JP2005511049A5 - - Google Patents
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- JP2005511049A5 JP2005511049A5 JP2003549524A JP2003549524A JP2005511049A5 JP 2005511049 A5 JP2005511049 A5 JP 2005511049A5 JP 2003549524 A JP2003549524 A JP 2003549524A JP 2003549524 A JP2003549524 A JP 2003549524A JP 2005511049 A5 JP2005511049 A5 JP 2005511049A5
- Authority
- JP
- Japan
- Prior art keywords
- cell
- cys
- nucleic acid
- transcription factor
- artificial transcription
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 210000004027 cell Anatomy 0.000 claims 49
- 102000039446 nucleic acids Human genes 0.000 claims 31
- 108020004707 nucleic acids Proteins 0.000 claims 31
- 150000007523 nucleic acids Chemical class 0.000 claims 31
- 108091023040 Transcription factor Proteins 0.000 claims 25
- 102000040945 Transcription factor Human genes 0.000 claims 25
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 claims 18
- 229910052725 zinc Inorganic materials 0.000 claims 18
- 239000011701 zinc Substances 0.000 claims 18
- 108090000623 proteins and genes Proteins 0.000 claims 17
- 238000000034 method Methods 0.000 claims 15
- 210000000130 stem cell Anatomy 0.000 claims 14
- 102000004169 proteins and genes Human genes 0.000 claims 11
- 102000037865 fusion proteins Human genes 0.000 claims 10
- 108020001507 fusion proteins Proteins 0.000 claims 10
- 230000001105 regulatory effect Effects 0.000 claims 10
- 150000001413 amino acids Chemical group 0.000 claims 8
- 229920001184 polypeptide Polymers 0.000 claims 7
- 102000004196 processed proteins & peptides Human genes 0.000 claims 7
- 108090000765 processed proteins & peptides Proteins 0.000 claims 7
- 108020004414 DNA Proteins 0.000 claims 6
- OUYCCCASQSFEME-QMMMGPOBSA-N L-tyrosine Chemical group OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-QMMMGPOBSA-N 0.000 claims 5
- 230000004069 differentiation Effects 0.000 claims 5
- 230000002209 hydrophobic effect Effects 0.000 claims 5
- COLNVLDHVKWLRT-UHFFFAOYSA-N phenylalanine Natural products OC(=O)C(N)CC1=CC=CC=C1 COLNVLDHVKWLRT-UHFFFAOYSA-N 0.000 claims 5
- COLNVLDHVKWLRT-QMMMGPOBSA-N phenylalanine group Chemical group N[C@@H](CC1=CC=CC=C1)C(=O)O COLNVLDHVKWLRT-QMMMGPOBSA-N 0.000 claims 5
- OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Chemical group OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 claims 5
- 210000003527 eukaryotic cell Anatomy 0.000 claims 4
- 230000004568 DNA-binding Effects 0.000 claims 3
- 241000251539 Vertebrata <Metazoa> Species 0.000 claims 3
- 238000013518 transcription Methods 0.000 claims 3
- 230000035897 transcription Effects 0.000 claims 3
- 230000027455 binding Effects 0.000 claims 2
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 230000002103 transcriptional effect Effects 0.000 claims 2
- 206010059866 Drug resistance Diseases 0.000 claims 1
- 241000196324 Embryophyta Species 0.000 claims 1
- 102000004877 Insulin Human genes 0.000 claims 1
- 108090001061 Insulin Proteins 0.000 claims 1
- 206010034133 Pathogen resistance Diseases 0.000 claims 1
- 230000006907 apoptotic process Effects 0.000 claims 1
- 230000001580 bacterial effect Effects 0.000 claims 1
- 230000006369 cell cycle progression Effects 0.000 claims 1
- 230000024245 cell differentiation Effects 0.000 claims 1
- 210000004748 cultured cell Anatomy 0.000 claims 1
- 210000001671 embryonic stem cell Anatomy 0.000 claims 1
- 230000007613 environmental effect Effects 0.000 claims 1
- 231100000024 genotoxic Toxicity 0.000 claims 1
- 230000001738 genotoxic effect Effects 0.000 claims 1
- 229910001385 heavy metal Inorganic materials 0.000 claims 1
- 210000003958 hematopoietic stem cell Anatomy 0.000 claims 1
- 229940125396 insulin Drugs 0.000 claims 1
- 230000003387 muscular Effects 0.000 claims 1
- 230000001537 neural effect Effects 0.000 claims 1
- 210000005155 neural progenitor cell Anatomy 0.000 claims 1
- 230000003204 osmotic effect Effects 0.000 claims 1
- 230000011164 ossification Effects 0.000 claims 1
- 244000052769 pathogen Species 0.000 claims 1
- 230000001717 pathogenic effect Effects 0.000 claims 1
- 230000035755 proliferation Effects 0.000 claims 1
- 230000035945 sensitivity Effects 0.000 claims 1
- 239000002904 solvent Substances 0.000 claims 1
- 239000000126 substance Substances 0.000 claims 1
- 230000014616 translation Effects 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US33844101P | 2001-12-07 | 2001-12-07 | |
| US37605302P | 2002-04-26 | 2002-04-26 | |
| US40090402P | 2002-08-02 | 2002-08-02 | |
| US40108902P | 2002-08-05 | 2002-08-05 | |
| PCT/KR2002/002309 WO2003048345A1 (en) | 2001-12-07 | 2002-12-07 | Phenotypic screen of chimeric proteins |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2005511049A JP2005511049A (ja) | 2005-04-28 |
| JP2005511049A5 true JP2005511049A5 (enExample) | 2006-02-02 |
Family
ID=27502584
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003549524A Pending JP2005511049A (ja) | 2001-12-07 | 2002-12-07 | キメラタンパク質の表現型スクリーニング |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US20030194727A1 (enExample) |
| EP (1) | EP1451297A4 (enExample) |
| JP (1) | JP2005511049A (enExample) |
| KR (1) | KR20040065235A (enExample) |
| CN (1) | CN100463962C (enExample) |
| AU (1) | AU2002365796A1 (enExample) |
| CA (1) | CA2469477A1 (enExample) |
| WO (1) | WO2003048345A1 (enExample) |
Families Citing this family (84)
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| US7026462B2 (en) * | 2000-12-07 | 2006-04-11 | Sangamo Biosciences, Inc. | Regulation of angiogenesis with zinc finger proteins |
| EP1417344B1 (en) * | 2001-08-17 | 2011-06-15 | Toolgen, Inc. | Zinc finger domain libraries |
| US20040214766A1 (en) * | 2001-10-01 | 2004-10-28 | Kari Alitalo | VEGF-C or VEGF-D materials and methods for treatment of neuropathologies |
| EP1451297A4 (en) * | 2001-12-07 | 2006-06-28 | Toolgen Inc | PHENOTYPIC SCANNING OF CHIMERIC PROTEINS |
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2002
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- 2002-12-07 JP JP2003549524A patent/JP2005511049A/ja active Pending
- 2002-12-07 CN CNB028244125A patent/CN100463962C/zh not_active Expired - Fee Related
- 2002-12-07 KR KR1020047008726A patent/KR20040065235A/ko not_active Ceased
- 2002-12-07 CA CA002469477A patent/CA2469477A1/en not_active Abandoned
- 2002-12-07 AU AU2002365796A patent/AU2002365796A1/en not_active Abandoned
- 2002-12-07 WO PCT/KR2002/002309 patent/WO2003048345A1/en not_active Ceased
- 2002-12-09 US US10/314,669 patent/US20030194727A1/en not_active Abandoned
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2003
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