JP2005519936A - Cox2阻害剤とオピエートとの医薬組合せ - Google Patents
Cox2阻害剤とオピエートとの医薬組合せ Download PDFInfo
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- JP2005519936A JP2005519936A JP2003569207A JP2003569207A JP2005519936A JP 2005519936 A JP2005519936 A JP 2005519936A JP 2003569207 A JP2003569207 A JP 2003569207A JP 2003569207 A JP2003569207 A JP 2003569207A JP 2005519936 A JP2005519936 A JP 2005519936A
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- Prior art keywords
- meloxicam
- combination
- pharmaceutically acceptable
- codeine
- pharmaceutical composition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
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Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ZA200201395 | 2002-02-19 | ||
| PCT/IB2003/000500 WO2003070251A1 (en) | 2002-02-19 | 2003-02-14 | Pharmaceutical combinations of cox-2 inhibitors and opiates |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2005519936A true JP2005519936A (ja) | 2005-07-07 |
| JP2005519936A5 JP2005519936A5 (enExample) | 2006-03-16 |
Family
ID=27758232
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003569207A Pending JP2005519936A (ja) | 2002-02-19 | 2003-02-14 | Cox2阻害剤とオピエートとの医薬組合せ |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US20050090517A1 (enExample) |
| EP (2) | EP2050453B1 (enExample) |
| JP (1) | JP2005519936A (enExample) |
| CN (1) | CN100418533C (enExample) |
| AP (1) | AP1862A (enExample) |
| AT (2) | ATE524186T1 (enExample) |
| AU (1) | AU2003208485B2 (enExample) |
| CA (1) | CA2476939C (enExample) |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2009537506A (ja) * | 2006-05-18 | 2009-10-29 | フォルメヴェート エセ.ペー.アー. | 疼痛および炎症の処置のための獣医学用薬学的組成物 |
| JP2013507408A (ja) * | 2009-10-16 | 2013-03-04 | ラボラトリオス・デル・デエレ・エステベ・エセ・ア | トラマドール及びセレコキシブを含む疼痛治療用組成物 |
| JP2013520459A (ja) * | 2010-02-26 | 2013-06-06 | フォルメヴェット ソシエタ ア レスポンサビリタ リミタータ | 獣医学領域における炎症および疼痛の治療のための、中枢作用性鎮痛剤と選択的シクロオキシゲナーゼ−2阻害剤抗炎症薬との組み合わせ |
| JP2013530952A (ja) * | 2010-06-04 | 2013-08-01 | ラボラトリオス デル ドクトル エステーヴ,エセ.ア. | トラマドールとコキシブとの共結晶の医薬品組成物 |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2007530620A (ja) * | 2004-04-01 | 2007-11-01 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | メロキシカムを含む組成物 |
| WO2005117895A2 (en) * | 2004-06-04 | 2005-12-15 | Boehringer Ingelheim International Gmbh | Compositions comprising meloxicam |
| WO2007138466A2 (en) * | 2006-06-01 | 2007-12-06 | Wockhardt Ltd | Pharmaceutical compositions comprising meloxicam and tramadol combination |
| US20080026054A1 (en) * | 2007-04-27 | 2008-01-31 | Nectid Inc. | Novel anelgesic combination |
| US20080031950A1 (en) * | 2007-04-27 | 2008-02-07 | Nectid Inc. | Novel anelgesic combination |
| EP2177215A1 (en) | 2008-10-17 | 2010-04-21 | Laboratorios Del. Dr. Esteve, S.A. | Co-crystals of tramadol and NSAIDs |
| WO2015004505A1 (es) * | 2013-07-11 | 2015-01-15 | More Pharma Corporation, S. De R.L. De C.V. | Combinación sinergística de paracetamol/celecoxib para el tratamiento de dolor inflamatorio |
