JP2005512946A - 選択的免疫調節法 - Google Patents

選択的免疫調節法 Download PDF

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Publication number
JP2005512946A
JP2005512946A JP2002586931A JP2002586931A JP2005512946A JP 2005512946 A JP2005512946 A JP 2005512946A JP 2002586931 A JP2002586931 A JP 2002586931A JP 2002586931 A JP2002586931 A JP 2002586931A JP 2005512946 A JP2005512946 A JP 2005512946A
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JP
Japan
Prior art keywords
pimecrolimus
treatment
asthma
ibd
less
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Pending
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JP2002586931A
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English (en)
Japanese (ja)
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JP2005512946A5 (enExample
Inventor
サラ−ディーヌ・シブー
アンドレ・コルディエ
ジャンヌ・ケーラン
ヘンリエッタ・デニーズ・ムーア
Original Assignee
ノバルティス アクチエンゲゼルシャフト
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Publication of JP2005512946A publication Critical patent/JP2005512946A/ja
Publication of JP2005512946A5 publication Critical patent/JP2005512946A5/ja
Pending legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/436—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having oxygen as a ring hetero atom, e.g. rapamycin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/439—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Pulmonology (AREA)
  • Transplantation (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
JP2002586931A 2001-05-09 2002-05-09 選択的免疫調節法 Pending JP2005512946A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US28984301P 2001-05-09 2001-05-09
PCT/US2002/014637 WO2002089796A2 (en) 2001-05-09 2002-05-09 Methods for selective immunomodulation using pimecrolimus

Publications (2)

Publication Number Publication Date
JP2005512946A true JP2005512946A (ja) 2005-05-12
JP2005512946A5 JP2005512946A5 (enExample) 2005-12-22

Family

ID=23113348

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2002586931A Pending JP2005512946A (ja) 2001-05-09 2002-05-09 選択的免疫調節法

Country Status (8)

Country Link
US (1) US20030119797A1 (enExample)
EP (1) EP1389108A2 (enExample)
JP (1) JP2005512946A (enExample)
CN (1) CN1543345A (enExample)
AU (1) AU2002256507A1 (enExample)
BR (1) BR0209474A (enExample)
CA (1) CA2442969A1 (enExample)
WO (1) WO2002089796A2 (enExample)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2006522057A (ja) * 2003-04-04 2006-09-28 ノバルティス アクチエンゲゼルシャフト マクロライドt細胞免疫調節剤または免疫抑制剤およびレチノイドの相乗的組合せ
WO2006126581A1 (ja) * 2005-04-28 2006-11-30 Dainippon Sumitomo Pharma Co., Ltd. 組合せ医薬

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040087527A1 (en) * 2002-10-31 2004-05-06 Day Brian J. Methods for treatment of thiol-containing compound deficient conditions
WO2004045578A2 (en) * 2002-11-15 2004-06-03 Novartis Ag Drug delivery system
AR043504A1 (es) * 2003-03-17 2005-08-03 Novartis Ag Composiciones farmaceuticas que comprenden rapamicina para el tratamiento de enfermedades inflamatorias
GB0307862D0 (en) * 2003-04-04 2003-05-14 Novartis Ag Pharmaceutical composition
GB0307865D0 (en) * 2003-04-04 2003-05-14 Novartis Ag Pharmaceutical composition
US8916546B2 (en) 2003-08-29 2014-12-23 Therapeutic Research Llc Materials and methods for treatment and diagnosis of disorders associated with oxidative stress
JP2007507460A (ja) * 2003-10-06 2007-03-29 ノバルティス アクチエンゲゼルシャフト 炎症性疾患の治療効力と関連している遺伝子多型の使用
MY162179A (en) * 2004-04-01 2017-05-31 Elan Pharm Inc Steroid sparing agents and methods of using same
GB0505539D0 (en) * 2005-03-17 2005-04-27 Novartis Ag Organic compounds
EP2392321A1 (en) 2007-06-13 2011-12-07 Jay Pravda Combined composition for rectal administration for the treatment of inflammatory bowel disease
EP2916818B1 (en) 2012-11-09 2017-02-01 Scidose LLC Enema composition for treatment of ulcerative colitis having long term stability
GB201319792D0 (en) * 2013-11-08 2013-12-25 Sigmoid Pharma Ltd Formulations
WO2016071515A1 (en) 2014-11-07 2016-05-12 Sigmoid Pharma Limited Compositions comprising cyclosporin

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH11509223A (ja) * 1995-07-14 1999-08-17 ノバルティス・アクチエンゲゼルシャフト 医薬組成物
WO1999049863A1 (en) * 1998-03-26 1999-10-07 Fujisawa Pharmaceutical Co., Ltd. Sustained release preparations
WO2001026605A2 (en) * 1999-10-11 2001-04-19 Fujisawa Pharmaceutical Co., Ltd. Immunosuppressive composition containing il-2 inhibitor and an adenosine deaminase inhibitor

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9318144D0 (en) * 1993-09-01 1993-10-20 Sandoz Ltd Organic compounds
AR004480A1 (es) * 1995-04-06 1998-12-16 Amico Derin C D Compuestos de ascomicina que poseen actividad antiinflamatoria, pro cedimiento para prepararlos, uso de dichos compuestos para preparar agentesfarmaceuticos y composiciones farmaceuticas que los incluyen
GB0012383D0 (en) * 2000-05-22 2000-07-12 Novartis Ag Organic compounds
GB0125443D0 (en) * 2001-10-23 2001-12-12 Novartis Ag Organic Compounds
GB0200429D0 (en) * 2002-01-09 2002-02-27 Novartis Ag Organic compounds

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH11509223A (ja) * 1995-07-14 1999-08-17 ノバルティス・アクチエンゲゼルシャフト 医薬組成物
WO1999049863A1 (en) * 1998-03-26 1999-10-07 Fujisawa Pharmaceutical Co., Ltd. Sustained release preparations
WO2001026605A2 (en) * 1999-10-11 2001-04-19 Fujisawa Pharmaceutical Co., Ltd. Immunosuppressive composition containing il-2 inhibitor and an adenosine deaminase inhibitor

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
HARPER J, BRITISH JOURNAL OF DERMATOLOGY, vol. V144N4, JPN5003017612, April 2001 (2001-04-01), pages 781 - 787, ISSN: 0001282566 *
RAPPERSBERGER K, JOURNAL OF INVESTIGATIVE DERMATOLOGY, vol. V114N4, JPN5003017611, April 2000 (2000-04-01), pages 776, ISSN: 0001282567 *
WELLINGTON KERI, BIODRUGS, vol. V14N6, JPN5003017610, December 2000 (2000-12-01), pages 409 - 416, ISSN: 0001282565 *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2006522057A (ja) * 2003-04-04 2006-09-28 ノバルティス アクチエンゲゼルシャフト マクロライドt細胞免疫調節剤または免疫抑制剤およびレチノイドの相乗的組合せ
WO2006126581A1 (ja) * 2005-04-28 2006-11-30 Dainippon Sumitomo Pharma Co., Ltd. 組合せ医薬

Also Published As

Publication number Publication date
US20030119797A1 (en) 2003-06-26
BR0209474A (pt) 2006-02-07
EP1389108A2 (en) 2004-02-18
AU2002256507A1 (en) 2002-11-18
CA2442969A1 (en) 2002-11-14
CN1543345A (zh) 2004-11-03
WO2002089796A2 (en) 2002-11-14
WO2002089796A3 (en) 2003-03-13

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