JP2005509661A - 規定のホウ素化合物を含む組成物及びキット、それらの調製方法、並びにそれらの使用及び投与 - Google Patents
規定のホウ素化合物を含む組成物及びキット、それらの調製方法、並びにそれらの使用及び投与 Download PDFInfo
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- WWRJFSIRMWUMAE-ZZMNMWMASA-L zinc;(2r)-2-[(1s)-1,2-dihydroxyethyl]-3-hydroxy-5-oxo-2h-furan-4-olate Chemical compound [Zn+2].OC[C@H](O)[C@H]1OC(=O)C(O)=C1[O-].OC[C@H](O)[C@H]1OC(=O)C(O)=C1[O-] WWRJFSIRMWUMAE-ZZMNMWMASA-L 0.000 description 1
- POEVDIARYKIEGF-CEOVSRFSSA-L zinc;(2s)-2-aminobutanedioate;hydron Chemical compound [Zn+2].[O-]C(=O)[C@@H](N)CC(O)=O.[O-]C(=O)[C@@H](N)CC(O)=O POEVDIARYKIEGF-CEOVSRFSSA-L 0.000 description 1
- 235000007680 β-tocopherol Nutrition 0.000 description 1
- 239000011590 β-tocopherol Substances 0.000 description 1
- 239000002478 γ-tocopherol Substances 0.000 description 1
- QUEDXNHFTDJVIY-DQCZWYHMSA-N γ-tocopherol Chemical compound OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1 QUEDXNHFTDJVIY-DQCZWYHMSA-N 0.000 description 1
- 239000002446 δ-tocopherol Substances 0.000 description 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/22—Boron compounds
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Their preparation
- A23L2/02—Non-alcoholic beverages; Dry compositions or concentrates therefor; Their preparation containing fruit or vegetable juices
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Their preparation
- A23L2/52—Adding ingredients
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Their preparation
- A23L2/52—Adding ingredients
- A23L2/54—Mixing with gases
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/16—Inorganic salts, minerals or trace elements
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Abstract
Description
しかし残念ながら、市販の食品及び飲料製品、特に飲料製品に実際にホウ素を配合するには問題が生じ得る。実際、本発明者は、特に水性飲料への溶解性が低いという点に関してホウ素にはこうした配合を困難にする溶解性の問題が存在し得ることを見出すに至った。通常溶解性が低いことは、水溶液中にホウ素が沈殿することによって観測されるが、それが外観上許容できない、または望ましくない配合につながる。加えて、更に一層問題になるのは、この低い溶解性により、ホウ素が適切に投与される見込みが低下し(例えば、飲料容器中でホウ素が沈殿することによってホウ素が消費されないかまたは消費量が減るという結果になり)、更にホウ素が溶解して生物学的に利用可能になるという見込みが、治療が必要な哺乳類にとって低下する。
