JP2005506087A5 - - Google Patents

Download PDF

Info

Publication number
JP2005506087A5
JP2005506087A5 JP2003538376A JP2003538376A JP2005506087A5 JP 2005506087 A5 JP2005506087 A5 JP 2005506087A5 JP 2003538376 A JP2003538376 A JP 2003538376A JP 2003538376 A JP2003538376 A JP 2003538376A JP 2005506087 A5 JP2005506087 A5 JP 2005506087A5
Authority
JP
Japan
Prior art keywords
dsrna
strand
helicase
medicament
virus
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
JP2003538376A
Other languages
English (en)
Japanese (ja)
Other versions
JP2005506087A (ja
Filing date
Publication date
Priority claimed from DE10160151A external-priority patent/DE10160151A1/de
Priority claimed from PCT/EP2002/000151 external-priority patent/WO2002055692A2/de
Application filed filed Critical
Priority claimed from PCT/EP2002/011973 external-priority patent/WO2003035876A1/de
Publication of JP2005506087A publication Critical patent/JP2005506087A/ja
Publication of JP2005506087A5 publication Critical patent/JP2005506087A5/ja
Withdrawn legal-status Critical Current

Links

JP2003538376A 2001-10-26 2002-10-25 プラス鎖ｒｎａウイルスによる感染症を処置するための２本鎖リボ核酸の使用 Withdrawn JP2005506087A (ja)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
DE10155280 2001-10-26
DE10158411 2001-11-29
DE10160151A DE10160151A1 (de) 2001-01-09 2001-12-07 Verfahren zur Hemmung der Expression eines vorgegebenen Zielgens
PCT/EP2002/000152 WO2002055693A2 (de) 2001-01-09 2002-01-09 Verfahren zur hemmung der expression eines zielgens
PCT/EP2002/000151 WO2002055692A2 (de) 2001-01-09 2002-01-09 Verfahren zur hemmung der expression eines zielgens und medikament zur therapie einer tumorerkrankung
DE10235621 2002-08-02
PCT/EP2002/011973 WO2003035876A1 (de) 2001-10-26 2002-10-25 Verwendung einer doppelsträngigen ribonukleinsäure zur behandlung einer infektion mit einem (+)-strang-rna-virus

Publications (2)

Publication Number Publication Date
JP2005506087A JP2005506087A (ja) 2005-03-03
JP2005506087A5 true JP2005506087A5 (enExample) 2006-01-05

Family

ID=34799649

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2003538376A Withdrawn JP2005506087A (ja) 2001-10-26 2002-10-25 プラス鎖ｒｎａウイルスによる感染症を処置するための２本鎖リボ核酸の使用

Country Status (4)

Country Link
US (2) US20050119202A1 (enExample)
JP (1) JP2005506087A (enExample)
CN (1) CN1608133A (enExample)
WO (1) WO2003035876A1 (enExample)

Families Citing this family (44)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19956568A1 (de) 1999-01-30 2000-08-17 Roland Kreutzer Verfahren und Medikament zur Hemmung der Expression eines vorgegebenen Gens
DE10100586C1 (de) 2001-01-09 2002-04-11 Ribopharma Ag Verfahren zur Hemmung der Expression eines Ziegens
US7829693B2 (en) 1999-11-24 2010-11-09 Alnylam Pharmaceuticals, Inc. Compositions and methods for inhibiting expression of a target gene
KR20080023768A (ko) 2000-03-30 2008-03-14 화이트헤드 인스티튜트 포 바이오메디칼 리서치 Ｒｎａ 간섭의 ｒｎａ 서열 특이적인 매개체
US20030114410A1 (en) 2000-08-08 2003-06-19 Technion Research And Development Foundation Ltd. Pharmaceutical compositions and methods useful for modulating angiogenesis and inhibiting metastasis and tumor fibrosis
CN100523215C (zh) 2000-12-01 2009-08-05 马普科技促进协会 介导rna干涉的小rna分子
US8546143B2 (en) 2001-01-09 2013-10-01 Alnylam Pharmaceuticals, Inc. Compositions and methods for inhibiting expression of a target gene
US7423142B2 (en) 2001-01-09 2008-09-09 Alnylam Pharmaceuticals, Inc. Compositions and methods for inhibiting expression of anti-apoptotic genes
US7767802B2 (en) 2001-01-09 2010-08-03 Alnylam Pharmaceuticals, Inc. Compositions and methods for inhibiting expression of anti-apoptotic genes
US20050143333A1 (en) * 2001-05-18 2005-06-30 Sirna Therapeutics, Inc. RNA interference mediated inhibition of interleukin and interleukin receptor gene expression using short interfering nucleic acid (SINA)
US20050182007A1 (en) * 2001-05-18 2005-08-18 Sirna Therapeutics, Inc. RNA interference mediated inhibition of interleukin and interleukin receptor gene expression using short interfering nucleic acid (SINA)
DE10163098B4 (de) 2001-10-12 2005-06-02 Alnylam Europe Ag Verfahren zur Hemmung der Replikation von Viren
US7745418B2 (en) 2001-10-12 2010-06-29 Alnylam Pharmaceuticals, Inc. Compositions and methods for inhibiting viral replication
DE10202419A1 (de) 2002-01-22 2003-08-07 Ribopharma Ag Verfahren zur Hemmung der Expression eines durch eine Chromosomen-Aberration entstandenen Zielgens
AU2003261449A1 (en) 2002-08-07 2004-02-25 Compositions for rna interference and methods of use thereof
US20070225242A1 (en) * 2005-06-21 2007-09-27 The Board Of Trustees Of The Leland Stanford Junior University Method and composition for treating and preventing tumor metastasis in vivo
US20070021365A1 (en) * 2005-06-21 2007-01-25 The Board Of Trustees Of The Leland Stanford Junior University Inhibition of Lysyl oxidase for treating tumor growth and diagnostics relating thereto
FR2898908A1 (fr) 2006-03-24 2007-09-28 Agronomique Inst Nat Rech Procede de preparation de cellules aviaires differenciees et genes impliques dans le maintien de la pluripotence
CA2693310C (en) 2007-08-02 2018-11-27 Arresto Biosciences, Inc. Lox and loxl2 inhibitors, antibodies and uses thereof
US8431692B2 (en) * 2008-06-06 2013-04-30 Quark Pharmaceuticals, Inc. Compositions and methods for treatment of ear disorders
EP2342340A1 (en) 2008-09-22 2011-07-13 Rxi Pharmaceuticals Corporation Rna interference in skin indications
US9107935B2 (en) * 2009-01-06 2015-08-18 Gilead Biologics, Inc. Chemotherapeutic methods and compositions
US8444983B2 (en) 2009-03-23 2013-05-21 Quark Pharmaceuticals, Inc. Composition of anti-ENDO180 antibodies and methods of use for the treatment of cancer and fibrotic diseases
WO2011022670A1 (en) * 2009-08-21 2011-02-24 Arresto Biosciences, Inc In vivo screening assays
MX2012002271A (es) * 2009-08-21 2012-07-20 Gilead Biologics Inc Metodos y composiciones terapeuticas.
CA2771702A1 (en) * 2009-08-21 2011-02-24 Gilead Biologics, Inc. Catalytic domains from lysyl oxidase and loxl2
US20110207144A1 (en) * 2009-08-21 2011-08-25 Derek Marshall In vitro screening assays
RU2012110580A (ru) * 2009-08-21 2013-09-27 Джилид Байолоджикс, Инк. Способы скрининга in vivo
BR112012019693A2 (pt) 2010-02-04 2017-06-20 Gilead Biologics Inc anticorpos que se ligam à lisil oxidase-like 2 (loxl2) e métodos de uso para eles.
US9095504B2 (en) 2010-03-24 2015-08-04 Rxi Pharmaceuticals Corporation RNA interference in ocular indications
CA2794189C (en) 2010-03-24 2022-01-11 Rxi Pharmaceuticals Corporation Rna interference in dermal and fibrotic indications
AR083445A1 (es) 2010-10-14 2013-02-27 Univ Mie siARN CONTRA LA FIBROSIS
CN103328633B (zh) 2010-10-22 2018-07-10 成均馆大学校产学协力团 诱导rna干扰的核酸分子及其用途
CN108148838B (zh) * 2012-05-22 2026-07-31 奥利克斯医药有限公司 具有细胞内穿透能力的诱导rna干扰的核酸分子及用途
MX384843B (es) 2014-05-15 2025-03-14 Insmed Inc Métodos para tratar infecciones pulmonares micobacterianas no tuberculosas.
HK1244035A1 (en) 2014-12-15 2018-07-27 Bonac Corporation Single-stranded nucleic acid molecule for inhibiting tgf- beta 1 expression
JP7027311B2 (ja) 2015-11-16 2022-03-01 オリックス ファーマシューティカルズ，インコーポレーテッド ＭｙＤ８８又はＴＬＲ３を標的とするＲＮＡ複合体を使用した加齢黄斑変性の治療
WO2017134525A1 (en) 2016-02-02 2017-08-10 Olix Pharmaceuticals, Inc. TREATMENT OF ATOPIC DERMATITIS AND ASTHMA USING RNA COMPLEXES THAT TARGET lL4Rα, TRPA1, OR F2RL1
KR102825945B1 (ko) 2016-02-02 2025-06-30 올릭스 주식회사 Angpt2 및 pdgfb를 표적화하는 rna 복합체를 사용하는 혈관신생 관련 질환의 치료
JP7049262B2 (ja) 2016-04-11 2022-04-06 オリックス ファーマシューティカルズ，インコーポレーテッド 結合組織成長因子を標的とするｒｎａ複合体を用いた特発性肺胞線維症の治療
KR101916652B1 (ko) 2016-06-29 2018-11-08 올릭스 주식회사 작은 간섭 rna의 rna 간섭효과 증진용 화합물 및 이의 용도
WO2018146557A2 (en) 2017-02-10 2018-08-16 Dong Ki Lee Long double-stranded rna for rna interference
EP3773505B1 (en) 2018-03-30 2026-04-29 Insmed Incorporated Methods for continuous manufacture of liposomal drug products
EP3787602A4 (en) 2018-05-02 2022-03-23 Insmed Incorporated PROCESS FOR THE MANUFACTURE OF LIPOSOMAL DRUG FORMULATIONS

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6506559B1 (en) * 1997-12-23 2003-01-14 Carnegie Institute Of Washington Genetic inhibition by double-stranded RNA
AU4411499A (en) * 1998-06-05 1999-12-20 Human Genome Sciences, Inc. Connective tissue growth factor-4
DE19956568A1 (de) * 1999-01-30 2000-08-17 Roland Kreutzer Verfahren und Medikament zur Hemmung der Expression eines vorgegebenen Gens
KR20080023768A (ko) * 2000-03-30 2008-03-14 화이트헤드 인스티튜트 포 바이오메디칼 리서치 Ｒｎａ 간섭의 ｒｎａ 서열 특이적인 매개체
CN100523215C (zh) * 2000-12-01 2009-08-05 马普科技促进协会 介导rna干涉的小rna分子

Similar Documents

Publication Publication Date Title
JP5513126B2 (ja) 肝疾患を予防および／または制御するための、キサントフモールまたはイソキサントフモールの活性物質としての使用
CN111557939A (zh) 法匹拉韦在治疗冠状病毒感染方面的应用
CN111991401A (zh) 一种化合物在治疗SARS-CoV-2感染中的应用
CN118384167B (zh) 巴洛沙韦钠在治疗克里米亚-刚果出血热病毒感染方面的应用
JP2010530423A (ja) 免疫活性化剤を用いたウイルス感染の早期介入
CN116459295B (zh) 一种肺炎清化方及其应用
JP2024528237A5 (enExample)
CN113101283A (zh) 一种多苯环共轭分子在制备抗病毒药物中的用途及抗病毒药物
CN115397410A (zh) 用于治疗、预防或限制病毒感染发生的方法和组合物
CN118490680A (zh) 瑞香素在制备治疗病毒性肺炎的药物中的应用
CN1179726C (zh) 柚皮苷在制备支持性治疗非典型性肺炎药物中的应用
JP2019510731A (ja) 抗ウイルス薬およびウイルス感染症の治療方法
CN101757018A (zh) 一种用于畜禽的聚肌胞干粉及其制备方法
CN106562970B (zh) Gs-9620的用途
CN104940955B (zh) 一种microRNA在制备治疗流感的药物中的应用
Deanasa et al. The potential of antisense oligonucleotides (ASO) through inhalation based on gold nanoparticle (AuNP) delivery system in inhibiting SARS-CoV-2 replication and transcription
CN121714563B (zh) 东莨菪内酯在制备抗白斑综合征药物中的应用
US20240415953A1 (en) Oral therapeutic vaccine compositions, methods and treatment of covid
CN110179785B (zh) 魏特酮在制备治疗或预防手足口病药物中的应用
CN102266387B (zh) 一种治疗口蹄疫的药剂及生产治疗口蹄疫的药剂的方法
CN117243946A (zh) 瑞香素及包含其的组合物在制备治疗心肌炎药物中的应用
JP2005532038A5 (enExample)
CN1527716A (zh) 抗病毒试剂
CN118662522A (zh) Mir2911在制备抗黄热病毒yfv的药物中的应用
CN120459175A (zh) 一种兽用防疫药物及其制备方法和应用