JP2005509445A5 - - Google Patents
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- Publication number
- JP2005509445A5 JP2005509445A5 JP2003545852A JP2003545852A JP2005509445A5 JP 2005509445 A5 JP2005509445 A5 JP 2005509445A5 JP 2003545852 A JP2003545852 A JP 2003545852A JP 2003545852 A JP2003545852 A JP 2003545852A JP 2005509445 A5 JP2005509445 A5 JP 2005509445A5
- Authority
- JP
- Japan
- Prior art keywords
- subject
- prostate cancer
- methylation
- kit
- level
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000000034 method Methods 0.000 claims 28
- 230000011987 methylation Effects 0.000 claims 27
- 238000007069 methylation reaction Methods 0.000 claims 27
- 206010060862 Prostate cancer Diseases 0.000 claims 22
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims 22
- 239000000523 sample Substances 0.000 claims 19
- 239000013615 primer Substances 0.000 claims 16
- 108020004707 nucleic acids Proteins 0.000 claims 14
- 150000007523 nucleic acids Chemical class 0.000 claims 14
- 102000039446 nucleic acids Human genes 0.000 claims 14
- 108700039691 Genetic Promoter Regions Proteins 0.000 claims 13
- 238000003752 polymerase chain reaction Methods 0.000 claims 13
- 102100030943 Glutathione S-transferase P Human genes 0.000 claims 10
- 101001010139 Homo sapiens Glutathione S-transferase P Proteins 0.000 claims 10
- 108020005187 Oligonucleotide Probes Proteins 0.000 claims 10
- 239000002751 oligonucleotide probe Substances 0.000 claims 10
- 108090000623 proteins and genes Proteins 0.000 claims 10
- 230000003321 amplification Effects 0.000 claims 7
- 238000003199 nucleic acid amplification method Methods 0.000 claims 7
- 102000005720 Glutathione transferase Human genes 0.000 claims 5
- 108010070675 Glutathione transferase Proteins 0.000 claims 5
- 210000002307 prostate Anatomy 0.000 claims 5
- 238000003753 real-time PCR Methods 0.000 claims 5
- 108091034117 Oligonucleotide Proteins 0.000 claims 4
- 238000004458 analytical method Methods 0.000 claims 4
- 108091029430 CpG site Proteins 0.000 claims 3
- 210000001124 body fluid Anatomy 0.000 claims 3
- 239000010839 body fluid Substances 0.000 claims 3
- 239000003795 chemical substances by application Substances 0.000 claims 3
- 238000003745 diagnosis Methods 0.000 claims 3
- 210000002381 plasma Anatomy 0.000 claims 3
- 210000000582 semen Anatomy 0.000 claims 3
- 210000002966 serum Anatomy 0.000 claims 3
- 210000002700 urine Anatomy 0.000 claims 3
- 101001023043 Homo sapiens Myoblast determination protein 1 Proteins 0.000 claims 2
- 102100035077 Myoblast determination protein 1 Human genes 0.000 claims 2
- 239000012472 biological sample Substances 0.000 claims 2
- OPTASPLRGRRNAP-UHFFFAOYSA-N cytosine Chemical class NC=1C=CNC(=O)N=1 OPTASPLRGRRNAP-UHFFFAOYSA-N 0.000 claims 2
- 210000001519 tissue Anatomy 0.000 claims 2
- LSNNMFCWUKXFEE-UHFFFAOYSA-M Bisulfite Chemical group OS([O-])=O LSNNMFCWUKXFEE-UHFFFAOYSA-M 0.000 claims 1
- 239000003155 DNA primer Substances 0.000 claims 1
- 206010029096 Neoplasm prostate Diseases 0.000 claims 1
- 239000013060 biological fluid Substances 0.000 claims 1
- 238000001514 detection method Methods 0.000 claims 1
