JP2005504507A5 - - Google Patents

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Publication number
JP2005504507A5
JP2005504507A5 JP2002570676A JP2002570676A JP2005504507A5 JP 2005504507 A5 JP2005504507 A5 JP 2005504507A5 JP 2002570676 A JP2002570676 A JP 2002570676A JP 2002570676 A JP2002570676 A JP 2002570676A JP 2005504507 A5 JP2005504507 A5 JP 2005504507A5
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JP
Japan
Prior art keywords
human
cells
gene
ungulate
cell
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JP2002570676A
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English (en)
Japanese (ja)
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JP2005504507A (ja
JP3797974B2 (ja
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Priority claimed from PCT/US2001/043128 external-priority patent/WO2002070648A2/en
Publication of JP2005504507A publication Critical patent/JP2005504507A/ja
Publication of JP2005504507A5 publication Critical patent/JP2005504507A5/ja
Application granted granted Critical
Publication of JP3797974B2 publication Critical patent/JP3797974B2/ja
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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JP2002570676A 2000-11-17 2001-11-16 クローン化トランスジェニック有蹄動物における異種(ヒト)免疫グロブリンの発現 Expired - Fee Related JP3797974B2 (ja)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US71418500A 2000-11-17 2000-11-17
US25645800P 2000-12-20 2000-12-20
US31162501P 2001-08-09 2001-08-09
PCT/US2001/043128 WO2002070648A2 (en) 2000-11-17 2001-11-16 Expression of xenogenous (human) immunoglobulins in cloned, transgenic ungulates

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2005136675A Division JP2005224250A (ja) 2000-11-17 2005-05-09 クローン化トランスジェニック有蹄動物における異種(ヒト)免疫グロブリンの発現

Publications (3)

Publication Number Publication Date
JP2005504507A JP2005504507A (ja) 2005-02-17
JP2005504507A5 true JP2005504507A5 (OSRAM) 2005-09-02
JP3797974B2 JP3797974B2 (ja) 2006-07-19

Family

ID=27400960

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2002570676A Expired - Fee Related JP3797974B2 (ja) 2000-11-17 2001-11-16 クローン化トランスジェニック有蹄動物における異種(ヒト)免疫グロブリンの発現
JP2005136675A Pending JP2005224250A (ja) 2000-11-17 2005-05-09 クローン化トランスジェニック有蹄動物における異種(ヒト)免疫グロブリンの発現

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2005136675A Pending JP2005224250A (ja) 2000-11-17 2005-05-09 クローン化トランスジェニック有蹄動物における異種(ヒト)免疫グロブリンの発現

Country Status (11)

Country Link
EP (2) EP1343880B1 (OSRAM)
JP (2) JP3797974B2 (OSRAM)
KR (2) KR100882029B1 (OSRAM)
CN (1) CN1486365B (OSRAM)
AT (2) ATE503012T1 (OSRAM)
AU (2) AU2001297523B2 (OSRAM)
CA (1) CA2428053C (OSRAM)
DE (2) DE60138832D1 (OSRAM)
MX (1) MXPA03004313A (OSRAM)
NZ (1) NZ525664A (OSRAM)
WO (1) WO2002070648A2 (OSRAM)

