JP2005519916A5 - - Google Patents
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- JP2005519916A5 JP2005519916A5 JP2003563467A JP2003563467A JP2005519916A5 JP 2005519916 A5 JP2005519916 A5 JP 2005519916A5 JP 2003563467 A JP2003563467 A JP 2003563467A JP 2003563467 A JP2003563467 A JP 2003563467A JP 2005519916 A5 JP2005519916 A5 JP 2005519916A5
- Authority
- JP
- Japan
- Prior art keywords
- limited
- dideoxy
- construction
- alkenyl
- alkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- -1 phosphate ester Chemical class 0.000 claims description 84
- 125000003342 alkenyl group Chemical group 0.000 claims description 62
- 125000000217 alkyl group Chemical group 0.000 claims description 62
- 125000000304 alkynyl group Chemical group 0.000 claims description 60
- 125000003118 aryl group Chemical group 0.000 claims description 52
- 150000001875 compounds Chemical class 0.000 claims description 49
- 229910052731 fluorine Inorganic materials 0.000 claims description 49
- 229910052794 bromium Inorganic materials 0.000 claims description 45
- 229910052801 chlorine Inorganic materials 0.000 claims description 45
- 229910052740 iodine Inorganic materials 0.000 claims description 41
- 125000001188 haloalkyl group Chemical group 0.000 claims description 38
- 125000004103 aminoalkyl group Chemical group 0.000 claims description 26
- 125000004001 thioalkyl group Chemical group 0.000 claims description 26
- 239000010452 phosphate Substances 0.000 claims description 24
- 125000000753 cycloalkyl group Chemical group 0.000 claims description 19
- 229910052739 hydrogen Inorganic materials 0.000 claims description 19
- 125000001072 heteroaryl group Chemical group 0.000 claims description 16
- 125000003545 alkoxy group Chemical group 0.000 claims description 15
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 claims description 15
- 150000003014 phosphoric acid esters Chemical class 0.000 claims description 15
- 150000003839 salts Chemical class 0.000 claims description 14
- 239000011780 sodium chloride Substances 0.000 claims description 14
- 239000003814 drug Substances 0.000 claims description 13
- 125000000262 haloalkenyl group Chemical group 0.000 claims description 13
- 125000000232 haloalkynyl group Chemical group 0.000 claims description 13
- 125000002252 acyl group Chemical group 0.000 claims description 10
- 229910052717 sulfur Inorganic materials 0.000 claims description 8
- 229910052760 oxygen Inorganic materials 0.000 claims description 7
- 125000002768 hydroxyalkyl group Chemical group 0.000 claims description 5
- 238000010276 construction Methods 0.000 claims 27
- UHDGCWIWMRVCDJ-PSQAKQOGSA-N Cytidine Natural products O=C1N=C(N)C=CN1[C@@H]1[C@@H](O)[C@@H](O)[C@H](CO)O1 UHDGCWIWMRVCDJ-PSQAKQOGSA-N 0.000 claims 13
- UHDGCWIWMRVCDJ-XVFCMESISA-N Cytidine Chemical compound O=C1N=C(N)C=CN1[C@H]1[C@H](O)[C@H](O)[C@@H](CO)O1 UHDGCWIWMRVCDJ-XVFCMESISA-N 0.000 claims 10
