JP2013542948A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2013542948A5 JP2013542948A5 JP2013537145A JP2013537145A JP2013542948A5 JP 2013542948 A5 JP2013542948 A5 JP 2013542948A5 JP 2013537145 A JP2013537145 A JP 2013537145A JP 2013537145 A JP2013537145 A JP 2013537145A JP 2013542948 A5 JP2013542948 A5 JP 2013542948A5
- Authority
- JP
- Japan
- Prior art keywords
- iii
- cest
- lanthanide
- complex
- ratiometric
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 229910052747 lanthanoid Inorganic materials 0.000 claims 11
- 150000002602 lanthanoids Chemical group 0.000 claims 11
- 150000001875 compounds Chemical class 0.000 claims 7
- 238000003384 imaging method Methods 0.000 claims 7
- 239000003795 chemical substances by application Substances 0.000 claims 5
- 241001465754 Metazoa Species 0.000 claims 4
- 210000001124 body fluid Anatomy 0.000 claims 3
- 239000010839 body fluid Substances 0.000 claims 3
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 3
- 239000013522 chelant Substances 0.000 claims 3
- 150000004697 chelate complex Chemical class 0.000 claims 3
- 239000000539 dimer Substances 0.000 claims 3
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 3
- 229910021645 metal ion Inorganic materials 0.000 claims 3
- 210000000056 organ Anatomy 0.000 claims 3
- 239000000126 substance Substances 0.000 claims 3
- LNBHUCHAFZUEGJ-UHFFFAOYSA-N europium(3+) Chemical compound [Eu+3] LNBHUCHAFZUEGJ-UHFFFAOYSA-N 0.000 claims 2
- 238000001727 in vivo Methods 0.000 claims 2
- 239000003446 ligand Substances 0.000 claims 2
- 230000000877 morphologic effect Effects 0.000 claims 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 2
- AWSFICBXMUKWSK-UHFFFAOYSA-N ytterbium(3+) Chemical compound [Yb+3] AWSFICBXMUKWSK-UHFFFAOYSA-N 0.000 claims 2
- 125000006273 (C1-C3) alkyl group Chemical group 0.000 claims 1
- JZNZSKXIEDHOBD-UHFFFAOYSA-N 2-[4,10-bis(carboxymethyl)-7-(1,3,4-trihydroxybutan-2-yl)-1,4,7,10-tetrazacyclododec-1-yl]acetic acid Chemical compound OCC(O)C(CO)N1CCN(CC(O)=O)CCN(CC(O)=O)CCN(CC(O)=O)CC1 JZNZSKXIEDHOBD-UHFFFAOYSA-N 0.000 claims 1
- 229910052692 Dysprosium Inorganic materials 0.000 claims 1
- 229910052691 Erbium Inorganic materials 0.000 claims 1
- 229910052693 Europium Inorganic materials 0.000 claims 1
- 229910052689 Holmium Inorganic materials 0.000 claims 1
- 238000012307 MRI technique Methods 0.000 claims 1
- 229910052777 Praseodymium Inorganic materials 0.000 claims 1
- 229910052771 Terbium Inorganic materials 0.000 claims 1
- 229910052775 Thulium Inorganic materials 0.000 claims 1
- 229910052769 Ytterbium Inorganic materials 0.000 claims 1
- 239000000654 additive Substances 0.000 claims 1
- 125000000217 alkyl group Chemical group 0.000 claims 1
- 239000000969 carrier Substances 0.000 claims 1
- 239000002872 contrast media Substances 0.000 claims 1
- KBQHZAAAGSGFKK-UHFFFAOYSA-N dysprosium atom Chemical compound [Dy] KBQHZAAAGSGFKK-UHFFFAOYSA-N 0.000 claims 1
- 230000000694 effects Effects 0.000 claims 1
- UYAHIZSMUZPPFV-UHFFFAOYSA-N erbium Chemical compound [Er] UYAHIZSMUZPPFV-UHFFFAOYSA-N 0.000 claims 1
