JP2005512976A5 - - Google Patents
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- JP2005512976A5 JP2005512976A5 JP2003537650A JP2003537650A JP2005512976A5 JP 2005512976 A5 JP2005512976 A5 JP 2005512976A5 JP 2003537650 A JP2003537650 A JP 2003537650A JP 2003537650 A JP2003537650 A JP 2003537650A JP 2005512976 A5 JP2005512976 A5 JP 2005512976A5
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- JP
- Japan
- Prior art keywords
- dsrna
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- nucleotides
- Prior art date
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- 108091032973 (ribonucleotides)n+m Proteins 0.000 claims description 16
- 102000040650 (ribonucleotides)n+m Human genes 0.000 claims description 9
- 239000003814 drug Substances 0.000 claims 22
- 239000002773 nucleotide Substances 0.000 claims 21
- 125000003729 nucleotide group Chemical group 0.000 claims 21
- 108090000623 proteins and genes Proteins 0.000 claims 21
- 230000000295 complement effect Effects 0.000 claims 13
- 230000015572 biosynthetic process Effects 0.000 claims 8
- 108010050808 Procollagen Proteins 0.000 claims 6
- 201000010099 disease Diseases 0.000 claims 6
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 6
- 230000003176 fibrotic effect Effects 0.000 claims 6
- 238000001802 infusion Methods 0.000 claims 4
- 238000002347 injection Methods 0.000 claims 4
- 239000007924 injection Substances 0.000 claims 4
- 102000008490 2-Oxoglutarate 5-Dioxygenase Procollagen-Lysine Human genes 0.000 claims 3
- 108010020504 2-Oxoglutarate 5-Dioxygenase Procollagen-Lysine Proteins 0.000 claims 3
- RZVAJINKPMORJF-UHFFFAOYSA-N Acetaminophen Chemical compound CC(=O)NC1=CC=C(O)C=C1 RZVAJINKPMORJF-UHFFFAOYSA-N 0.000 claims 3
- 102100031168 CCN family member 2 Human genes 0.000 claims 3
- 108010037362 Extracellular Matrix Proteins Proteins 0.000 claims 3
- 102000010834 Extracellular Matrix Proteins Human genes 0.000 claims 3
- 101000777550 Homo sapiens CCN family member 2 Proteins 0.000 claims 3
- 108091034117 Oligonucleotide Proteins 0.000 claims 3
- 108090000630 Oncostatin M Proteins 0.000 claims 3
- 102000004140 Oncostatin M Human genes 0.000 claims 3
- 108010003894 Protein-Lysine 6-Oxidase Proteins 0.000 claims 3
- 102000004669 Protein-Lysine 6-Oxidase Human genes 0.000 claims 3
- 238000012228 RNA interference-mediated gene silencing Methods 0.000 claims 3
- 108091005735 TGF-beta receptors Proteins 0.000 claims 3
- 102000016715 Transforming Growth Factor beta Receptors Human genes 0.000 claims 3
- 102000014172 Transforming Growth Factor-beta Type I Receptor Human genes 0.000 claims 3
- 108010011702 Transforming Growth Factor-beta Type I Receptor Proteins 0.000 claims 3
- 102000004060 Transforming Growth Factor-beta Type II Receptor Human genes 0.000 claims 3
- 108010082684 Transforming Growth Factor-beta Type II Receptor Proteins 0.000 claims 3
- 208000019425 cirrhosis of liver Diseases 0.000 claims 3
- 229940079593 drug Drugs 0.000 claims 3
- 210000002744 extracellular matrix Anatomy 0.000 claims 3
- 238000009472 formulation Methods 0.000 claims 3
- 230000009368 gene silencing by RNA Effects 0.000 claims 3
- 239000000203 mixture Substances 0.000 claims 3
- 208000005069 pulmonary fibrosis Diseases 0.000 claims 3