- 241000580858 Simian-Human immunodeficiency virus Species 0.000 claims 6
- ZZOWHGNRJBACEC-OBNKUBODSA-N C1=C(F)C(N)(C(=O)C=2C=CC(Br)=CC=2)NC(=O)N1[C@H]1CC[C@@H](CO)O1 Chemical compound C1=C(F)C(N)(C(=O)C=2C=CC(Br)=CC=2)NC(=O)N1[C@H]1CC[C@@H](CO)O1 ZZOWHGNRJBACEC-OBNKUBODSA-N 0.000 claims 3
- QFZSFOGFWZZUNY-OBNKUBODSA-N ClC1=CC=C(C(=O)C2(NC(N([C@H]3CC[C@@H](CO)O3)C=C2F)=O)N)C=C1 Chemical compound ClC1=CC=C(C(=O)C2(NC(N([C@H]3CC[C@@H](CO)O3)C=C2F)=O)N)C=C1 QFZSFOGFWZZUNY-OBNKUBODSA-N 0.000 claims 3
- 239000000203 mixture Substances 0.000 claims 3
- 239000008194 pharmaceutical composition Substances 0.000 claims 3
- DJVMNMGZLLNCOX-OBNKUBODSA-N C1=C(F)C(N)(C(=O)C=2C=CC(F)=CC=2)NC(=O)N1[C@H]1CC[C@@H](CO)O1 Chemical compound C1=C(F)C(N)(C(=O)C=2C=CC(F)=CC=2)NC(=O)N1[C@H]1CC[C@@H](CO)O1 DJVMNMGZLLNCOX-OBNKUBODSA-N 0.000 claims 2
- GYKMBBKSGZJFDI-POXCNRTASA-N C1=CC(CC)=CC=C1C(=O)C1(N)C(F)=CN([C@@H]2O[C@H](CO)CC2)C(=O)N1 Chemical compound C1=CC(CC)=CC=C1C(=O)C1(N)C(F)=CN([C@@H]2O[C@H](CO)CC2)C(=O)N1 GYKMBBKSGZJFDI-POXCNRTASA-N 0.000 claims 2
- XPZKEBBLAZUJAS-OBNKUBODSA-N IC1=CC=C(C(=O)C2(NC(N([C@H]3CC[C@@H](CO)O3)C=C2F)=O)N)C=C1 Chemical compound IC1=CC=C(C(=O)C2(NC(N([C@H]3CC[C@@H](CO)O3)C=C2F)=O)N)C=C1 XPZKEBBLAZUJAS-OBNKUBODSA-N 0.000 claims 2
- 239000003795 chemical substances by application Substances 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- OEPQUYSQHIUHDR-UHFFFAOYSA-N 4-amino-1-[2-fluoro-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidin-2-one Chemical compound O=C1N=C(N)C=CN1C1(F)C(O)C(O)C(CO)O1 OEPQUYSQHIUHDR-UHFFFAOYSA-N 0.000 claims 1
- STRZQWQNZQMHQR-UAKXSSHOSA-N 5-fluorocytidine Chemical compound C1=C(F)C(N)=NC(=O)N1[C@H]1[C@H](O)[C@H](O)[C@@H](CO)O1 STRZQWQNZQMHQR-UAKXSSHOSA-N 0.000 claims 1
- WLVNAHXIMSQHMW-OCDMVOQQSA-N C(C)C1=CC=C(C(=O)C2(NC(N([C@H]3[C@H](O)[C@H](O)[C@@H](CO)O3)C=C2F)=O)N)C=C1 Chemical compound C(C)C1=CC=C(C(=O)C2(NC(N([C@H]3[C@H](O)[C@H](O)[C@@H](CO)O3)C=C2F)=O)N)C=C1 WLVNAHXIMSQHMW-OCDMVOQQSA-N 0.000 claims 1
- AMHSVLOKQVVFRS-OBNKUBODSA-N C1(CCCCC1)C(=O)C1(NC(N([C@H]2CC[C@@H](CO)O2)C=C1F)=O)N Chemical compound C1(CCCCC1)C(=O)C1(NC(N([C@H]2CC[C@@H](CO)O2)C=C1F)=O)N AMHSVLOKQVVFRS-OBNKUBODSA-N 0.000 claims 1
- YLCCKDTVZYPNME-OBNKUBODSA-N C1=C(F)C(N)(C(=O)C2CCCCC2)NC(=O)N1[C@@H]1O[C@H](CO)C=C1 Chemical compound C1=C(F)C(N)(C(=O)C2CCCCC2)NC(=O)N1[C@@H]1O[C@H](CO)C=C1 YLCCKDTVZYPNME-OBNKUBODSA-N 0.000 claims 1
- BSSDTTPDXHUFRY-OBNKUBODSA-N C1=C(F)C(N)(C(=O)C=2C=C(Br)C=CC=2)NC(=O)N1[C@H]1CC[C@@H](CO)O1 Chemical compound C1=C(F)C(N)(C(=O)C=2C=C(Br)C=CC=2)NC(=O)N1[C@H]1CC[C@@H](CO)O1 BSSDTTPDXHUFRY-OBNKUBODSA-N 0.000 claims 1
- BDVFEQPECMQQEK-OBNKUBODSA-N C1=C(F)C(N)(C(=O)C=2C=CC(Br)=CC=2)NC(=O)N1[C@@H]1O[C@H](CO)C=C1 Chemical compound C1=C(F)C(N)(C(=O)C=2C=CC(Br)=CC=2)NC(=O)N1[C@@H]1O[C@H](CO)C=C1 BDVFEQPECMQQEK-OBNKUBODSA-N 0.000 claims 1
