JP2005517452A - 短干渉核酸(siNA)を用いるBCL2遺伝子発現のRNA干渉媒介性阻害 - Google Patents
短干渉核酸(siNA)を用いるBCL2遺伝子発現のRNA干渉媒介性阻害 Download PDFInfo
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Applications Claiming Priority (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US35858002P | 2002-02-20 | 2002-02-20 | |
| US36312402P | 2002-03-11 | 2002-03-11 | |
| US38678202P | 2002-06-06 | 2002-06-06 | |
| US39690502P | 2002-07-18 | 2002-07-18 | |
| US40678402P | 2002-08-29 | 2002-08-29 | |
| US40837802P | 2002-09-05 | 2002-09-05 | |
| US40929302P | 2002-09-09 | 2002-09-09 | |
| US44012903P | 2003-01-15 | 2003-01-15 | |
| PCT/US2003/004908 WO2003070969A2 (en) | 2002-02-20 | 2003-02-18 | RNA INTERFERENCE MEDIATED INHIBITION OF BCL2 GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACID (siNA) |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2005517452A true JP2005517452A (ja) | 2005-06-16 |
| JP2005517452A5 JP2005517452A5 (enExample) | 2006-03-30 |
Family
ID=27761716
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003569860A Pending JP2005517452A (ja) | 2002-02-20 | 2003-02-18 | 短干渉核酸(siNA)を用いるBCL2遺伝子発現のRNA干渉媒介性阻害 |
Country Status (5)
| Country | Link |
|---|---|
| EP (1) | EP1442143A4 (enExample) |
| JP (1) | JP2005517452A (enExample) |
| AU (1) | AU2003213119A1 (enExample) |
| CA (1) | CA2463595A1 (enExample) |
| WO (1) | WO2003070969A2 (enExample) |
Cited By (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2009507918A (ja) * | 2005-09-12 | 2009-02-26 | ジ・オハイオ・ステイト・ユニバーシティ・リサーチ・ファウンデイション | Bcl2関連癌の診断及び療法のための組成物及び方法 |
| JP2010503414A (ja) * | 2006-09-15 | 2010-02-04 | エンゾン ファーマスーティカルズ インコーポレイテッド | 正に荷電した部分を含有するポリマー複合体 |
| WO2010021389A1 (ja) * | 2008-08-21 | 2010-02-25 | 協和発酵キリン株式会社 | Bcl-2蛋白質の発現を抑制する核酸 |
| JP2010510810A (ja) * | 2006-11-27 | 2010-04-08 | エンゾン ファーマスーティカルズ インコーポレイテッド | ポリマー低分子干渉rna複合体 |
| WO2013133221A1 (ja) * | 2012-03-04 | 2013-09-12 | 株式会社ボナック | microRNA阻害剤 |
| US8859202B2 (en) | 2012-01-20 | 2014-10-14 | The Ohio State University | Breast cancer biomarker signatures for invasiveness and prognosis |
| US8865885B2 (en) | 2006-03-20 | 2014-10-21 | The Ohio State University Research Foundation | MicroRNA fingerprints during human megakaryocytopoiesis |
| US8916533B2 (en) | 2009-11-23 | 2014-12-23 | The Ohio State University | Materials and methods useful for affecting tumor cell growth, migration and invasion |
| US8946187B2 (en) | 2010-11-12 | 2015-02-03 | The Ohio State University | Materials and methods related to microRNA-21, mismatch repair, and colorectal cancer |
| US9017939B2 (en) | 2006-01-05 | 2015-04-28 | The Ohio State University | Methods for diagnosing breast, colon, lung, pancreatic and prostate cancer using miR-21 and miR-17-5p |
| US9085804B2 (en) | 2007-08-03 | 2015-07-21 | The Ohio State University Research Foundation | Ultraconserved regions encoding ncRNAs |
| US9249468B2 (en) | 2011-10-14 | 2016-02-02 | The Ohio State University | Methods and materials related to ovarian cancer |
| US9481885B2 (en) | 2011-12-13 | 2016-11-01 | Ohio State Innovation Foundation | Methods and compositions related to miR-21 and miR-29a, exosome inhibition, and cancer metastasis |