- 229920002477 rna polymer Polymers 0.000 claims 3
- 230000036573 scar formation Effects 0.000 claims 3
- 239000002904 solvent Substances 0.000 claims 3
- ZRKFYGHZFMAOKI-QMGMOQQFSA-N tgfbeta Chemical compound C([C@H](NC(=O)[C@H](C(C)C)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)CCSC)C(C)C)[C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](C)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N1[C@@H](CCC1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(O)=O)C1=CC=C(O)C=C1 ZRKFYGHZFMAOKI-QMGMOQQFSA-N 0.000 claims 3
- 206010023421 Kidney fibrosis Diseases 0.000 claims 2
- 230000037396 body weight Effects 0.000 claims 2
- 230000035876 healing Effects 0.000 claims 2
- 210000003734 kidney Anatomy 0.000 claims 2
- 231100000241 scar Toxicity 0.000 claims 2
- 210000001519 tissue Anatomy 0.000 claims 2
- 108010035532 Collagen Proteins 0.000 claims 1
- 102000008186 Collagen Human genes 0.000 claims 1
- 102000004079 Prolyl Hydroxylases Human genes 0.000 claims 1
- 108010043005 Prolyl Hydroxylases Proteins 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 229920001436 collagen Polymers 0.000 claims 1
- 230000002401 inhibitory effect Effects 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 201000002793 renal fibrosis Diseases 0.000 claims 1
- 101100505328 Colletotrichum trifolii CTG1 gene Proteins 0.000 description 2
- 108020004566 Transfer RNA Proteins 0.000 description 1
- 102000015736 beta 2-Microglobulin Human genes 0.000 description 1
- 108010081355 beta 2-Microglobulin Proteins 0.000 description 1
- 238000001890 transfection Methods 0.000 description 1
Applications Claiming Priority (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10155280 | 2001-10-26 | ||
| DE10158411 | 2001-11-29 | ||
| DE10160151A DE10160151A1 (de) | 2001-01-09 | 2001-12-07 | Verfahren zur Hemmung der Expression eines vorgegebenen Zielgens |
| PCT/EP2002/000152 WO2002055693A2 (de) | 2001-01-09 | 2002-01-09 | Verfahren zur hemmung der expression eines zielgens |
| PCT/EP2002/000151 WO2002055692A2 (de) | 2001-01-09 | 2002-01-09 | Verfahren zur hemmung der expression eines zielgens und medikament zur therapie einer tumorerkrankung |
| PCT/EP2002/011972 WO2003035083A1 (de) | 2001-10-26 | 2002-10-25 | Medikament zur behandlung einer fibrotischen erkrankung durch rna interferenz |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2005512976A JP2005512976A (ja) | 2005-05-12 |
| JP2005512976A5 true JP2005512976A5 (enExample) | 2006-03-09 |
Family
ID=39189390
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003537650A Pending JP2005512976A (ja) | 2001-10-26 | 2002-10-25 | Ｒｎａ干渉により線維化疾患を処置するための医薬 |
Country Status (4)
| Country | Link |
|---|---|
| US (1) | US20080070856A1 (enExample) |
| JP (1) | JP2005512976A (enExample) |
| CN (1) | CN1604783A (enExample) |
| WO (2) | WO2003035083A1 (enExample) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9340786B2 (en) | 2010-03-24 | 2016-05-17 | Rxi Pharmaceuticals Corporation | RNA interference in dermal and fibrotic indications |
Families Citing this family (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19956568A1 (de) | 1999-01-30 | 2000-08-17 | Roland Kreutzer | Verfahren und Medikament zur Hemmung der Expression eines vorgegebenen Gens |