a)ホウ素化合物;及び
b)組成物の少なくとも約10重量%の水;
を含む組成物であって、該組成物のpHが、該ホウ素化合物のpKaよりも少なくとも約2pH単位低い。
a)該ホウ素化合物を含む水溶液を提供する工程であって、該水溶液のpHが、該ホウ素化合物のpKaよりも少なくとも約2pH単位低く、該水溶液が実質的にペクチン及び炭水化物を含まない工程;及び
b)該水溶液と1以上の追加の飲料成分とを組み合わせる工程;
を含む飲料組成物の好ましい調製方法が提供される。
更に前記組成物を使用(投与を含む)する方法、並びに前記組成物を含むキットも開示される。
パーセント及び比率はすべて、他に指示がない限り、重量で計算される。パーセント及び比率はすべて、他に指示がない限り、総組成物基準で計算される。
すべての成分または組成物の濃度は、その成分または組成物の有効濃度に関するものであり、不純物、例えば、市販の供給源中に存在する可能性がある残存溶媒または副生成物は除外されている。
本明細書の組成物は、本明細書に記載されているようないかなる要素を含むことも、いずれの要素から本質的に成ることも、またはいずれの要素から成ることも可能である。
本発明は、種々の目的に有用であるホウ素を含有する組成物を対象とし、その目的には、骨の健康上の促進、関節炎及び痛み並びに炎症の緩和、並びに他の有益な健康上の効果の提供が含まれる。組成物は、水性飲料へのホウ素の配合に関連する問題、及び付随する生物学的利用能及び安定性の低下を克服できる。本発明はいくつかの実施形態を含み、その実施形態としては、ホウ素を含有する組成物の配合に関して観察されてきた問題を克服できる種々の組成物、並びにこれら化合物を製造する方法及びこれら化合物を含むキットが挙げられる。
(a)ホウ素化合物;及び
(b)組成物の少なくとも約10重量%の水;
を含む飲料組成物であって、該組成物のpHは、前記ホウ素化合物のpKaよりも少なくとも約2pH単位低い。
本明細書の飲料組成物は、ホウ素化合物、及び組成物の少なくとも約10重量%の水を含み、組成物のpHが、ホウ素化合物のpKaよりも少なくとも約2pH単位低い。より好ましくは組成物のpHは、ホウ素化合物のpKaよりも少なくとも約2.5pH単位低い、またはホウ素化合物のpKaよりも少なくとも約3pH単位低い。
本明細書に用いるのに好適なホウ素化合物の非限定例としては、ホウ酸(約9.2のpKaを有する)、ホウ酸ナトリウム(例えば、ボラックス(BORAX)(登録商標))(約9.2のpKaを有する)、クエン酸ホウ素(約7.5のpKaを有する)、ボロングリシネート(約4.9のpKaを有する)、アスパラギン酸ホウ素(約5.6のpKaを有する)が挙げられる。本明細書に用いるのに最も好ましいホウ素化合物は、ホウ酸及びクエン酸ホウ素である。
記載したように、本明細書に使用される組成物は、使用されるホウ素化合物のpKaよりも少なくとも約2pH単位低いpHを有する。本明細書で論じてきたように、この規定されたpHを有する組成物は、ホウ素化合物の錯化、不溶性、及び/または沈殿を回避または最小限にし、配合の容易性及び望ましい生物学的利用能を達成するために本明細書に用いるために最適である。
好ましくは、組成物は、約7.2以下、更により好ましくは約6以下、最も好ましくは約5以下のpHを有する。酸性pHでは、本発明は約2.5〜約4のpHで最適に利用されることが発見されている。
しかし、酸性成分を使用する必要がない場合もある。例えば本組成物が、必要なpHに改質する傾向の成分を使用しなくても本質的に必要なpHを有する場合がある。
本明細書の好ましい飲料組成物は、飲料濃縮物及びすぐ飲める飲料組成物である。本明細書に使用される組成物は、組成物の少なくとも約10重量%の水を含む。より好ましくは、組成物は、組成物の少なくとも約40重量%の水、一層より好ましくは少なくとも約50重量%の水、更により好ましくは少なくとも約75重量%の水、最も好ましくは少なくとも約80重量%の水を含む。尚、更に、すぐ飲める飲料組成物は、典型的に組成物の少なくとも約82重量%の水、より典型的には少なくとも約85重量%の水を含む。所与の組成物に存在する水は、全ての添加水及び他の成分、例えば果実または野菜ジュースに本質的に存在する水を含む。
