1 TVYLLZQTGLZFBW-GOEBONIOSA-N 0.000 claims 2
- 208000005171 Dysmenorrhea Diseases 0.000 claims 1
- 206010013935 Dysmenorrhoea Diseases 0.000 claims 1
- 206010061218 Inflammation Diseases 0.000 claims 1
- 208000000112 Myalgia Diseases 0.000 claims 1
- 239000002775 capsule Substances 0.000 claims 1
- 229960000590 celecoxib Drugs 0.000 claims 1
- RZEKVGVHFLEQIL-UHFFFAOYSA-N celecoxib Chemical compound C1=CC(C)=CC=C1C1=CC(C(F)(F)F)=NN1C1=CC=C(S(N)(=O)=O)C=C1 RZEKVGVHFLEQIL-UHFFFAOYSA-N 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 230000000694 effects Effects 0.000 claims 1
- PJMPHNIQZUBGLI-UHFFFAOYSA-N fentanyl Chemical compound C=1C=CC=CC=1N(C(=O)CC)C(CC1)CCN1CCC1=CC=CC=C1 PJMPHNIQZUBGLI-UHFFFAOYSA-N 0.000 claims 1
- 229960002428 fentanyl Drugs 0.000 claims 1
- 239000008187 granular material Substances 0.000 claims 1
- 230000002757 inflammatory effect Effects 0.000 claims 1
- 230000004054 inflammatory process Effects 0.000 claims 1
- 238000001802 infusion Methods 0.000 claims 1
- 208000014674 injury Diseases 0.000 claims 1
- 239000007788 liquid Substances 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 229960005181 morphine Drugs 0.000 claims 1
- 201000008482 osteoarthritis Diseases 0.000 claims 1
- 206010039073 rheumatoid arthritis Diseases 0.000 claims 1
- 229960000371 rofecoxib Drugs 0.000 claims 1
- RZJQGNCSTQAWON-UHFFFAOYSA-N rofecoxib Chemical compound C1=CC(S(=O)(=O)C)=CC=C1C1=C(C=2C=CC=CC=2)C(=O)OC1 RZJQGNCSTQAWON-UHFFFAOYSA-N 0.000 claims 1
- 239000000243 solution Substances 0.000 claims 1
- 239000000725 suspension Substances 0.000 claims 1
- 239000003826 tablet Substances 0.000 claims 1
- 230000001225 therapeutic effect Effects 0.000 claims 1
- 230000008733 trauma Effects 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ZA200201395 | 2002-02-19 | ||
| PCT/IB2003/000500 WO2003070251A1 (en) | 2002-02-19 | 2003-02-14 | Pharmaceutical combinations of cox-2 inhibitors and opiates |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2005519936A JP2005519936A (ja) | 2005-07-07 |
| JP2005519936A5 true JP2005519936A5 (enExample) | 2006-03-16 |
Family
ID=27758232
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003569207A Pending JP2005519936A (ja) | 2002-02-19 | 2003-02-14 | Ｃｏｘ２阻害剤とオピエートとの医薬組合せ |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US20050090517A1 (enExample) |
| EP (2) | EP2050453B1 (enExample) |
| JP (1) | JP2005519936A (enExample) |
| CN (1) | CN100418533C (enExample) |
| AP (1) | AP1862A (enExample) |
| AT (2) | ATE524186T1 (enExample) |
| AU (1) | AU2003208485B2 (enExample) |
| CA (1) | CA2476939C (enExample) |
| CY (1) | CY1108839T1 (enExample) |
| DE (1) | DE60325020D1 (enExample) |
| DK (1) | DK1478366T3 (enExample) |
| EG (1) | EG24845A (enExample) |
| ES (2) | ES2376500T3 (enExample) |
| IL (2) | IL163637A0 (enExample) |
| NZ (1) | NZ535500A (enExample) |
| OA (1) | OA12778A (enExample) |
| PT (2) | PT2050453E (enExample) |
| SI (1) | SI1478366T1 (enExample) |
| WO (1) | WO2003070251A1 (enExample) |
| ZA (1) | ZA200407485B (enExample) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2005094832A1 (en) * | 2004-04-01 | 2005-10-13 | Boehringer Ingelheim International Gmbh | Compositions comprising meloxicam |
| WO2005117895A2 (en) * | 2004-06-04 | 2005-12-15 | Boehringer Ingelheim International Gmbh | Compositions comprising meloxicam |
| ITMI20060983A1 (it) * | 2006-05-18 | 2007-11-19 | Formevet S P A | Composizioni farmaceutiche veterinarie per il trattamento del dolore e dell'inifiamazione |
| WO2007138466A2 (en) * | 2006-06-01 | 2007-12-06 | Wockhardt Ltd | Pharmaceutical compositions comprising meloxicam and tramadol combination |
| US20080031950A1 (en) * | 2007-04-27 | 2008-02-07 | Nectid Inc. | Novel anelgesic combination |
| US20080026054A1 (en) * | 2007-04-27 | 2008-01-31 | Nectid Inc. | Novel anelgesic combination |
| EP2177215A1 (en) | 2008-10-17 | 2010-04-21 | Laboratorios Del. Dr. Esteve, S.A. | Co-crystals of tramadol and NSAIDs |
| EP2311446A1 (en) * | 2009-10-16 | 2011-04-20 | Laboratorios Del. Dr. Esteve, S.A. | Compositions comprising Tramadol and Celecoxib in the treatment of pain |
