JP2005505270A - 単球性樹状細胞およびｔ細胞にｔｈ−１応答をプライミングするための組成物および方法 - Google Patents

単球性樹状細胞およびｔ細胞にｔｈ−１応答をプライミングするための組成物および方法 Download PDF

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JP2005505270A
JP2005505270A JP2003526345A JP2003526345A JP2005505270A JP 2005505270 A JP2005505270 A JP 2005505270A JP 2003526345 A JP2003526345 A JP 2003526345A JP 2003526345 A JP2003526345 A JP 2003526345A JP 2005505270 A JP2005505270 A JP 2005505270A
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cells
antigen
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dendritic cells
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マルニックス エル． ボッシュ，
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ノースウエスト バイオセラピューティクス，インコーポレイティド
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JP2003526345A 2001-09-06 2002-09-06 単球性樹状細胞およびｔ細胞にｔｈ−１応答をプライミングするための組成物および方法 Pending JP2005505270A (ja)

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US31759201P 2001-09-06 2001-09-06
PCT/US2002/028620 WO2003022215A2 (en) 2001-09-06 2002-09-06 Compositions and methods for priming monocytic dendritic cells and t cells for th-1 response

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JP2011148711A Division JP5777956B2 (ja) 2001-09-06 2011-07-04 単球性樹状細胞およびｔ細胞にｔｈ−１応答をプライミングするための組成物および方法

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JP2005505270A5 JP2005505270A5 (enExample) 2005-12-08

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JP2003526345A Pending JP2005505270A (ja) 2001-09-06 2002-09-06 単球性樹状細胞およびｔ細胞にｔｈ−１応答をプライミングするための組成物および方法
JP2011148711A Expired - Fee Related JP5777956B2 (ja) 2001-09-06 2011-07-04 単球性樹状細胞およびｔ細胞にｔｈ−１応答をプライミングするための組成物および方法
JP2015040165A Expired - Fee Related JP6114768B2 (ja) 2001-09-06 2015-03-02 単球性樹状細胞およびｔ細胞にｔｈ−１応答をプライミングするための組成物および方法

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JP2015040165A Expired - Fee Related JP6114768B2 (ja) 2001-09-06 2015-03-02 単球性樹状細胞およびｔ細胞にｔｈ−１応答をプライミングするための組成物および方法

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EP (3) EP2322603B1 (enExample)
JP (3) JP2005505270A (enExample)
KR (3) KR20110081341A (enExample)
CN (2) CN102973928B (enExample)
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BR (1) BRPI0212545B8 (enExample)
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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4762887B2 (ja) * 2003-02-27 2011-08-31 ノースウエスト バイオセラピューティクス，インコーポレイティド 付加的なサイトカインの非存在下でｇｍ−ｃｓｆを用いる単球樹状前駆細胞からの樹状細胞の産生
JP2022552200A (ja) * 2019-10-07 2022-12-15 ノースウエスト バイオセラピューティクス，インコーポレイティド 樹状細胞およびＴ細胞の活性化を増強するためのならびにＴＨ－１免疫応答を誘導するためのｉｎ ｖｉｔｒｏの方法および組成物

