JP2005512976A5 - - Google Patents
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- JP2005512976A5 JP2005512976A5 JP2003537650A JP2003537650A JP2005512976A5 JP 2005512976 A5 JP2005512976 A5 JP 2005512976A5 JP 2003537650 A JP2003537650 A JP 2003537650A JP 2003537650 A JP2003537650 A JP 2003537650A JP 2005512976 A5 JP2005512976 A5 JP 2005512976A5
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- JP
- Japan
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- sequence
- nucleotides
- Prior art date
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- 108091032973 (ribonucleotides)n+m Proteins 0.000 claims description 16
- 102000040650 (ribonucleotides)n+m Human genes 0.000 claims description 9
- 239000003814 drug Substances 0.000 claims 22
- 239000002773 nucleotide Substances 0.000 claims 21
- 125000003729 nucleotide group Chemical group 0.000 claims 21
- 108090000623 proteins and genes Proteins 0.000 claims 21
- 230000000295 complement effect Effects 0.000 claims 13
- 230000015572 biosynthetic process Effects 0.000 claims 8
- 108010050808 Procollagen Proteins 0.000 claims 6
- 201000010099 disease Diseases 0.000 claims 6
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 6
- 230000003176 fibrotic effect Effects 0.000 claims 6
- 238000001802 infusion Methods 0.000 claims 4
- 238000002347 injection Methods 0.000 claims 4
- 239000007924 injection Substances 0.000 claims 4
- 102000008490 2-Oxoglutarate 5-Dioxygenase Procollagen-Lysine Human genes 0.000 claims 3
- 108010020504 2-Oxoglutarate 5-Dioxygenase Procollagen-Lysine Proteins 0.000 claims 3
- RZVAJINKPMORJF-UHFFFAOYSA-N Acetaminophen Chemical compound CC(=O)NC1=CC=C(O)C=C1 RZVAJINKPMORJF-UHFFFAOYSA-N 0.000 claims 3
- 102100031168 CCN family member 2 Human genes 0.000 claims 3
- 108010037362 Extracellular Matrix Proteins Proteins 0.000 claims 3
- 102000010834 Extracellular Matrix Proteins Human genes 0.000 claims 3
- 101000777550 Homo sapiens CCN family member 2 Proteins 0.000 claims 3
- 108091034117 Oligonucleotide Proteins 0.000 claims 3
- 108090000630 Oncostatin M Proteins 0.000 claims 3
- 102000004140 Oncostatin M Human genes 0.000 claims 3
- 108010003894 Protein-Lysine 6-Oxidase Proteins 0.000 claims 3
- 102000004669 Protein-Lysine 6-Oxidase Human genes 0.000 claims 3
- 238000012228 RNA interference-mediated gene silencing Methods 0.000 claims 3
- 108091005735 TGF-beta receptors Proteins 0.000 claims 3
- 102000016715 Transforming Growth Factor beta Receptors Human genes 0.000 claims 3
- 102000014172 Transforming Growth Factor-beta Type I Receptor Human genes 0.000 claims 3
- 108010011702 Transforming Growth Factor-beta Type I Receptor Proteins 0.000 claims 3
- 102000004060 Transforming Growth Factor-beta Type II Receptor Human genes 0.000 claims 3
- 108010082684 Transforming Growth Factor-beta Type II Receptor Proteins 0.000 claims 3
- 208000019425 cirrhosis of liver Diseases 0.000 claims 3
- 229940079593 drug Drugs 0.000 claims 3
- 210000002744 extracellular matrix Anatomy 0.000 claims 3
- 238000009472 formulation Methods 0.000 claims 3
- 230000009368 gene silencing by RNA Effects 0.000 claims 3
- 239000000203 mixture Substances 0.000 claims 3
- 208000005069 pulmonary fibrosis Diseases 0.000 claims 3
- 229920002477 rna polymer Polymers 0.000 claims 3
