ATE519505T1 - Reaktive paramagnetische kontrastmittel für magnetresonanzbildgebung - Google Patents

Reaktive paramagnetische kontrastmittel für magnetresonanzbildgebung

Info

Publication number
ATE519505T1
ATE519505T1 AT03702538T AT03702538T ATE519505T1 AT E519505 T1 ATE519505 T1 AT E519505T1 AT 03702538 T AT03702538 T AT 03702538T AT 03702538 T AT03702538 T AT 03702538T AT E519505 T1 ATE519505 T1 AT E519505T1
Authority
AT
Austria
Prior art keywords
magnetic resonance
resonance imaging
contrast agents
paramagnetic contrast
reactive
Prior art date
Application number
AT03702538T
Other languages
German (de)
English (en)
Inventor
Silvio Aime
Castelli Daniela Delli
Franco Fedeli
Enzo Terreno
Original Assignee
Bracco Imaging Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bracco Imaging Spa filed Critical Bracco Imaging Spa
Application granted granted Critical
Publication of ATE519505T1 publication Critical patent/ATE519505T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/0002—General or multifunctional contrast agents, e.g. chelated agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A61K49/101—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals
    • A61K49/106—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals the complex-forming compound being cyclic, e.g. DOTA

Landscapes

  • Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Radiology & Medical Imaging (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
AT03702538T 2002-01-29 2003-01-27 Reaktive paramagnetische kontrastmittel für magnetresonanzbildgebung ATE519505T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP20020001178 EP1331012A1 (en) 2002-01-29 2002-01-29 Responsive paramagnetic MRI contrast agents
PCT/EP2003/000796 WO2003063912A1 (en) 2002-01-29 2003-01-27 Responsive paramagnetic mri contrast agents

Publications (1)

Publication Number Publication Date
ATE519505T1 true ATE519505T1 (de) 2011-08-15

Family

ID=8185284

Family Applications (1)

Application Number Title Priority Date Filing Date
AT03702538T ATE519505T1 (de) 2002-01-29 2003-01-27 Reaktive paramagnetische kontrastmittel für magnetresonanzbildgebung

Country Status (6)

Country Link
US (2) US7524483B2 (https=)
EP (3) EP1331012A1 (https=)
JP (3) JP4850391B2 (https=)
AT (1) ATE519505T1 (https=)
DK (2) DK1469890T3 (https=)
WO (1) WO2003063912A1 (https=)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1178837A2 (en) 1999-04-21 2002-02-13 THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES Method for enhancing contrast produced by mri
EP1331012A1 (en) * 2002-01-29 2003-07-30 BRACCO IMAGING S.p.A. Responsive paramagnetic MRI contrast agents
EP1466629A1 (en) * 2003-04-11 2004-10-13 BRACCO IMAGING S.p.A. Adducts between magnetic resonance shift reagents and substrates containing exchangeable protons for "CEST" applications
JP2008513533A (ja) * 2004-09-23 2008-05-01 ゲルベ Ｃｅｓｔイメージング用の造影剤封入システム
WO2006114765A2 (en) * 2005-04-26 2006-11-02 Koninklijke Philips Electronics N.V. Mri involving contrast agent with time modulated contrast enhancement
JP5638752B2 (ja) 2005-04-26 2014-12-10 コーニンクレッカ フィリップス エヌ ヴェ Ｃｅｓｔ活性な常磁性の錯体を含むｍｒｉ造影剤
EP1889086B1 (en) * 2005-04-26 2010-01-13 Koninklijke Philips Electronics N.V. Method for using cest contrast agents in mri
WO2006121889A2 (en) * 2005-05-06 2006-11-16 Epix Pharmaceuticals, Inc. Chemical exchange saturation transfer contrast agents
US7610077B2 (en) * 2005-12-08 2009-10-27 General Electric Compnay Quantitation of sample properties using contrast enhancement from saturation transfer
WO2007115115A2 (en) * 2006-03-29 2007-10-11 Kereos, Inc. Targeted mr imaging agents
US8463358B2 (en) 2006-06-09 2013-06-11 Koninklijke Philips Electronics N.V. Elimination of contrast agent concentration dependency in MRI
US8536866B2 (en) 2007-09-26 2013-09-17 The Johns Hopkins University Frequency referencing for chemical exchange saturation transfer (CEST) MRI
US9701694B2 (en) 2008-12-02 2017-07-11 The University Of Melbourne Nitrogen-containing macrocyclic conjugates as radiopharmaceuticals
WO2011071778A1 (en) 2009-12-07 2011-06-16 Mayo Foundation For Medical Education And Research Device for the delineation of cardiovascular or other anatomical structures
WO2011083730A1 (ja) * 2010-01-06 2011-07-14 株式会社資生堂 Ｎｍｒ用の標準物質、ｎｍｒ用の試料管、ｎｍｒ用のキャピラリー、及び試料のｎｍｒを測定する方法
WO2012006038A2 (en) * 2010-06-28 2012-01-12 The Board Of Regents, The University Of Texas System Agents and compounds for imaging and other applications, and methods of use and synthesis thereof
EP2457594A1 (en) * 2010-11-05 2012-05-30 Bracco Imaging S.p.A Cest systems exhibiting a concentration independent responsiveness
WO2012155076A2 (en) * 2011-05-11 2012-11-15 The Research Foundation Of State University Of New York Imaging contrast agents and uses thereof
JP6047581B2 (ja) 2011-12-06 2016-12-21 ザ ユニバーシティ オブ メルボルン 金属放射性医薬品のためのケージアミン配位子
US10551455B2 (en) 2015-05-04 2020-02-04 Duke University Magnetic resonance imaging (MRI) systems and methods using adiabatic tip-down and matched adiabatic flip-back pulses
JP6964583B2 (ja) * 2015-12-23 2021-11-10 ブラッコ・イメージング・ソシエタ・ペル・アチオニBracco Imaging S.P.A. レシオメトリックパルスｃｅｓｔイメージング

