JP2005504749A5 - - Google Patents

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Publication number

JP2005504749A5

JP2005504749A5 JP2003516455A JP2003516455A JP2005504749A5 JP 2005504749 A5 JP2005504749 A5 JP 2005504749A5 JP 2003516455 A JP2003516455 A JP 2003516455A JP 2003516455 A JP2003516455 A JP 2003516455A JP 2005504749 A5 JP2005504749 A5 JP 2005504749A5

Authority

JP

Japan

Prior art keywords

alkyl

alkoxy

group

compound

independently

Prior art date

2002-07-31

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

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• 125000000217 alkyl group Chemical group 0.000 claims 33
• 150000001875 compounds Chemical class 0.000 claims 33
• 125000003545 alkoxy group Chemical group 0.000 claims 28
• 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 22
• 239000000427 antigen Substances 0.000 claims 16
• 102000036639 antigens Human genes 0.000 claims 16
• 108091007433 antigens Proteins 0.000 claims 16
• 238000009472 formulation Methods 0.000 claims 13
• 239000000203 mixture Substances 0.000 claims 13
• 125000003342 alkenyl group Chemical group 0.000 claims 12
• 125000003282 alkyl amino group Chemical group 0.000 claims 10
• 125000004043 oxo group Chemical group O=* 0.000 claims 10
• 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 claims 6
• 230000028993 immune response Effects 0.000 claims 6
• 229910052760 oxygen Inorganic materials 0.000 claims 6
• 125000004178 (C1-C4) alkyl group Chemical group 0.000 claims 5
• 239000002671 adjuvant Substances 0.000 claims 5
• -1 methylene, amino Chemical group 0.000 claims 5
• QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims 4
• 125000001153 fluoro group Chemical group F* 0.000 claims 4
• 239000001301 oxygen Substances 0.000 claims 4
• 230000004936 stimulating effect Effects 0.000 claims 4
• 239000000568 immunological adjuvant Substances 0.000 claims 3
• 238000000034 method Methods 0.000 claims 3
• 150000003839 salts Chemical class 0.000 claims 3
• 229960005486 vaccine Drugs 0.000 claims 3
• 229910019142 PO4 Inorganic materials 0.000 claims 2
• 125000004442 acylamino group Chemical group 0.000 claims 2
• 125000004423 acyloxy group Chemical group 0.000 claims 2
• 125000000033 alkoxyamino group Chemical group 0.000 claims 2
• 125000005530 alkylenedioxy group Chemical group 0.000 claims 2
• 125000003118 aryl group Chemical group 0.000 claims 2
• 125000000732 arylene group Chemical group 0.000 claims 2
• 229910052799 carbon Inorganic materials 0.000 claims 2
• 229910052736 halogen Inorganic materials 0.000 claims 2
• 150000002367 halogens Chemical group 0.000 claims 2
• 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 2
• 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 2
• 229910052757 nitrogen Inorganic materials 0.000 claims 2
• 235000021317 phosphate Nutrition 0.000 claims 2
• 125000002467 phosphate group Chemical group [H]OP(=O)(O[H])O[*] 0.000 claims 2
• 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 2
• LZOZLBFZGFLFBV-UHFFFAOYSA-N sulfene Chemical compound C=S(=O)=O LZOZLBFZGFLFBV-UHFFFAOYSA-N 0.000 claims 2
• 150000003462 sulfoxides Chemical class 0.000 claims 2
• 150000003573 thiols Chemical class 0.000 claims 2
• NLFBCYMMUAKCPC-KQQUZDAGSA-N ethyl (e)-3-[3-amino-2-cyano-1-[(e)-3-ethoxy-3-oxoprop-1-enyl]sulfanyl-3-oxoprop-1-enyl]sulfanylprop-2-enoate Chemical compound CCOC(=O)\C=C\SC(=C(C#N)C(N)=O)S\C=C\C(=O)OCC NLFBCYMMUAKCPC-KQQUZDAGSA-N 0.000 claims 1
• NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 claims 1
• 239000010452 phosphate Substances 0.000 claims 1
• 150000003013 phosphoric acid derivatives Chemical class 0.000 claims 1
• LMBFAGIMSUYTBN-MPZNNTNKSA-N teixobactin Chemical compound C([C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H]1C(N[C@@H](C)C(=O)N[C@@H](C[C@@H]2NC(=N)NC2)C(=O)N[C@H](C(=O)O[C@H]1C)[C@@H](C)CC)=O)NC)C1=CC=CC=C1 LMBFAGIMSUYTBN-MPZNNTNKSA-N 0.000 claims 1