記載してきたように、本発明には種々の実施形態があり、それらは本知見に従って利用することが可能である。好ましいpKa値、pHレベル、及び水濃度は本明細書の上記で記載された通りである。このような組成物は、更なる成分を任意選択的に含むことも可能で、本明細書の以下に記載される好ましい任意成分が挙げられるが、これらに限定されない。
種々の軟骨保護剤、及びその好ましい実施形態を、次に更に詳細に記載する。
記載したように、本発明の組成物は飲料組成物として利用することも可能で、そのため種々の任意成分を含むことも可能である。ペクチン(例えば、果実または野菜ジュース)及び軟骨保護剤が特に好ましく、それらは既に説明してきた。また、本発明の組成物は、例えば1以上の前述の健康上の利益(例えば関節炎の軽減)を提供すること、望ましい栄養側面を提供すること及び/または向上した感覚器の特性を提供すること、においてそれらの性能を向上させる他の任意成分を含むこともできる。このような任意成分は、本組成物中に分散、溶解することも可能で、或いは混合することもできる。本明細書に用いるのに好適な他の任意成分の非限定的な例を以下に挙げる。
フラバノールは多様な植物に存在する天然物質である(例えば、果物、野菜及び花)。本発明に利用され得るフラバノールは例えば果物、野菜、緑茶または他の天然資源から当業者に周知のいずれかの好適な方法によって抽出することも可能である。例えば、酢酸エチルまたは塩素化有機溶媒での抽出が緑茶からフラバノールを分離するための一般的な方法である。フラバノールは1つの植物または植物の混合物から抽出することができる。多くの果物、野菜、及び花がフラバノールを含有するが、緑茶に比較して程度は低い。フラバノールを含有する植物は当業者には既知である。茶植物及びカテキュー・ガンビール(ウンカリア属)の他のものから抽出される最も一般的なフラバノールとしては、例えばカテキン、エピカテキン、ガロカテキン、エピガロカテキン、エピカテキンガレート、及びエピガロカテキンガレートが挙げられる。
或いは、これらの同じフラバノールを合成的にまたは他の適切な化学的な方法で調製することができ、及び本組成物に組み込むことができる。カテキン、エピカテキン、及びこれらの誘導体を包含するフラバノールが市販されている。
本発明の組成物は、炭水化物甘味料並びに天然及び/または人工のノンカロリー/低カロリー甘味料を包含する、1以上の甘味料有効量を含有することができ、通常は含有する。本発明の飲料に使用される甘味料の量は典型的に、使用される特定の甘味料と望ましい甘味強度によって決まる。ノンカロリー/低カロリー甘味料については、この量は、特定の甘味料の甘味強度に依存して変化する。
本明細書の組成物は、任意選択的に、1以上のビタミン及び/またはミネラルで強化されることも可能で、それらは本明細書において栄養素と称される。推奨日常食事許容量 − 食物及び栄養局、国立科学学会 − 国立調査審議会において、ビタミン及びミネラルについての米国推奨日常摂取量(The U.S.Recommended Daily Intake)(USRDI)で規定され及び記載されている。本明細書で特に指示がない限り、所与のビタミンが組成物に存在する場合、組成物は、こうしたビタミンのUSRDIの少なくとも約1%、好ましくは少なくとも約5%、より好ましくは約10%〜約200%、更により好ましくは約10%〜約150%、及び最も好ましくは約10%〜約100%を含む。本明細書で特に指定しない限りは、組成物中にホウ素以外の所与のミネラルが存在する場合、組成物は典型的にこのようなミネラルのUSRDIの少なくとも約1%、好ましくは少なくとも約5%、より好ましくは約5%〜約100%、更により好ましくは約10%〜約40%、最も好ましくは約10%〜約30%を含む。
利用されるビタミンCは、いかなる形態、例えば、遊離の形態またはカプセル封入の形態でも可能である。
Fe(L)2
