CN100418533C - 环加氧酶-2抑制剂和阿片剂的药物组合体 - Google Patents

环加氧酶-2抑制剂和阿片剂的药物组合体 Download PDF

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Publication number
CN100418533C
CN100418533C CNB038085321A CN03808532A CN100418533C CN 100418533 C CN100418533 C CN 100418533C CN B038085321 A CNB038085321 A CN B038085321A CN 03808532 A CN03808532 A CN 03808532A CN 100418533 C CN100418533 C CN 100418533C
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China
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pain
meloxicam
codeine
acetaminophen
combination
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Expired - Fee Related
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CNB038085321A
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English (en)
Chinese (zh)
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CN1646133A (zh
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迈克尔·克里斯蒂安·诺里斯
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Adcock Ingram Ltd
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Adcock Ingram Ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/485—Morphinan derivatives, e.g. morphine, codeine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/5415—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with carbocyclic ring systems, e.g. phenothiazine, chlorpromazine, piroxicam
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Pain & Pain Management (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Neurology (AREA)
  • Reproductive Health (AREA)
  • Endocrinology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Emergency Medicine (AREA)
  • Biomedical Technology (AREA)
  • Rheumatology (AREA)
  • Neurosurgery (AREA)
  • Dermatology (AREA)
  • Immunology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pregnancy & Childbirth (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CNB038085321A 2002-02-19 2003-02-14 环加氧酶-2抑制剂和阿片剂的药物组合体 Expired - Fee Related CN100418533C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ZA200201395 2002-02-19
ZA2002/1395 2002-02-19

Publications (2)

Publication Number Publication Date
CN1646133A CN1646133A (zh) 2005-07-27
CN100418533C true CN100418533C (zh) 2008-09-17

Family

ID=27758232

Family Applications (1)

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CNB038085321A Expired - Fee Related CN100418533C (zh) 2002-02-19 2003-02-14 环加氧酶-2抑制剂和阿片剂的药物组合体

Country Status (20)

Country Link
US (1) US20050090517A1 (enExample)
EP (2) EP2050453B1 (enExample)
JP (1) JP2005519936A (enExample)
CN (1) CN100418533C (enExample)
AP (1) AP1862A (enExample)
AT (2) ATE524186T1 (enExample)
AU (1) AU2003208485B2 (enExample)
CA (1) CA2476939C (enExample)
CY (1) CY1108839T1 (enExample)
DE (1) DE60325020D1 (enExample)
DK (1) DK1478366T3 (enExample)
EG (1) EG24845A (enExample)
ES (2) ES2318113T3 (enExample)
IL (2) IL163637A0 (enExample)
NZ (1) NZ535500A (enExample)
OA (1) OA12778A (enExample)
PT (2) PT2050453E (enExample)
SI (1) SI1478366T1 (enExample)
WO (1) WO2003070251A1 (enExample)
ZA (1) ZA200407485B (enExample)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005094832A1 (en) * 2004-04-01 2005-10-13 Boehringer Ingelheim International Gmbh Compositions comprising meloxicam
JP2008501655A (ja) * 2004-06-04 2008-01-24 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング メロキシカム含有組成物
ITMI20060983A1 (it) * 2006-05-18 2007-11-19 Formevet S P A Composizioni farmaceutiche veterinarie per il trattamento del dolore e dell'inifiamazione
WO2007138466A2 (en) * 2006-06-01 2007-12-06 Wockhardt Ltd Pharmaceutical compositions comprising meloxicam and tramadol combination
US20080026054A1 (en) * 2007-04-27 2008-01-31 Nectid Inc. Novel anelgesic combination
US20080031950A1 (en) * 2007-04-27 2008-02-07 Nectid Inc. Novel anelgesic combination
EP2177215A1 (en) 2008-10-17 2010-04-21 Laboratorios Del. Dr. Esteve, S.A. Co-crystals of tramadol and NSAIDs
EP2311446A1 (en) * 2009-10-16 2011-04-20 Laboratorios Del. Dr. Esteve, S.A. Compositions comprising Tramadol and Celecoxib in the treatment of pain
IT1398321B1 (it) * 2010-02-26 2013-02-22 Formevet Spa Ora Formevet Srl Associazione tra un analgesico ad azione centrale e un antinfiammatorio inibitore selettivo della cicloossigenasi 2 per il trattamento dell'infiammazione e del dolore in campo veterinario
EP2392319A1 (en) * 2010-06-04 2011-12-07 Laboratorios Del. Dr. Esteve, S.A. Pharmaceutical compositions of co-crystals of tramadol and coxibs
WO2015004505A1 (es) * 2013-07-11 2015-01-15 More Pharma Corporation, S. De R.L. De C.V. Combinación sinergística de paracetamol/celecoxib para el tratamiento de dolor inflamatorio
MX2018013070A (es) 2017-12-29 2019-10-15 Gruenenthal Gmbh Combinación farmacéutica que comprende clorhidrato de tramadol de liberación extendida y etoricoxib de liberación inmediata, y su uso para el tratamiento del dolor.
WO2020061475A2 (en) * 2018-09-21 2020-03-26 The Johns Hopkins University Compositions and methods for treating metabolic disorders
CN115300515A (zh) * 2022-08-11 2022-11-08 南京红地生物科技有限公司 一种含有美洛昔康和盐酸曲马多的长效注射液

