JP2005519633A5 - - Google Patents
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- Publication number
- JP2005519633A5 JP2005519633A5 JP2003586344A JP2003586344A JP2005519633A5 JP 2005519633 A5 JP2005519633 A5 JP 2005519633A5 JP 2003586344 A JP2003586344 A JP 2003586344A JP 2003586344 A JP2003586344 A JP 2003586344A JP 2005519633 A5 JP2005519633 A5 JP 2005519633A5
- Authority
- JP
- Japan
- Prior art keywords
- gene
- nuclear
- pig
- lipid
- donor cell
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 101150099983 GT gene Proteins 0.000 claims 11
- 238000000034 method Methods 0.000 claims 11
- 210000004027 cell Anatomy 0.000 claims 9
- 230000014509 gene expression Effects 0.000 claims 9
- 150000002632 lipids Chemical class 0.000 claims 9
- 108090000623 proteins and genes Proteins 0.000 claims 8
- 210000001161 mammalian embryo Anatomy 0.000 claims 5
- 102000004169 proteins and genes Human genes 0.000 claims 5
- 101150066002 GFP gene Proteins 0.000 claims 4
- 229920006317 cationic polymer Polymers 0.000 claims 4
- 238000010363 gene targeting Methods 0.000 claims 4
- RXWNCPJZOCPEPQ-NVWDDTSBSA-N puromycin Chemical compound C1=CC(OC)=CC=C1C[C@H](N)C(=O)N[C@H]1[C@@H](O)[C@H](N2C3=NC=NC(=C3N=C2)N(C)C)O[C@@H]1CO RXWNCPJZOCPEPQ-NVWDDTSBSA-N 0.000 claims 4
- 108091008146 restriction endonucleases Proteins 0.000 claims 4
- 108091034057 RNA (poly(A)) Proteins 0.000 claims 2
- 241000282887 Suidae Species 0.000 claims 2
- 102000006612 Transducin Human genes 0.000 claims 2
- 108010087042 Transducin Proteins 0.000 claims 2
- 125000003275 alpha amino acid group Chemical group 0.000 claims 2
- 239000006143 cell culture medium Substances 0.000 claims 2
- 239000012634 fragment Substances 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 229950010131 puromycin Drugs 0.000 claims 2
- 230000003362 replicative effect Effects 0.000 claims 2
- 238000012258 culturing Methods 0.000 claims 1
- 210000003754 fetus Anatomy 0.000 claims 1
- 210000002950 fibroblast Anatomy 0.000 claims 1
- 230000006801 homologous recombination Effects 0.000 claims 1
- 238000002744 homologous recombination Methods 0.000 claims 1
- 239000003550 marker Substances 0.000 claims 1
- 239000002609 medium Substances 0.000 claims 1
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/KR2001/002304 WO2003089632A1 (en) | 2001-12-29 | 2001-12-29 | Gfp-transfected clon pig, gt knock-out clon pig and methods for production thereof |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2005519633A JP2005519633A (ja) | 2005-07-07 |
| JP2005519633A5 true JP2005519633A5 (https=) | 2005-12-22 |
| JP4153878B2 JP4153878B2 (ja) | 2008-09-24 |
Family
ID=29244661
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003586344A Expired - Fee Related JP4153878B2 (ja) | 2001-12-29 | 2001-12-29 | Ｇｔ遺伝子が除去された複製豚及びその生産方法 |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US20050076399A1 (https=) |
| EP (1) | EP1465986A4 (https=) |
| JP (1) | JP4153878B2 (https=) |
| CN (1) | CN1582332A (https=) |
| AU (1) | AU2002217606A1 (https=) |
| CA (1) | CA2472040A1 (https=) |
| WO (1) | WO2003089632A1 (https=) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1119760C (zh) | 1998-08-31 | 2003-08-27 | 索尼株式会社 | 自然语言处理装置及方法 |
| CA2533259C (en) * | 2003-07-21 | 2014-01-28 | Lifecell Corporation | Acellular tissue matrices made from galactose .alpha.-1,3-galactose-deficient tissue |
| CA2958259C (en) * | 2004-10-22 | 2020-06-30 | Revivicor, Inc. | Ungulates with genetically modified immune systems |