- 230000036573 scar formation Effects 0.000 claims 3
- 239000002904 solvent Substances 0.000 claims 3
- ZRKFYGHZFMAOKI-QMGMOQQFSA-N tgfbeta Chemical compound C([C@H](NC(=O)[C@H](C(C)C)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)CCSC)C(C)C)[C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](C)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N1[C@@H](CCC1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(O)=O)C1=CC=C(O)C=C1 ZRKFYGHZFMAOKI-QMGMOQQFSA-N 0.000 claims 3
- 206010023421 Kidney fibrosis Diseases 0.000 claims 2
- 230000037396 body weight Effects 0.000 claims 2
- 230000035876 healing Effects 0.000 claims 2
- 210000003734 kidney Anatomy 0.000 claims 2
- 231100000241 scar Toxicity 0.000 claims 2
- 210000001519 tissue Anatomy 0.000 claims 2
- 108010035532 Collagen Proteins 0.000 claims 1
- 102000008186 Collagen Human genes 0.000 claims 1
- 102000004079 Prolyl Hydroxylases Human genes 0.000 claims 1
- 108010043005 Prolyl Hydroxylases Proteins 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 229920001436 collagen Polymers 0.000 claims 1
- 230000002401 inhibitory effect Effects 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 201000002793 renal fibrosis Diseases 0.000 claims 1
- 101100505328 Colletotrichum trifolii CTG1 gene Proteins 0.000 description 2
- 108020004566 Transfer RNA Proteins 0.000 description 1
- 102000015736 beta 2-Microglobulin Human genes 0.000 description 1
- 108010081355 beta 2-Microglobulin Proteins 0.000 description 1
- 238000001890 transfection Methods 0.000 description 1
Applications Claiming Priority (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10155280 | 2001-10-26 | ||
| DE10158411 | 2001-11-29 | ||
| DE10160151A DE10160151A1 (de) | 2001-01-09 | 2001-12-07 | Verfahren zur Hemmung der Expression eines vorgegebenen Zielgens |
| PCT/EP2002/000152 WO2002055693A2 (de) | 2001-01-09 | 2002-01-09 | Verfahren zur hemmung der expression eines zielgens |
| PCT/EP2002/000151 WO2002055692A2 (de) | 2001-01-09 | 2002-01-09 | Verfahren zur hemmung der expression eines zielgens und medikament zur therapie einer tumorerkrankung |
| PCT/EP2002/011972 WO2003035083A1 (de) | 2001-10-26 | 2002-10-25 | Medikament zur behandlung einer fibrotischen erkrankung durch rna interferenz |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2005512976A JP2005512976A (ja) | 2005-05-12 |
| JP2005512976A5 true JP2005512976A5 (enExample) | 2006-03-09 |
Family
ID=39189390
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003537650A Pending JP2005512976A (ja) | 2001-10-26 | 2002-10-25 | Ｒｎａ干渉により線維化疾患を処置するための医薬 |
Country Status (4)
| Country | Link |
|---|---|
| US (1) | US20080070856A1 (enExample) |
| JP (1) | JP2005512976A (enExample) |
| CN (1) | CN1604783A (enExample) |
| WO (2) | WO2003035083A1 (enExample) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9340786B2 (en) | 2010-03-24 | 2016-05-17 | Rxi Pharmaceuticals Corporation | RNA interference in dermal and fibrotic indications |
Families Citing this family (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19956568A1 (de) | 1999-01-30 | 2000-08-17 | Roland Kreutzer | Verfahren und Medikament zur Hemmung der Expression eines vorgegebenen Gens |
| DE10100586C1 (de) | 2001-01-09 | 2002-04-11 | Ribopharma Ag | Verfahren zur Hemmung der Expression eines Ziegens |
| US7829693B2 (en) | 1999-11-24 | 2010-11-09 | Alnylam Pharmaceuticals, Inc. | Compositions and methods for inhibiting expression of a target gene |
| US7423142B2 (en) | 2001-01-09 | 2008-09-09 | Alnylam Pharmaceuticals, Inc. | Compositions and methods for inhibiting expression of anti-apoptotic genes |
| US7767802B2 (en) | 2001-01-09 | 2010-08-03 | Alnylam Pharmaceuticals, Inc. | Compositions and methods for inhibiting expression of anti-apoptotic genes |
| US8546143B2 (en) | 2001-01-09 | 2013-10-01 | Alnylam Pharmaceuticals, Inc. | Compositions and methods for inhibiting expression of a target gene |
| DE10163098B4 (de) | 2001-10-12 | 2005-06-02 | Alnylam Europe Ag | Verfahren zur Hemmung der Replikation von Viren |
| US7745418B2 (en) | 2001-10-12 | 2010-06-29 | Alnylam Pharmaceuticals, Inc. | Compositions and methods for inhibiting viral replication |
| DE10202419A1 (de) | 2002-01-22 | 2003-08-07 | Ribopharma Ag | Verfahren zur Hemmung der Expression eines durch eine Chromosomen-Aberration entstandenen Zielgens |
| EP1486564A1 (de) * | 2003-06-13 | 2004-12-15 | Ribopharma AG | SiRNA mit erhöhter Stabilität in Serum |
| EP2336317B1 (en) | 2003-06-13 | 2019-09-11 | Alnylam Europe AG | Double-stranded ribonucleic acid with increased effectiveness in an organism |
| WO2005046565A2 (en) * | 2003-11-17 | 2005-05-26 | Quark Biotech, Inc. | Diagnosis and treatment of kidney fibrosis and other fibrotic diseases |
| JP2007513611A (ja) * | 2003-11-26 | 2007-05-31 | ザ クイーンズ ユニヴァーシティ オブ ベルファスト | 癌治療 |
| JP4543189B2 (ja) * | 2004-03-10 | 2010-09-15 | 学校法人日本医科大学 | ＴＧＦβ１レセプターＩＩ型に対するＲＮＡｉとして作用するＲＮＡ配列 |
| FR2898908A1 (fr) | 2006-03-24 | 2007-09-28 | Agronomique Inst Nat Rech | Procede de preparation de cellules aviaires differenciees et genes impliques dans le maintien de la pluripotence |
| WO2010021720A1 (en) | 2008-08-19 | 2010-02-25 | Nektar Therapeutics | Conjugates of small-interfering nucleic acids |
| EP2331141B1 (en) | 2008-08-25 | 2016-01-06 | Excaliard Pharmaceuticals, Inc. | Antisense oligonucleotides directed against connective tissue growth factor and uses thereof |
| US8946172B2 (en) * | 2008-08-25 | 2015-02-03 | Excaliard Pharmaceuticals, Inc. | Method for reducing scarring during wound healing using antisense compounds directed to CTGF |
| CN108165548B (zh) * | 2008-09-22 | 2022-10-14 | 菲奥医药公司 | 减小大小的自递送RNAi化合物 |
| CN102666587A (zh) | 2009-07-02 | 2012-09-12 | 菲布罗根有限公司 | 用于治疗肌营养不良的方法 |
| WO2011035065A1 (en) | 2009-09-17 | 2011-03-24 | Nektar Therapeutics | Monoconjugated chitosans as delivery agents for small interfering nucleic acids |
| WO2011056234A1 (en) | 2009-11-06 | 2011-05-12 | Fibrogen, Inc. | Treatment for radiation-induced disorders |
| CN103200945B (zh) | 2010-03-24 | 2016-07-06 | 雷克西制药公司 | 眼部症候中的rna干扰 |
| EP3456827A3 (en) | 2010-06-02 | 2019-05-08 | Alnylam Pharmaceuticals, Inc. | Compositions and methods directed to treating liver fibrosis |
| AR083445A1 (es) | 2010-10-14 | 2013-02-27 | Univ Mie | siARN CONTRA LA FIBROSIS |
| US20140134181A1 (en) | 2010-11-05 | 2014-05-15 | Kenneth E. Lipson | Treatment Method For Lung Remodeling Diseases |
| MX365647B (es) | 2011-02-02 | 2019-06-10 | Excaliard Pharmaceuticals Inc | El uso de compuestos antisentido dirigidos al factor de crecimiento del tejido conectivo (ctgf) para tratar queloides o cicatrices hipertroficas. |
