JP2005508960A - 5’−カルバモイル−1,1’−ビフェニル−4−カルボキサミド誘導体およびそのp38キナーゼ阻害剤としての使用 - Google Patents

5’−カルバモイル−1,1’−ビフェニル−4−カルボキサミド誘導体およびそのp38キナーゼ阻害剤としての使用 Download PDF

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JP2005508960A
JP2005508960A JP2003535783A JP2003535783A JP2005508960A JP 2005508960 A JP2005508960 A JP 2005508960A JP 2003535783 A JP2003535783 A JP 2003535783A JP 2003535783 A JP2003535783 A JP 2003535783A JP 2005508960 A JP2005508960 A JP 2005508960A
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alkyl
optionally substituted
methyl
compound
halogen
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JP2005508960A5 (enExample
Inventor
アンジェル,リチャード,マーティン
アストン,ニコラ,マリー
バムボロー,ポール
バムフォード,マーク,ジェームズ
コッカリル,ジョージ,スチュアート
マーリック,スザンヌ,ジョイ
ウォルカー,アン,ルイーズ
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Glaxo Group Ltd
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Glaxo Group Ltd
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Publication of JP2005508960A publication Critical patent/JP2005508960A/ja
Publication of JP2005508960A5 publication Critical patent/JP2005508960A5/ja
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    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
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    • C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
    • C07D295/125—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/13—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
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JP2003535783A 2001-10-17 2002-10-16 5’−カルバモイル−1,1’−ビフェニル−4−カルボキサミド誘導体およびそのp38キナーゼ阻害剤としての使用 Pending JP2005508960A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0124931.7A GB0124931D0 (en) 2001-10-17 2001-10-17 Chemical compounds
PCT/EP2002/011573 WO2003032980A1 (en) 2001-10-17 2002-10-16 5'-carbamoyl-1,1'-biphenyl-4-carboxamide derivatives and their use as p38 kinase inhibitors

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Publication Number Publication Date
JP2005508960A true JP2005508960A (ja) 2005-04-07
JP2005508960A5 JP2005508960A5 (enExample) 2006-01-05

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JP2003535783A Pending JP2005508960A (ja) 2001-10-17 2002-10-16 5’−カルバモイル−1,1’−ビフェニル−4−カルボキサミド誘導体およびそのp38キナーゼ阻害剤としての使用

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US (1) US7396843B2 (enExample)
EP (1) EP1435942A1 (enExample)
JP (1) JP2005508960A (enExample)
GB (1) GB0124931D0 (enExample)
WO (1) WO2003032980A1 (enExample)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2008542365A (ja) * 2005-05-31 2008-11-27 アストラゼネカ・アクチエボラーグ 新規なmchr1アンタゴニスト並びにmchr1媒介状態及び障害の処置のためのそれらの使用
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JP2013533879A (ja) * 2010-06-29 2013-08-29 アイアールエム・リミテッド・ライアビリティ・カンパニー Wntシグナル伝達経路調節のための組成物および方法
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