- VCLLXLWPTDLADT-OBNKUBODSA-N C1=C(F)C(N)(C(=O)C=2C=CC(Cl)=CC=2)NC(=O)N1[C@@H]1O[C@H](CO)C=C1 Chemical compound C1=C(F)C(N)(C(=O)C=2C=CC(Cl)=CC=2)NC(=O)N1[C@@H]1O[C@H](CO)C=C1 VCLLXLWPTDLADT-OBNKUBODSA-N 0.000 claims 1
- ORAFXVZDHPCYMY-QQDBQQHDSA-N C1=C(F)C(N)(C(=O)C=2SC3=CC=CC=C3C=2)NC(=O)N1[C@H]1CC[C@@H](CO)O1 Chemical compound C1=C(F)C(N)(C(=O)C=2SC3=CC=CC=C3C=2)NC(=O)N1[C@H]1CC[C@@H](CO)O1 ORAFXVZDHPCYMY-QQDBQQHDSA-N 0.000 claims 1
- NOIZCHKDVXBABB-DBMQZSJKSA-N C1=CC(C(C)(C)C)=CC=C1C(=O)C1(N)C(F)=CN([C@@H]2O[C@H](CO)CC2)C(=O)N1 Chemical compound C1=CC(C(C)(C)C)=CC=C1C(=O)C1(N)C(F)=CN([C@@H]2O[C@H](CO)CC2)C(=O)N1 NOIZCHKDVXBABB-DBMQZSJKSA-N 0.000 claims 1
- LJTXIDHLSJRCRI-JYCRYNECSA-N C1=CC(OC)=CC=C1C(=O)C1(N)C(F)=CN([C@H]2C=C[C@@H](CO)O2)C(=O)N1 Chemical compound C1=CC(OC)=CC=C1C(=O)C1(N)C(F)=CN([C@H]2C=C[C@@H](CO)O2)C(=O)N1 LJTXIDHLSJRCRI-JYCRYNECSA-N 0.000 claims 1
- 239000002259 anti human immunodeficiency virus agent Substances 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 125000004401 m-toluyl group Chemical group [H]C1=C([H])C(=C([H])C(=C1[H])C([H])([H])[H])C(*)=O 0.000 claims 1
- 125000003232 p-nitrobenzoyl group Chemical group [N+](=O)([O-])C1=CC=C(C(=O)*)C=C1 0.000 claims 1
- 229910052736 halogen Inorganic materials 0.000 description 29
- 150000002367 halogens Chemical class 0.000 description 29
- HVYWMOMLDIMFJA-DPAQBDIFSA-N (3β)-Cholest-5-en-3-ol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 description 22
- 239000000651 prodrug Substances 0.000 description 22
- 229940002612 prodrugs Drugs 0.000 description 22
- 229940107161 Cholesterol Drugs 0.000 description 11
- 229940067631 Phospholipids Drugs 0.000 description 11
- 239000002253 acid Substances 0.000 description 11
- 150000001413 amino acids Chemical class 0.000 description 11
- 125000005140 aralkylsulfonyl group Chemical group 0.000 description 11
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 description 11
- 235000012000 cholesterol Nutrition 0.000 description 11
- 239000001177 diphosphate Substances 0.000 description 11
- 235000011180 diphosphates Nutrition 0.000 description 11
- 150000002148 esters Chemical class 0.000 description 11
- 239000001257 hydrogen Substances 0.000 description 11
- 125000004435 hydrogen atoms Chemical class [H]* 0.000 description 11
- 150000002632 lipids Chemical class 0.000 description 11
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 description 11
- 150000003904 phospholipids Chemical class 0.000 description 11
- 102000004196 processed proteins & peptides Human genes 0.000 description 11
- 108090000765 processed proteins & peptides Proteins 0.000 description 11
- 125000001424 substituent group Chemical group 0.000 description 11
- 239000001226 triphosphate Substances 0.000 description 11
- 235000011178 triphosphate Nutrition 0.000 description 11
- 125000004390 alkyl sulfonyl group Chemical group 0.000 description 10
