RU2605823C2 - Cest-системы, проявляющие не зависящую от концентрации чувствительность - Google Patents
Cest-системы, проявляющие не зависящую от концентрации чувствительность Download PDFInfo
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- RU2605823C2 RU2605823C2 RU2013125778/15A RU2013125778A RU2605823C2 RU 2605823 C2 RU2605823 C2 RU 2605823C2 RU 2013125778/15 A RU2013125778/15 A RU 2013125778/15A RU 2013125778 A RU2013125778 A RU 2013125778A RU 2605823 C2 RU2605823 C2 RU 2605823C2
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- iii
- cest
- complex
- lanthanide
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Classifications
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- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
- A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
- A61K49/10—Organic compounds
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- A—HUMAN NECESSITIES
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- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
- A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
- A61K49/10—Organic compounds
- A61K49/101—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals
- A61K49/106—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals the complex-forming compound being cyclic, e.g. DOTA
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
- A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
- A61K49/10—Organic compounds
- A61K49/12—Macromolecular compounds
- A61K49/124—Macromolecular compounds dendrimers, dendrons, hyperbranched compounds
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- G—PHYSICS
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- G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
- G01R33/00—Arrangements or instruments for measuring magnetic variables
- G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
- G01R33/44—Arrangements or instruments for measuring magnetic variables involving magnetic resonance using nuclear magnetic resonance [NMR]
- G01R33/48—NMR imaging systems
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
- A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
- A61K49/10—Organic compounds
- A61K49/101—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
- A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
- A61K49/10—Organic compounds
- A61K49/101—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals
- A61K49/106—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals the complex-forming compound being cyclic, e.g. DOTA
- A61K49/108—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals the complex-forming compound being cyclic, e.g. DOTA the metal complex being Gd-DOTA
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
- G01R33/00—Arrangements or instruments for measuring magnetic variables
- G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
- G01R33/44—Arrangements or instruments for measuring magnetic variables involving magnetic resonance using nuclear magnetic resonance [NMR]
- G01R33/48—NMR imaging systems
- G01R33/54—Signal processing systems, e.g. using pulse sequences ; Generation or control of pulse sequences; Operator console
- G01R33/56—Image enhancement or correction, e.g. subtraction or averaging techniques, e.g. improvement of signal-to-noise ratio and resolution
- G01R33/5601—Image enhancement or correction, e.g. subtraction or averaging techniques, e.g. improvement of signal-to-noise ratio and resolution involving use of a contrast agent for contrast manipulation, e.g. a paramagnetic, super-paramagnetic, ferromagnetic or hyperpolarised contrast agent
Landscapes
- Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Physics & Mathematics (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
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- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Radiology & Medical Imaging (AREA)
- Chemical & Material Sciences (AREA)
- High Energy & Nuclear Physics (AREA)
- Condensed Matter Physics & Semiconductors (AREA)
- General Physics & Mathematics (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Magnetic Resonance Imaging Apparatus (AREA)
- Investigating Or Analyzing Non-Biological Materials By The Use Of Chemical Means (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP10190161A EP2457594A1 (en) | 2010-11-05 | 2010-11-05 | Cest systems exhibiting a concentration independent responsiveness |
