JP2005513111A - 消化管の特定部分に物質を統制送達(adirecteddelivery)するための微生物の使用 - Google Patents
消化管の特定部分に物質を統制送達(adirecteddelivery)するための微生物の使用 Download PDFInfo
- Publication number
- JP2005513111A JP2005513111A JP2003554230A JP2003554230A JP2005513111A JP 2005513111 A JP2005513111 A JP 2005513111A JP 2003554230 A JP2003554230 A JP 2003554230A JP 2003554230 A JP2003554230 A JP 2003554230A JP 2005513111 A JP2005513111 A JP 2005513111A
- Authority
- JP
- Japan
- Prior art keywords
- microorganism
- microorganisms
- substance
- gastrointestinal tract
- use according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/42—Proteins; Polypeptides; Degradation products thereof; Derivatives thereof, e.g. albumin, gelatin or zein
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
- A61K47/6901—Conjugates being cells, cell fragments, viruses, ghosts, red blood cells or viral vectors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/66—Microorganisms or materials therefrom
- A61K35/74—Bacteria
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Abstract
Description
Claims (15)
- 宿主に有益な物質を、胃腸管の特定の部分に送達するための微生物の使用であって、前記微生物が前記物質を消化管の所定の位置に放出する状態にある、微生物の使用。
- 前記微生物が、前記化合物を送達する胃腸管の前記特定の部分で支配的な環境条件に感受性である、請求項1に記載の上記使用。
- 前記微生物が、前記化合物を送達する胃腸管の前記部分で支配的な特定の環境条件で死滅するように前処理されている、請求項2に記載の上記使用。
- 前記微生物を、高温、低温、様々なpH値、ファージに曝露すること、タンパク質、炭水化物、脂質若しくは任意の他の有機及び無機物質によってカプセル被包すること、特定の発酵条件に供すること、或いは細菌性SOS応答を作動させること、又は調節レベル若しくは遺伝子発現レベルで損傷した細胞内タンパク質を修復する内因性保護的ストレス応答系を不活性化させることによって、前処理する、請求項3に記載の上記使用。
- 前記微生物が、乳酸桿菌(Lactobacillus)、ビフィズス菌(Bifidobacterium)、連鎖球菌(Streptococci)、ペジオコッカス(Pediococcus)、腸球菌(Enterococcus)、ラクトコッカス(Lactococcus)、オエノコッカス(Oenococcus)、ブドウ球菌(Staphylococci)、バクテロイド、又はそれらの混合物からなる群から選択される、前記請求項のいずれかに記載の上記使用。
- 前記微生物がプロバイオティックである、前記請求項のいずれかに記載の上記使用。
- 前記微生物が、前記宿主に有益な少なくとも1種の物質を産生する1つ又は複数の遺伝子を保有している改変した微生物である、前記請求項のいずれかに記載の上記使用。
- 前記宿主に有益な少なくとも1種の物質を産生する前記1つ又は複数の遺伝子が、その発現がより多くなるよう改変されている、或いは前記1つ又は複数の遺伝子が外来源から前記微生物中に導入されている、請求項7に記載の上記使用。
- 前記微生物が、胃、十二指腸、空腸、回腸又は大腸で死滅する、前記請求項のいずれかに記載の上記使用。
- 前記送達する物質が、ペプチド、ペプトン、タンパク質、単糖、二糖、複合糖質又は脂質からなる群から選択される、前記請求項のいずれかに記載の上記使用。
- 前記宿主に有益な物質をその胃腸管の特定の部分に送達するのに使用する微生物を含む、摂食可能な製品。
- 薬剤、生薬又は食品である、請求項11に記載の前記摂食可能な製品。
- 乳、ヨーグルト、カード、チーズ、発酵乳、乳ベースの発酵製品、アイスクリーム、発酵穀類ベースの製品、乳ベースの粉末、特殊調製粉末、ペットフード、錠剤、細菌懸濁液、ドライ経口サプリメント、ウェット経口サプリメント、ドライ経管栄養又はウェット経管栄養からなる群から選択される、請求項12に記載の上記製品。
- 前記宿主に有益な物質を含む微生物を用意し、
任意選択で、目的の1種又は複数の物質を消化管の前記選択された部分に送達することを確保するのに適切な方法で前記微生物を前処理し、
前記微生物を適切な担体中に含有させる
ことを含む、前記請求項11から13までのいずれか一項に記載の摂食可能な製品を調製する方法。 - 前記1種又は複数の微生物を消化する個体の健康を支援し、かつ/又は疾病を治療及び/若しくは予防するための、前記宿主に有益な物質をその前記胃腸管の特定の部分に送達する能力を有する微生物の使用。
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP01129563A EP1319410A1 (en) | 2001-12-11 | 2001-12-11 | Use of micro-organisms for a directed delivery of substances to specific parts of the gut |