- VNWKTOKETHGBQD-UHFFFAOYSA-N methane Chemical compound C VNWKTOKETHGBQD-UHFFFAOYSA-N 0.000 description 7
- 0 *C[C@@](*1)*C(*)(*)[C@]1N(C=C(*)C(NC(*)=O)=N1)C1=O Chemical compound *C[C@@](*1)*C(*)(*)[C@]1N(C=C(*)C(NC(*)=O)=N1)C1=O 0.000 description 3
- COVZYZSDYWQREU-UHFFFAOYSA-N 1,4-Butanediol, dimethanesulfonate Chemical compound CS(=O)(=O)OCCCCOS(C)(=O)=O COVZYZSDYWQREU-UHFFFAOYSA-N 0.000 description 3
- 125000004946 alkenylalkyl group Chemical group 0.000 description 2
- 125000005038 alkynylalkyl group Chemical group 0.000 description 2
- 125000004170 methylsulfonyl group Chemical group [H]C([H])([H])S(*)(=O)=O 0.000 description 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US34155501P | 2001-12-14 | 2001-12-14 | |
| PCT/US2002/040081 WO2003063771A2 (en) | 2001-12-14 | 2002-12-13 | N4-acylcytosine nucleosides for treatment of viral iinfections |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2005519916A JP2005519916A (ja) | 2005-07-07 |
| JP2005519916A5 true JP2005519916A5 (US06780888-20040824-C00057.png) | 2010-03-18 |
Family
ID=23338072
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003563467A Pending JP2005519916A (ja) | 2001-12-14 | 2002-12-13 | ウィルス感染治療用ｎ４−アシルシトシンヌクレオシド類 |
Country Status (10)
Families Citing this family (41)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6790228B2 (en) * | 1999-12-23 | 2004-09-14 | Advanced Cardiovascular Systems, Inc. | Coating for implantable devices and a method of forming the same |
| DE60136620D1 (de) | 2000-04-13 | 2009-01-02 | Pharmasset Inc | 3 oder 2 hydroxymethyl substituierte nucleoside derivate und ihre verwendung zur behandlung von virusinfektionen |
| MY164523A (en) | 2000-05-23 | 2017-12-29 | Univ Degli Studi Cagliari | Methods and compositions for treating hepatitis c virus |
| NZ547204A (en) | 2000-05-26 | 2008-01-31 | Idenix Cayman Ltd | Methods and compositions for treating flaviviruses and pestiviruses |
| AU2002365234B2 (en) * | 2001-12-14 | 2009-01-29 | Pharmasset Inc | N4-acylcytosine nucleosides for treatment of viral infections |
| US7608600B2 (en) | 2002-06-28 | 2009-10-27 | Idenix Pharmaceuticals, Inc. | Modified 2′ and 3′-nucleoside prodrugs for treating Flaviviridae infections |
| NZ537662A (en) * | 2002-06-28 | 2007-10-26 | Idenix Cayman Ltd | 2'-C-methyl-3'-O-L-valine ester ribofuranosyl cytidine for treatment of flaviviridae infections |
| AU2003248748A1 (en) * | 2002-06-28 | 2004-01-19 | Idenix (Cayman) Limited | 2'-c-methyl-3'-o-l-valine ester ribofuranosyl cytidine for treatment of flaviviridae infections |
| CA2494340C (en) | 2002-08-01 | 2012-01-24 | Pharmasset Inc. | Compounds with the bicyclo[4.2.1]nonane system for the treatment of flaviviridae infections |
| KR20050088079A (ko) * | 2002-11-15 | 2005-09-01 | 이데닉스 (케이만) 리미티드 | 2'-분지형 뉴클레오시드 및 플라비비리다에 돌연변이 |
| CA2509687C (en) * | 2002-12-12 | 2012-08-14 | Idenix (Cayman) Limited | Process for the production of 2'-branched nucleosides |