| US10758619B2 (en) | 2010-11-15 | 2020-09-01 | The Ohio State University | Controlled release mucoadhesive systems |
| JPWO2020196736A1 (enExample) * | 2019-03-28 | 2020-10-01 |
Families Citing this family (47)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19956568A1 (de) | 1999-01-30 | 2000-08-17 | Roland Kreutzer | Verfahren und Medikament zur Hemmung der Expression eines vorgegebenen Gens |
| US7829693B2 (en) | 1999-11-24 | 2010-11-09 | Alnylam Pharmaceuticals, Inc. | Compositions and methods for inhibiting expression of a target gene |
| DE10100586C1 (de) | 2001-01-09 | 2002-04-11 | Ribopharma Ag | Verfahren zur Hemmung der Expression eines Ziegens |
| US8546143B2 (en) | 2001-01-09 | 2013-10-01 | Alnylam Pharmaceuticals, Inc. | Compositions and methods for inhibiting expression of a target gene |
| US7423142B2 (en) | 2001-01-09 | 2008-09-09 | Alnylam Pharmaceuticals, Inc. | Compositions and methods for inhibiting expression of anti-apoptotic genes |
| US7767802B2 (en) | 2001-01-09 | 2010-08-03 | Alnylam Pharmaceuticals, Inc. | Compositions and methods for inhibiting expression of anti-apoptotic genes |
| DE10163098B4 (de) | 2001-10-12 | 2005-06-02 | Alnylam Europe Ag | Verfahren zur Hemmung der Replikation von Viren |
| US7745418B2 (en) | 2001-10-12 | 2010-06-29 | Alnylam Pharmaceuticals, Inc. | Compositions and methods for inhibiting viral replication |
| FR2832154B1 (fr) | 2001-11-09 | 2007-03-16 | Centre Nat Rech Scient | Oligonucleotides inhibiteurs et leur utilisation pour reprimer specifiquement un gene |
| DE10202419A1 (de) | 2002-01-22 | 2003-08-07 | Ribopharma Ag | Verfahren zur Hemmung der Expression eines durch eine Chromosomen-Aberration entstandenen Zielgens |
| US9181551B2 (en) | 2002-02-20 | 2015-11-10 | Sirna Therapeutics, Inc. | RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (siNA) |
| US9657294B2 (en) | 2002-02-20 | 2017-05-23 | Sirna Therapeutics, Inc. | RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (siNA) |
| US9719092B2 (en) | 2002-11-14 | 2017-08-01 | Thermo Fisher Scientific Inc. | RNAi targeting CNTD2 |
| WO2006006948A2 (en) | 2002-11-14 | 2006-01-19 | Dharmacon, Inc. | METHODS AND COMPOSITIONS FOR SELECTING siRNA OF IMPROVED FUNCTIONALITY |
| US9771586B2 (en) | 2002-11-14 | 2017-09-26 | Thermo Fisher Scientific Inc. | RNAi targeting ZNF205 |
| US7951935B2 (en) | 2002-11-14 | 2011-05-31 | Dharmacon, Inc. | siRNA targeting v-myc myelocytomatosis viral oncogene homolog (MYC) |
| US7612196B2 (en) | 2002-11-14 | 2009-11-03 | Dharmacon, Inc. | siRNA targeting cyclin-dependent kinase inhibitor 1B (p27, Kip1) (CDKN1B) |
| US7691998B2 (en) | 2002-11-14 | 2010-04-06 | Dharmacon, Inc. | siRNA targeting nucleoporin 62kDa (Nup62) |
| EP1560931B1 (en) | 2002-11-14 | 2011-07-27 | Dharmacon, Inc. | Functional and hyperfunctional sirna |
| US10011836B2 (en) | 2002-11-14 | 2018-07-03 | Thermo Fisher Scientific Inc. | Methods and compositions for selecting siRNA of improved functionality |
| US7977471B2 (en) | 2002-11-14 | 2011-07-12 | Dharmacon, Inc. | siRNA targeting TNFα |
| US7619081B2 (en) | 2002-11-14 | 2009-11-17 | Dharmacon, Inc. | siRNA targeting coatomer protein complex, subunit beta 2 (COPB2) |