のものであり、式中、Lはαアミノ酸、ジペプチド、トリペプチドまたはクアドラペプチド(quadrapeptide)の反応配位子である。このようにLは、アラニン、アルギニン、アスパラギン、アスパラギン酸、システイン、シスチン、グルタミン、グルタミン酸、グリシン、ヒスチジン、ヒドロキシプロリン、イソロイシン、ロイシン、リシン、メチオニン、オルニチン、フェニルアラニン、プロリン、セリン、スレオニン、トリプトファン、チロシン、及びバリンから選択される天然に存在するα−アミノ酸;またはこれらのアミノ酸の組み合わせによって形成されるジペプチド、トリペプチド、若しくはクアドラペプチド(quadrapeptide)であるいかなる反応配位子でもあり得る。例えば、米国特許第5,516,925号、米国特許第5,292,729号、及び米国特許第4,830,716号を参照のこと。特に好ましいアミノ酸キレート第一鉄は、反応配位子がグリシン、リシン、及びロイシンであるものである。最も好ましいのは、商品名フェローシェル(FERROCHEL)(登録商標)で販売されている、反応する配位子がグリシンであるアミノ酸キレート第一鉄である。フェローシェル(FERROCHEL)(登録商標)は、ユタ州ソルトレイクシティ(Salt Lake City, Utah)のアルビオン研究所(Albion Laboratories)から市販されている。本明細書のフェローシェル(FERROCHEL)(登録商標)の使用は、組成物のpHが低い場合に特に有用である。
本発明の希釈ジュース飲料は、任意選択的に、約0.2%〜約5%、好ましくは約0.5%〜約3%、及び最も好ましくは約0.8%〜約2%の飲料エマルションを含む。この飲料エマルションは、クラウドエマルションでもフレーバエマルションでも可能である。
1以上の着香剤がそれらの美味性を高めるために本明細書の実施形態として推奨される。いずれかの天然または合成着香剤を本発明に使用し得る。例えば、1以上の植物及び/または果実風味を本明細書に使用することも可能である。本明細書で使用する時、かかる風味は合成または天然の風味でもよい。
本発明の組成物中には少量の1以上の着色剤を使用することが可能である。FD&C染料(例:黄色5号、青色2号、赤色40号)、及び/またはFD&Cレーキの使用が好ましい。レーキを他の粉末成分に加えることによって、全粒子、特に着色鉄化合物は、完全に且つ均一に着色され、一様に着色した飲料混合物ができあがる。本発明に用いることも可能な好ましいレーキは、赤色40号、黄色6号、青色1号などのようなFDAが認可したレーキである。加えて、FD&C染料、またはFD&Cレーキ染料と他の従来の食品、及び食品用着色料と組み合わせた混合物を使用することもできる。リボフラビン、及びβ−カロチンもまた使用可能である。加えて、例えば、果実、野菜、及び/またはぶどう、黒すぐり、アロニア、ニンジン、ビートの根、赤キャベツ、及びハイビスカスなどの植物抽出物を包含する他の天然着色剤を使用することもできる。
防腐剤は、本組成物の使用に必要或いは不必要の場合がある。滅菌及び/または無菌充填加工のような技法を利用して防腐剤を回避することも可能である。
しかしながら、1以上の防腐剤を任意で本組成物に添加することも可能である。好ましい防腐剤には、例えば、ソルビン酸塩、安息香酸塩、及びポリリン酸塩の防腐剤(例えば、ヘキサメタポリリン酸ナトリウム)が挙げられる。
二酸化炭素は炭酸化を得るため、飲料濃縮物と混ぜ合わせる水に、または希釈後の飲料組成物中に、注入することができる。炭酸飲料は、瓶または缶のような容器へ収容することができ、その後密封される。従来の炭酸化の方法はどれでも、本発明の炭酸飲料組成物を作るのに用いることが可能である。飲料に入れる二酸化炭素の量は、利用される特定の風味系、及び所望の炭酸化の量に依存する。
本明細書でより深く見出されてきたように、ホウ素は、以下で記載される規定された工程に従って配合されるのが最適である。或いは本組成物は、当業者に周知の様式を含む種々の様式で配合することもできる。
a)該ホウ素化合物を含む水溶液を提供する工程であって、該水溶液のpHが、該ホウ素化合物のpKaよりも少なくとも約2pH単位低く、該水溶液が実質的にペクチン及び炭水化物を含まない工程;及び
b)該水溶液と1以上の追加の飲料成分とを組み合わせる工程;
を含む方法。
本発明の組成物は、本明細書に記載されているキットで使用することもできる。本発明のキットは1つ以上の本発明の組成物と共に、そのキットを使用することで、これに限定されないが、関節の健康上の利益(関節炎及び/または変形性関節症の軽減、予防、及び/または阻止、並びに柔軟性の強化を包含する)、骨の健康上の利益(骨の維持及び/または構築を包含する)、抗炎症及び鎮痛活性(例えば、痛みの軽減)、並びに抗がん上の利益(前立腺がんの治療を包含する)及び神経系上の利益を包含する1以上の一般的な健康上及び/または一般的な生理学的利益を提供するであろうことを、キットのユーザーに言葉、絵、及び/またはその他同様のものによって知らせる情報を含む。
本発明の方法は、関節機能不全、骨の機能不全、痛み及び/または炎症の治療のために、哺乳類、好ましくはヒトに本発明の組成物を経口投与すること(即ち、摂取による)を含む。好ましくは関節及び/または骨の機能不全を経験している哺乳類または現在の関節及び/骨機能の維持(即ち予防的使用)を望む者が組成物を摂取する。本発明の組成物はまた通常の栄養必要物の補助剤として摂取され得る。投与の頻度は限定されないが、かかる投与は典型的には少なくとも週に1回、より好ましくは少なくとも週に3回、及び最も好ましくは少なくとも1日に1回である。投与は典型的には継続される。
本明細書に利用されるホウ素化合物のpKaは、次のように測定することが可能である。pKa値は、ホウ素化合物の飽和水溶液を調製し、その溶液を期待pKa値よりも低くなるまで塩酸で酸性化することによって測定することも可能である。自動滴定器を用い、標準的な方法に従って溶液を滴定する。ホウ素化合物のpKaは、得られた滴定曲線に変曲点が生じる際のpHである。
次の成分が示されている量を有するように次の飲料組成物を調製する:
次の炭酸オレンジ飲料組成物を、炭酸水(塩基性特性を有する傾向にある)以外の全ての所望の成分を組み合わせることによって調製する。組成物のpHを必要によりクエン酸を用いて4に調整する。ホウ素化合物を添加して、最終飲料組成物236mL当たり約3mgのホウ素を送達する。炭酸水を最後に添加して最終飲料組成物を得る。
次成分が示されている量を有するように次の果実及び野菜ジュース組成物を調製する:
次の成分が示されている量を有するように次のジュース組成物を調製する:
Claims (25)
- a)ホウ素化合物;及び
b)組成物の少なくとも約10重量%の水;
を含む飲料組成物であって、該組成物のpHが、前記ホウ素化合物のpKaよりも少なくとも約2pH単位低いことを特徴とする飲料組成物。 - 該組成物のpHが約7.2以下であることを特徴とする請求項1に記載の組成物。
- 該ホウ素化合物のpKaが約4以上であることを特徴とする請求項2に記載の組成物。
- 該組成物の少なくとも約50重量%の水を含む、すぐ飲める飲料組成物であることを特徴とする請求項3に記載の組成物。
- 該組成物のpHが、該ホウ素化合物のpKaよりも少なくとも約2.5pH単位低いことを特徴とする請求項4に記載の組成物。
- 該組成物のpHが約6以下であり、該ホウ素化合物のpKaが約7.5以上であることを特徴とする請求項5に記載の組成物。
- 該組成物のpHが約5以下であり、該ホウ素化合物のpKaが約9以上であることを特徴とする請求項6に記載の組成物。
- ペクチンを更に含むことを特徴とする請求項2に記載の組成物。
- 果汁を含むことを特徴とする請求項8に記載の組成物。
- 該ホウ素に加えて1以上の栄養素を更に含むことを特徴とする請求項9に記載の組成物。
- 該組成物の少なくとも約50重量%の水を含む、すぐ飲める飲料組成物であることを特徴とする請求項10に記載の組成物。
- 該ホウ素化合物が、ホウ酸、クエン酸ホウ素、及びこれらの混合物から成る群より選択されることを特徴とする請求項11に記載の組成物。
- 該組成物のpHが約2.5〜約4であることを特徴とする請求項12に記載の組成物。
- 該栄養素の少なくとも1つが、カルシウム及びビタミンDから成る群より選択されることを特徴とする請求項13に記載の組成物。
- 該栄養素の少なくとも1つがカルシウムであることを特徴とする請求項14に記載の組成物。
- 1以上の更なる軟骨保護剤を更に含むことを特徴とする請求項2に記載の組成物。
- 該軟骨保護剤の少なくとも1つがアミノ糖またはそれらの塩であることを特徴とする請求項16に記載の組成物。
- 該軟骨保護剤の少なくとも1つがグルコサミン塩であることを特徴とする請求項17に記載の組成物。
- 該組成物のpHが、前記ホウ素化合物のpKaよりも少なくとも約2.5pH単位低いことを特徴とする請求項18に記載の組成物。
- 果汁を更に含むことを特徴とする請求項19に記載の組成物。
- ホウ素化合物を含む飲料組成物を調製する方法であって:該方法が、
a)該ホウ素化合物を含む水溶液を提供する工程であって、該水溶液のpHが、該ホウ素化合物のpKaよりも少なくとも約2pH単位低く、該水溶液が実質的にペクチン及び炭水化物を含まない工程;及び
