JP2005516604A - 131、148、199、12303、13906、15513、17822、302、5677、194、14393、28059、7366、12212、1981、261、12416、270、1410、137、1871、13051、1847、1849、15402、340、10217、837、1761、8990または13249分子を用いて血液障害を処置するための方法および組成物 - Google Patents

131、148、199、12303、13906、15513、17822、302、5677、194、14393、28059、7366、12212、1981、261、12416、270、1410、137、1871、13051、1847、1849、15402、340、10217、837、1761、8990または13249分子を用いて血液障害を処置するための方法および組成物 Download PDF

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Publication number
JP2005516604A
JP2005516604A JP2003565304A JP2003565304A JP2005516604A JP 2005516604 A JP2005516604 A JP 2005516604A JP 2003565304 A JP2003565304 A JP 2003565304A JP 2003565304 A JP2003565304 A JP 2003565304A JP 2005516604 A JP2005516604 A JP 2005516604A
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Prior art keywords
protein
gene
activity
expression
nucleic acid
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Pending
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JP2003565304A
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JP2005516604A5 (enExample
Inventor
ジョセフ エム. キャロル,
アイリーン ヒーリー,
ナディン エス. ウェイチ,
ルイーズ エム. ケリー,
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Millennium Pharmaceuticals Inc
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Millennium Pharmaceuticals Inc
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    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/94Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving narcotics or drugs or pharmaceuticals, neurotransmitters or associated receptors
    • G01N33/9406Neurotransmitters
    • G01N33/9413Dopamine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/12Drugs for disorders of the urinary system of the kidneys
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00Antiparasitic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/02Antineoplastic agents specific for leukemia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00General protective or antinoxious agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06Antianaemics
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/136Screening for pharmacological compounds
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/156Polymorphic or mutational markers
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/158Expression markers
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00Screening for compounds of potential therapeutic value
    • G01N2500/04Screening involving studying the effect of compounds C directly on molecule A (e.g. C are potential ligands for a receptor A, or potential substrates for an enzyme A)
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00Screening for compounds of potential therapeutic value
    • G01N2500/10Screening for compounds of potential therapeutic value involving cells

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Analytical Chemistry (AREA)
  • Immunology (AREA)
  • Urology & Nephrology (AREA)
  • Biotechnology (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • Wood Science & Technology (AREA)
  • Microbiology (AREA)
  • Diabetes (AREA)
  • Genetics & Genomics (AREA)
  • Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Biochemistry (AREA)
  • Cell Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Food Science & Technology (AREA)
  • General Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Oncology (AREA)
  • Toxicology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2003565304A 2002-02-04 2003-01-28 131、148、199、12303、13906、15513、17822、302、5677、194、14393、28059、7366、12212、1981、261、12416、270、1410、137、1871、13051、1847、1849、15402、340、10217、837、1761、8990または13249分子を用いて血液障害を処置するための方法および組成物 Pending JP2005516604A (ja)

Applications Claiming Priority (13)

Application Number Priority Date Filing Date Title
US35433302P 2002-02-04 2002-02-04
US36025802P 2002-02-28 2002-02-28
US36447602P 2002-03-15 2002-03-15
US37562602P 2002-04-26 2002-04-26
US38649402P 2002-06-06 2002-06-06
US39096502P 2002-06-24 2002-06-24
US39248002P 2002-06-28 2002-06-28
US39412802P 2002-07-03 2002-07-03
US39978302P 2002-07-31 2002-07-31
US40322102P 2002-08-13 2002-08-13
US40704502P 2002-08-30 2002-08-30
US42904802P 2002-11-25 2002-11-25
PCT/US2003/002484 WO2003065871A2 (en) 2002-02-04 2003-01-28 Methods and compositions for treating hematological disorders

Publications (2)

Publication Number Publication Date
JP2005516604A true JP2005516604A (ja) 2005-06-09
JP2005516604A5 JP2005516604A5 (enExample) 2006-03-09

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Family Applications (1)