| IT1398321B1 (it) * | 2010-02-26 | 2013-02-22 | Formevet Spa Ora Formevet Srl | Associazione tra un analgesico ad azione centrale e un antinfiammatorio inibitore selettivo della cicloossigenasi 2 per il trattamento dell'infiammazione e del dolore in campo veterinario |
| EP2392319A1 (en) * | 2010-06-04 | 2011-12-07 | Laboratorios Del. Dr. Esteve, S.A. | Pharmaceutical compositions of co-crystals of tramadol and coxibs |
| WO2015004505A1 (es) * | 2013-07-11 | 2015-01-15 | More Pharma Corporation, S. De R.L. De C.V. | Combinación sinergística de paracetamol/celecoxib para el tratamiento de dolor inflamatorio |
| MX2018013070A (es) | 2017-12-29 | 2019-10-15 | Gruenenthal Gmbh | Combinación farmacéutica que comprende clorhidrato de tramadol de liberación extendida y etoricoxib de liberación inmediata, y su uso para el tratamiento del dolor. |
| WO2020061475A2 (en) * | 2018-09-21 | 2020-03-26 | The Johns Hopkins University | Compositions and methods for treating metabolic disorders |
| CN115300515A (zh) * | 2022-08-11 | 2022-11-08 | 南京红地生物科技有限公司 | 一种含有美洛昔康和盐酸曲马多的长效注射液 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ZA845785B (en) * | 1983-06-10 | 1985-03-27 | Adcock Ingram Lab Ltd | Pharmaceutical unit |
| ZA893422B (en) * | 1988-02-24 | 1991-01-30 | Adcock Ingram Lab Ltd | Pharmaceutical composition |
| AU3990895A (en) * | 1995-12-05 | 1997-06-27 | Adcock Ingram Limited | Pharmaceutical composition comprising a skeletal muscle relaxant, a non-steroidal antiinflammatory agent and an analgesic |
| RS49982B (sr) * | 1997-09-17 | 2008-09-29 | Euro-Celtique S.A., | Sinergistička analgetička kombinacija analgetičkog opijata i inhibitora ciklooksigenaze-2 |
| FR2770131A1 (fr) * | 1997-10-27 | 1999-04-30 | Union Pharma Scient Appl | Nouvelle association pharmaceutique a activite analgesique |
| US6375957B1 (en) * | 1997-12-22 | 2002-04-23 | Euro-Celtique, S.A. | Opioid agonist/opioid antagonist/acetaminophen combinations |
| UA55507C2 (uk) * | 1997-12-22 | 2003-04-15 | Еро-Селтік, С.А. | Лікарська форма для перорального введення та спосіб запобігання зловживанню пероральною опіоїдною композицією |
| CA2409927A1 (en) * | 2000-05-31 | 2001-12-06 | Warner-Lambert Company | Combinations of an endothelin receptor antagonist and an antiepileptic compound having pain alleviating properties or analgesic |
| IL153303A0 (en) * | 2000-06-13 | 2003-07-06 | Wyeth Corp | Analgesic and anti-inflammatory compositions conaining cox-2 inhibitors |
-
2003
- 2003-02-14 AT AT08170195T patent/ATE524186T1/de not_active IP Right Cessation
- 2003-02-14 JP JP2003569207A patent/JP2005519936A/ja active Pending
- 2003-02-14 DE DE60325020T patent/DE60325020D1/de not_active Expired - Lifetime
- 2003-02-14 OA OA1200400220A patent/OA12778A/en unknown
- 2003-02-14 PT PT08170195T patent/PT2050453E/pt unknown
- 2003-02-14 ES ES08170195T patent/ES2376500T3/es not_active Expired - Lifetime
- 2003-02-14 EP EP08170195A patent/EP2050453B1/en not_active Expired - Lifetime
- 2003-02-14 PT PT03706774T patent/PT1478366E/pt unknown
- 2003-02-14 NZ NZ535500A patent/NZ535500A/en not_active IP Right Cessation
- 2003-02-14 CA CA2476939A patent/CA2476939C/en not_active Expired - Lifetime
- 2003-02-14 AP APAP/P/2004/003134A patent/AP1862A/en active
- 2003-02-14 SI SI200331530T patent/SI1478366T1/sl unknown
- 2003-02-14 AT AT03706774T patent/ATE415971T1/de active
- 2003-02-14 WO PCT/IB2003/000500 patent/WO2003070251A1/en not_active Ceased
- 2003-02-14 AU AU2003208485A patent/AU2003208485B2/en not_active Ceased
- 2003-02-14 US US10/505,291 patent/US20050090517A1/en not_active Abandoned
- 2003-02-14 ES ES03706774T patent/ES2318113T3/es not_active Expired - Lifetime
- 2003-02-14 IL IL16363703A patent/IL163637A0/xx unknown
- 2003-02-14 EP EP03706774A patent/EP1478366B1/en not_active Expired - Lifetime
- 2003-02-14 DK DK03706774T patent/DK1478366T3/da active
- 2003-02-14 CN CNB038085321A patent/CN100418533C/zh not_active Expired - Fee Related
-
2004
- 2004-08-19 IL IL163637A patent/IL163637A/en active IP Right Grant
- 2004-08-19 EG EGNA2004000074 patent/EG24845A/xx active
- 2004-09-17 ZA ZA2004/07485A patent/ZA200407485B/en unknown
-
2009
- 2009-02-27 CY CY20091100239T patent/CY1108839T1/el unknown
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