- OGPBJKLSAFTDLK-UHFFFAOYSA-N europium atom Chemical compound [Eu] OGPBJKLSAFTDLK-UHFFFAOYSA-N 0.000 claims 1
- 125000005843 halogen group Chemical group 0.000 claims 1
- KJZYNXUDTRRSPN-UHFFFAOYSA-N holmium atom Chemical compound [Ho] KJZYNXUDTRRSPN-UHFFFAOYSA-N 0.000 claims 1
- 125000005113 hydroxyalkoxy group Chemical group 0.000 claims 1
- 150000002500 ions Chemical class 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- QEFYFXOXNSNQGX-UHFFFAOYSA-N neodymium atom Chemical compound [Nd] QEFYFXOXNSNQGX-UHFFFAOYSA-N 0.000 claims 1
- 230000005298 paramagnetic effect Effects 0.000 claims 1
- PUDIUYLPXJFUGB-UHFFFAOYSA-N praseodymium atom Chemical group [Pr] PUDIUYLPXJFUGB-UHFFFAOYSA-N 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 238000001228 spectrum Methods 0.000 claims 1
- GZCRRIHWUXGPOV-UHFFFAOYSA-N terbium atom Chemical compound [Tb] GZCRRIHWUXGPOV-UHFFFAOYSA-N 0.000 claims 1
- FRNOGLGSGLTDKL-UHFFFAOYSA-N thulium atom Chemical compound [Tm] FRNOGLGSGLTDKL-UHFFFAOYSA-N 0.000 claims 1
- 210000001519 tissue Anatomy 0.000 claims 1
- NAWDYIZEMPQZHO-UHFFFAOYSA-N ytterbium Chemical compound [Yb] NAWDYIZEMPQZHO-UHFFFAOYSA-N 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP10190161A EP2457594A1 (en) | 2010-11-05 | 2010-11-05 | Cest systems exhibiting a concentration independent responsiveness |
| EP10190161.9 | 2010-11-05 | ||
| PCT/EP2011/069406 WO2012059576A1 (en) | 2010-11-05 | 2011-11-04 | Cest systems exhibiting a concentration independent responsiveness |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016243189A Division JP6542748B2 (ja) | 2010-11-05 | 2016-12-15 | 濃度非依存応答性を示すｃｅｓｔシステム |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2013542948A JP2013542948A (ja) | 2013-11-28 |
| JP2013542948A5 true JP2013542948A5 (https=) | 2014-10-30 |
Family
ID=43530158
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013537145A Pending JP2013542948A (ja) | 2010-11-05 | 2011-11-04 | 濃度非依存応答性を示すｃｅｓｔシステム |
| JP2016243189A Expired - Fee Related JP6542748B2 (ja) | 2010-11-05 | 2016-12-15 | 濃度非依存応答性を示すｃｅｓｔシステム |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016243189A Expired - Fee Related JP6542748B2 (ja) | 2010-11-05 | 2016-12-15 | 濃度非依存応答性を示すｃｅｓｔシステム |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US10232060B2 (https=) |
| EP (2) | EP2457594A1 (https=) |
| JP (2) | JP2013542948A (https=) |
| KR (1) | KR20130138807A (https=) |
| CN (1) | CN103260652B (https=) |
| AU (1) | AU2011325112B2 (https=) |
| CA (1) | CA2816948C (https=) |
| IL (1) | IL226123A (https=) |
| MX (1) | MX349239B (https=) |
| RU (1) | RU2605823C2 (https=) |
| WO (1) | WO2012059576A1 (https=) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2014165719A1 (en) | 2013-04-05 | 2014-10-09 | The Trustees Of The University Of Pennsylvania | Non-invasive imaging of tissue redox state by mri |
| KR101653064B1 (ko) | 2014-12-26 | 2016-09-09 | 에스티팜 주식회사 | 가도부트롤의 제조방법 |
| WO2016123446A1 (en) * | 2015-01-30 | 2016-08-04 | The Johns Hopkins University | Label-free mr imaging of tumor malignancy |