- 238000006073 displacement reaction Methods 0.000 claims 1
- 239000007850 fluorescent dye Substances 0.000 claims 1
- 238000001215 fluorescent labelling Methods 0.000 claims 1
- 230000001404 mediated effect Effects 0.000 claims 1
- 239000002987 primer (paints) Substances 0.000 claims 1
- 230000035945 sensitivity Effects 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US33329601P | 2001-11-16 | 2001-11-16 | |
| PCT/US2002/036784 WO2003044232A1 (en) | 2001-11-16 | 2002-11-15 | Method of detection of prostate cancer |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2005509445A JP2005509445A (ja) | 2005-04-14 |
| JP2005509445A5 true JP2005509445A5 (https=) | 2006-01-05 |
| JP4381142B2 JP4381142B2 (ja) | 2009-12-09 |
Family
ID=23302188
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003545852A Expired - Lifetime JP4381142B2 (ja) | 2001-11-16 | 2002-11-15 | 前立腺癌の検出法 |
Country Status (9)
| Country | Link |
|---|---|
| US (3) | US7252935B2 (https=) |
| EP (1) | EP1456413B1 (https=) |
| JP (1) | JP4381142B2 (https=) |
| AT (1) | ATE393240T1 (https=) |
| AU (1) | AU2002352745A1 (https=) |
| CA (1) | CA2467455C (https=) |
| DE (1) | DE60226271T2 (https=) |
| ES (1) | ES2304462T3 (https=) |
| WO (1) | WO2003044232A1 (https=) |
Families Citing this family (72)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20090215058A1 (en) * | 2001-01-24 | 2009-08-27 | Health Discovery Corporation | Methods for screening, predicting and monitoring prostate cancer |
| US20090215024A1 (en) * | 2001-01-24 | 2009-08-27 | Health Discovery Corporation | Biomarkers upregulated in prostate cancer |
| US20090226915A1 (en) * | 2001-01-24 | 2009-09-10 | Health Discovery Corporation | Methods for Screening, Predicting and Monitoring Prostate Cancer |
| US8008012B2 (en) * | 2002-01-24 | 2011-08-30 | Health Discovery Corporation | Biomarkers downregulated in prostate cancer |
| US7718364B2 (en) * | 2003-03-25 | 2010-05-18 | John Wayne Cancer Institute | DNA markers for management of cancer |
| US20060078893A1 (en) | 2004-10-12 | 2006-04-13 | Medical Research Council | Compartmentalised combinatorial chemistry by microfluidic control |
| GB0307403D0 (en) | 2003-03-31 | 2003-05-07 | Medical Res Council | Selection by compartmentalised screening |
| GB0307428D0 (en) | 2003-03-31 | 2003-05-07 | Medical Res Council | Compartmentalised combinatorial chemistry |
| WO2005024068A2 (en) | 2003-09-05 | 2005-03-17 | Sequenom, Inc. | Allele-specific sequence variation analysis |
| CN1898396A (zh) * | 2003-10-20 | 2007-01-17 | 圣文森特医院（悉尼）有限公司 | 通过定量测定正常组织中的表观突变评价疾病的风险 |
| ES2801379T3 (es) | 2003-12-01 | 2021-01-11 | Epigenomics Ag | Métodos y ácidos nucleicos para el análisis de la expresión génica asociada con el desarrollo de trastornos proliferativos de células de próstata |
| JP4537050B2 (ja) * | 2003-12-25 | 2010-09-01 | 国立大学法人三重大学 | 前立腺癌、そのリスク又はその初期罹患の判定方法 |
| EP1730160A4 (en) * | 2004-03-17 | 2008-04-09 | Univ Johns Hopkins | Neoplasia diagnostic compositions and methods of use |
| US7608394B2 (en) * | 2004-03-26 | 2009-10-27 | Sequenom, Inc. | Methods and compositions for phenotype identification based on nucleic acid methylation |