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US7414170B2 (en) 1999-11-19 2008-08-19 Kirin Beer Kabushiki Kaisha Transgenic bovines capable of human antibody production
US7074983B2 (en) 1999-11-19 2006-07-11 Kirin Beer Kabushiki Kaisha Transgenic bovine comprising human immunoglobulin loci and producing human immunoglobulin
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WO2003097812A2 (en) * 2002-05-17 2003-11-27 Hematech, Llc Transgenic ungulates capable of human antibody production
CN1717483A (zh) * 2002-10-04 2006-01-04 麒麟麦酒株式会社 人类人工染色体(hac)载体
KR20050093761A (ko) 2002-11-08 2005-09-23 헤마테크, 엘엘씨 프리온 단백질 활성이 감소된 트랜스제닉 유제동물 및 그의용도
AU2004266246A1 (en) 2003-08-14 2005-03-03 Dyax Corp. Endotheliase-2 ligands
EP1685245A4 (en) * 2003-09-30 2007-01-03 Sterrenbeld Biotechnologie North America Inc METHOD FOR PRODUCING TRANSGENER MAMMERS THAT PRODUCE EXOGENE PROTEINS IN THE MILK, AND THEREFORE PRODUCED TRANSGENIC MAMMALS
CA2563064A1 (en) 2004-04-22 2005-11-10 Kirin Beer Kabushiki Kaisha Transgenic animals and uses thereof
US20060130157A1 (en) * 2004-10-22 2006-06-15 Kevin Wells Ungulates with genetically modified immune systems
US20080026457A1 (en) 2004-10-22 2008-01-31 Kevin Wells Ungulates with genetically modified immune systems
WO2006117910A1 (ja) 2005-04-28 2006-11-09 Mochida Pharmaceutical Co., Ltd. 抗血小板膜糖蛋白質ⅵモノクローナル抗体
DK2348827T3 (en) 2008-10-27 2015-07-20 Revivicor Inc IMMUNICIPLY COMPROMATED PETS
KR101711222B1 (ko) * 2008-12-18 2017-02-28 에라스무스 유니버시티 메디컬 센터 로테르담 인간화 항체들을 발현하는 비-인간 유전자이식 동물들 및 그의 이용
US9445581B2 (en) 2012-03-28 2016-09-20 Kymab Limited Animal models and therapeutic molecules
ES2948572T3 (es) 2009-07-08 2023-09-14 Kymab Ltd Modelos de roedores y moléculas terapéuticas
WO2011062207A1 (ja) 2009-11-17 2011-05-26 協和発酵キリン株式会社 ヒト人工染色体ベクター
EP2757875B2 (en) 2011-09-19 2023-03-22 Kymab Limited Manipulation of immunoglobulin gene diversity and multi-antibody therapeutics
EP2759551B1 (en) 2011-09-21 2019-05-22 Fujirebio Inc. Antibodies binding to an affinity complex comprising 25oh vitamin d2 or d3 and an antibody thereto
WO2013045916A1 (en) 2011-09-26 2013-04-04 Kymab Limited Chimaeric surrogate light chains (slc) comprising human vpreb
US9253965B2 (en) 2012-03-28 2016-02-09 Kymab Limited Animal models and therapeutic molecules
BR112014012667A2 (pt) 2011-12-22 2018-10-09 F Hoffmann-La Roche Ag vetor de expressão, usos de vetor de expressão, método de transfecção de células eucarióticas, uso de método, uso de célula, métodos de produção de anticorpos e método de transfecção
US10251377B2 (en) 2012-03-28 2019-04-09 Kymab Limited Transgenic non-human vertebrate for the expression of class-switched, fully human, antibodies
GB2502127A (en) 2012-05-17 2013-11-20 Kymab Ltd Multivalent antibodies and in vivo methods for their production
EP2880055B1 (en) 2012-08-03 2017-06-28 Sab, Llc Complex chromosome engineering for production of human antibodies in transgenic animals
US9788534B2 (en) 2013-03-18 2017-10-17 Kymab Limited Animal models and therapeutic molecules
US9783618B2 (en) 2013-05-01 2017-10-10 Kymab Limited Manipulation of immunoglobulin gene diversity and multi-antibody therapeutics
US11707056B2 (en) 2013-05-02 2023-07-25 Kymab Limited Animals, repertoires and methods
US9783593B2 (en) 2013-05-02 2017-10-10 Kymab Limited Antibodies, variable domains and chains tailored for human use
ES2993142T3 (en) 2013-10-01 2024-12-23 Kymab Ltd Animal models and therapeutic molecules
US9888673B2 (en) 2014-12-10 2018-02-13 Regents Of The University Of Minnesota Genetically modified cells, tissues, and organs for treating disease
JP7519660B2 (ja) * 2016-06-14 2024-07-22 リージェンツ オブ ザ ユニバーシティ オブ ミネソタ 疾患を処置するための遺伝子改変された細胞、組織、および臓器
CN109906272A (zh) 2016-10-31 2019-06-18 国立大学法人鸟取大学 产生人抗体的非人动物和使用该非人动物的人抗体制作方法
CA3167191A1 (en) * 2020-02-12 2021-08-19 Eddie J. Sullivan Anti-thymocyte globulin

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