| JP2006129736A (ja) * | 2004-11-02 | 2006-05-25 | Nippon Dobutsu Kogaku Kenkyusho:Kk | 異種移植用豚細胞、その選抜方法及び異種移植用豚 |
| US20060148080A1 (en) * | 2004-12-30 | 2006-07-06 | Paul Diamond | Methods for supporting and producing human cells and tissues in non-human mammal hosts |
| US20060147429A1 (en) * | 2004-12-30 | 2006-07-06 | Paul Diamond | Facilitated cellular reconstitution of organs and tissues |
| CN100404675C (zh) * | 2006-02-22 | 2008-07-23 | 李宁 | 一种生产体细胞克隆猪的方法 |
| CN101805402B (zh) * | 2007-06-28 | 2012-10-03 | 北京大学 | 抗阿片肽的一种活性片段 |
| CN101798338B (zh) * | 2007-06-28 | 2012-10-03 | 北京大学 | 一种抗阿片肽的拮抗肽与该拮抗肽的应用 |
| ES2680636T3 (es) | 2011-02-14 | 2018-09-10 | Revivicor Inc. | Cerdos genéticamente modificados para xenotrasplante de xenoinjertos vascularizados y derivados de los mismos |
| WO2014178485A1 (ko) | 2013-04-30 | 2014-11-06 | 건국대학교 산학협력단 | Ｃｍｐ-아세틸뉴라미닌산 히드록실라아제 타겟팅 벡터, 그 벡터가 도입된 이종간 이식용 형질전환 동물 및 그 제조방법 |
| WO2015066668A1 (en) | 2013-11-04 | 2015-05-07 | Lifecell Corporation | Methods of removing alpha-galactose |
| CN106172237B (zh) * | 2016-08-08 | 2019-05-10 | 贵州大学 | Ghr基因敲除纯合香猪的选育方法 |
| KR102176161B1 (ko) * | 2019-07-23 | 2020-11-09 | 주식회사 옵티팜 | 돼지 내인성 레트로바이러스 Envlope C 음성, GGTA1, CMAH, iGb3s, β4GalNT2 유전자가 넉아웃되고, 인간 CD46 및 TBM 유전자를 발현하는 이종장기이식을 위한 형질전환 복제돼지 및 이의 제조방법 |
| CN111955422A (zh) * | 2020-08-21 | 2020-11-20 | 五邑大学 | 一种可用于异种器官移植的供体猪的构建方法 |
| CN116411022B (zh) * | 2022-11-21 | 2024-06-21 | 华中农业大学 | 一种指示猪体细胞克隆胚胎基因组激活程度的载体及细胞 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0759170B1 (en) * | 1993-09-10 | 2008-07-09 | The Trustees Of Columbia University In The City Of New York | Uses of green fluorescent protein |
| US5576201A (en) * | 1994-01-14 | 1996-11-19 | Alexion Pharmaceuticals, Inc. | Retroviral vector particles for transducing non-proliferating cells |
| US6235969B1 (en) * | 1997-01-10 | 2001-05-22 | University Of Massachusetts | Cloning pigs using donor nuclei from non-quiescent differentiated cells |
| US6258998B1 (en) * | 1998-11-24 | 2001-07-10 | Infigen, Inc. | Method of cloning porcine animals |
| US6700037B2 (en) * | 1998-11-24 | 2004-03-02 | Infigen, Inc. | Method of cloning porcine animals |
| CN1304445A (zh) * | 1999-06-30 | 2001-07-18 | 黄禹锡 | 一种通过用种间核转移技术生产克隆虎的方法 |
| RU2205536C2 (ru) * | 1999-06-30 | 2003-06-10 | Воо-Сук ХВАНГ | Способ получения клонированной коровы |
| EP1241935A2 (en) * | 1999-12-17 | 2002-09-25 | Gerald Schatten | Methods for producing transgenic animals |
| AU2002332724A1 (en) * | 2001-08-30 | 2003-03-18 | Discoverx, Inc. | Genetic construct intracellular monitoring system |
| WO2003055302A1 (en) * | 2001-12-21 | 2003-07-10 | The Curators Of The University Of Missouri | Knockout swine and methods for making the same |
-
2001
- 2001-12-29 US US10/500,748 patent/US20050076399A1/en not_active Abandoned
- 2001-12-29 WO PCT/KR2001/002304 patent/WO2003089632A1/en not_active Ceased
- 2001-12-29 JP JP2003586344A patent/JP4153878B2/ja not_active Expired - Fee Related
- 2001-12-29 CA CA002472040A patent/CA2472040A1/en not_active Abandoned
- 2001-12-29 EP EP01275161A patent/EP1465986A4/en not_active Withdrawn
- 2001-12-29 CN CNA018239196A patent/CN1582332A/zh active Pending
- 2001-12-29 AU AU2002217606A patent/AU2002217606A1/en not_active Abandoned
-
2009
- 2009-10-14 US US12/579,032 patent/US20100115641A1/en not_active Abandoned
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