| CA2561381C (en) | 2004-03-26 | 2015-05-12 | Sequenom, Inc. | Base specific cleavage of methylation-specific amplification products in combination with mass analysis |
| US20050221339A1 (en) | 2004-03-31 | 2005-10-06 | Medical Research Council Harvard University | Compartmentalised screening by microfluidic control |
| EP1756311A2 (en) * | 2004-05-17 | 2007-02-28 | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Berlin | Silencing of tumor-suppressive genes by cpg-methylation in prostate cancer |
| US7968287B2 (en) | 2004-10-08 | 2011-06-28 | Medical Research Council Harvard University | In vitro evolution in microfluidic systems |
| US11105808B2 (en) | 2004-11-12 | 2021-08-31 | Health Discovery Corporation | Methods for screening, predicting and monitoring prostate cancer |
| US7632634B2 (en) * | 2005-04-15 | 2009-12-15 | University Of Maryland Biotechnology Institute | Method and assay for early diagnosis of prostate cancer |
| US8268549B2 (en) * | 2005-04-15 | 2012-09-18 | University Of Maryland, Baltimore | Method and assay for determining methylation of GAL3 promoter for early diagnosis of prostate cancer |
| US7851154B2 (en) * | 2005-07-22 | 2010-12-14 | Simon Daniel Spivack | GC tag-modified bisulfite genomic DNA sequencing for continuous methylation spectra |
| US20070059753A1 (en) * | 2005-09-15 | 2007-03-15 | Tatiana Vener | Detecting gene methylation |
| JP2009514555A (ja) | 2005-11-08 | 2009-04-09 | ユークリッド ダイアグノスティックス リミテッド ライアビリティー カンパニー | 癌評価の遺伝子関連ＣｐＧアイランドのメチル化アッセイのための材料と方法 |
| US7906288B2 (en) * | 2006-01-04 | 2011-03-15 | The Johns Hopkins University | Compare-MS: method rapid, sensitive and accurate detection of DNA methylation |
| WO2007081385A2 (en) | 2006-01-11 | 2007-07-19 | Raindance Technologies, Inc. | Microfluidic devices and methods of use in the formation and control of nanoreactors |
| EP2530167A1 (en) | 2006-05-11 | 2012-12-05 | Raindance Technologies, Inc. | Microfluidic Devices |
| US9562837B2 (en) | 2006-05-11 | 2017-02-07 | Raindance Technologies, Inc. | Systems for handling microfludic droplets |
| EP2077912B1 (en) | 2006-08-07 | 2019-03-27 | The President and Fellows of Harvard College | Fluorocarbon emulsion stabilizing surfactants |
| IL186935A0 (en) * | 2006-10-31 | 2008-02-09 | Veridex Llc | Prostate cancer field effect analysis methods and kits |
| WO2008097559A2 (en) | 2007-02-06 | 2008-08-14 | Brandeis University | Manipulation of fluids and reactions in microfluidic systems |
| US20080213781A1 (en) * | 2007-02-15 | 2008-09-04 | Baden Jonathan F | Methods of detecting methylation patterns within a CpG island |
| JP2008202978A (ja) * | 2007-02-16 | 2008-09-04 | Hirosaki Univ | 前立腺癌の診断方法 |
| US20080254455A1 (en) * | 2007-04-12 | 2008-10-16 | Haiying Wang | Detecting prostate cancer |
| US8592221B2 (en) | 2007-04-19 | 2013-11-26 | Brandeis University | Manipulation of fluids, fluid components and reactions in microfluidic systems |
| MX2010008009A (es) * | 2008-01-22 | 2010-08-10 | Veridex Llc | Deteccion de hipermetilacion de gstp1 en el cancer de prostata. |
| EP4047367A1 (en) | 2008-07-18 | 2022-08-24 | Bio-Rad Laboratories, Inc. | Method for detecting target analytes with droplet libraries |
