JP2005519048A5 - - Google Patents
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- JP2005519048A5 JP2005519048A5 JP2003556056A JP2003556056A JP2005519048A5 JP 2005519048 A5 JP2005519048 A5 JP 2005519048A5 JP 2003556056 A JP2003556056 A JP 2003556056A JP 2003556056 A JP2003556056 A JP 2003556056A JP 2005519048 A5 JP2005519048 A5 JP 2005519048A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- independently selected
- use according
- ring
- membered
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 229910052739 hydrogen Inorganic materials 0.000 claims 3
- 239000001257 hydrogen Substances 0.000 claims 3
- 229910052757 nitrogen Inorganic materials 0.000 claims 3
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 3
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 2
- 125000003118 aryl group Chemical group 0.000 claims 2
- 125000005842 heteroatom Chemical group 0.000 claims 2
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 claims 1
- 125000002373 5 membered heterocyclic group Chemical group 0.000 claims 1
- 125000004070 6 membered heterocyclic group Chemical group 0.000 claims 1
- 125000002723 alicyclic group Chemical group 0.000 claims 1
- 125000006615 aromatic heterocyclic group Chemical group 0.000 claims 1
- 125000004618 benzofuryl group Chemical group O1C(=CC2=C1C=CC=C2)* 0.000 claims 1
- 125000005874 benzothiadiazolyl group Chemical group 0.000 claims 1
- 125000004196 benzothienyl group Chemical group S1C(=CC2=C1C=CC=C2)* 0.000 claims 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims 1
- 125000002619 bicyclic group Chemical group 0.000 claims 1
- 125000004432 carbon atom Chemical group C* 0.000 claims 1
- 125000003016 chromanyl group Chemical group O1C(CCC2=CC=CC=C12)* 0.000 claims 1
- 125000004230 chromenyl group Chemical group O1C(C=CC2=CC=CC=C12)* 0.000 claims 1
- 150000001875 compounds Chemical class 0.000 claims 1
- 125000000753 cycloalkyl group Chemical group 0.000 claims 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 1
- 150000002431 hydrogen Chemical class 0.000 claims 1
- -1 imidazolisothiazolyl Chemical group 0.000 claims 1
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims 1
- 125000005956 isoquinolyl group Chemical group 0.000 claims 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 1
- 125000002950 monocyclic group Chemical group 0.000 claims 1
- 125000001624 naphthyl group Chemical group 0.000 claims 1
- 125000004593 naphthyridinyl group Chemical group N1=C(C=CC2=CC=CN=C12)* 0.000 claims 1
- 229910052760 oxygen Inorganic materials 0.000 claims 1
- 125000005493 quinolyl group Chemical group 0.000 claims 1
- 229910052717 sulfur Inorganic materials 0.000 claims 1
- 125000001544 thienyl group Chemical group 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0130696.8A GB0130696D0 (en) | 2001-12-21 | 2001-12-21 | Chemical Compounds |
| PCT/GB2002/005819 WO2003055478A1 (en) | 2001-12-21 | 2002-12-19 | Glyt1 transporter inhibitors and uses thereof in treatment of neurological and neuropsychiatric disorders |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2005519048A JP2005519048A (ja) | 2005-06-30 |
| JP2005519048A5 true JP2005519048A5 (cg-RX-API-DMAC10.html) | 2006-01-05 |
Family
ID=9928203
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003556056A Pending JP2005519048A (ja) | 2001-12-21 | 2002-12-19 | ＧｌｙＴ１トランスポーター阻害剤ならびに神経病学および神経精神病学的障害の治療におけるその使用 |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US20050267152A1 (cg-RX-API-DMAC10.html) |
| EP (1) | EP1455777B1 (cg-RX-API-DMAC10.html) |
| JP (1) | JP2005519048A (cg-RX-API-DMAC10.html) |
| AU (1) | AU2002352483A1 (cg-RX-API-DMAC10.html) |
| DE (1) | DE60223715T2 (cg-RX-API-DMAC10.html) |
| ES (1) | ES2297030T3 (cg-RX-API-DMAC10.html) |
| GB (1) | GB0130696D0 (cg-RX-API-DMAC10.html) |
| WO (1) | WO2003055478A1 (cg-RX-API-DMAC10.html) |
Families Citing this family (43)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0314479D0 (en) * | 2003-06-20 | 2003-07-23 | Glaxo Group Ltd | Compounds |
| GB0314478D0 (en) * | 2003-06-20 | 2003-07-23 | Glaxo Group Ltd | Compounds |
| EA009903B1 (ru) * | 2003-10-14 | 2008-04-28 | Пфайзер Продактс Инк. | Бициклические [3.1.0] производные в качестве ингибиторов переносчиков глицина |
| GB0326840D0 (en) * | 2003-11-18 | 2003-12-24 | Glaxo Group Ltd | Compounds |
| GB0329362D0 (en) * | 2003-12-18 | 2004-01-21 | Glaxo Group Ltd | Compounds |
| GB0408772D0 (en) * | 2004-04-20 | 2004-05-26 | Glaxo Group Ltd | Compounds |
| GB0408777D0 (en) * | 2004-04-20 | 2004-05-26 | Glaxo Group Ltd | Compounds |
| DE602005024838D1 (en) | 2004-09-30 | 2010-12-30 | Merck Sharp & Dohme | Cyclopropylpiperidinglycin-transporter-inhibitor |
| GB0428233D0 (en) * | 2004-12-23 | 2005-01-26 | Glaxo Group Ltd | Compounds |
| PE20061156A1 (es) * | 2004-12-23 | 2006-12-16 | Glaxo Group Ltd | Derivados de benzamida como agentes inhibidores del transportador de glicina |
| PE20061330A1 (es) * | 2004-12-23 | 2006-12-27 | Glaxo Group Ltd | Compuestos derivados de benzamida como inhibidores del transportador de glicina |
| GB0428232D0 (en) * | 2004-12-23 | 2005-01-26 | Glaxo Group Ltd | Compounds |
| JP2008525398A (ja) * | 2004-12-23 | 2008-07-17 | グラクソ グループ リミテッド | グリシン輸送阻害剤 |
| WO2007014762A2 (en) * | 2005-08-02 | 2007-02-08 | Glaxo Group Limited | Glyt1 transporter inhibitors and uses thereof in treatment of neurological and neuropsychiatric disorders |
| US20090062360A1 (en) | 2006-03-16 | 2009-03-05 | Steven Coulton | Compounds Which Inhibit the Glycine Transporter and Uses Thereof |
| GB0612425D0 (en) * | 2006-06-22 | 2006-08-02 | Glaxo Group Ltd | Compounds |
| GB0612420D0 (en) * | 2006-06-22 | 2006-08-02 | Glaxo Group Ltd | Compounds |
| CN101784533B (zh) * | 2007-08-22 | 2013-08-21 | 艾博特股份有限两合公司 | 4-苄基氨基喹啉、含有它们的药物组合物和它们在治疗中的用途 |
| EP2271625B1 (en) | 2008-04-01 | 2012-09-12 | Abbott GmbH & Co. KG | Tetrahydroisoquinolines, pharmaceutical compositions containing them, and their use in therapy |
| CA2726610C (en) * | 2008-06-05 | 2015-05-05 | Asahi Kasei Pharma Corporation | Sulfonamide compounds and use thereof |
| AR075442A1 (es) | 2009-02-16 | 2011-03-30 | Abbott Gmbh & Co Kg | Derivados de aminotetralina, composiciones farmaceuticas que las contienen y sus usos en terapia |
| TW201038569A (en) | 2009-02-16 | 2010-11-01 | Abbott Gmbh & Co Kg | Heterocyclic compounds, pharmaceutical compositions containing them, and their use in therapy |
| WO2011012622A1 (en) | 2009-07-30 | 2011-02-03 | Glaxo Group Limited | Benzoxazinone derivatives for the treatment of glytl mediated disorders |
| WO2011023753A1 (en) | 2009-08-27 | 2011-03-03 | Glaxo Group Limited | Benzoxazine derivatives as glycine transport inhibitors |
| CN101781244B (zh) * | 2010-02-10 | 2014-04-16 | 中国农业大学 | 化合物4-溴-n-(吡啶-2-甲基)萘-1-磺酰胺的制备方法 |
| US9051280B2 (en) | 2010-08-13 | 2015-06-09 | AbbVie Deutschland GmbH & Co. KG | Tetraline and indane derivatives, pharmaceutical compositions containing them, and their use in therapy |
| US9045459B2 (en) | 2010-08-13 | 2015-06-02 | AbbVie Deutschland GmbH & Co. KG | Phenalkylamine derivatives, pharmaceutical compositions containing them, and their use in therapy |
| US8883839B2 (en) | 2010-08-13 | 2014-11-11 | Abbott Laboratories | Tetraline and indane derivatives, pharmaceutical compositions containing them, and their use in therapy |
| US8877794B2 (en) | 2010-08-13 | 2014-11-04 | Abbott Laboratories | Phenalkylamine derivatives, pharmaceutical compositions containing them, and their use in therapy |