| MX2018013070A (es) | 2017-12-29 | 2019-10-15 | Gruenenthal Gmbh | Combinación farmacéutica que comprende clorhidrato de tramadol de liberación extendida y etoricoxib de liberación inmediata, y su uso para el tratamiento del dolor. |
| WO2020061475A2 (en) * | 2018-09-21 | 2020-03-26 | The Johns Hopkins University | Compositions and methods for treating metabolic disorders |
| CN115300515A (zh) * | 2022-08-11 | 2022-11-08 | 南京红地生物科技有限公司 | 一种含有美洛昔康和盐酸曲马多的长效注射液 |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1997020551A1 (en) * | 1995-12-05 | 1997-06-12 | Adcock Ingram Limited | Pharmaceutical composition comprising a skeletal muscle relaxant, a non-steroidal antiinflammatory agent and an analgesic |
| WO2001091736A2 (en) * | 2000-05-31 | 2001-12-06 | Warner-Lambert Company | Combinations of an endothelin receptor antagonist and an antiepileptic compound having pain alleviating properties or analgesic |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ZA845785B (en) * | 1983-06-10 | 1985-03-27 | Adcock Ingram Lab Ltd | Pharmaceutical unit |
| ZA893422B (en) * | 1988-02-24 | 1991-01-30 | Adcock Ingram Lab Ltd | Pharmaceutical composition |
| RS49982B (sr) * | 1997-09-17 | 2008-09-29 | Euro-Celtique S.A., | Sinergistička analgetička kombinacija analgetičkog opijata i inhibitora ciklooksigenaze-2 |
| FR2770131A1 (fr) * | 1997-10-27 | 1999-04-30 | Union Pharma Scient Appl | Nouvelle association pharmaceutique a activite analgesique |
| ES2412409T3 (es) * | 1997-12-22 | 2013-07-11 | Euro-Celtique S.A. | Forma farmacéutica para dosificación oral que comprende una combinación de un agonista opiáceo y un antagonista opiáceo |
| US6375957B1 (en) * | 1997-12-22 | 2002-04-23 | Euro-Celtique, S.A. | Opioid agonist/opioid antagonist/acetaminophen combinations |
| AU6837701A (en) * | 2000-06-13 | 2001-12-24 | American Home Prod | Analgesic and anti-inflammatory compositions containing cox-2 inhibitors |
-
2003
- 2003-02-14 AT AT08170195T patent/ATE524186T1/de not_active IP Right Cessation
- 2003-02-14 ES ES08170195T patent/ES2376500T3/es not_active Expired - Lifetime
- 2003-02-14 OA OA1200400220A patent/OA12778A/en unknown
- 2003-02-14 JP JP2003569207A patent/JP2005519936A/ja active Pending
- 2003-02-14 AP APAP/P/2004/003134A patent/AP1862A/en active
- 2003-02-14 PT PT03706774T patent/PT1478366E/pt unknown
- 2003-02-14 DE DE60325020T patent/DE60325020D1/de not_active Expired - Lifetime
- 2003-02-14 EP EP08170195A patent/EP2050453B1/en not_active Expired - Lifetime
- 2003-02-14 NZ NZ535500A patent/NZ535500A/en not_active IP Right Cessation
- 2003-02-14 EP EP03706774A patent/EP1478366B1/en not_active Expired - Lifetime
- 2003-02-14 AT AT03706774T patent/ATE415971T1/de active
- 2003-02-14 CA CA2476939A patent/CA2476939C/en not_active Expired - Lifetime
- 2003-02-14 WO PCT/IB2003/000500 patent/WO2003070251A1/en not_active Ceased