PCT/EP2002/013244 WO2003053474A2 (en) | 2001-12-11 | 2002-11-25 | Use of micro-organisms for a directed delivery of substances to specific parts of the gut |
Publications (2)
Publication Number | Publication Date |
---|---|
JP2005513111A true JP2005513111A (ja) | 2005-05-12 |
JP2005513111A5 JP2005513111A5 (ja) | 2006-02-02 |
Family
ID=8179510
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2003554230A Pending JP2005513111A (ja) | 2001-12-11 | 2002-11-25 | 消化管の特定部分に物質を統制送達(adirecteddelivery)するための微生物の使用 |
Country Status (16)
Country | Link |
---|---|
US (1) | US20050084479A1 (ja) |
EP (2) | EP1319410A1 (ja) |
JP (1) | JP2005513111A (ja) |
KR (1) | KR20040063942A (ja) |
CN (1) | CN100450550C (ja) |
AU (1) | AU2002352135A1 (ja) |
BR (1) | BR0214835A (ja) |
CA (1) | CA2469894A1 (ja) |
IL (1) | IL161658A0 (ja) |
MX (1) | MXPA04005346A (ja) |
NO (1) | NO20042152L (ja) |
NZ (1) | NZ533376A (ja) |
PL (1) | PL370439A1 (ja) |
RU (1) | RU2311929C2 (ja) |
WO (1) | WO2003053474A2 (ja) |
ZA (1) | ZA200405453B (ja) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2011526486A (ja) * | 2008-07-03 | 2011-10-13 | ネステク ソシエテ アノニム | 微生物による胃腸管への栄養素の温度誘導送達 |
Families Citing this family (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2004001020A2 (en) * | 2002-06-19 | 2003-12-31 | Vlaams Interuniversitair Instituut Voor Biotechnologie Vzw | Methods and means to promote gut absorption |
US8871266B2 (en) * | 2003-10-01 | 2014-10-28 | Commonwealth Scientific & Industrial Research Organisation | Probiotic storage and delivery |
US8877178B2 (en) | 2003-12-19 | 2014-11-04 | The Iams Company | Methods of use of probiotic bifidobacteria for companion animals |
US20050158294A1 (en) | 2003-12-19 | 2005-07-21 | The Procter & Gamble Company | Canine probiotic Bifidobacteria pseudolongum |
DK1880001T3 (da) | 2005-05-31 | 2011-09-12 | Iams Company | Feline probiotiske lactobacilli |
CA2607949C (en) | 2005-05-31 | 2012-09-25 | Thomas William-Maxwell Boileau | Feline probiotic bifidobacteria |
JP5410759B2 (ja) | 2005-11-29 | 2014-02-05 | アクトジェニックス・エヌブイ | 抗原に対する粘膜寛容の誘導 |
EP2774621B1 (en) | 2007-01-25 | 2018-01-24 | Intrexon Actobiotics NV | Treatment of immune disease by mucosal delivery of antigens |
AU2008211600B8 (en) | 2007-02-01 | 2014-02-13 | Mars, Incorporated | Method for decreasing inflammation and stress in a mammal using glucose antimetabolites, avocado or avocado extracts |
US9771199B2 (en) * | 2008-07-07 | 2017-09-26 | Mars, Incorporated | Probiotic supplement, process for making, and packaging |
WO2010002241A1 (en) * | 2008-06-30 | 2010-01-07 | N.V. Nutricia | Nutritional composition for infants delivered via caesarean section |
US9232813B2 (en) * | 2008-07-07 | 2016-01-12 | The Iams Company | Probiotic supplement, process for making, and packaging |
US10104903B2 (en) | 2009-07-31 | 2018-10-23 | Mars, Incorporated | Animal food and its appearance |