| US7829693B2 (en) | 1999-11-24 | 2010-11-09 | Alnylam Pharmaceuticals, Inc. | Compositions and methods for inhibiting expression of a target gene |
| DE10100586C1 (de) | 2001-01-09 | 2002-04-11 | Ribopharma Ag | Verfahren zur Hemmung der Expression eines Ziegens |
| US7767802B2 (en) | 2001-01-09 | 2010-08-03 | Alnylam Pharmaceuticals, Inc. | Compositions and methods for inhibiting expression of anti-apoptotic genes |
| US8546143B2 (en) | 2001-01-09 | 2013-10-01 | Alnylam Pharmaceuticals, Inc. | Compositions and methods for inhibiting expression of a target gene |
| US7423142B2 (en) | 2001-01-09 | 2008-09-09 | Alnylam Pharmaceuticals, Inc. | Compositions and methods for inhibiting expression of anti-apoptotic genes |
| DE10163098B4 (de) | 2001-10-12 | 2005-06-02 | Alnylam Europe Ag | Verfahren zur Hemmung der Replikation von Viren |
| US7745418B2 (en) | 2001-10-12 | 2010-06-29 | Alnylam Pharmaceuticals, Inc. | Compositions and methods for inhibiting viral replication |
| DE10202419A1 (de) | 2002-01-22 | 2003-08-07 | Ribopharma Ag | Verfahren zur Hemmung der Expression eines durch eine Chromosomen-Aberration entstandenen Zielgens |
| ES2905724T3 (es) * | 2003-06-13 | 2022-04-11 | Alnylam Europe Ag | Acido ribonucleico bicatenario con elevada eficacia en un organismo |
| EP1486564A1 (de) * | 2003-06-13 | 2004-12-15 | Ribopharma AG | SiRNA mit erhöhter Stabilität in Serum |
| US20070004657A1 (en) * | 2003-11-17 | 2007-01-04 | Orna Mor | Diagnosis and treatment of kidney fibrosis and other fibrotic diseases |
| WO2005053725A2 (en) * | 2003-11-26 | 2005-06-16 | The Queen's University Of Belfast | Cancer treatment |
| JP4543189B2 (ja) * | 2004-03-10 | 2010-09-15 | 学校法人日本医科大学 | ＴＧＦβ１レセプターＩＩ型に対するＲＮＡｉとして作用するＲＮＡ配列 |
| FR2898908A1 (fr) | 2006-03-24 | 2007-09-28 | Agronomique Inst Nat Rech | Procede de preparation de cellules aviaires differenciees et genes impliques dans le maintien de la pluripotence |
| US9433684B2 (en) | 2008-08-19 | 2016-09-06 | Nektar Therapeutics | Conjugates of small-interfering nucleic acids |
| US8946172B2 (en) * | 2008-08-25 | 2015-02-03 | Excaliard Pharmaceuticals, Inc. | Method for reducing scarring during wound healing using antisense compounds directed to CTGF |
| CN107083386A (zh) | 2008-08-25 | 2017-08-22 | 埃克斯雷德制药有限公司 | 阻止结缔组织生长因子的反义核苷酸及其用途 |
| EP2342340A1 (en) | 2008-09-22 | 2011-07-13 | Rxi Pharmaceuticals Corporation | Rna interference in skin indications |
| EP2448971A1 (en) | 2009-07-02 | 2012-05-09 | Fibrogen, Inc. | Methods for treatment of muscular dystrophy |
| WO2011035065A1 (en) | 2009-09-17 | 2011-03-24 | Nektar Therapeutics | Monoconjugated chitosans as delivery agents for small interfering nucleic acids |
| WO2011056234A1 (en) | 2009-11-06 | 2011-05-12 | Fibrogen, Inc. | Treatment for radiation-induced disorders |
| US9095504B2 (en) | 2010-03-24 | 2015-08-04 | Rxi Pharmaceuticals Corporation | RNA interference in ocular indications |
| EP3456827A3 (en) | 2010-06-02 | 2019-05-08 | Alnylam Pharmaceuticals, Inc. | Compositions and methods directed to treating liver fibrosis |
| AR083445A1 (es) | 2010-10-14 | 2013-02-27 | Univ Mie | siARN CONTRA LA FIBROSIS |
| WO2012061811A2 (en) | 2010-11-05 | 2012-05-10 | Fibrogen, Inc. | Treatment method for lung remodeling diseases |