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AT412145B (de) * 2002-09-13 2004-10-25 Forsch Krebskranke Kinder Verfahren zur herstellung eines zellulären immuntherapeutikums auf basis von il-12-freisetzenden dendritischen zellen
US20040057935A1 (en) * 2002-09-20 2004-03-25 Cedars-Sinai Medical Center Intratumoral delivery of dendritic cells
WO2004053072A2 (en) * 2002-12-06 2004-06-24 Northwest Biotherapeutics, Inc. Administration of dendritic cells partially matured in vitro for the treatment of tumors
EP1484064A1 (en) 2003-06-04 2004-12-08 Gesellschaft für Biotechnologische Forschung Therapeutical composition containing dentritic cells and use thereof
EP1670513B1 (en) * 2003-10-06 2013-01-23 Cedars-Sinai Medical Center Cox-2 inhibitors and dendritic cells for use in the treatment of cancer.
WO2005043155A1 (en) * 2003-10-21 2005-05-12 Cedars-Sinai Medical Center System and method for the treatment of cancer, including cancers of the central nervous system
JPWO2005042737A1 (ja) * 2003-11-04 2007-05-10 株式会社ディナベック研究所 遺伝子導入された樹状細胞の製造方法
CA2571849A1 (en) 2004-06-24 2006-01-05 Dnavec Research Inc. Anticancer agent containing dendritic cell having rna virus transferred thereinto
KR20150082688A (ko) * 2005-12-08 2015-07-15 노쓰웨스트 바이오써라퓨틱스, 인크. 미성숙 단핵구성 수지상 세포의 활성화를 유도하기 위한 조성물 및 방법
EP1840206A1 (en) * 2006-03-28 2007-10-03 Gsf-Forschungszentrum Für Umwelt Und Gesundheit, Gmbh Compositions for the preparation of mature dendritic cells
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ES2565779T3 (es) * 2008-09-02 2016-04-06 Cedars-Sinai Medical Center Epítopos CD133
WO2010129895A2 (en) * 2009-05-07 2010-11-11 Immunocellular Therapeutics, Ltd. Cd133 epitopes
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US20140065173A1 (en) * 2012-09-06 2014-03-06 Orbis Health Solutions Llc Tumor lysate loaded particles
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US10137182B2 (en) 2013-02-14 2018-11-27 Immunocellular Therapeutics, Ltd. Cancer vaccines and vaccination methods
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Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2000143534A (ja) * 1998-11-13 2000-05-23 Asahi Chem Ind Co Ltd 樹状細胞ワクチン及びその製造方法
WO2001048154A1 (en) * 1999-12-28 2001-07-05 Toyoshima, Kumao Maturation-promoting agent for immature dendritic cells
US6274378B1 (en) * 1997-10-27 2001-08-14 The Rockefeller University Methods and compositions for obtaining mature dendritic cells
WO2003010292A2 (en) * 2001-07-25 2003-02-06 Northwest Biotherapeutics, Inc. Methods and apparatus for enrichment and culture of monocytic dendritic cell precursors
JP2003533486A (ja) * 2000-05-12 2003-11-11 ノースウエスト バイオセラピューティクス，インコーポレイティド ヒト樹状細胞による外因性抗原のクラスｉ提示を増加させる方法
JP2004520033A (ja) * 2001-01-15 2004-07-08 イ・デ・エム・イミュノ−デジネ・モレキュル 分化拘束された成熟樹状細胞の調製用補助組成物

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5162504A (en) 1988-06-03 1992-11-10 Cytogen Corporation Monoclonal antibodies to a new antigenic marker in epithelial prostatic cells and serum of prostatic cancer patients
US5366866A (en) * 1991-07-25 1994-11-22 Duke University Method of diagnosing ovarian and endometrial cancer with monoclonal antibodies OXA and OXB
US5227471A (en) * 1992-01-30 1993-07-13 Eastern Virginia Medical School Of The Medical College Of Hampton Roads Monoclonal antibody PD41 that binds to a prostate mucin antigen that is expressed in human prostatic carcinoma
US5788963A (en) 1995-07-31 1998-08-04 Pacific Northwest Cancer Foundation Isolation and/or preservation of dendritic cells for prostate cancer immunotherapy
EA199800272A1 (ru) * 1995-10-04 1998-10-29 Иммунекс Корпорейшн Фактор, стимулирующий дендритные клетки
US7659119B2 (en) * 1996-02-12 2010-02-09 Argos Therapeutics, Inc. Method and compositions for obtaining mature dendritic cells
JP2000279181A (ja) * 1999-04-01 2000-10-10 Japan Science & Technology Corp ヒト樹状細胞の発現遺伝子群
US6247378B1 (en) * 2000-01-06 2001-06-19 Deere & Company Operator control device for an infinitely variable transmission

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6274378B1 (en) * 1997-10-27 2001-08-14 The Rockefeller University Methods and compositions for obtaining mature dendritic cells
JP2000143534A (ja) * 1998-11-13 2000-05-23 Asahi Chem Ind Co Ltd 樹状細胞ワクチン及びその製造方法
WO2001048154A1 (en) * 1999-12-28 2001-07-05 Toyoshima, Kumao Maturation-promoting agent for immature dendritic cells
JP2003533486A (ja) * 2000-05-12 2003-11-11 ノースウエスト バイオセラピューティクス，インコーポレイティド ヒト樹状細胞による外因性抗原のクラスｉ提示を増加させる方法
JP2004520033A (ja) * 2001-01-15 2004-07-08 イ・デ・エム・イミュノ−デジネ・モレキュル 分化拘束された成熟樹状細胞の調製用補助組成物
WO2003010292A2 (en) * 2001-07-25 2003-02-06 Northwest Biotherapeutics, Inc. Methods and apparatus for enrichment and culture of monocytic dendritic cell precursors

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4762887B2 (ja) * 2003-02-27 2011-08-31 ノースウエスト バイオセラピューティクス，インコーポレイティド 付加的なサイトカインの非存在下でｇｍ−ｃｓｆを用いる単球樹状前駆細胞からの樹状細胞の産生
JP2022552200A (ja) * 2019-10-07 2022-12-15 ノースウエスト バイオセラピューティクス，インコーポレイティド 樹状細胞およびＴ細胞の活性化を増強するためのならびにＴＨ－１免疫応答を誘導するためのｉｎ ｖｉｔｒｏの方法および組成物

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