JP2005508983A - Ｐｄｅ４又はｐｄｅ３／４阻害剤及び抗リウマチ薬の複合薬 - Google Patents
Ｐｄｅ４又はｐｄｅ３／４阻害剤及び抗リウマチ薬の複合薬 Download PDFInfo
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- JP2005508983A JP2005508983A JP2003541843A JP2003541843A JP2005508983A JP 2005508983 A JP2005508983 A JP 2005508983A JP 2003541843 A JP2003541843 A JP 2003541843A JP 2003541843 A JP2003541843 A JP 2003541843A JP 2005508983 A JP2005508983 A JP 2005508983A
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- methyl
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- dione
- rheumatic
- dmard
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- DDYUBCCTNHWSQM-UHFFFAOYSA-N 3-(3-cyclopentyloxy-4-methoxyphenyl)-3-(1,3-dioxoisoindol-2-yl)propanamide Chemical compound COC1=CC=C(C(CC(N)=O)N2C(C3=CC=CC=C3C2=O)=O)C=C1OC1CCCC1 DDYUBCCTNHWSQM-UHFFFAOYSA-N 0.000 claims description 7
- JEXXKWQSTOIMJW-UHFFFAOYSA-N 5-methyl-n-[4-(trifluoromethyl)phenyl]-1,2-oxazole-3-carboxamide Chemical compound O1C(C)=CC(C(=O)NC=2C=CC(=CC=2)C(F)(F)F)=N1 JEXXKWQSTOIMJW-UHFFFAOYSA-N 0.000 claims description 7
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- 125000003668 acetyloxy group Chemical group [H]C([H])([H])C(=O)O[*] 0.000 claims description 7
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- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 5
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| JP2005508983A true JP2005508983A (ja) | 2005-04-07 |
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| JP2005533104A (ja) * | 2002-07-15 | 2005-11-04 | ユニテック ファーマシューティカルズ， インコーポレイテッド | 慢性関節リウマチを処置するためのレフルノミド類似体 |
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| US7718644B2 (en) * | 2004-01-22 | 2010-05-18 | The Trustees Of Columbia University In The City Of New York | Anti-arrhythmic and heart failure drugs that target the leak in the ryanodine receptor (RyR2) and uses thereof |
| MY140561A (en) * | 2002-02-20 | 2009-12-31 | Nycomed Gmbh | Dosage form containing pde 4 inhibitor as active ingredient |
| DK1511481T3 (da) * | 2002-05-28 | 2011-01-24 | Nycomed Gmbh | Ophthalmologisk anvendelse af roflumilast til behandling af øjensygdomme |
| UA82323C2 (uk) * | 2002-08-09 | 2008-04-10 | Меда Фарма Гмбх & Ко. Кг | Нова комбінація глюкокортикоїду та pde-інгібітору для лікування респіраторних захворювань, алергічних захворювань, астми та хронічних обструктивних легеневих захворювань |
| MXPA04008070A (es) | 2003-03-10 | 2004-11-26 | Altana Pharma Ag | Novedoso proceso para la preparacion de roflumilasto. |
| EP1755595A1 (en) * | 2004-05-10 | 2007-02-28 | Altana Pharma AG | Use of roflumilast for the prophylaxis or treatment of emphysema |
| US20080255121A1 (en) * | 2004-11-02 | 2008-10-16 | Dainippon Sumitomo Pharma Co., Ltd. | Combination Drug for Treating Autoimmune Disease |
| JP5385605B2 (ja) * | 2005-03-11 | 2014-01-08 | バーテックス ファーマシューティカルズ インコーポレイテッド | Ａｔｐ結合カセットトランスポーターのモジュレーター |
| JP5383183B2 (ja) * | 2005-03-16 | 2014-01-08 | タケダ ゲゼルシャフト ミット ベシュレンクテル ハフツング | ロフルミラストを含有する矯味された剤形 |
| KR100838702B1 (ko) * | 2007-02-08 | 2008-06-16 | 한국화학연구원 | 1-[1-(3,4-디알콕시아릴)-피리딜메틸]-1ｈ-피라졸 화합물의제조방법 |
| WO2010091381A2 (en) * | 2009-02-09 | 2010-08-12 | Callisto Pharmaceuticals, Inc. | An intermittent dosing strategy for treating rheumatoid arthrtis |
| US20150098993A1 (en) * | 2011-07-28 | 2015-04-09 | Shireen Vali | Compositions, process of preparation of said compositions and method of treating inflammatory diseases |
| JP6505023B2 (ja) | 2013-02-19 | 2019-04-24 | ファイザー・インク | Ｃｎｓおよび他の障害を治療するための、ｐｄｅ４アイソザイムの阻害薬としてのアザベンゾイミダゾール化合物 |
| JP6713982B2 (ja) | 2014-07-24 | 2020-06-24 | ファイザー・インク | ピラゾロピリミジン化合物 |
| CN106795165B (zh) | 2014-08-06 | 2019-09-10 | 辉瑞公司 | 咪唑并哒嗪化合物 |
| US11977085B1 (en) | 2023-09-05 | 2024-05-07 | Elan Ehrlich | Date rape drug detection device and method of using same |
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| DE60015098T2 (de) * | 1999-03-10 | 2006-02-02 | Altana Pharma Ag | 3-cyclopropylmethoxy-4-difluormethoxy-n-(3,5-dichlor-pyrid-4-yl)-benzamid zur behandlung von multipler sklerose |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2005533104A (ja) * | 2002-07-15 | 2005-11-04 | ユニテック ファーマシューティカルズ， インコーポレイテッド | 慢性関節リウマチを処置するためのレフルノミド類似体 |
| JP2010168402A (ja) * | 2002-07-15 | 2010-08-05 | Unitech Pharmaceuticals Inc | 慢性関節リウマチを処置するためのレフルノミド類似体 |
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| CA2399840C (en) | 2010-10-19 |
| EP1448202A1 (en) | 2004-08-25 |
| WO2003039552A1 (en) | 2003-05-15 |
| CA2399840A1 (en) | 2003-05-09 |
| US20070270441A1 (en) | 2007-11-22 |
| US20030092706A1 (en) | 2003-05-15 |
| AU2002300754B2 (en) | 2008-05-15 |
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