- 2003-02-14 IL IL16363703A patent/IL163637A0/xx unknown
- 2003-02-14 SI SI200331530T patent/SI1478366T1/sl unknown
- 2003-02-14 AU AU2003208485A patent/AU2003208485B2/en not_active Ceased
- 2003-02-14 ES ES03706774T patent/ES2318113T3/es not_active Expired - Lifetime
- 2003-02-14 PT PT08170195T patent/PT2050453E/pt unknown
- 2003-02-14 US US10/505,291 patent/US20050090517A1/en not_active Abandoned
- 2003-02-14 DK DK03706774T patent/DK1478366T3/da active
- 2003-02-14 CN CNB038085321A patent/CN100418533C/zh not_active Expired - Fee Related
-
2004
- 2004-08-19 IL IL163637A patent/IL163637A/en active IP Right Grant
- 2004-08-19 EG EGNA2004000074 patent/EG24845A/xx active
- 2004-09-17 ZA ZA2004/07485A patent/ZA200407485B/en unknown
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- 2009-02-27 CY CY20091100239T patent/CY1108839T1/el unknown
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1997020551A1 (en) * | 1995-12-05 | 1997-06-12 | Adcock Ingram Limited | Pharmaceutical composition comprising a skeletal muscle relaxant, a non-steroidal antiinflammatory agent and an analgesic |
| WO2001091736A2 (en) * | 2000-05-31 | 2001-12-06 | Warner-Lambert Company | Combinations of an endothelin receptor antagonist and an antiepileptic compound having pain alleviating properties or analgesic |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2009537506A (ja) * | 2006-05-18 | 2009-10-29 | フォルメヴェート エセ.ペー.アー. | 疼痛および炎症の処置のための獣医学用薬学的組成物 |
| JP2013507408A (ja) * | 2009-10-16 | 2013-03-04 | ラボラトリオス・デル・デエレ・エステベ・エセ・ア | トラマドール及びセレコキシブを含む疼痛治療用組成物 |
| JP2013520459A (ja) * | 2010-02-26 | 2013-06-06 | フォルメヴェット ソシエタ ア レスポンサビリタ リミタータ | 獣医学領域における炎症および疼痛の治療のための、中枢作用性鎮痛剤と選択的シクロオキシゲナーゼ−2阻害剤抗炎症薬との組み合わせ |
| JP2013530952A (ja) * | 2010-06-04 | 2013-08-01 | ラボラトリオス デル ドクトル エステーヴ,エセ.ア. | トラマドールとコキシブとの共結晶の医薬品組成物 |
Also Published As
| Publication number | Publication date |
|---|---|
| OA12778A (en) | 2006-07-06 |
| IL163637A (en) | 2010-11-30 |
| CA2476939A1 (en) | 2003-08-28 |
| IL163637A0 (en) | 2005-12-18 |
| EP2050453B1 (en) | 2011-09-14 |
| CN100418533C (zh) | 2008-09-17 |
| EP2050453A1 (en) | 2009-04-22 |
| CA2476939C (en) | 2012-08-28 |
| WO2003070251A1 (en) | 2003-08-28 |
| PT1478366E (pt) | 2009-03-10 |
| CN1646133A (zh) | 2005-07-27 |
| AP1862A (en) | 2008-07-07 |
| EP1478366A1 (en) | 2004-11-24 |
| DE60325020D1 (de) | 2009-01-15 |
| AP2004003134A0 (en) | 2004-09-30 |
| EP1478366B1 (en) | 2008-12-03 |
| ZA200407485B (en) | 2005-12-28 |
| US20050090517A1 (en) | 2005-04-28 |
| ATE415971T1 (de) | 2008-12-15 |
| PT2050453E (pt) | 2012-01-03 |
| AU2003208485B2 (en) | 2009-05-28 |
| ES2376500T3 (es) | 2012-03-14 |
| ES2318113T3 (es) | 2009-05-01 |
| DK1478366T3 (da) | 2009-03-30 |
| SI1478366T1 (sl) | 2009-06-30 |
| EG24845A (en) | 2010-10-21 |
| ATE524186T1 (de) | 2011-09-15 |
| CY1108839T1 (el) | 2014-07-02 |
| NZ535500A (en) | 2006-09-29 |
| AU2003208485A1 (en) | 2003-09-09 |
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