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5190744A (en) * 1990-03-09 1993-03-02 Salutar Methods for detecting blood perfusion variations by magnetic resonance imaging
JP3759765B2 (ja) * 1994-03-28 2006-03-29 第一製薬株式会社 リポソーム
WO1995026205A1 (en) 1994-03-28 1995-10-05 Nycomed Imaging A/S Liposomes
EP1178837A2 (en) * 1999-04-21 2002-02-13 THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES Method for enhancing contrast produced by mri
WO2002043775A2 (en) * 2000-11-20 2002-06-06 GODFREY, Cullen, M. Paramagnetic metal ion-based macrocyclic contrast agents
EP1302465A1 (en) 2001-10-11 2003-04-16 BRACCO IMAGING S.p.A. Enhanced substrate imaging by reversible binding to a paramagnetic complex
EP1331012A1 (en) * 2002-01-29 2003-07-30 BRACCO IMAGING S.p.A. Responsive paramagnetic MRI contrast agents

Also Published As

Publication number Publication date
JP2010088901A (ja) 2010-04-22
EP2298362B1 (en) 2013-03-13
DK1469890T3 (da) 2011-11-14
JP4796643B2 (ja) 2011-10-19
WO2003063912A1 (en) 2003-08-07
US8318134B2 (en) 2012-11-27
JP2011235125A (ja) 2011-11-24
DK2298362T3 (da) 2013-06-10
US20050191243A1 (en) 2005-09-01
EP1469890B1 (en) 2011-08-10
EP1469890A1 (en) 2004-10-27
JP2005515842A (ja) 2005-06-02
EP1331012A1 (en) 2003-07-30
US20090234221A1 (en) 2009-09-17
US7524483B2 (en) 2009-04-28
JP4850391B2 (ja) 2012-01-11
EP2298362A1 (en) 2011-03-23

Similar Documents

Publication Publication Date Title
ATE519505T1 (de) Reaktive paramagnetische kontrastmittel für magnetresonanzbildgebung
SE9903185D0 (sv) Terapeutisk metod och anordning baserad på magnetism
ATE439866T1 (de) Kontrastmittel für die magnetresonanzbildgebung mit cest-aktivem paramagnetischem komplex
IL180896A0 (en) Method of tumour imaging
ATE460753T1 (de) Gewölbtes gehäuse für eine implantierbare medizinische vorrichtung
ATE552768T1 (de) Vorrichtung für in-vivo-verfahren
DE60223176D1 (de) Metallkomplexverbindungen
ATE295203T1 (de) Patientenpositionierungssystem für die radiotherapie
MXPA02011427A (es) Procedimiento para revestir dispositivos medicos utilizando dioxido de carbono supercritico.
AU2001256973A1 (en) Diffusion imaging of tissues
ATE269524T1 (de) Kühlgerät und verfahren zur verkeimungsindikation
PL366421A1 (pl) Koniugaty makrocyklicznych kompleksów metali z cząsteczkami biologicznymi i ich zastosowanie w wytwarzaniu środków dla diagnozy NMR, diagnostyki radiologicznej oraz radioterapii
DE60141233D1 (de) Messgerät für lebende Körper mit eingebauter Waage
WO2008017879A3 (en) Imaging magnet with illuminated bore
ATE452655T1 (de) Verwendung von l-polynukleotiden zur diagnostischen bilderzeugung
NO20062118L (no) Inhibitor kontrastmidler
IL109115A0 (en) Methods for measurement of nmr-detectable xenobiotic compounds
DE60207288D1 (de) Gewebespezifische fluoreszierende chelate
TW200712534A (en) Wireless device
WO2003084384A3 (en) Diagnosis of flavivirus infection
DE60332791D1 (de) NMR-Magnet für Lösungsanalyse und NMR-Gerät
DE60014064D1 (de) Einetenascin-c isoform als marker für neoplasmen
DE60026743D1 (de) Verwendung von kontrastmitteln zur herstellung eines diagnostischen mittels für die darm-lumenbildgebung
DK1411992T3 (da) Ioniske og ikke-ioniske, radiografiske kontrastmidler til anvendelse ved kombineret röntgenstråle- og kernemagnetisk resonansdiagnostik
WO2003086563A3 (en) Diabetes imaging probes

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties