JP2005510531A5 - - Google Patents
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- JP2005510531A5 JP2005510531A5 JP2003546813A JP2003546813A JP2005510531A5 JP 2005510531 A5 JP2005510531 A5 JP 2005510531A5 JP 2003546813 A JP2003546813 A JP 2003546813A JP 2003546813 A JP2003546813 A JP 2003546813A JP 2005510531 A5 JP2005510531 A5 JP 2005510531A5
- Authority
- JP
- Japan
- Prior art keywords
- formulation
- gum
- natural
- locust bean
- stabilizer
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US33207401P | 2001-11-21 | 2001-11-21 | |
| US60/332,074 | 2001-11-21 | ||
| PCT/US2002/037385 WO2003045308A2 (en) | 2001-11-21 | 2002-11-21 | Formulations for use in medical or diagnostic procedures |
Publications (3)
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| JP2005510531A JP2005510531A (ja) | 2005-04-21 |
| JP2005510531A5 true JP2005510531A5 (https=) | 2005-12-22 |
| JP4820054B2 JP4820054B2 (ja) | 2011-11-24 |
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| US (2) | US7427391B2 (https=) |
| EP (1) | EP1458328B1 (https=) |
| JP (1) | JP4820054B2 (https=) |
| KR (1) | KR20040071143A (https=) |
| AU (1) | AU2002365395B2 (https=) |
| BR (1) | BR0214314A (https=) |
| CA (1) | CA2466808C (https=) |
| IL (1) | IL162095A0 (https=) |
| RU (1) | RU2004119035A (https=) |
| WO (1) | WO2003045308A2 (https=) |
| ZA (1) | ZA200404023B (https=) |
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| US7427391B2 (en) * | 2001-11-21 | 2008-09-23 | E-Z-Em, Inc. | Formulations for use in medical and diagnostic procedures |
| US7378081B2 (en) * | 2003-01-29 | 2008-05-27 | Vincon Research Enterprises, Llc | Composition and method for direct visualization of the human appendix |
| US20050180920A1 (en) * | 2003-01-29 | 2005-08-18 | Vincenzo Giuliano | Oral contrast media composition for computerized axial tomographic examinations and method |
| CN100388313C (zh) * | 2003-02-05 | 2008-05-14 | 皇家飞利浦电子股份有限公司 | 定量分析精度指示 |
| US7582283B2 (en) * | 2004-02-13 | 2009-09-01 | Wisconsin Alumni Research Foundation | Contrast agents to improve gastrointestinal tract opacification during abdominal and pelvic CT scans |
| ES2331195T3 (es) | 2004-07-15 | 2009-12-23 | Gynaecologiq B.V. | Composicion y metodo para imagineria medica de cavidades corporales. |
| US9585973B1 (en) * | 2008-06-05 | 2017-03-07 | Peter Quagliano | Palatable liquid dilution vehicles for oral contrast agents |
| NL2003660C2 (en) | 2009-10-16 | 2011-04-19 | Giskit B V | Composition and method for medical imaging of body cavities. |
| WO2011136336A1 (ja) * | 2010-04-30 | 2011-11-03 | 味の素株式会社 | Ｃｔコロノグラフィに用いられる経口投与用液剤及び消化管造影用組成物 |
| AU2019227840B2 (en) * | 2018-02-27 | 2022-12-15 | Trisco ICAP Pty Ltd | An ingredient |
| IT201900003113A1 (it) * | 2019-03-04 | 2020-09-04 | Azienda Ospedaliero Univ Policlinico S Orsola Malpighi Bologna | Bevanda coadiuvante |
| US11730831B2 (en) | 2019-03-26 | 2023-08-22 | Sicreations, Llc | Imaging agents and methods of using the same |
| US11833227B2 (en) | 2019-05-29 | 2023-12-05 | Sicreations, Llc | Methods for preserving a subject and using imaging contrast agents |
Family Cites Families (38)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB657979A (en) * | 1948-07-03 | 1951-10-03 | Miles Lab | Improvements in or relating to x-ray contrast mediums |
| US3975512A (en) * | 1970-12-21 | 1976-08-17 | University Of Illinois Foundation | Non-toxic brominated perfluorocarbons radiopaque agents |
| US4074709A (en) * | 1976-04-15 | 1978-02-21 | Kaplan Leopold S | Method and device for facilitating double-contrast studies of the upper gastrointestinal tract |
| GB1599881A (en) * | 1977-02-02 | 1981-10-07 | Millington A R | Preparation for diagnostic radiology |
| US4448207A (en) * | 1981-11-03 | 1984-05-15 | Vital Metrics, Inc. | Medical fluid measuring system |
| SE8601563D0 (sv) * | 1986-04-08 | 1986-04-08 | Carbomatrix Ab | Matrismaterial, forfarande for framstellning derav och anvendning derav |
| US5019059A (en) * | 1986-12-15 | 1991-05-28 | Uresil Corporation | Apparatus and method for collecting body fluids |
| US4930997A (en) * | 1987-08-19 | 1990-06-05 | Bennett Alan N | Portable medical suction device |
| AU4492989A (en) * | 1988-10-20 | 1990-05-14 | Fusen H. Chen | Incontinence device |
| US5783171A (en) * | 1989-06-16 | 1998-07-21 | Neorx Corporation | Radionuclide metal N2 S2 chelates substituted with glucose and biotin moieties |
| GB8916782D0 (en) * | 1989-07-21 | 1989-09-06 | Nycomed As | Compositions |
