JP4850391B2 - 応答性常磁性ｍｒｉ造影剤 - Google Patents

応答性常磁性ｍｒｉ造影剤 Download PDF

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Publication number
JP4850391B2
JP4850391B2 JP2003563601A JP2003563601A JP4850391B2 JP 4850391 B2 JP4850391 B2 JP 4850391B2 JP 2003563601 A JP2003563601 A JP 2003563601A JP 2003563601 A JP2003563601 A JP 2003563601A JP 4850391 B2 JP4850391 B2 JP 4850391B2
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iii
paramagnetic
proton
dotam
complex
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Japanese (ja)
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JP2005515842A5 (https=
JP2005515842A (ja
JP2005515842A6 (ja
Inventor
アイメ，シルヴィオ
デッリ・カステッリ，ダニエーラ
フェデリ，フランコ
テッレノ，エンツォ
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Bracco Imaging SpA
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Bracco Imaging SpA
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/0002—General or multifunctional contrast agents, e.g. chelated agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A61K49/101—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals
    • A61K49/106—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals the complex-forming compound being cyclic, e.g. DOTA

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  • Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Radiology & Medical Imaging (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
JP2003563601A 2002-01-29 2003-01-27 応答性常磁性ｍｒｉ造影剤 Expired - Fee Related JP4850391B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP20020001178 EP1331012A1 (en) 2002-01-29 2002-01-29 Responsive paramagnetic MRI contrast agents
EP02001178.9 2002-01-29
PCT/EP2003/000796 WO2003063912A1 (en) 2002-01-29 2003-01-27 Responsive paramagnetic mri contrast agents

Related Child Applications (2)

Application Number Title Priority Date Filing Date
JP2009264106A Division JP4796643B2 (ja) 2002-01-29 2009-11-19 応答性常磁性ｍｒｉ造影剤
JP2011151981A Division JP2011235125A (ja) 2002-01-29 2011-07-08 応答性常磁性ｍｒｉ造影剤

Publications (4)

Publication Number Publication Date
JP2005515842A JP2005515842A (ja) 2005-06-02
JP2005515842A6 JP2005515842A6 (ja) 2005-08-11
JP2005515842A5 JP2005515842A5 (https=) 2006-03-16
JP4850391B2 true JP4850391B2 (ja) 2012-01-11

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ID=8185284

Family Applications (3)

Application Number Title Priority Date Filing Date
JP2003563601A Expired - Fee Related JP4850391B2 (ja) 2002-01-29 2003-01-27 応答性常磁性ｍｒｉ造影剤
JP2009264106A Expired - Fee Related JP4796643B2 (ja) 2002-01-29 2009-11-19 応答性常磁性ｍｒｉ造影剤
JP2011151981A Withdrawn JP2011235125A (ja) 2002-01-29 2011-07-08 応答性常磁性ｍｒｉ造影剤

Family Applications After (2)

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JP2009264106A Expired - Fee Related JP4796643B2 (ja) 2002-01-29 2009-11-19 応答性常磁性ｍｒｉ造影剤
JP2011151981A Withdrawn JP2011235125A (ja) 2002-01-29 2011-07-08 応答性常磁性ｍｒｉ造影剤

Country Status (6)