| US8198427B1 (en) | 2002-11-14 | 2012-06-12 | Dharmacon, Inc. | SiRNA targeting catenin, beta-1 (CTNNB1) |
| US9719094B2 (en) | 2002-11-14 | 2017-08-01 | Thermo Fisher Scientific Inc. | RNAi targeting SEC61G |
| US7635770B2 (en) | 2002-11-14 | 2009-12-22 | Dharmacon, Inc. | siRNA targeting protein kinase N-3 (PKN-3) |
| US9839649B2 (en) | 2002-11-14 | 2017-12-12 | Thermo Fisher Scientific Inc. | Methods and compositions for selecting siRNA of improved functionality |
| US7592442B2 (en) | 2002-11-14 | 2009-09-22 | Dharmacon, Inc. | siRNA targeting ribonucleotide reductase M2 polypeptide (RRM2 or RNR-R2) |
| US9228186B2 (en) | 2002-11-14 | 2016-01-05 | Thermo Fisher Scientific Inc. | Methods and compositions for selecting siRNA of improved functionality |
| US9879266B2 (en) | 2002-11-14 | 2018-01-30 | Thermo Fisher Scientific Inc. | Methods and compositions for selecting siRNA of improved functionality |
| GB0306148D0 (en) * | 2003-03-18 | 2003-04-23 | Milner Jo | Regulation of gene expression |
| EP2251039A3 (en) * | 2003-05-30 | 2010-12-08 | Nippon Shinyaku Co., Ltd. | Oligo double-stranded rna inhibiting the expression of bcl-2 and pharmaceutical composition containing the same |
| EP1706489B9 (en) | 2003-12-23 | 2011-01-05 | Santaris Pharma A/S | Oligomeric compounds for the modulation of bcl-2 |
| US20050244869A1 (en) | 2004-04-05 | 2005-11-03 | Brown-Driver Vickie L | Modulation of transthyretin expression |
| US7605250B2 (en) | 2004-05-12 | 2009-10-20 | Dharmacon, Inc. | siRNA targeting cAMP-specific phosphodiesterase 4D |
| WO2006035432A2 (en) * | 2004-09-27 | 2006-04-06 | Tel Hashomer Medical Research Infrastructure And Services Ltd. | Gene silencing for use in dermatology |
| US20100041140A1 (en) * | 2007-03-02 | 2010-02-18 | Mdrna, Inc. | Nucleic acid compounds for inhibiting bcl2 gene expression and uses thereof |
| WO2008124927A1 (en) * | 2007-04-13 | 2008-10-23 | Vincent Research & Consulting Inc. | Sirna against thymidylate synthase and uses thereof in cancer treatment regimens |
| WO2010006111A2 (en) * | 2008-07-10 | 2010-01-14 | Merck & Co., Inc. | Methods of using compositions comprising mir-192 and/or mir-215 for the treatment of cancer |
| GB2468477A (en) * | 2009-03-02 | 2010-09-15 | Mina Therapeutics Ltd | Double stranded RNA molecule comprising siRNA and miRNA precursors |
| MX343559B (es) | 2010-04-29 | 2016-11-10 | Ionis Pharmaceuticals Inc | Modulacion de la expresion de transtiretina. |
| EP2609198B8 (en) | 2010-08-24 | 2018-03-28 | Sirna Therapeutics, Inc. | SINGLE-STRANDED RNAi AGENTS CONTAINING AN INTERNAL, NON-NUCLEIC ACID SPACER |
| EP3327125B1 (en) | 2010-10-29 | 2020-08-05 | Sirna Therapeutics, Inc. | Rna interference mediated inhibition of gene expression using short interfering nucleic acids (sina) |
| WO2014054927A1 (ko) | 2012-10-05 | 2014-04-10 | (주)바이오니아 | 엠피레귤린 특이적 이중 나선 올리고 rna, 그러한 이중나선 올리고 rna를 포함하는 이중나선 올리고 rna 구조체 및 이를 포함하는 호흡기 질환의 예방 또는 치료용 조성물 |
| CN104884637A (zh) * | 2012-11-05 | 2015-09-02 | 普隆奈治疗公司 | 利用生物标志物通过bcl2表达的调节治疗癌症的方法 |
| EP3128008B1 (en) | 2014-04-04 | 2024-05-29 | Bioneer Corporation | Double-stranded oligo rna and pharmaceutical composition comprising same for preventing or treating fibrosis or respiratory diseases |
