JP2005511595A5 - - Google Patents

Info

Publication number

JP2005511595A5

JP2005511595A5 JP2003541839A JP2003541839A JP2005511595A5 JP 2005511595 A5 JP2005511595 A5 JP 2005511595A5 JP 2003541839 A JP2003541839 A JP 2003541839A JP 2003541839 A JP2003541839 A JP 2003541839A JP 2005511595 A5 JP2005511595 A5 JP 2005511595A5

Authority

JP

Japan

Prior art keywords

phenyl

hal

methanoyl

hydrazono

pyridazin

Prior art date

2002-10-10

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
• Global Dossier
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• -1 3-Chloro-4- {1- [3- (3-ethoxy-4-methoxy-phenyl) -5,6-dihydro-4H-pyridazin-1-yl] -methanoyl} -phenyl Chemical group 0.000 claims description 9
• 150000001875 compounds Chemical class 0.000 claims 11
• 239000002904 solvent Substances 0.000 claims 7
• 125000004432 carbon atom Chemical group C* 0.000 claims 6
• 150000003839 salts Chemical class 0.000 claims 4
• 125000000217 alkyl group Chemical group 0.000 claims 3
• 125000004093 cyano group Chemical group *C#N 0.000 claims 3
• 125000001309 chloro group Chemical group Cl* 0.000 claims 2
• 125000001153 fluoro group Chemical group F* 0.000 claims 2
• 238000000034 method Methods 0.000 claims 2
• 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 2
• 238000002360 preparation method Methods 0.000 claims 2
• JXPDNDHCMMOJPC-UHFFFAOYSA-N 2-hydroxybutanedinitrile Chemical compound N#CC(O)CC#N JXPDNDHCMMOJPC-UHFFFAOYSA-N 0.000 claims 1
• KECMONQNDOGWMD-UHFFFAOYSA-N C1=C(OC)C(OCC)=CC(C=2CCCN(N=2)C(=O)C=2C(=CC(NN=C(C#N)C=3NN=NN=3)=CC=2)F)=C1 Chemical compound C1=C(OC)C(OCC)=CC(C=2CCCN(N=2)C(=O)C=2C(=CC(NN=C(C#N)C=3NN=NN=3)=CC=2)F)=C1 KECMONQNDOGWMD-UHFFFAOYSA-N 0.000 claims 1
• 101100516554 Caenorhabditis elegans nhr-5 gene Proteins 0.000 claims 1
• 125000003342 alkenyl group Chemical group 0.000 claims 1
• 125000006297 carbonyl amino group Chemical group [H]N([*:2])C([*:1])=O 0.000 claims 1
• 125000000896 monocarboxylic acid group Chemical group 0.000 claims 1
• 239000012453 solvate Substances 0.000 claims 1
• 238000007614 solvation Methods 0.000 claims 1
• LMBFAGIMSUYTBN-MPZNNTNKSA-N teixobactin Chemical compound C([C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H]1C(N[C@@H](C)C(=O)N[C@@H](C[C@@H]2NC(=N)NC2)C(=O)N[C@H](C(=O)O[C@H]1C)[C@@H](C)CC)=O)NC)C1=CC=CC=C1 LMBFAGIMSUYTBN-MPZNNTNKSA-N 0.000 claims 1
• 150000003536 tetrazoles Chemical group 0.000 claims 1
• XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 5
• OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 3
• LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
• KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 2
• 239000000203 mixture Substances 0.000 description 2
• XAEFZNCEHLXOMS-UHFFFAOYSA-M potassium benzoate Chemical compound [K+].[O-]C(=O)C1=CC=CC=C1 XAEFZNCEHLXOMS-UHFFFAOYSA-M 0.000 description 2
• LPXPTNMVRIOKMN-UHFFFAOYSA-M sodium nitrite Chemical compound [Na+].[O-]N=O LPXPTNMVRIOKMN-UHFFFAOYSA-M 0.000 description 2
• VMHLLURERBWHNL-UHFFFAOYSA-M Sodium acetate Chemical compound [Na+].CC([O-])=O VMHLLURERBWHNL-UHFFFAOYSA-M 0.000 description 1
• 239000006185 dispersion Substances 0.000 description 1
• CUONGYYJJVDODC-UHFFFAOYSA-N malononitrile Chemical compound N#CCC#N CUONGYYJJVDODC-UHFFFAOYSA-N 0.000 description 1
• 239000002244 precipitate Substances 0.000 description 1
• 239000001632 sodium acetate Substances 0.000 description 1
• 235000017281 sodium acetate Nutrition 0.000 description 1
• 235000010288 sodium nitrite Nutrition 0.000 description 1
• 238000003756 stirring Methods 0.000 description 1