Country Link
US (2) US7524483B2 (https=)
EP (3) EP1331012A1 (https=)
JP (3) JP4850391B2 (https=)
AT (1) ATE519505T1 (https=)
DK (2) DK1469890T3 (https=)
WO (1) WO2003063912A1 (https=)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1178837A2 (en) 1999-04-21 2002-02-13 THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES Method for enhancing contrast produced by mri
EP1331012A1 (en) * 2002-01-29 2003-07-30 BRACCO IMAGING S.p.A. Responsive paramagnetic MRI contrast agents
EP1466629A1 (en) * 2003-04-11 2004-10-13 BRACCO IMAGING S.p.A. Adducts between magnetic resonance shift reagents and substrates containing exchangeable protons for "CEST" applications
JP2008513533A (ja) * 2004-09-23 2008-05-01 ゲルベ Ｃｅｓｔイメージング用の造影剤封入システム
WO2006114765A2 (en) * 2005-04-26 2006-11-02 Koninklijke Philips Electronics N.V. Mri involving contrast agent with time modulated contrast enhancement
JP5638752B2 (ja) 2005-04-26 2014-12-10 コーニンクレッカ フィリップス エヌ ヴェ Ｃｅｓｔ活性な常磁性の錯体を含むｍｒｉ造影剤
EP1889086B1 (en) * 2005-04-26 2010-01-13 Koninklijke Philips Electronics N.V. Method for using cest contrast agents in mri
WO2006121889A2 (en) * 2005-05-06 2006-11-16 Epix Pharmaceuticals, Inc. Chemical exchange saturation transfer contrast agents
US7610077B2 (en) * 2005-12-08 2009-10-27 General Electric Compnay Quantitation of sample properties using contrast enhancement from saturation transfer
WO2007115115A2 (en) * 2006-03-29 2007-10-11 Kereos, Inc. Targeted mr imaging agents
US8463358B2 (en) 2006-06-09 2013-06-11 Koninklijke Philips Electronics N.V. Elimination of contrast agent concentration dependency in MRI
US8536866B2 (en) 2007-09-26 2013-09-17 The Johns Hopkins University Frequency referencing for chemical exchange saturation transfer (CEST) MRI
US9701694B2 (en) 2008-12-02 2017-07-11 The University Of Melbourne Nitrogen-containing macrocyclic conjugates as radiopharmaceuticals
WO2011071778A1 (en) 2009-12-07 2011-06-16 Mayo Foundation For Medical Education And Research Device for the delineation of cardiovascular or other anatomical structures
WO2011083730A1 (ja) * 2010-01-06 2011-07-14 株式会社資生堂 Ｎｍｒ用の標準物質、ｎｍｒ用の試料管、ｎｍｒ用のキャピラリー、及び試料のｎｍｒを測定する方法
WO2012006038A2 (en) * 2010-06-28 2012-01-12 The Board Of Regents, The University Of Texas System Agents and compounds for imaging and other applications, and methods of use and synthesis thereof
EP2457594A1 (en) * 2010-11-05 2012-05-30 Bracco Imaging S.p.A Cest systems exhibiting a concentration independent responsiveness
WO2012155076A2 (en) * 2011-05-11 2012-11-15 The Research Foundation Of State University Of New York Imaging contrast agents and uses thereof
JP6047581B2 (ja) 2011-12-06 2016-12-21 ザ ユニバーシティ オブ メルボルン 金属放射性医薬品のためのケージアミン配位子
US10551455B2 (en) 2015-05-04 2020-02-04 Duke University Magnetic resonance imaging (MRI) systems and methods using adiabatic tip-down and matched adiabatic flip-back pulses
JP6964583B2 (ja) * 2015-12-23 2021-11-10 ブラッコ・イメージング・ソシエタ・ペル・アチオニBracco Imaging S.P.A. レシオメトリックパルスｃｅｓｔイメージング

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5190744A (en) * 1990-03-09 1993-03-02 Salutar Methods for detecting blood perfusion variations by magnetic resonance imaging
JPH07316079A (ja) * 1994-03-28 1995-12-05 Dai Ichi Seiyaku Co Ltd リポソーム
WO2000066180A2 (en) * 1999-04-21 2000-11-09 The Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services, The National Institutes Of Health Method for enhancing contrast produced by mri
JP2010088901A (ja) * 2002-01-29 2010-04-22 Bracco Imaging Spa 応答性常磁性ｍｒｉ造影剤

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995026205A1 (en) 1994-03-28 1995-10-05 Nycomed Imaging A/S Liposomes
WO2002043775A2 (en) * 2000-11-20 2002-06-06 GODFREY, Cullen, M. Paramagnetic metal ion-based macrocyclic contrast agents
EP1302465A1 (en) 2001-10-11 2003-04-16 BRACCO IMAGING S.p.A. Enhanced substrate imaging by reversible binding to a paramagnetic complex

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5190744A (en) * 1990-03-09 1993-03-02 Salutar Methods for detecting blood perfusion variations by magnetic resonance imaging
JPH07316079A (ja) * 1994-03-28 1995-12-05 Dai Ichi Seiyaku Co Ltd リポソーム
WO2000066180A2 (en) * 1999-04-21 2000-11-09 The Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services, The National Institutes Of Health Method for enhancing contrast produced by mri
JP2010088901A (ja) * 2002-01-29 2010-04-22 Bracco Imaging Spa 応答性常磁性ｍｒｉ造影剤

Also Published As

Publication number Publication date
JP2010088901A (ja) 2010-04-22
EP2298362B1 (en) 2013-03-13
DK1469890T3 (da) 2011-11-14
JP4796643B2 (ja) 2011-10-19
WO2003063912A1 (en) 2003-08-07
US8318134B2 (en) 2012-11-27
JP2011235125A (ja) 2011-11-24
DK2298362T3 (da) 2013-06-10
US20050191243A1 (en) 2005-09-01
EP1469890B1 (en) 2011-08-10
EP1469890A1 (en) 2004-10-27
JP2005515842A (ja) 2005-06-02
EP1331012A1 (en) 2003-07-30
US20090234221A1 (en) 2009-09-17
US7524483B2 (en) 2009-04-28
EP2298362A1 (en) 2011-03-23
ATE519505T1 (de) 2011-08-15

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