| CA2425031A1 (en) * | 2003-04-01 | 2004-10-01 | Smithkline Beecham Corporation | Pharmaceutical compositions |
| CA2734052A1 (en) | 2003-05-30 | 2005-01-13 | Pharmasset, Inc. | Modified fluorinated nucleoside analogues |
| WO2005097618A2 (en) * | 2004-04-01 | 2005-10-20 | Achillion Pharmaceuticals, Inc. | Low dose therapy for treating viral infections |
| CN101023094B (zh) * | 2004-07-21 | 2011-05-18 | 法莫赛特股份有限公司 | 烷基取代的2-脱氧-2-氟代-d-呋喃核糖基嘧啶和嘌呤及其衍生物的制备 |
| RU2433124C2 (ru) | 2004-09-14 | 2011-11-10 | Фармассет, Инк. | Способ получения 2'-фтор-2'-алкилзамещенных или других замещенных рибофуранозилпиримидинов и пуринов и их производных |
| CA2584670A1 (en) * | 2004-10-19 | 2006-04-27 | Achillion Pharmaceuticals, Inc. | Combination therapy for treating viral infections |
| US7968703B2 (en) * | 2005-03-07 | 2011-06-28 | Shire Canada Inc. | Process and methods for the preparation of optically active cis-2-hydroxymethyl-4- (cytosin-1'-yl)-1,3-oxathiolane or pharmaceutically acceptable salts thereof |
| JP5254033B2 (ja) * | 2005-12-23 | 2013-08-07 | イデニク プハルマセウティカルス，インコーポレイテッド | 分岐型ヌクレオシドを調製するための合成中間体の製造方法 |
| GB0623493D0 (en) | 2006-11-24 | 2007-01-03 | Univ Cardiff | Chemical compounds |
| US7964580B2 (en) | 2007-03-30 | 2011-06-21 | Pharmasset, Inc. | Nucleoside phosphoramidate prodrugs |
| US8173621B2 (en) | 2008-06-11 | 2012-05-08 | Gilead Pharmasset Llc | Nucleoside cyclicphosphates |
| NZ593648A (en) | 2008-12-23 | 2013-09-27 | Gilead Pharmasset Llc | Nucleoside phosphoramidates |
| EA201100851A1 (ru) | 2008-12-23 | 2012-04-30 | Фармассет, Инк. | Аналоги нуклеозидов |
| CL2009002206A1 (es) | 2008-12-23 | 2011-08-26 | Gilead Pharmasset Llc | Compuestos derivados de pirrolo -(2-3-d]-pirimidin-7(6h)-tetrahidrofuran-2-il fosfonamidato, composicion farmaceutica; y su uso en el tratamiento de enfermedades virales. |
| US8618076B2 (en) | 2009-05-20 | 2013-12-31 | Gilead Pharmasset Llc | Nucleoside phosphoramidates |
| TWI576352B (zh) | 2009-05-20 | 2017-04-01 | 基利法瑪席特有限責任公司 | 核苷磷醯胺 |
| BR112012024884A2 (pt) | 2010-03-31 | 2016-10-18 | Gilead Pharmasset Llc | síntese estereosseletiva de ativos contendo fósforo |
| US8563530B2 (en) | 2010-03-31 | 2013-10-22 | Gilead Pharmassel LLC | Purine nucleoside phosphoramidate |
| AR084044A1 (es) | 2010-11-30 | 2013-04-17 | Pharmasset Inc | Compuestos 2’-espiro-nucleosidos |
| CN104244945B (zh) | 2011-09-16 | 2016-08-31 | 吉利德制药有限责任公司 | 用于治疗hcv的方法 |
| US8889159B2 (en) | 2011-11-29 | 2014-11-18 | Gilead Pharmasset Llc | Compositions and methods for treating hepatitis C virus |
| CN103242400B (zh) * | 2012-02-08 | 2016-06-08 | 河南师范大学 | 具有抗hiv活性的5-取代嘧啶核苷-噻唑啉酮杂化体及其制备方法 |
| DK2950786T3 (da) | 2013-01-31 | 2020-02-17 | Gilead Pharmasset Llc | Kombinationsformulering af to antivirale forbindelser |
| ES2792503T3 (es) | 2013-08-27 | 2020-11-11 | Gilead Pharmasset Llc | Formulación combinada de dos compuestos antivirales |