| KR101993377B1 (ko) * | 2017-07-20 | 2019-06-26 | (주)큐리진 | Bcl2 유전자 및 bi-1 유전자의 발현을 동시에 억제하는 핵산 |
| WO2020116537A1 (ja) * | 2018-12-05 | 2020-06-11 | 日東電工株式会社 | がん処置用RNAi分子 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5831066A (en) * | 1988-12-22 | 1998-11-03 | The Trustees Of The University Of Pennsylvania | Regulation of bcl-2 gene expression |
| US5877309A (en) * | 1997-08-13 | 1999-03-02 | Isis Pharmaceuticals, Inc. | Antisense oligonucleotides against JNK |
| DE19956568A1 (de) * | 1999-01-30 | 2000-08-17 | Roland Kreutzer | Verfahren und Medikament zur Hemmung der Expression eines vorgegebenen Gens |
| DE10100586C1 (de) * | 2001-01-09 | 2002-04-11 | Ribopharma Ag | Verfahren zur Hemmung der Expression eines Ziegens |
| US7662791B2 (en) * | 2000-08-02 | 2010-02-16 | University Of Southern California | Gene silencing using mRNA-cDNA hybrids |
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- 2003-02-18 WO PCT/US2003/004908 patent/WO2003070969A2/en not_active Ceased
- 2003-02-18 AU AU2003213119A patent/AU2003213119A1/en not_active Abandoned
- 2003-02-18 JP JP2003569860A patent/JP2005517452A/ja active Pending
- 2003-02-18 CA CA002463595A patent/CA2463595A1/en not_active Abandoned
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| JP2009507918A (ja) * | 2005-09-12 | 2009-02-26 | ジ・オハイオ・ステイト・ユニバーシティ・リサーチ・ファウンデイション | Bcl2関連癌の診断及び療法のための組成物及び方法 |
| US9017940B2 (en) | 2006-01-05 | 2015-04-28 | The Ohio State University | Methods for diagnosing colon cancer using MicroRNA signatures |
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| US8865885B2 (en) | 2006-03-20 | 2014-10-21 | The Ohio State University Research Foundation | MicroRNA fingerprints during human megakaryocytopoiesis |
| JP2010503414A (ja) * | 2006-09-15 | 2010-02-04 | エンゾン ファーマスーティカルズ インコーポレイテッド | 正に荷電した部分を含有するポリマー複合体 |
| JP2010510810A (ja) * | 2006-11-27 | 2010-04-08 | エンゾン ファーマスーティカルズ インコーポレイテッド | ポリマー低分子干渉rna複合体 |
| US9085804B2 (en) | 2007-08-03 | 2015-07-21 | The Ohio State University Research Foundation | Ultraconserved regions encoding ncRNAs |
| WO2010021389A1 (ja) * | 2008-08-21 | 2010-02-25 | 協和発酵キリン株式会社 | Bcl-2蛋白質の発現を抑制する核酸 |
| US8916533B2 (en) | 2009-11-23 | 2014-12-23 | The Ohio State University | Materials and methods useful for affecting tumor cell growth, migration and invasion |
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| US9404108B2 (en) | 2012-03-04 | 2016-08-02 | Bonac Corporation | Micro-RMA inhibitor |
| US10233446B2 (en) | 2012-03-04 | 2019-03-19 | Bonac Corporation | Micro-RNA inhibitor |
| JP5536963B2 (ja) * | 2012-03-04 | 2014-07-02 | 株式会社ボナック | microRNA阻害剤 |
| WO2013133221A1 (ja) * | 2012-03-04 | 2013-09-12 | 株式会社ボナック | microRNA阻害剤 |
| JPWO2020196736A1 (enExample) * | 2019-03-28 | 2020-10-01 | ||
| WO2020196736A1 (ja) * | 2019-03-28 | 2020-10-01 | 日東電工株式会社 | RNAi分子 |
Also Published As
| Publication number | Publication date |
|---|---|
| CA2463595A1 (en) | 2003-08-28 |
| EP1442143A2 (en) | 2004-08-04 |
| WO2003070969A2 (en) | 2003-08-28 |
| AU2003213119A1 (en) | 2003-09-09 |
| EP1442143A4 (en) | 2005-02-16 |
| WO2003070969A3 (en) | 2004-01-08 |
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