JP2005508971A5 - - Google Patents
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- Publication number
- JP2005508971A5 JP2005508971A5 JP2003537610A JP2003537610A JP2005508971A5 JP 2005508971 A5 JP2005508971 A5 JP 2005508971A5 JP 2003537610 A JP2003537610 A JP 2003537610A JP 2003537610 A JP2003537610 A JP 2003537610A JP 2005508971 A5 JP2005508971 A5 JP 2005508971A5
- Authority
- JP
- Japan
- Prior art keywords
- tablet
- dry
- granules
- effective amount
- lubricant
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 239000008187 granular material Substances 0.000 claims 14
- 239000000314 lubricant Substances 0.000 claims 7
- 239000000203 mixture Substances 0.000 claims 6
- 239000008194 pharmaceutical composition Substances 0.000 claims 6
- YBBLVLTVTVSKRW-UHFFFAOYSA-N anastrozole Chemical compound N#CC(C)(C)C1=CC(C(C)(C#N)C)=CC(CN2N=CN=C2)=C1 YBBLVLTVTVSKRW-UHFFFAOYSA-N 0.000 claims 5
- 229960002932 anastrozole Drugs 0.000 claims 5
- 239000003085 diluting agent Substances 0.000 claims 5
- FQZYTYWMLGAPFJ-OQKDUQJOSA-N tamoxifen citrate Chemical compound [H+].[H+].[H+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O.C=1C=CC=CC=1C(/CC)=C(C=1C=CC(OCCN(C)C)=CC=1)/C1=CC=CC=C1 FQZYTYWMLGAPFJ-OQKDUQJOSA-N 0.000 claims 5
- 229960003454 tamoxifen citrate Drugs 0.000 claims 5
- NKANXQFJJICGDU-QPLCGJKRSA-N Tamoxifen Chemical compound C=1C=CC=CC=1C(/CC)=C(C=1C=CC(OCCN(C)C)=CC=1)/C1=CC=CC=C1 NKANXQFJJICGDU-QPLCGJKRSA-N 0.000 claims 4
- 238000000034 method Methods 0.000 claims 4
- 238000002156 mixing Methods 0.000 claims 4
- 239000011230 binding agent Substances 0.000 claims 3
- 239000007884 disintegrant Substances 0.000 claims 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 3
- WSVLPVUVIUVCRA-KPKNDVKVSA-N Alpha-lactose monohydrate Chemical compound O.O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O WSVLPVUVIUVCRA-KPKNDVKVSA-N 0.000 claims 2
- 229920002785 Croscarmellose sodium Polymers 0.000 claims 2
- 229920000168 Microcrystalline cellulose Polymers 0.000 claims 2
- WHNWPMSKXPGLAX-UHFFFAOYSA-N N-Vinyl-2-pyrrolidone Chemical compound C=CN1CCCC1=O WHNWPMSKXPGLAX-UHFFFAOYSA-N 0.000 claims 2
- GWEVSGVZZGPLCZ-UHFFFAOYSA-N Titan oxide Chemical compound O=[Ti]=O GWEVSGVZZGPLCZ-UHFFFAOYSA-N 0.000 claims 2
- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 claims 2
- 239000011248 coating agent Substances 0.000 claims 2
- 229960001681 croscarmellose sodium Drugs 0.000 claims 2
- 235000010947 crosslinked sodium carboxy methyl cellulose Nutrition 0.000 claims 2
- 238000001035 drying Methods 0.000 claims 2
- 239000008202 granule composition Substances 0.000 claims 2
- 239000004615 ingredient Substances 0.000 claims 2
- 229960001021 lactose monohydrate Drugs 0.000 claims 2
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 claims 2
- 235000019813 microcrystalline cellulose Nutrition 0.000 claims 2
- 239000008108 microcrystalline cellulose Substances 0.000 claims 2
- 229940016286 microcrystalline cellulose Drugs 0.000 claims 2
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 claims 2
- 229920000036 polyvinylpyrrolidone Polymers 0.000 claims 2
- 229940069328 povidone Drugs 0.000 claims 2
- 229960001603 tamoxifen Drugs 0.000 claims 2
- 238000000576 coating method Methods 0.000 claims 1
- 238000007580 dry-mixing Methods 0.000 claims 1
- 238000009472 formulation Methods 0.000 claims 1
- 239000001866 hydroxypropyl methyl cellulose Substances 0.000 claims 1
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 claims 1
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 claims 1
- UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 claims 1
- 235000019359 magnesium stearate Nutrition 0.000 claims 1
- 239000003605 opacifier Substances 0.000 claims 1
- 239000000825 pharmaceutical preparation Substances 0.000 claims 1
- 239000004014 plasticizer Substances 0.000 claims 1
- 229940068886 polyethylene glycol 300 Drugs 0.000 claims 1
- 238000002360 preparation method Methods 0.000 claims 1
- 238000010298 pulverizing process Methods 0.000 claims 1
- 239000004408 titanium dioxide Substances 0.000 claims 1
- 238000009827 uniform distribution Methods 0.000 claims 1
- 238000005550 wet granulation Methods 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0125492.9A GB0125492D0 (en) | 2001-10-24 | 2001-10-24 | Formulation |
| PCT/GB2002/004835 WO2003035043A2 (en) | 2001-10-24 | 2002-10-23 | Pharmaceutical formulation comprising more than 15% tamoxifen |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2005508971A JP2005508971A (ja) | 2005-04-07 |
| JP2005508971A5 true JP2005508971A5 (enExample) | 2006-01-05 |
Family
ID=9924411
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003537610A Withdrawn JP2005508971A (ja) | 2001-10-24 | 2002-10-23 | 製剤 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US20050042279A1 (enExample) |
| EP (1) | EP1448171A2 (enExample) |
| JP (1) | JP2005508971A (enExample) |
| AU (1) | AU2002341145A1 (enExample) |
| GB (1) | GB0125492D0 (enExample) |
| WO (1) | WO2003035043A2 (enExample) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI547431B (zh) * | 2004-06-09 | 2016-09-01 | 史密斯克萊美占公司 | 生產藥物之裝置及方法 |
| CZ297446B6 (cs) * | 2004-09-30 | 2006-12-13 | Pliva - Lachema A. S. | Zpusob prípravy orální pevné lékové formy a orální pevná léková forma pripravená tímto zpusobem |
| US10201549B2 (en) * | 2013-06-14 | 2019-02-12 | Professional Compounding Centers Of America (Pcca) | Testosterone combined with anastrozole injection solutions |
| CN103393603B (zh) * | 2013-07-22 | 2015-04-01 | 南通广泰生化制品有限公司 | 枸橼酸他莫昔芬颗粒 |
| MX390899B (es) | 2015-10-30 | 2025-03-21 | Cancer Prevention Pharmaceuticals Inc | Formulación de combinación de dosis fija, eflornitina y sulindaco. |
| CN113133982B (zh) * | 2021-03-30 | 2022-08-02 | 北京鑫开元医药科技有限公司 | 一种阿那曲唑片及其制备方法 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4543370A (en) * | 1979-11-29 | 1985-09-24 | Colorcon, Inc. | Dry edible film coating composition, method and coating form |
| US4683256A (en) * | 1980-11-06 | 1987-07-28 | Colorcon, Inc. | Dry edible film coating composition, method and coating form |
| GB8501035D0 (en) * | 1985-01-16 | 1985-02-20 | Senior J | Prostaglandins |
| US4832956A (en) * | 1985-09-25 | 1989-05-23 | Gerhard Gergely | Disintegrating tablet and process for its preparation |
| US5681382A (en) * | 1995-08-22 | 1997-10-28 | Shin-Etsu Chemical Co., Ltd. | Rapidly soluble coating composition and method for preparing same |
| US6245352B1 (en) * | 1999-04-27 | 2001-06-12 | Eli Lilly And Company | Pharmaceutical formulation |
-
2001
- 2001-10-24 GB GBGB0125492.9A patent/GB0125492D0/en not_active Ceased
-
2002
- 2002-10-23 JP JP2003537610A patent/JP2005508971A/ja not_active Withdrawn
- 2002-10-23 US US10/493,166 patent/US20050042279A1/en not_active Abandoned
- 2002-10-23 AU AU2002341145A patent/AU2002341145A1/en not_active Abandoned
- 2002-10-23 EP EP02774953A patent/EP1448171A2/en not_active Withdrawn
- 2002-10-23 WO PCT/GB2002/004835 patent/WO2003035043A2/en not_active Ceased
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