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JP2003565304A Pending JP2005516604A (ja) 2002-02-04 2003-01-28 131、148、199、12303、13906、15513、17822、302、5677、194、14393、28059、7366、12212、1981、261、12416、270、1410、137、1871、13051、1847、1849、15402、340、10217、837、1761、8990または13249分子を用いて血液障害を処置するための方法および組成物

Country Status (5)

Country Link
US (1) US7250262B2 (enExample)
EP (1) EP1471818A4 (enExample)
JP (1) JP2005516604A (enExample)
AU (1) AU2003214920A1 (enExample)
WO (1) WO2003065871A2 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2012508185A (ja) * 2008-11-06 2012-04-05 インディアナ・ユニバーシティ・リサーチ・アンド・テクノロジー・コーポレーション 造血幹細胞の生着手順を強化するための材料および方法

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006010492A1 (en) * 2004-07-28 2006-02-02 Bayer Healthcare Ag Diagnostics and therapeutics for diseases associated with tryptase 1 (tps1)
US7947436B2 (en) 2004-12-13 2011-05-24 Alethia Biotherapeutics Inc. Polynucleotides and polypeptide sequences involved in the process of bone remodeling
WO2006066064A2 (en) * 2004-12-13 2006-06-22 Monell Chemical Senses Center A voltage-gated, ph-sensitive anion channel and its novel splice variant involved in taste sensation
UA114796C2 (uk) 2011-09-30 2017-08-10 Блубьод Байо, Інк. Спосіб підвищення ефективності трансдукції
RU2744603C2 (ru) 2016-02-12 2021-03-11 Блубёрд Био, Инк. Композиции, повышающие число копий вектора (чкв), и способы их применения
CN108883136A (zh) 2016-02-12 2018-11-23 蓝鸟生物公司 Vcn增强子组合物及其使用方法
CA3035203A1 (en) * 2016-08-31 2018-03-08 Rutgers, The State University Of New Jersey Methods and compositions for treating diseases and disorders of the nervous system

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5880260A (en) * 1988-11-18 1999-03-09 Oregon Health Sciences University Dopamine receptors and genes
DE19922443A1 (de) 1999-05-07 2000-11-09 Basf Ag Verwendung von Dopamin-D3-Rezeptorliganden zur Herstellung von Arzneimittel für die Behandlung von Nierenfunktionsstörungen
PL353035A1 (en) * 1999-07-14 2003-10-06 Novo Nordisk A/S Use of fviia or a tissue factor antagonist for regulating gene expression and cell migration or chemotaxis
WO2001027270A1 (en) * 1999-10-08 2001-04-19 Chugai Seiyaku Kabushiki Kaisha Gene ys68 concerning early hematopoiesis
JP2002000279A (ja) 1999-10-08 2002-01-08 Chugai Bunshi Igaku Kenkyusho:Kk 初期造血に関わるys68遺伝子
DE10102977A1 (de) 2001-01-23 2002-08-01 Thomas Jentsch Testsystem zur Entwicklung von Therapeutika, insbesondere von Wirkstoffen zur Behandlung von Osteoporose
US20030033625A1 (en) 2001-03-29 2003-02-13 Allen Keith D. Transgenic mice containing CLCN4 chloride ion channel gene disruptions
WO2003016475A2 (en) 2001-08-14 2003-02-27 The General Hospital Corporation Nucleic acid and amino acid sequences involved in pain

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2012508185A (ja) * 2008-11-06 2012-04-05 インディアナ・ユニバーシティ・リサーチ・アンド・テクノロジー・コーポレーション 造血幹細胞の生着手順を強化するための材料および方法

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Publication number Publication date
WO2003065871A3 (en) 2004-03-04
EP1471818A4 (en) 2007-03-28
US20030215452A1 (en) 2003-11-20
EP1471818A2 (en) 2004-11-03
AU2003214920A1 (en) 2003-09-02
WO2003065871A2 (en) 2003-08-14
AU2003214920A8 (en) 2003-09-02
US7250262B2 (en) 2007-07-31

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