| US12038438B2 (en) | 2008-07-18 | 2024-07-16 | Bio-Rad Laboratories, Inc. | Enzyme quantification |
| US11298113B2 (en) | 2008-10-01 | 2022-04-12 | Covidien Lp | Device for needle biopsy with integrated needle protection |
| US9186128B2 (en) | 2008-10-01 | 2015-11-17 | Covidien Lp | Needle biopsy device |
| US9332973B2 (en) | 2008-10-01 | 2016-05-10 | Covidien Lp | Needle biopsy device with exchangeable needle and integrated needle protection |
| US8968210B2 (en) | 2008-10-01 | 2015-03-03 | Covidien LLP | Device for needle biopsy with integrated needle protection |
| US9782565B2 (en) | 2008-10-01 | 2017-10-10 | Covidien Lp | Endoscopic ultrasound-guided biliary access system |
| WO2010091296A2 (en) * | 2009-02-06 | 2010-08-12 | The Regents Of The University Of California | Emx2 in cancer diagnosis and prognosis |
| WO2010111231A1 (en) | 2009-03-23 | 2010-09-30 | Raindance Technologies, Inc. | Manipulation of microfluidic droplets |
| US10520500B2 (en) | 2009-10-09 | 2019-12-31 | Abdeslam El Harrak | Labelled silica-based nanomaterial with enhanced properties and uses thereof |
| US10837883B2 (en) | 2009-12-23 | 2020-11-17 | Bio-Rad Laboratories, Inc. | Microfluidic systems and methods for reducing the exchange of molecules between droplets |
| US9366632B2 (en) | 2010-02-12 | 2016-06-14 | Raindance Technologies, Inc. | Digital analyte analysis |
| EP4484577A3 (en) | 2010-02-12 | 2025-03-26 | Bio-Rad Laboratories, Inc. | Digital analyte analysis |
| US10351905B2 (en) | 2010-02-12 | 2019-07-16 | Bio-Rad Laboratories, Inc. | Digital analyte analysis |
| US9399797B2 (en) | 2010-02-12 | 2016-07-26 | Raindance Technologies, Inc. | Digital analyte analysis |
| US9562897B2 (en) | 2010-09-30 | 2017-02-07 | Raindance Technologies, Inc. | Sandwich assays in droplets |
| CA2826696C (en) | 2011-02-02 | 2019-12-03 | Mayo Foundation For Medical Education And Research | Digital sequence analysis of dna methylation |
| EP3412778A1 (en) | 2011-02-11 | 2018-12-12 | Raindance Technologies, Inc. | Methods for forming mixed droplets |
| WO2012112804A1 (en) | 2011-02-18 | 2012-08-23 | Raindance Technoligies, Inc. | Compositions and methods for molecular labeling |
| US8841071B2 (en) | 2011-06-02 | 2014-09-23 | Raindance Technologies, Inc. | Sample multiplexing |
| EP3216872B1 (en) | 2011-06-02 | 2020-04-01 | Bio-Rad Laboratories, Inc. | Enzyme quantification |
| US8658430B2 (en) | 2011-07-20 | 2014-02-25 | Raindance Technologies, Inc. | Manipulating droplet size |
| WO2013120089A1 (en) | 2012-02-10 | 2013-08-15 | Raindance Technologies, Inc. | Molecular diagnostic screening assay |
| EP2844768B1 (en) | 2012-04-30 | 2019-03-13 | Raindance Technologies, Inc. | Digital analyte analysis |
| US20140274767A1 (en) | 2013-01-23 | 2014-09-18 | The Johns Hopkins University | Dna methylation markers for metastatic prostate cancer |
| US20140274757A1 (en) | 2013-03-14 | 2014-09-18 | Marie K. Kirby | Differential Methylation Level of CpG Loci That Are Determinative of a Biochemical Reoccurrence of Prostate Cancer |
| WO2014172288A2 (en) | 2013-04-19 | 2014-10-23 | Raindance Technologies, Inc. | Digital analyte analysis |