| EP3101012A1 (en) | 2015-06-04 | 2016-12-07 | Bayer Pharma Aktiengesellschaft | New gadolinium chelate compounds for use in magnetic resonance imaging |
| LT3386954T (lt) * | 2015-12-10 | 2021-04-12 | Bracco Imaging Spa | Dimeriniai kontrastiniai agentai |
| JP6964583B2 (ja) * | 2015-12-23 | 2021-11-10 | ブラッコ・イメージング・ソシエタ・ペル・アチオニBracco Imaging S.P.A. | レシオメトリックパルスｃｅｓｔイメージング |
| RU2755181C2 (ru) | 2016-11-28 | 2021-09-14 | Байер Фарма Акциенгезельшафт | Новые хелатные соединения гадолиния с высокой релаксивностью для применения в магнитно-резонансной визуализации |
| FR3069245B1 (fr) * | 2017-07-21 | 2019-07-26 | Guerbet | Ligands macrocycliques lipophiles, leurs complexes ainsi que leurs utilisations medicales |
| CN108047151B (zh) * | 2018-01-03 | 2020-08-04 | 广州康瑞泰药业有限公司 | 一种高收率钆布醇的制备方法 |
| CN113164628A (zh) | 2018-11-23 | 2021-07-23 | 拜耳股份有限公司 | 造影介质制剂及其制备方法 |
| WO2020127154A1 (en) | 2018-12-18 | 2020-06-25 | Bracco Imaging Spa | Pharmaceutical compositions comprising gd-complexes and polyarylene additives |
| US20200397924A1 (en) * | 2019-01-28 | 2020-12-24 | Hubei Tianshu Pharmaceutical Co., Ltd | Preparation method of intermediate of gadolinium-based ionic contrast agent and use thereof |
| US12529739B2 (en) | 2022-07-26 | 2026-01-20 | Canon Medical Systems Corporation | pH calculating apparatus, magnetic resonance imaging apparatus, and pH calculating method |
| CN120609858A (zh) * | 2025-05-30 | 2025-09-09 | 中国科学院精密测量科学与技术创新研究院 | 镧系金属配合物作为31p cest高场造影剂在识别atp中的应用 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE4009119A1 (de) | 1990-03-19 | 1991-09-26 | Schering Ag | 1,4,7,10-tetraazacyclododecan-butyltriole, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische mittel |
| GB9504910D0 (en) | 1995-03-10 | 1995-04-26 | Nycomed Imaging As | Compounds |
| EP1178837A2 (en) | 1999-04-21 | 2002-02-13 | THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES | Method for enhancing contrast produced by mri |
| WO2002043775A2 (en) * | 2000-11-20 | 2002-06-06 | GODFREY, Cullen, M. | Paramagnetic metal ion-based macrocyclic contrast agents |
| EP1331012A1 (en) | 2002-01-29 | 2003-07-30 | BRACCO IMAGING S.p.A. | Responsive paramagnetic MRI contrast agents |
| EP1466629A1 (en) * | 2003-04-11 | 2004-10-13 | BRACCO IMAGING S.p.A. | Adducts between magnetic resonance shift reagents and substrates containing exchangeable protons for "CEST" applications |
| JP2008513533A (ja) * | 2004-09-23 | 2008-05-01 | ゲルベ | Ｃｅｓｔイメージング用の造影剤封入システム |
| US8463358B2 (en) * | 2006-06-09 | 2013-06-11 | Koninklijke Philips Electronics N.V. | Elimination of contrast agent concentration dependency in MRI |
| US20100247445A1 (en) * | 2007-12-07 | 2010-09-30 | Koninklijke Philips Electronics N.V. | Polymeric drug carrier for image-guided delivery |
| EP2067485A1 (en) * | 2007-12-07 | 2009-06-10 | Koninklijke Philips Electronics N.V. | Drug carrier providing MRI contrast enhancement |
-
2010
- 2010-11-05 EP EP10190161A patent/EP2457594A1/en not_active Withdrawn
-
2011