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA845785B (en) * 1983-06-10 1985-03-27 Adcock Ingram Lab Ltd Pharmaceutical unit
ZA893422B (en) * 1988-02-24 1991-01-30 Adcock Ingram Lab Ltd Pharmaceutical composition
WO1997020551A1 (en) * 1995-12-05 1997-06-12 Adcock Ingram Limited Pharmaceutical composition comprising a skeletal muscle relaxant, a non-steroidal antiinflammatory agent and an analgesic
WO1999021585A1 (en) * 1997-10-27 1999-05-06 Laboratoires Upsa Pharmaceutical combination of a cyclooxigenase-2 inhibitor and acetaminophen or an opiate

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RS49982B (sr) * 1997-09-17 2008-09-29 Euro-Celtique S.A., Sinergistička analgetička kombinacija analgetičkog opijata i inhibitora ciklooksigenaze-2
AU773642C (en) * 1997-12-22 2006-04-06 Mundipharma Pty Limited Opioid agonist/antagonist combinations
US6375957B1 (en) * 1997-12-22 2002-04-23 Euro-Celtique, S.A. Opioid agonist/opioid antagonist/acetaminophen combinations
AU2001264570A1 (en) * 2000-05-31 2001-12-11 Warner Lambert Company Combinations of an endothelin receptor antagonist and an antiepileptic compound having pain alleviating properties or analgesic
NZ522957A (en) * 2000-06-13 2004-03-26 Wyeth Corp COX-2 inhibitors in combination with NSAIDs for a reduced onset time of analgesia

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA845785B (en) * 1983-06-10 1985-03-27 Adcock Ingram Lab Ltd Pharmaceutical unit
ZA893422B (en) * 1988-02-24 1991-01-30 Adcock Ingram Lab Ltd Pharmaceutical composition
WO1997020551A1 (en) * 1995-12-05 1997-06-12 Adcock Ingram Limited Pharmaceutical composition comprising a skeletal muscle relaxant, a non-steroidal antiinflammatory agent and an analgesic
WO1999021585A1 (en) * 1997-10-27 1999-05-06 Laboratoires Upsa Pharmaceutical combination of a cyclooxigenase-2 inhibitor and acetaminophen or an opiate

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
Postoperative analgesia is not different after local vs systemicadministration of meloxicam in patients undergoing inguinalhernia repair.. Romsing-Janne {a}, Mysager-Steffen, Vilmann-Peter,Sonne-Jesper, Larsen-Niels-Erik, Ostergaard-Doris.Canadian-Journal-of-Anesthesia.,Vol.48 No.10. 2001
Postoperative analgesia is not different after local vs systemicadministration of meloxicam in patients undergoing inguinalhernia repair.. Romsing-Janne {a}, Mysager-Steffen, Vilmann-Peter,Sonne-Jesper, Larsen-Niels-Erik, Ostergaard-Doris.Canadian-Journal-of-Anesthesia.,Vol.48 No.10. 2001 *

Also Published As

Publication number Publication date
ES2318113T3 (es) 2009-05-01
AU2003208485A1 (en) 2003-09-09
IL163637A0 (en) 2005-12-18
NZ535500A (en) 2006-09-29
JP2005519936A (ja) 2005-07-07
CN1646133A (zh) 2005-07-27
IL163637A (en) 2010-11-30
CA2476939C (en) 2012-08-28
EP1478366A1 (en) 2004-11-24
ATE415971T1 (de) 2008-12-15
SI1478366T1 (sl) 2009-06-30
PT2050453E (pt) 2012-01-03
EP1478366B1 (en) 2008-12-03
ES2376500T3 (es) 2012-03-14
EP2050453A1 (en) 2009-04-22
AU2003208485B2 (en) 2009-05-28
AP2004003134A0 (en) 2004-09-30
EP2050453B1 (en) 2011-09-14
EG24845A (en) 2010-10-21
DK1478366T3 (da) 2009-03-30
PT1478366E (pt) 2009-03-10
ATE524186T1 (de) 2011-09-15
OA12778A (en) 2006-07-06
WO2003070251A1 (en) 2003-08-28
CY1108839T1 (el) 2014-07-02
ZA200407485B (en) 2005-12-28
US20050090517A1 (en) 2005-04-28
AP1862A (en) 2008-07-07
DE60325020D1 (de) 2009-01-15
CA2476939A1 (en) 2003-08-28

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