| US10337009B2 (en) | 2014-12-15 | 2019-07-02 | Bonac Corporation | Single-stranded nucleic acid molecule for inhibiting TGF-β1 expression |
| US11299537B2 (en) | 2015-12-10 | 2022-04-12 | Fibrogen, Inc. | Methods for treatment of motor neuron diseases |
| KR102666000B1 (ko) * | 2016-07-29 | 2024-05-14 | 서울대학교 산학협력단 | cFLIP siRNA를 포함하는 인터페론 베타 저항성 암 질환 치료용 또는 감작용 조성물 |
| CN109432047B (zh) * | 2018-10-29 | 2021-07-20 | 中国药科大学 | 一种逆转肺纤维化纳米制剂及其制备方法 |
| US20200369759A1 (en) | 2019-05-23 | 2020-11-26 | Fibrogen, Inc. | Methods of treatment of muscular dystrophies |
| CN112843253B (zh) * | 2021-01-13 | 2023-07-14 | 上海交通大学 | 一种基因/药物复合脂质制剂及其制备方法和用途 |
| WO2024262593A1 (ja) * | 2023-06-22 | 2024-12-26 | 公益財団法人川崎市産業振興財団 | 核酸の血中安定性を向上させ、標的化効率を向上させる方法 |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0737071A1 (en) * | 1993-06-15 | 1996-10-16 | Il- Yang Pharm. Co., Ltd. | Anti-sense oligodeoxynucleotide to fibrogenic cytokines and use thereof |
| DE19631919C2 (de) * | 1996-08-07 | 1998-07-16 | Deutsches Krebsforsch | Anti-Sinn-RNA mit Sekundärstruktur |
| US6242569B1 (en) * | 1997-02-05 | 2001-06-05 | Tularik, Inc. | Regulators of apoptosis |
| DE19713393C2 (de) * | 1997-04-01 | 2002-12-05 | Apotech Res & Dev Ltd | Flip-Gen und Flip-Protein |
| US6506559B1 (en) * | 1997-12-23 | 2003-01-14 | Carnegie Institute Of Washington | Genetic inhibition by double-stranded RNA |
| AU4411499A (en) * | 1998-06-05 | 1999-12-20 | Human Genome Sciences, Inc. | Connective tissue growth factor-4 |
| JP2002532384A (ja) * | 1998-10-08 | 2002-10-02 | ステイヒテイング・ボール・デ・テヒニシエ・ベテンシヤツペン | 星状細胞のためのペプチドを基剤としたキャリヤーデバイス |
| CN1332801A (zh) * | 1998-11-06 | 2002-01-23 | 法布罗根公司 | 结缔组织生长因子(ctgf)及应用方法 |
| US6492129B1 (en) * | 1998-12-14 | 2002-12-10 | University Of Miami | Fragments of connective tissue growth factor that induce extracellular matrix synthesis, collagen synthesis and/or myofibroblast differentiation |
| DE19956568A1 (de) * | 1999-01-30 | 2000-08-17 | Roland Kreutzer | Verfahren und Medikament zur Hemmung der Expression eines vorgegebenen Gens |
| JP2003509030A (ja) * | 1999-09-17 | 2003-03-11 | アイシス・ファーマシューティカルス・インコーポレーテッド | トランスフォーミング成長因子−β発現のアンチセンスオリゴヌクレオチド調節 |
| GB9927444D0 (en) * | 1999-11-19 | 2000-01-19 | Cancer Res Campaign Tech | Inhibiting gene expression |
| EP1309726B2 (en) * | 2000-03-30 | 2018-10-03 | Whitehead Institute For Biomedical Research | Rna sequence-specific mediators of rna interference |
| RU2322500C2 (ru) * | 2000-12-01 | 2008-04-20 | Макс-Планк-Гезелльшафт Цур Фердерунг Дер Виссеншафтен Е.Ф. | Малые молекулы рнк, опосредующие интерференцию рнк |
-
2002
- 2002-10-25 WO PCT/EP2002/011972 patent/WO2003035083A1/de not_active Ceased
- 2002-10-25 JP JP2003537650A patent/JP2005512976A/ja active Pending
- 2002-10-25 CN CNA028251636A patent/CN1604783A/zh active Pending
- 2002-10-25 WO PCT/EP2002/011968 patent/WO2003035868A1/de not_active Ceased
-
2007
- 2007-05-11 US US11/747,549 patent/US20080070856A1/en not_active Abandoned
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9340786B2 (en) | 2010-03-24 | 2016-05-17 | Rxi Pharmaceuticals Corporation | RNA interference in dermal and fibrotic indications |
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