JP2005515842A5 - - Google Patents
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- Publication number
- JP2005515842A5 JP2005515842A5 JP2003563601A JP2003563601A JP2005515842A5 JP 2005515842 A5 JP2005515842 A5 JP 2005515842A5 JP 2003563601 A JP2003563601 A JP 2003563601A JP 2003563601 A JP2003563601 A JP 2003563601A JP 2005515842 A5 JP2005515842 A5 JP 2005515842A5
- Authority
- JP
- Japan
- Prior art keywords
- belongs
- proton
- mobile
- cest
- compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000003446 ligand Substances 0.000 claims description 10
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 8
- 238000000034 method Methods 0.000 claims description 6
- 230000005298 paramagnetic effect Effects 0.000 claims description 6
- 125000003368 amide group Chemical group 0.000 claims description 5
- 150000001875 compounds Chemical class 0.000 claims description 4
- 229910052751 metal Inorganic materials 0.000 claims description 4
- 239000000126 substance Substances 0.000 claims description 4
- 239000002872 contrast media Substances 0.000 claims description 3
- 239000002184 metal Substances 0.000 claims description 3
- 210000000056 organ Anatomy 0.000 claims description 3
- 238000012307 MRI technique Methods 0.000 claims description 2
- 210000001124 body fluid Anatomy 0.000 claims description 2
- 239000010839 body fluid Substances 0.000 claims description 2
- 230000002596 correlated effect Effects 0.000 claims description 2
- 210000001519 tissue Anatomy 0.000 claims description 2
- 239000013522 chelant Substances 0.000 claims 2
- 229910021645 metal ion Inorganic materials 0.000 description 7
- 229910052757 nitrogen Inorganic materials 0.000 description 3
- IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Substances N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 3
- 125000004437 phosphorous atom Chemical group 0.000 description 3
- 229910052717 sulfur Inorganic materials 0.000 description 3
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical group [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 229910052760 oxygen Inorganic materials 0.000 description 2
- 239000001301 oxygen Chemical group 0.000 description 2
- 229910052698 phosphorus Inorganic materials 0.000 description 2
- 150000003839 salts Chemical class 0.000 description 2
- 239000011593 sulfur Chemical group 0.000 description 2
- 229910001428 transition metal ion Inorganic materials 0.000 description 2
- MYMOFIZGZYHOMD-UHFFFAOYSA-N Dioxygen Chemical compound O=O MYMOFIZGZYHOMD-UHFFFAOYSA-N 0.000 description 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
- 239000000539 dimer Substances 0.000 description 1
- 238000011835 investigation Methods 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 125000004433 nitrogen atom Chemical group N* 0.000 description 1
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 description 1
- 125000004430 oxygen atom Chemical group O* 0.000 description 1
- 230000005408 paramagnetism Effects 0.000 description 1
- 125000004434 sulfur atom Chemical group 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP02001178.9 | 2002-01-29 | ||
| EP20020001178 EP1331012A1 (en) | 2002-01-29 | 2002-01-29 | Responsive paramagnetic MRI contrast agents |
| PCT/EP2003/000796 WO2003063912A1 (en) | 2002-01-29 | 2003-01-27 | Responsive paramagnetic mri contrast agents |
Related Child Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009264106A Division JP4796643B2 (ja) | 2002-01-29 | 2009-11-19 | 応答性常磁性ｍｒｉ造影剤 |
| JP2011151981A Division JP2011235125A (ja) | 2002-01-29 | 2011-07-08 | 応答性常磁性ｍｒｉ造影剤 |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| JP2005515842A JP2005515842A (ja) | 2005-06-02 |
| JP2005515842A6 JP2005515842A6 (ja) | 2005-08-11 |
| JP2005515842A5 true JP2005515842A5 (https=) | 2006-03-16 |
| JP4850391B2 JP4850391B2 (ja) | 2012-01-11 |
Family
ID=8185284
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003563601A Expired - Fee Related JP4850391B2 (ja) | 2002-01-29 | 2003-01-27 | 応答性常磁性ｍｒｉ造影剤 |
| JP2009264106A Expired - Fee Related JP4796643B2 (ja) | 2002-01-29 | 2009-11-19 | 応答性常磁性ｍｒｉ造影剤 |
| JP2011151981A Withdrawn JP2011235125A (ja) | 2002-01-29 | 2011-07-08 | 応答性常磁性ｍｒｉ造影剤 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009264106A Expired - Fee Related JP4796643B2 (ja) | 2002-01-29 | 2009-11-19 | 応答性常磁性ｍｒｉ造影剤 |
| JP2011151981A Withdrawn JP2011235125A (ja) | 2002-01-29 | 2011-07-08 | 応答性常磁性ｍｒｉ造影剤 |
Country Status (6)
| Country | Link |
|---|---|
| US (2) | US7524483B2 (https=) |
| EP (3) | EP1331012A1 (https=) |
| JP (3) | JP4850391B2 (https=) |
| AT (1) | ATE519505T1 (https=) |
| DK (2) | DK1469890T3 (https=) |
| WO (1) | WO2003063912A1 (https=) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6963769B1 (en) * | 1999-04-21 | 2005-11-08 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Method for enhancing contrast produced by MRI |