HUE039577T2 (hu) * | 2011-06-01 | 2019-01-28 | Intrexon Actobiotics Nv | Policisztronos expressziós rendszer baktériumokhoz |
KR102219239B1 (ko) * | 2018-12-12 | 2021-02-24 | 피부생명공학센터 주식회사 | 레스베라트롤이 세포내에 축적되어 있는 미생물 제제 및 이의 제조방법 |
CN113403375A (zh) * | 2021-02-20 | 2021-09-17 | 北京金则医学检验实验室有限公司 | 一种用于预测儿童肥胖症的组合物及其应用 |
Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH11504049A (ja) * | 1996-02-14 | 1999-04-06 | ザ、プロクター、エンド、ギャンブル、カンパニー | ツツジ科の植物種より由来する物質および乳酸バクテリア成長因子を含む泌尿生殖器および腸の疾患用の組成物 |
JPH11506451A (ja) * | 1995-06-02 | 1999-06-08 | ラフォー・ラボラトリーズ・リミテッド | 医学的利用のためのマイクロカプセル封入されたラクトバシルス |
JPH11199495A (ja) * | 1998-01-10 | 1999-07-27 | Nichinichi Seiyaku Kk | 腸溶性カプセルを用いた抗アレルギー剤 |
JPH11302158A (ja) * | 1998-04-16 | 1999-11-02 | Oruto Corporation:Kk | 腸溶性シームカプセルを用いた整腸作用を有する健康食品 |
WO2001021200A1 (en) * | 1999-09-17 | 2001-03-29 | Nederlandse Organisatie Voor Toegepast-Natuurwetenschappelijk Onderzoek Tno | Oral recombinant lactobacilli vaccines |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5830463A (en) * | 1993-07-07 | 1998-11-03 | University Technology Corporation | Yeast-based delivery vehicles |
CN1153002A (zh) * | 1995-12-29 | 1997-07-02 | 中国科学院上海细胞生物学研究所 | 抗人体消化道病原微生物免疫牛奶 |
CN1121817C (zh) * | 1996-02-28 | 2003-09-24 | 中国科学院上海细胞生物学研究所 | 抗人体消化道病原微生物免疫乳制品 |
AT406166B (de) * | 1997-12-30 | 2000-03-27 | Erber Erich Kg | Mikroorganismus, verfahren zur gewinnung desselben sowie futtermittelzusatz |
US6368591B2 (en) * | 1998-05-15 | 2002-04-09 | Shanghai Sine Pharmaceutical Corporation Ltd. | Beneficial microbe composition, new protective materials for the microbes, method to prepare the same and uses thereof |
US6713073B1 (en) * | 1998-07-24 | 2004-03-30 | Megan Health, Inc. | Method of vaccination of newly hatched poultry |
JP2004514424A (ja) * | 2000-09-25 | 2004-05-20 | ソシエテ デ プロデユイ ネツスル ソシエテ アノニム | アレルギー反応を起こす個人の傾向を減少させることができる乳酸菌 |
CA2607949C (en) * | 2005-05-31 | 2012-09-25 | Thomas William-Maxwell Boileau | Feline probiotic bifidobacteria |
-
2001
- 2001-12-11 EP EP01129563A patent/EP1319410A1/en not_active Withdrawn
-
2002
- 2002-11-25 WO PCT/EP2002/013244 patent/WO2003053474A2/en active Application Filing
- 2002-11-25 AU AU2002352135A patent/AU2002352135A1/en not_active Abandoned
- 2002-11-25 MX MXPA04005346A patent/MXPA04005346A/es unknown
- 2002-11-25 BR BR0214835-8A patent/BR0214835A/pt not_active IP Right Cessation
- 2002-11-25 CN CNB028240162A patent/CN100450550C/zh not_active Expired - Fee Related
- 2002-11-25 KR KR10-2004-7008820A patent/KR20040063942A/ko not_active Application Discontinuation
- 2002-11-25 IL IL16165802A patent/IL161658A0/xx unknown
- 2002-11-25 EP EP02787808A patent/EP1455836A2/en not_active Withdrawn
- 2002-11-25 RU RU2004121169/15A patent/RU2311929C2/ru not_active IP Right Cessation