| MY190867A (en) | 2015-03-06 | 2022-05-13 | Atea Pharmaceuticals Inc | ? -d-2'-deoxy-2'-?-fluoro-2'- ? -c-substituted-2-modified-n6-substituted purine nucleotides for hcv treatment |
| LU100724B1 (en) | 2016-07-14 | 2018-07-31 | Atea Pharmaceuticals Inc | Beta-d-2'-deoxy-2'-alpha-fluoro-2'-beta-c-substituted-4'-fluoro-n6-substituted-6-amino-2-substituted purine nucleotides for the treatment of hepatitis c virus infection |
| EA037868B1 (ru) | 2016-09-07 | 2021-05-28 | Атеа Фармасьютикалс, Инк. | 2'-замещенные-n6-замещенные пуриновые нуклеотиды для лечения вызванных рнк-вирусом заболеваний |
| JP7066728B2 (ja) | 2017-02-01 | 2022-05-13 | アテア ファーマシューティカルズ， インコーポレイテッド | Ｃ型肝炎ウイルスの治療のためのヌクレオチドヘミ硫酸塩 |
| CN112351799A (zh) | 2018-04-10 | 2021-02-09 | 阿堤亚制药公司 | 具有硬化的hcv感染患者的治疗 |
| US10874687B1 (en) | 2020-02-27 | 2020-12-29 | Atea Pharmaceuticals, Inc. | Highly active compounds against COVID-19 |
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| BR9908270A (pt) * | 1998-02-25 | 2004-06-29 | Univ Emory | 2-fluoro-nucleosìdeos, composições farmacêuticas e seus usos |
| PL361310A1 (en) * | 2000-10-13 | 2004-10-04 | Shire Biochem Inc. | Dioxolane analogs for improved inter-cellular delivery |
| CN1646141B (zh) * | 2000-10-18 | 2014-06-25 | 吉利德制药有限责任公司 | 用于治疗病毒感染和异常细胞增殖的修饰核苷类化合物 |
| AU2002365234B2 (en) * | 2001-12-14 | 2009-01-29 | Pharmasset Inc | N4-acylcytosine nucleosides for treatment of viral infections |
-
2002
- 2002-12-13 AU AU2002365234A patent/AU2002365234B2/en not_active Ceased
- 2002-12-13 KR KR1020047009263A patent/KR100978904B1/ko not_active IP Right Cessation
- 2002-12-13 CA CA2470255A patent/CA2470255C/en not_active Expired - Fee Related
- 2002-12-13 CN CNB028278402A patent/CN100560073C/zh not_active Expired - Fee Related
- 2002-12-13 WO PCT/US2002/040081 patent/WO2003063771A2/en active Application Filing
- 2002-12-13 BR BR0214944-3A patent/BR0214944A/pt not_active Application Discontinuation
- 2002-12-13 JP JP2003563467A patent/JP2005519916A/ja active Pending
- 2002-12-13 EP EP02804833A patent/EP1569652A4/en not_active Withdrawn
- 2002-12-13 US US10/318,511 patent/US7105527B2/en not_active Expired - Fee Related
- 2002-12-13 MX MXPA04005779A patent/MXPA04005779A/es active IP Right Grant
- 2002-12-16 AU AU2002364730A patent/AU2002364730A1/en not_active Abandoned
- 2002-12-16 US US10/320,350 patent/US6908924B2/en not_active Ceased
- 2002-12-16 WO PCT/US2002/040090 patent/WO2003051306A2/en not_active Application Discontinuation
-
2006
- 2006-07-31 US US11/461,338 patent/US20070078080A1/en not_active Abandoned
-
2007
- 2007-06-21 US US11/821,076 patent/USRE42015E1/en not_active Expired - Fee Related
-
2008
- 2008-01-04 US US11/969,427 patent/US8114997B2/en not_active Expired - Fee Related
-
2012
- 2012-02-13 US US13/371,654 patent/US20120202766A1/en not_active Abandoned
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