| EP10190161.9 | 2010-11-05 | ||
| PCT/EP2011/069406 WO2012059576A1 (en) | 2010-11-05 | 2011-11-04 | Cest systems exhibiting a concentration independent responsiveness |
Publications (2)
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| RU2013125778A RU2013125778A (ru) | 2014-12-10 |
| RU2605823C2 true RU2605823C2 (ru) | 2016-12-27 |
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| RU2013125778/15A RU2605823C2 (ru) | 2010-11-05 | 2011-11-04 | Cest-системы, проявляющие не зависящую от концентрации чувствительность |
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| EP (2) | EP2457594A1 (https=) |
| JP (2) | JP2013542948A (https=) |
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| CN (1) | CN103260652B (https=) |
| AU (1) | AU2011325112B2 (https=) |
| CA (1) | CA2816948C (https=) |
| IL (1) | IL226123A (https=) |
| MX (1) | MX349239B (https=) |
| RU (1) | RU2605823C2 (https=) |
| WO (1) | WO2012059576A1 (https=) |
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| WO2014165719A1 (en) | 2013-04-05 | 2014-10-09 | The Trustees Of The University Of Pennsylvania | Non-invasive imaging of tissue redox state by mri |
| KR101653064B1 (ko) | 2014-12-26 | 2016-09-09 | 에스티팜 주식회사 | 가도부트롤의 제조방법 |
| WO2016123446A1 (en) * | 2015-01-30 | 2016-08-04 | The Johns Hopkins University | Label-free mr imaging of tumor malignancy |
| EP3101012A1 (en) | 2015-06-04 | 2016-12-07 | Bayer Pharma Aktiengesellschaft | New gadolinium chelate compounds for use in magnetic resonance imaging |
| LT3386954T (lt) * | 2015-12-10 | 2021-04-12 | Bracco Imaging Spa | Dimeriniai kontrastiniai agentai |
| JP6964583B2 (ja) * | 2015-12-23 | 2021-11-10 | ブラッコ・イメージング・ソシエタ・ペル・アチオニBracco Imaging S.P.A. | レシオメトリックパルスｃｅｓｔイメージング |
| RU2755181C2 (ru) | 2016-11-28 | 2021-09-14 | Байер Фарма Акциенгезельшафт | Новые хелатные соединения гадолиния с высокой релаксивностью для применения в магнитно-резонансной визуализации |
| FR3069245B1 (fr) * | 2017-07-21 | 2019-07-26 | Guerbet | Ligands macrocycliques lipophiles, leurs complexes ainsi que leurs utilisations medicales |
| CN108047151B (zh) * | 2018-01-03 | 2020-08-04 | 广州康瑞泰药业有限公司 | 一种高收率钆布醇的制备方法 |
| CN113164628A (zh) | 2018-11-23 | 2021-07-23 | 拜耳股份有限公司 | 造影介质制剂及其制备方法 |
| WO2020127154A1 (en) | 2018-12-18 | 2020-06-25 | Bracco Imaging Spa | Pharmaceutical compositions comprising gd-complexes and polyarylene additives |
| US20200397924A1 (en) * | 2019-01-28 | 2020-12-24 | Hubei Tianshu Pharmaceutical Co., Ltd | Preparation method of intermediate of gadolinium-based ionic contrast agent and use thereof |
| US12529739B2 (en) | 2022-07-26 | 2026-01-20 | Canon Medical Systems Corporation | pH calculating apparatus, magnetic resonance imaging apparatus, and pH calculating method |
| CN120609858A (zh) * | 2025-05-30 | 2025-09-09 | 中国科学院精密测量科学与技术创新研究院 | 镧系金属配合物作为31p cest高场造影剂在识别atp中的应用 |
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| DE4009119A1 (de) | 1990-03-19 | 1991-09-26 | Schering Ag | 1,4,7,10-tetraazacyclododecan-butyltriole, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische mittel |
| GB9504910D0 (en) | 1995-03-10 | 1995-04-26 | Nycomed Imaging As | Compounds |
| EP1178837A2 (en) | 1999-04-21 | 2002-02-13 | THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES | Method for enhancing contrast produced by mri |
| WO2002043775A2 (en) * | 2000-11-20 | 2002-06-06 | GODFREY, Cullen, M. | Paramagnetic metal ion-based macrocyclic contrast agents |
| EP1466629A1 (en) * | 2003-04-11 | 2004-10-13 | BRACCO IMAGING S.p.A. | Adducts between magnetic resonance shift reagents and substrates containing exchangeable protons for "CEST" applications |
| JP2008513533A (ja) * | 2004-09-23 | 2008-05-01 | ゲルベ | Ｃｅｓｔイメージング用の造影剤封入システム |
| US8463358B2 (en) * | 2006-06-09 | 2013-06-11 | Koninklijke Philips Electronics N.V. | Elimination of contrast agent concentration dependency in MRI |
| US20100247445A1 (en) * | 2007-12-07 | 2010-09-30 | Koninklijke Philips Electronics N.V. | Polymeric drug carrier for image-guided delivery |
| EP2067485A1 (en) * | 2007-12-07 | 2009-06-10 | Koninklijke Philips Electronics N.V. | Drug carrier providing MRI contrast enhancement |
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| KR20130138807A (ko) | 2013-12-19 |
| JP2013542948A (ja) | 2013-11-28 |
| JP2017078080A (ja) | 2017-04-27 |
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