| US11901041B2 (en) | 2013-10-04 | 2024-02-13 | Bio-Rad Laboratories, Inc. | Digital analysis of nucleic acid modification |
| US9944977B2 (en) | 2013-12-12 | 2018-04-17 | Raindance Technologies, Inc. | Distinguishing rare variations in a nucleic acid sequence from a sample |
| WO2015103367A1 (en) | 2013-12-31 | 2015-07-09 | Raindance Technologies, Inc. | System and method for detection of rna species |
| US10647981B1 (en) | 2015-09-08 | 2020-05-12 | Bio-Rad Laboratories, Inc. | Nucleic acid library generation methods and compositions |
| US10998178B2 (en) | 2017-08-28 | 2021-05-04 | Purdue Research Foundation | Systems and methods for sample analysis using swabs |
| US11427874B1 (en) | 2019-08-26 | 2022-08-30 | Epi One Inc. | Methods and systems for detection of prostate cancer by DNA methylation analysis |
| CN110951871B (zh) * | 2019-11-21 | 2024-01-05 | 瑞博奥(广州)生物科技股份有限公司 | Pca3和psa rna检测试剂盒和扩增体系 |
| CN116179694B (zh) * | 2022-11-02 | 2024-11-05 | 武汉艾米森生命科技有限公司 | 检测甲基化水平的试剂在制备前列腺癌诊断产品中的应用以及前列腺癌诊断试剂盒 |
| CN119391860B (zh) * | 2024-12-25 | 2025-03-21 | 慧算基因科技(上海)有限公司 | 一种用于胰腺癌术后mrd检测及动态监测的引物探针组合物、试剂盒及应用 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6017704A (en) * | 1996-06-03 | 2000-01-25 | The Johns Hopkins University School Of Medicine | Method of detection of methylated nucleic acid using agents which modify unmethylated cytosine and distinguishing modified methylated and non-methylated nucleic acids |
| AUPP312998A0 (en) * | 1998-04-23 | 1998-05-14 | Commonwealth Scientific And Industrial Research Organisation | Diagnostic assay |
| US6331393B1 (en) * | 1999-05-14 | 2001-12-18 | University Of Southern California | Process for high-throughput DNA methylation analysis |
| US20040033490A1 (en) * | 2000-03-31 | 2004-02-19 | Laird Peter W. | Epigenetic sequences for esophageal adenocarcinoma |
| US20050021240A1 (en) * | 2000-11-02 | 2005-01-27 | Epigenomics Ag | Systems, methods and computer program products for guiding selection of a therapeutic treatment regimen based on the methylation status of the DNA |
| DE10112515B4 (de) * | 2001-03-09 | 2004-02-12 | Epigenomics Ag | Verfahren zum Nachweis von Cytosin-Methylierungsmustern mit hoher Sensitivität |
-
2002
- 2002-11-15 AU AU2002352745A patent/AU2002352745A1/en not_active Abandoned
- 2002-11-15 JP JP2003545852A patent/JP4381142B2/ja not_active Expired - Lifetime
- 2002-11-15 DE DE2002626271 patent/DE60226271T2/de not_active Expired - Lifetime
- 2002-11-15 WO PCT/US2002/036784 patent/WO2003044232A1/en not_active Ceased
- 2002-11-15 US US10/295,483 patent/US7252935B2/en not_active Expired - Lifetime
- 2002-11-15 AT AT02789696T patent/ATE393240T1/de not_active IP Right Cessation
- 2002-11-15 CA CA 2467455 patent/CA2467455C/en not_active Expired - Lifetime
- 2002-11-15 EP EP20020789696 patent/EP1456413B1/en not_active Expired - Lifetime
- 2002-11-15 ES ES02789696T patent/ES2304462T3/es not_active Expired - Lifetime
-
2007
- 2007-07-06 US US11/825,479 patent/US7524633B2/en not_active Expired - Lifetime
-
2009
- 2009-03-16 US US12/404,964 patent/US20090181400A1/en not_active Abandoned
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