- 2002-11-25 JP JP2003554230A patent/JP2005513111A/ja active Pending
- 2002-11-25 NZ NZ533376A patent/NZ533376A/en unknown
- 2002-11-25 CA CA002469894A patent/CA2469894A1/en not_active Abandoned
- 2002-11-25 PL PL02370439A patent/PL370439A1/xx not_active Application Discontinuation
- 2002-11-25 US US10/497,923 patent/US20050084479A1/en not_active Abandoned
-
2004
- 2004-05-25 NO NO20042152A patent/NO20042152L/no not_active Application Discontinuation
- 2004-07-08 ZA ZA200405453A patent/ZA200405453B/en unknown
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH11506451A (ja) * | 1995-06-02 | 1999-06-08 | ラフォー・ラボラトリーズ・リミテッド | 医学的利用のためのマイクロカプセル封入されたラクトバシルス |
JPH11504049A (ja) * | 1996-02-14 | 1999-04-06 | ザ、プロクター、エンド、ギャンブル、カンパニー | ツツジ科の植物種より由来する物質および乳酸バクテリア成長因子を含む泌尿生殖器および腸の疾患用の組成物 |
JPH11199495A (ja) * | 1998-01-10 | 1999-07-27 | Nichinichi Seiyaku Kk | 腸溶性カプセルを用いた抗アレルギー剤 |
JPH11302158A (ja) * | 1998-04-16 | 1999-11-02 | Oruto Corporation:Kk | 腸溶性シームカプセルを用いた整腸作用を有する健康食品 |
WO2001021200A1 (en) * | 1999-09-17 | 2001-03-29 | Nederlandse Organisatie Voor Toegepast-Natuurwetenschappelijk Onderzoek Tno | Oral recombinant lactobacilli vaccines |
Non-Patent Citations (7)
Title |
---|
JPN5004005635, WELLS J M, ANTONIE VAN LEEUWENHOEK, 199610, V70 N2−4, P317−330, NL * |
JPN5004005636, GEOFFROY MARIE−CLAUDE, APPLIED AND ENVIRONMENTAL MICROBIOLOGY, 200001, V66 N1, P383−391 * |
JPN5004005638, SINGH JAGVEER, CARCINOGENESIS, 1997, V18 N4, P833−841, GB * |
JPN5004005639, FORESTIER CHRISTIANE, RESEARCH IN MICROBIOLOGY, 200103, V152 N2, P167−173, NL * |
JPN5004005640, MURPHY L, MICROBIAL ECOLOGY IN HEALTH & DISEASE, 1999, V11, P149−157, GB * |
JPN5004005641, O’SULLIVAN D J, INTERNATIONAL DAIRY JOURNAL, 1998, V8, P513−525, GB, ELSEVIER APPLIED SCIENCE * |
JPN5004005642, CHARTERIS W P, JOURNAL OF APPLIED MICROBIOLOGY, 199805, V84 N5, P759−768, GB * |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2011526486A (ja) * | 2008-07-03 | 2011-10-13 | ネステク ソシエテ アノニム | 微生物による胃腸管への栄養素の温度誘導送達 |
Also Published As
Publication number | Publication date |
---|---|
EP1455836A2 (en) | 2004-09-15 |
CN100450550C (zh) | 2009-01-14 |
WO2003053474A3 (en) | 2004-02-19 |
KR20040063942A (ko) | 2004-07-14 |
RU2004121169A (ru) | 2005-06-10 |
US20050084479A1 (en) | 2005-04-21 |
EP1319410A1 (en) | 2003-06-18 |
WO2003053474A2 (en) | 2003-07-03 |
NZ533376A (en) | 2006-05-26 |
PL370439A1 (en) | 2005-05-30 |
CN1599626A (zh) | 2005-03-23 |
RU2311929C2 (ru) | 2007-12-10 |
IL161658A0 (en) | 2004-09-27 |
NO20042152L (no) | 2004-09-08 |
MXPA04005346A (es) | 2004-09-27 |
ZA200405453B (en) | 2005-07-08 |
AU2002352135A1 (en) | 2003-07-09 |
CA2469894A1 (en) | 2003-07-03 |
BR0214835A (pt) | 2004-11-03 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