| US4957486A (en) * | 1989-10-02 | 1990-09-18 | Davis Emsley A | Rectal-stomal insert apparatus and method |
| US6088613A (en) | 1989-12-22 | 2000-07-11 | Imarx Pharmaceutical Corp. | Method of magnetic resonance focused surgical and therapeutic ultrasound |
| US5368840A (en) * | 1990-04-10 | 1994-11-29 | Imarx Pharmaceutical Corp. | Natural polymers as contrast media for magnetic resonance imaging |
| US5107842A (en) * | 1991-02-22 | 1992-04-28 | Molecular Biosystems, Inc. | Method of ultrasound imaging of the gastrointestinal tract |
| US5179955A (en) | 1991-02-22 | 1993-01-19 | Molecular Biosystems, Inc. | Method of abdominal ultrasound imaging |
| JP3238485B2 (ja) * | 1992-08-07 | 2001-12-17 | 明治乳業株式会社 | 消化管造影用組成物 |
| US5380522A (en) | 1992-08-11 | 1995-01-10 | Day; Charles E. | Method for treatment of irritable bowel syndrome |
| EP0669823A4 (en) * | 1992-10-06 | 1996-03-13 | Molecular Biosystems Inc | Ultrasound imaging of body cavity. |
| JPH06157355A (ja) * | 1992-11-13 | 1994-06-03 | Dai Ichi Seiyaku Co Ltd | Ｍｒｉ用粒状製剤 |
| EP0741581A1 (en) * | 1994-01-28 | 1996-11-13 | Nycomed Imaging As | Oral magnetic particle formulation |
| US5611342A (en) * | 1994-02-15 | 1997-03-18 | Molecular Biosystems, Inc. | Method of computer tomography imaging the gastrointestinal tract and surrounding upper abdominal tissues and organs using an orally administered low density contrast medium |
| US5736121A (en) | 1994-05-23 | 1998-04-07 | Imarx Pharmaceutical Corp. | Stabilized homogenous suspensions as computed tomography contrast agents |
| DE4424233C1 (de) * | 1994-07-09 | 1995-12-07 | Thomas Gieselmann | Orales Echokontrastmittel für Ultraschalldiagnostik |
| US5782762A (en) * | 1994-10-27 | 1998-07-21 | Wake Forest University | Method and system for producing interactive, three-dimensional renderings of selected body organs having hollow lumens to enable simulated movement through the lumen |
| US6066139A (en) * | 1996-05-14 | 2000-05-23 | Sherwood Services Ag | Apparatus and method for sterilization and embolization |
| US5779662A (en) * | 1996-05-20 | 1998-07-14 | Linvatec Corporation | Laparoscopic tissue resection system |
| JP2002511837A (ja) * | 1996-09-10 | 2002-04-16 | メデイノックス，インコーポレイテッド | ポリジチオカルバメート含有マクロ分子と、治療及び診断用途へのその使用 |
| EP0959693A1 (en) * | 1997-01-31 | 1999-12-01 | Fmc Corporation | Texture and stabilizer composition |
| GB9710699D0 (en) * | 1997-05-24 | 1997-07-16 | Danbiosyst Uk | Gastro-retentive controlled release system |
| CN1233505A (zh) * | 1998-04-24 | 1999-11-03 | 胡挽华 | 一种胃肠阴性造影剂及其生产方法 |
| US6214376B1 (en) * | 1998-08-25 | 2001-04-10 | Banner Pharmacaps, Inc. | Non-gelatin substitutes for oral delivery capsules, their composition and process of manufacture |
| JP3099293B2 (ja) * | 1999-02-12 | 2000-10-16 | イトー海外事業株式会社 | 可食印刷用シート及びその製造装置並びに製造方法 |
| JP2001048810A (ja) * | 1999-08-04 | 2001-02-20 | Ina Food Ind Co Ltd | 造影剤用増粘剤 |
| IN192748B (https=) * | 2000-08-29 | 2004-05-15 | Ranbaxy Lab Ltd | |
| IL155204A0 (en) * | 2000-10-02 | 2003-11-23 | Arizeke Pharmaceuticals Inc | Compositions and methods for the transport of biologically active agents across cellular barriers |
| KR20040032918A (ko) | 2001-08-16 | 2004-04-17 | 더 스테이트 오브 오레곤 액팅 바이 앤드 쓰루 더 스테이트 보드 오브 하이어 에쥬케이션 온 비해프 오브 오레곤 스테이트 유니버시티 | 팽창 가능한 위 정지 장치 |
| US7427391B2 (en) * | 2001-11-21 | 2008-09-23 | E-Z-Em, Inc. | Formulations for use in medical and diagnostic procedures |
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2002
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- 2002-11-21 RU RU2004119035/15A patent/RU2004119035A/ru not_active Application Discontinuation
- 2002-11-21 AU AU2002365395A patent/AU2002365395B2/en not_active Expired
- 2002-11-21 CA CA002466808A patent/CA2466808C/en not_active Expired - Lifetime
- 2002-11-21 ZA ZA200404023A patent/ZA200404023B/en unknown
- 2002-11-21 WO PCT/US2002/037385 patent/WO2003045308A2/en not_active Ceased
- 2002-11-21 BR BR0214314-3A patent/BR0214314A/pt not_active IP Right Cessation
- 2002-11-21 JP JP2003546813A patent/JP4820054B2/ja not_active Expired - Lifetime
- 2002-11-21 EP EP02804018A patent/EP1458328B1/en not_active Expired - Lifetime
- 2002-11-21 KR KR10-2004-7007813A patent/KR20040071143A/ko not_active Ceased
- 2002-11-21 IL IL16209502A patent/IL162095A0/xx unknown
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2008
- 2008-09-19 US US12/234,147 patent/US8343462B2/en not_active Expired - Fee Related
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