b)該水溶液と1以上の追加の飲料成分とを組み合わせる工程;
を含むことを特徴とする方法。 - 該追加の飲料成分の少なくとも1つが、果汁及び炭水化物から成る群より選択されることを特徴とする請求項21に記載の方法。
- 関節機能不全、骨機能不全、痛み、炎症及びこれらの組み合わせから成る群より選択される状態を治療する方法であって、請求項1に記載の組成物を哺乳類に経口投与する工程を含むことを特徴とする方法。
- 該投与が1日1回であることを特徴とする請求項23に記載の方法。
- (a)請求項1に記載の組成物;及び
組成物の使用が1以上の健康上の利益に有用であるという情報であって、該利益の少なくとも1つが、関節の健康上の利益、骨の健康上の利益、鎮痛活性、及び抗炎症から成る群より選択される情報を含むことを特徴とするキット。
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US09/989,641 US6632449B2 (en) | 2001-11-20 | 2001-11-20 | Compositions and kits comprising a defined boron compound and methods of their preparation |
PCT/US2002/036531 WO2003043617A1 (en) | 2001-11-20 | 2002-11-15 | Compositions and kits comprising a defined boron compound, methods of their preparation, and use and administration thereof |
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EP (2) | EP1450776A1 (ja) |
JP (1) | JP2005509661A (ja) |
CN (2) | CN101371710A (ja) |
AU (1) | AU2002346396A1 (ja) |
BR (1) | BR0214289A (ja) |
CA (1) | CA2463668C (ja) |
MX (1) | MXPA04004732A (ja) |
WO (1) | WO2003043617A1 (ja) |
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JP2015232016A (ja) * | 2006-01-27 | 2015-12-24 | エール ユニバーシティー | 胃酸分泌の即効性阻害剤 |
JP2013538823A (ja) * | 2010-09-23 | 2013-10-17 | タタ グローバル ビバレッジ リミテッド | 体力増進用(forstrength)カルシウム強化組成物、栄養補助水、及びその調製方法 |
JP2013538822A (ja) * | 2010-09-23 | 2013-10-17 | タタ グローバル ビバレッジ リミテッド | 三価クロム・ホウ素強化組成物、栄養補助水、及びその調製方法 |
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US20030096794A1 (en) | 2003-05-22 |
CN101371710A (zh) | 2009-02-25 |
WO2003043617A1 (en) | 2003-05-30 |
CN1589134A (zh) | 2005-03-02 |
MXPA04004732A (es) | 2004-07-30 |
EP1450776A1 (en) | 2004-09-01 |
AU2002346396A1 (en) | 2003-06-10 |
CA2463668A1 (en) | 2003-05-30 |
US6632449B2 (en) | 2003-10-14 |
CA2463668C (en) | 2010-06-15 |
BR0214289A (pt) | 2004-09-21 |
EP2266551A1 (en) | 2010-12-29 |
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