| US8846743B2 (en) | 2010-08-13 | 2014-09-30 | Abbott Laboratories | Aminoindane derivatives, pharmaceutical compositions containing them, and their use in therapy |
| US9309200B2 (en) | 2011-05-12 | 2016-04-12 | AbbVie Deutschland GmbH & Co. KG | Benzazepine derivatives, pharmaceutical compositions containing them, and their use in therapy |
| MX2014001457A (es) | 2011-08-05 | 2014-08-21 | Abbvie Deutschland | Derivados de aminocromano, de aminotiocromano y de amino-1,2,3,4-tetrahidroquinolina composiciones farmaceuticas que los contienen, y su uso en terapia. |
| WO2013072520A1 (en) | 2011-11-18 | 2013-05-23 | AbbVie Deutschland GmbH & Co. KG | N-substituted aminobenzocycloheptene, aminotetraline, aminoindane and phenalkylamine derivatives, pharmaceutical compositions containing them, and their use in therapy |
| US9365512B2 (en) | 2012-02-13 | 2016-06-14 | AbbVie Deutschland GmbH & Co. KG | Isoindoline derivatives, pharmaceutical compositions containing them, and their use in therapy |
| US9650334B2 (en) | 2013-03-15 | 2017-05-16 | Abbvie Inc. | Pyrrolidine derivatives, pharmaceutical compositions containing them, and their use in therapy |
| US9656955B2 (en) | 2013-03-15 | 2017-05-23 | Abbvie Inc. | Pyrrolidine derivatives, pharmaceutical compositions containing them, and their use in therapy |
| CA2924689A1 (en) | 2013-10-17 | 2015-04-23 | AbbVie Deutschland GmbH & Co. KG | Aminochromane, aminothiochromane and amino-1,2,3,4-tetrahydroquinoline derivatives, pharmaceutical compositions containing them, and their use in therapy |
| JP2016533375A (ja) | 2013-10-17 | 2016-10-27 | アッヴィ・ドイチュラント・ゲー・エム・ベー・ハー・ウント・コー・カー・ゲー | アミノテトラリン誘導体およびアミノインダン誘導体、これらを含有する医薬組成物、および治療におけるこれらの使用 |
| US9550754B2 (en) | 2014-09-11 | 2017-01-24 | AbbVie Deutschland GmbH & Co. KG | 4,5-dihydropyrazole derivatives, pharmaceutical compositions containing them, and their use in therapy |
| JP6858712B2 (ja) | 2015-01-30 | 2021-04-14 | リーバー インスティテュート フォー ブレイン ディベロップメントＬｉｅｂｅｒ Ｉｎｓｔｉｔｕｔｅ Ｆｏｒ Ｂｒａｉｎ Ｄｅｖｅｌｏｐｍｅｎｔ | Ｃｏｍｔ阻害方法及び組成物 |
| WO2017091818A1 (en) | 2015-11-25 | 2017-06-01 | Lieber Institute For Brain Development | Comt inhibiting methods and compositions |
| ES3010713T3 (en) * | 2018-12-18 | 2025-04-04 | D Western Therapeutics Inst Inc | Isoquinoline sulfonyl chloride acid addition salts and method of manufacture thereof |
| CN115989219B (zh) * | 2020-06-29 | 2026-02-13 | 贝凯恩生物医疗技术有限公司 | 用于治疗炎症小体介导的肺部疾病的丙磺舒化合物 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0076072B1 (en) * | 1981-09-24 | 1987-05-13 | BEECHAM - WUELFING GmbH & Co. KG | Sulphonamides |
| ZA9610745B (en) * | 1995-12-22 | 1997-06-24 | Warner Lambert Co | 4-Subsituted piperidine analogs and their use as subtype selective nmda receptor antagonists |
| WO1999023072A1 (en) * | 1997-10-31 | 1999-05-14 | Suntory Limited | Arylpiperidinopropanol and arylpiperazinopropanol derivatives and pharmaceuticals containing the same |
| AU2030999A (en) * | 1998-01-09 | 1999-07-26 | Allelix Neuroscience, Inc. | Glycine transport inhibitors |
-
2001
- 2001-12-21 GB GBGB0130696.8A patent/GB0130696D0/en not_active Ceased
-
2002
- 2002-12-19 JP JP2003556056A patent/JP2005519048A/ja active Pending
- 2002-12-19 AU AU2002352483A patent/AU2002352483A1/en not_active Abandoned
- 2002-12-19 US US10/499,621 patent/US20050267152A1/en not_active Abandoned
- 2002-12-19 WO PCT/GB2002/005819 patent/WO2003055478A1/en not_active Ceased
- 2002-12-19 ES ES02788198T patent/ES2297030T3/es not_active Expired - Lifetime
- 2002-12-19 DE DE60223715T patent/DE60223715T2/de not_active Expired - Fee Related
- 2002-12-19 EP EP02788198A patent/EP1455777B1/en not_active Expired - Lifetime
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