| DK2670411T3 (da) | 2011-02-02 | 2019-05-13 | Excaliard Pharmaceuticals Inc | Antisense-forbindelser rettet mod bindevævsvækstfaktor (CTGF) til anvendelse i en fremgangsmåde til behandling af keloider eller hypertrofiske ar |
| HK1244035A1 (en) | 2014-12-15 | 2018-07-27 | Bonac Corporation | Single-stranded nucleic acid molecule for inhibiting tgf- beta 1 expression |
| EP3386544B1 (en) | 2015-12-10 | 2020-11-25 | Fibrogen, Inc. | Methods for treatment of motor neuron diseases |
| KR102666000B1 (ko) * | 2016-07-29 | 2024-05-14 | 서울대학교 산학협력단 | cFLIP siRNA를 포함하는 인터페론 베타 저항성 암 질환 치료용 또는 감작용 조성물 |
| CN109432047B (zh) * | 2018-10-29 | 2021-07-20 | 中国药科大学 | 一种逆转肺纤维化纳米制剂及其制备方法 |
| US20200369759A1 (en) | 2019-05-23 | 2020-11-26 | Fibrogen, Inc. | Methods of treatment of muscular dystrophies |
| CN112843253B (zh) * | 2021-01-13 | 2023-07-14 | 上海交通大学 | 一种基因/药物复合脂质制剂及其制备方法和用途 |
| CN121311249A (zh) * | 2023-06-22 | 2026-01-09 | 公益财团法人川崎市产业振兴财团 | 提高核酸的血中稳定性、提高靶向效率的方法 |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1995000103A2 (en) * | 1993-06-15 | 1995-01-05 | Il-Yang Pharm. Co., Ltd. | Anti-sense oligodeoxynucleotide to fibrogenic cytokines and use thereof |
| DE19631919C2 (de) * | 1996-08-07 | 1998-07-16 | Deutsches Krebsforsch | Anti-Sinn-RNA mit Sekundärstruktur |
| US6242569B1 (en) * | 1997-02-05 | 2001-06-05 | Tularik, Inc. | Regulators of apoptosis |
| DE19713393C2 (de) * | 1997-04-01 | 2002-12-05 | Apotech Res & Dev Ltd | Flip-Gen und Flip-Protein |
| US6506559B1 (en) * | 1997-12-23 | 2003-01-14 | Carnegie Institute Of Washington | Genetic inhibition by double-stranded RNA |
| AU4411499A (en) * | 1998-06-05 | 1999-12-20 | Human Genome Sciences, Inc. | Connective tissue growth factor-4 |
| AU770340B2 (en) * | 1998-10-08 | 2004-02-19 | Biorion Technologies B.V. | Peptide-based carrier devices for stellate cells |
| AU765133B2 (en) * | 1998-11-06 | 2003-09-11 | Fibrogen, Inc. | Connective tissue growth factor (CTGF) and methods of use |
| MXPA01005949A (es) * | 1998-12-14 | 2002-09-18 | Univ Miami | Fragmentos de factor de crecimiento de tejido conectivo y metodos y usos de los mismos. |
| DE19956568A1 (de) * | 1999-01-30 | 2000-08-17 | Roland Kreutzer | Verfahren und Medikament zur Hemmung der Expression eines vorgegebenen Gens |
| US6436909B1 (en) * | 1999-09-17 | 2002-08-20 | Isis Pharmaceuticals, Inc. | Antisense inhibition of transforming growth factor-β expression |
| GB9927444D0 (en) * | 1999-11-19 | 2000-01-19 | Cancer Res Campaign Tech | Inhibiting gene expression |
| KR20080023768A (ko) * | 2000-03-30 | 2008-03-14 | 화이트헤드 인스티튜트 포 바이오메디칼 리서치 | Ｒｎａ 간섭의 ｒｎａ 서열 특이적인 매개체 |
| CN100523215C (zh) * | 2000-12-01 | 2009-08-05 | 马普科技促进协会 | 介导rna干涉的小rna分子 |
-
2002
- 2002-10-25 WO PCT/EP2002/011972 patent/WO2003035083A1/de not_active Ceased
- 2002-10-25 CN CNA028251636A patent/CN1604783A/zh active Pending
- 2002-10-25 WO PCT/EP2002/011968 patent/WO2003035868A1/de not_active Ceased
- 2002-10-25 JP JP2003537650A patent/JP2005512976A/ja active Pending
-
2007
- 2007-05-11 US US11/747,549 patent/US20080070856A1/en not_active Abandoned
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9340786B2 (en) | 2010-03-24 | 2016-05-17 | Rxi Pharmaceuticals Corporation | RNA interference in dermal and fibrotic indications |
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