| EP1331012A1 (en) * | 2002-01-29 | 2003-07-30 | BRACCO IMAGING S.p.A. | Responsive paramagnetic MRI contrast agents |
| EP1466629A1 (en) * | 2003-04-11 | 2004-10-13 | BRACCO IMAGING S.p.A. | Adducts between magnetic resonance shift reagents and substrates containing exchangeable protons for "CEST" applications |
| US20070292354A1 (en) * | 2004-09-23 | 2007-12-20 | Guerbet | Contrast Agents Encapsulating Systems for Cest Imaging |
| EP1881852B1 (en) | 2005-04-26 | 2009-08-19 | Koninklijke Philips Electronics N.V. | Mri contrast agents comprising cest active paramagnetic complex |
| US7917188B2 (en) | 2005-04-26 | 2011-03-29 | Koninklijke Philips Electronics N.V. | Method for using CEST contrast agents in MRI |
| CN101166988B (zh) * | 2005-04-26 | 2012-06-13 | 皇家飞利浦电子股份有限公司 | 改进对mri对比增强的检测的方法和设备 |
| US20060275217A1 (en) * | 2005-05-06 | 2006-12-07 | Caravan Peter D | Chemical exchange saturation transfer contrast agents |
| US7610077B2 (en) * | 2005-12-08 | 2009-10-27 | General Electric Compnay | Quantitation of sample properties using contrast enhancement from saturation transfer |
| US8003078B2 (en) * | 2006-03-29 | 2011-08-23 | Barnes-Jewish Hospital | Targeted MR imaging agents |
| RU2446829C2 (ru) * | 2006-06-09 | 2012-04-10 | Конинклейке Филипс Электроникс Н.В. | Устранение зависимости от концентрации контрастного агента в мрт |
| US8536866B2 (en) | 2007-09-26 | 2013-09-17 | The Johns Hopkins University | Frequency referencing for chemical exchange saturation transfer (CEST) MRI |
| EP2370447B1 (en) | 2008-12-02 | 2016-07-27 | The University of Melbourne | Nitrogen-containing macrocyclic conjugates as radiopharmaceuticals |
| WO2011071778A1 (en) | 2009-12-07 | 2011-06-16 | Mayo Foundation For Medical Education And Research | Device for the delineation of cardiovascular or other anatomical structures |
| EP2752677B1 (en) | 2010-01-06 | 2015-07-22 | Shiseido Company, Ltd. | Sample tube for NMR measurements |
| WO2012006038A2 (en) * | 2010-06-28 | 2012-01-12 | The Board Of Regents, The University Of Texas System | Agents and compounds for imaging and other applications, and methods of use and synthesis thereof |
| EP2457594A1 (en) | 2010-11-05 | 2012-05-30 | Bracco Imaging S.p.A | Cest systems exhibiting a concentration independent responsiveness |
| US9302019B2 (en) | 2011-05-11 | 2016-04-05 | The Research Foundation For The State University Of New York | Fe(II) sequestering agents and uses thereof |
| WO2013082656A1 (en) | 2011-12-06 | 2013-06-13 | The University Of Melbourne | Cage amine ligands for metallo-radiopharmaceuticals |
| US10551455B2 (en) | 2015-05-04 | 2020-02-04 | Duke University | Magnetic resonance imaging (MRI) systems and methods using adiabatic tip-down and matched adiabatic flip-back pulses |
| EP3394627B1 (en) * | 2015-12-23 | 2020-06-03 | Bracco Imaging S.p.A | Ratiometric pulsed cest imaging |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5190744A (en) * | 1990-03-09 | 1993-03-02 | Salutar | Methods for detecting blood perfusion variations by magnetic resonance imaging |
| DE69527194T2 (de) | 1994-03-28 | 2003-02-06 | Daiichi Pharmaceutical Co., Ltd. | Liposomen enthaltend ein röntgen- oder ultraschallkontrastmittel |
| JP3759765B2 (ja) * | 1994-03-28 | 2006-03-29 | 第一製薬株式会社 | リポソーム |
| US6963769B1 (en) * | 1999-04-21 | 2005-11-08 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Method for enhancing contrast produced by MRI |
| WO2002043775A2 (en) | 2000-11-20 | 2002-06-06 | GODFREY, Cullen, M. | Paramagnetic metal ion-based macrocyclic contrast agents |
| EP1302465A1 (en) | 2001-10-11 | 2003-04-16 | BRACCO IMAGING S.p.A. | Enhanced substrate imaging by reversible binding to a paramagnetic complex |
| EP1331012A1 (en) * | 2002-01-29 | 2003-07-30 | BRACCO IMAGING S.p.A. | Responsive paramagnetic MRI contrast agents |
-
2002
- 2002-01-29 EP EP20020001178 patent/EP1331012A1/en not_active Withdrawn
-
2003
- 2003-01-27 DK DK03702538.4T patent/DK1469890T3/da active
- 2003-01-27 US US10/502,701 patent/US7524483B2/en not_active Expired - Lifetime
- 2003-01-27 JP JP2003563601A patent/JP4850391B2/ja not_active Expired - Fee Related
- 2003-01-27 AT AT03702538T patent/ATE519505T1/de not_active IP Right Cessation
- 2003-01-27 EP EP10176761A patent/EP2298362B1/en not_active Expired - Lifetime
- 2003-01-27 DK DK10176761.4T patent/DK2298362T3/da active
- 2003-01-27 WO PCT/EP2003/000796 patent/WO2003063912A1/en not_active Ceased
- 2003-01-27 EP EP03702538A patent/EP1469890B1/en not_active Expired - Lifetime
-
2009
- 2009-04-03 US US12/418,155 patent/US8318134B2/en not_active Expired - Fee Related
- 2009-11-19 JP JP2009264106A patent/JP4796643B2/ja not_active Expired - Fee Related
-
2011
- 2011-07-08 JP JP2011151981A patent/JP2011235125A/ja not_active Withdrawn
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