- 2011-11-04 KR KR1020137014354A patent/KR20130138807A/ko not_active Withdrawn
- 2011-11-04 MX MX2013004825A patent/MX349239B/es active IP Right Grant
- 2011-11-04 AU AU2011325112A patent/AU2011325112B2/en not_active Ceased
- 2011-11-04 RU RU2013125778/15A patent/RU2605823C2/ru active
- 2011-11-04 CA CA2816948A patent/CA2816948C/en active Active
- 2011-11-04 EP EP11778892.7A patent/EP2635311B1/en active Active
- 2011-11-04 US US13/879,083 patent/US10232060B2/en active Active
- 2011-11-04 JP JP2013537145A patent/JP2013542948A/ja active Pending
- 2011-11-04 WO PCT/EP2011/069406 patent/WO2012059576A1/en not_active Ceased
- 2011-11-04 CN CN201180053033.7A patent/CN103260652B/zh not_active Expired - Fee Related
-
2013
- 2013-05-02 IL IL226123A patent/IL226123A/en active IP Right Grant
-
2016
- 2016-12-15 JP JP2016243189A patent/JP6542748B2/ja not_active Expired - Fee Related
-
2019
- 2019-01-24 US US16/256,749 patent/US10328162B1/en active Active
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2013542948A5 (https=) | ||
| RU2013125778A (ru) | Cest-системы, проявляющие не зависящую от концентрации чувствительность | |
| ES2593127T3 (es) | Proceso para preparar una formulación farmacéutica de agentes de contraste | |
| JP2548436B2 (ja) | Ｎｍｒ−診断剤 | |
| JP2005515842A5 (https=) | ||
| CN1127040A (zh) | 增强图像反差的方法和组合物 | |
| SK4842000A3 (en) | Contrast-enhanced diagnostic imaging method for monitoring interventional therapies | |
| EP0806968A2 (en) | Diagnostic imaging contrast agents with extended blood retention | |
| JP6964583B2 (ja) | レシオメトリックパルスｃｅｓｔイメージング | |
| CN109641900B (zh) | 螯合化合物 | |
| BR112015026473B1 (pt) | composições farmacêuticas líquidas e processo de preparação das mesmas e meio de contraste para imagiologia médica | |
| Yu et al. | Multifunctional gold nanoparticles as smart nanovehicles with enhanced tumour-targeting abilities for intracellular pH mapping and in vivo MR/fluorescence imaging | |
| JP5563299B2 (ja) | リンパ系撮像方法 | |
| US9302019B2 (en) | Fe(II) sequestering agents and uses thereof | |
| Xiao et al. | A smart copper (II)-responsive binuclear gadolinium (III) complex-based magnetic resonance imaging contrast agent | |
| EP2564852A1 (en) | Anti-brain-tumor drug | |
| KR102441674B1 (ko) | 중수소화된 2-아미노-2-메틸프로피온산 및/또는 2-(n-메틸아미노)-2-메틸프로피온산을 포함하는, 종양성 질환의 자기공명진단을 위한 제제, 및 상기 제제를 이용한 진단방법 | |
| Pushparaj et al. | Development of novel dinuclear [Gd (III) DO3VA] complexes decorated with isovaleric acid as MRI contrast agents for tumor diagnosis | |
| ES2759316B2 (es) | Ligandos tetraazamacrociclicos y los correspondientes complejos de niquel utiles como agentes de contraste | |
| Harvey | Paramagnetic Probes for Magnetic Resonance | |
| EA044027B1 (ru) | Препарат для магнитно-резонансной диагностики онкологических заболеваний, содержащий дейтерированную 2-амино-2-метилпропионовую кислоту и/или 2-(n-метиламино)-2-метилпропионовую кислоту, и способ диагностики с использованием этого препарата | |
| CZ20001189A3 (cs) | Diagnostické činidlo pro monitorování intervenčních terapií |