US11911516B2 (en) | Protection of microbial cells from acidic degradation | |
Islam et al. | Microencapsulation of live probiotic bacteria | |
KR101370143B1 (ko) | 프로바이오틱 저장 및 전달 | |
CN100469869C (zh) | 一种肠道益生菌包埋保护方法 | |
CN100360658C (zh) | 肠道微生态制剂及其制备方法 | |
US8496923B2 (en) | Probiotic treatment for infectious gastrointestinal diseases | |
Todorov et al. | Bacteriocin production and resistance to drugs are advantageous features for Lactobacillus acidophilus La-14, a potential probiotic strain | |
JP2005513111A (ja) | 消化管の特定部分に物質を統制送達(adirecteddelivery)するための微生物の使用 | |
US20060008511A1 (en) | Probiotic products for pet applications | |
AU2012210575A1 (en) | Protection of microbial cells from acidic degradation | |
Brashears et al. | Lactic acid bacteria and their uses in animal feeding to improve food safety | |
CN112877233B (zh) | 一种瑞士乳杆菌菌株及其应用 | |
CA2466022A1 (en) | Probiotic compositions | |
US20220151929A1 (en) | Drug and small molecule delivery via microbial vesicles | |
US20130115328A1 (en) | Microencapsulated probiotics for reducing fecal shedding of pathogenic microbes in animals | |
Mukhammadiev et al. | Survival of probiotic strains of microorganisms under imitating digestion in the stomach and intestines of farm animals | |
O'Sullivan et al. | Bifidobacteria and siderophores produced thereby and methods of use | |
Huyghebaert | Development of an oral formulation of viable, recombinant Lactococcus lactis and F4 fimbriae | |
Kailasapathy et al. | Recent trends in the role of micro encapsulation in the development of bio-functional foods | |
Huyghebaert | FACULTY OF PHARMACEUTICAL SCIENCES | |
PANDEY | Encapsulation of Probiotic Organisms Isolated from Fermented Food (Koozh) |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20051125 |
|
A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20051206 |
|
RD03 | Notification of appointment of power of attorney |
Free format text: JAPANESE INTERMEDIATE CODE: A7423 Effective date: 20061110 |
|
RD05 | Notification of revocation of power of attorney |
Free format text: JAPANESE INTERMEDIATE CODE: A7425 Effective date: 20070314 |
|
A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20090714 |
|
A601 | Written request for extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A601 Effective date: 20091009 |
|
A602 | Written permission of extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A602 Effective date: 20091019 |
|
A601 | Written request for extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A601 Effective date: 20091116 |
|
A602 | Written permission of extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A602 Effective date: 20091124 |
|
A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20091214 |
|
A02 | Decision of refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A02 Effective date: 20101026 |